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Importance of incorporating systemic cerebroarterial hemodynamics into computational modeling of blood flow in intracranial aneurysm

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Journal of Hydrodynamics 2020年第3期32卷 510-522页

作者： Zhi-qiang zhang Li-jian Xu Rong Liu Xiao-sheng Liu bing-Zhao Fu-you Liang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai 200240China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHong KongChina Department of Radiology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Institute for Personalized Medicine Sechenov UniversityMoscow 119991Russia

The importance of properly treating boundary conditions (BCs) in numerical simulation of hemodynamics in intracranial aneurysm (IA) has been increasingly recognized. In this study, we constructed three types of computational model for each IA to investigate how the outcome of numerical simulation is affected by the treatment of BCs. The first type of model (i.e., Type-A model) was obtained by applying 3-D hemodynamic modeling to the entire cerebral arterial network, with its solution being taken as the reference for evaluating the performance of the other two types of model (i.e., Type-B and Type-C models) in which 3-D modeling was confined to the aneurysm region. In addition, patient-specific 1-D models of the cerebral arterial network were developed to provide hemodynamic information for setting the inflow/outflow BCs of the 3-D models. Numerical tests on three IAs revealed that prescribing the outflow BCs of a localized 3-D aneurysm model based on 1-D model-simulated outflow division (i.e., Type-B model) instead of imposing the free outflow BC on all outlets (i.e., Type-C model) helped to improve the fidelity of the simulation of intra-aneurysmal hemodynamics, but could not guarantee a complete reproduction of the reference solution obtained by the Type-A model. Moreover, it was found that the outcome of hemodynamic simulation was more sensitive to the treatment of BCs when an aneurysm was located at arterial bifurcation rather than sidewall. These findings highlight the importance of taking into account systemic cerebroarterial hemodynamics in computational modeling of hemodynamics in IAs, especially those located at bifurcations.

关键词： Intracranial aneurysm systemic cerebroarterial hemodynamics boundary conditions computational model

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Silicon-carbide fiber-reinforced polymer electrolyte for all-solid-state lithium-metal batteries

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Rare Metals 2022年第11期41卷 3774-3782页

作者： Wen-Qing Wei bing-qiang Liu Yan-Qing Wang Kai Yan Hao zhang Yu-Song Qi School of Mechanical and Automation Weifang UniversityWeifang261061China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao266590China School of Mechanical and Electrical Weifang University of Science and TechnologyShouguang262700China

Silicon carbide(SiC) with various morphologies was employed as reinforcing fillers for poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs).Specific ally,the SiC nanoparticles with an average size of 5-10 μm endow a significant enhancement of the interaction between carbon atoms for the fillers and the oxygen atoms from the PEO-lithium bis(trifluoromethanesulfonyl)imide(LiTFSI) matrix,which provides rapid transport channels for mobile Li+and enhances the mechanical strength of *** SPEs reinforced with one-dimensional SiC nanoparticles exhibit superior Li^(+)conduction,good mechanical property,and uniform Li ***,a dendrite-free plating of lithium for 0.58 mAh at 0.1 mA·cm^(-2) and excellent cycle stability at various current densities for 250 h are achieved in Li/Li symmetric cells using SPEs electrolytes with 5.0 wt% SiC ***,the LiFePO_(4)/Li full cells assembled using SPEs electrolytes with 5.0 wt% SiC nanoparticles provide a capacity of 151.5 mAh·g^(-1) at 0.1 mA·cm^(-2)(55℃),and maintained a Coulombic efficiency of 99% for 120 cycles.

关键词： All-solid-state batteries Polymer electrolyte Ionic conductivity Mechanical property Lithium dendrites

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Preparation and characterization of porous ceramics prepared by kaolinite gangue and Al(OH)_3 with double addition of MgCO_3 and CaCO_3

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 450-454页

作者： Wen Yan Nan Li bing-qiang Han The Key State Laboratory Breeding Base of Refractories and Ceramics Wuhan University of Science and Technology Wuhan 430081 China

Porous ceramics were prepared from kaolinite gangue and Al（OH）3 with double addition of MgCO3 and CaCO3 by the pore-forming in-situ *** characterizations of porous ceramics were investigated by X-ray diffractometry,scanning electron microscopy,and mercury porosimetry measurements,*** is found that although the decomposition of MgCO3 and CaCO3 has little contribution to the porosity,the double addition of MgCO3 and CaCO3 strongly affects the formation of liquid phase,and then changes the phase compositions,pore characterization,and *** appropriate mode is the sample containing 1.17wt% MgCO3 and 1.17wt% CaCO3,which has high apparent porosity（41.0%）,high crushing strength（53.5 MPa）,high mullite content（76wt%）,and small average pore size（3.24 μm）.

关键词： porous ceramics characterization kaolinite aluminum hydrxide additives

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Complex adaptive system theory,agent-based modeling,and simulation in dominant technology formation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 130-153页

作者： zhang Ruihan SUN bing Glorious Sun School of Business and Management Donghua UniversityShanghai 200051China School of Economics and Management Harbin Engineering UniversityHarbin 150001China

Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and ***,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical *** results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and ***,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical *** is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different *** study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.

关键词： complex adaptive system theory agent-based modeling and simulation dominant technology socio-technical landscape adaptation-choice

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Insight into the selective separation of CO_(2)from biomass pyrolysis gas over metal-incorporated nitrogen-doped carbon materials:a first-principles study

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 1-12页

作者： Li Zhao Xinru Liu Zihao Ye Bin Hu Haoyu Wang Ji Liu bing zhang qiang Lu National Engineering Research Center of New Energy Power Generation North China Electric Power UniversityBeijing102206China

The composition of biomass pyrolysis gas is complex,and the selective separation of its components is crucial for its further ***-incorporated nitrogen-doped materials exhibit enormous potential,whereas the relevant adsorption mechanism is still ***,16 metal-incorporated nitrogen-doped carbon materials were designed based on the density functional theory calculation,and the adsorption mechanism of pyrolysis gas components H2,CO,CO_(2),CH_(4),and C2H6 was *** results indicate that metal-incorporated nitrogen-doped carbon materials generally have better adsorption effects on CO and CO_(2)than on H_(2),CH_(4),and C_(2)H_(6).Transition metal Mo-and alkaline earth metal Mg-and Ca-incorporated nitrogen-doped carbon materials show the potential to separate CO and CO_(2).The mixed adsorption results of CO_(2)and CO further indicate that when the CO_(2)ratio is significantly higher than that of CO,the saturated adsorption of CO_(2)will precede that of ***,the three metal-incorporated nitrogen-doped carbon materials can selectively separate CO_(2),and the alkaline earth metal Mg-incorporated nitrogen-doped carbon material has the best *** study provides theoretical guidance for the design of carbon capture materials and lays the foundation for the efficient utilization of biomass pyrolysis gas.

关键词： CO_(2)capture biomass pyrolysis gas selective adsorption carbon materials first-principles

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Experiments on film cooling with sonic injection into a supersonic flow

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航空动力学报 2015年第5期30卷 1084-1091页

作者： zhang Jia SUN bing School of Astronautics Beijing University of Aeronautics and Astronautics

Film cooling experiments with sonic injection were conducted to investigate the effects of the number of the injection holes,the mass flow ratio,and the hole spacing on the film cooling *** mainstream was obtained by the hydrogen-oxygen combustion,entering the experimental section at a Mach number of *** nitrogen with ambient temperature was injected into the experimental section at a sonic *** measured mainstream recovery temperature was approximately *** mass flow ratio was regulated by varying the nitrogen injection *** experimental results show that for the investigated cooling surface,the cooling effectiveness increases with the increase in the number of the injection holes with other parameters held *** a fixed cooling configuration,the cooling effectiveness increases with the increase in the mass flow *** from the subsonic film cooling,the optimal mass flow ratio is not *** the hole spacing is less than 4,no obvious difference is observed on the cooling effectiveness and lateral *** the mass flow ratio increasing further,this difference becomes much *** shock wave also has an effect on the cooling *** the incident point of the shock wave,the cooling effectiveness is lower than that in the case without the shock wave.

关键词： supersonic film cooling discrete hole film cooling effectiveness mass flow ratio hole spacing

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An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal

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Bioactive Materials 2023年第4期22卷 47-59页

作者： Yanan Sun Bochen Lyu Chang Yang bing He Hua zhang Xueqing Wang qiang zhang Wenbing Dai Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing100191China Department of Pharmaceutics School of Pharmaceutical SciencesHebei Medical UniversityShijiazhuang050017China

Mild photothermal therapy combined with immune checkpoint blockade has received increasing attention for the treatment of advanced or metastatic cancers due to its good therapeutic ***,it remains a challenge to facilely integrate the two therapies and make it potential for clinical *** work designed a peptide-photosensitizer conjugate(PPC),which consisted of a PD-L1 antagonist peptide(CVRARTR),an MMP-2 specific cleavable sequence,a self-assembling motif,and the photosensitizer Purpurin *** single-component PPC can self-assemble into nanospheres which is suitable for intravenous *** PPC nanosphere is cleaved by MMP-2 when it accumulates in tumor sites,thereby initiating the cancer-specific release of the antagonist ***,the nanospheres gradually transform into co-assembled nanofibers,which promotes the retention of the remaining parts within the *** vivo studies demonstrated that PPC nanospheres under laser irradiation promote the infiltration of cytotoxic T lymphocytes and maturation of DCs,which sensitize 4T1 tumor cells to immune checkpoint blockade ***,PPC nanospheres inhibit tumor growth efficiently both in situ and distally and blocked the formation of lung *** present study provides a simple and efficient integrated strategy for breast cancer photoimmunotherapy.

关键词： Transformable nanomedicine Self-assembled peptide Immune checkpoint blockade Photothermal therapy Photoimmunotherapy

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Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme‑Induced Proximity Labeling

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Nano-Micro Letters 2024年第6期16卷 14-37页

作者： Junji Ren Zibin zhang Shuo Geng Yuxi Cheng Huize Han Zhipu Fan Wenbing Dai Hua zhang Xueqing Wang qiang zhang bing He Department of Pharmaceutics School of Pharmaceutical Sciences Peking University38 Xueyuan RdHaidian DistrictBeijing 100191People’s Republic of China

Achieving increasingly finely targeted drug delivery to organs,tissues,cells,and even to intracellular biomacromolecules is one of the core goals of *** the delivery destination is refined to cellular and subcellular targets,it is essential to explore the delivery of nanomedicines at the molecular ***,due to the lack of technical methods,the molecular mechanism of the intracellular delivery of nanomedicines remains unclear to ***,we develop an enzyme-induced proximity labeling technology in nanoparticles(nano-EPL)for the real-time monitoring of proteins that interact with intracellular ***(lactic-co-glycolic acid)nanoparticles coupled with horseradish peroxidase(HRP)were fabricated as a model(HRP(+)-PNPs)to evaluate the molecular mechanism of nano delivery in *** adding the labeling probe biotin-phenol and the catalytic substrate H_(2)O_(2)at different time points in cellular delivery,nano-EPL technology was validated for the real-time in situ labeling of proteins interacting with ***-EPL achieves the dynamic molecular profiling of 740 proteins to map the intracellular delivery of HRP(+)-PNPs in macrophages over *** on dynamic clustering analysis of these proteins,we further discovered that different organelles,including endosomes,lysosomes,the endoplasmic reticulum,and the Golgi apparatus,are involved in delivery with distinct participation *** importantly,the engagement of these organelles differentially affects the drug delivery efficiency,reflecting the spatial–temporal heterogeneity of nano delivery in *** summary,these findings highlight a significant methodological advance toward understanding the molecular mechanisms involved in the intracellular delivery of nanomedicines.

关键词： Enzyme-induced proximity labeling Intracellular delivery Nano-protein interaction Dynamic molecule profiling Macrophages

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The delay time of gravitational wave-gamma-ray burst associations

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Frontiers of physics 2019年第6期14卷 133-143页

作者： bing zhang Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA

The first gravitational wave(GW)-gamma-ray burst(GRB)association,GW170817/GRB 170817A,had an offset in time,with the GRB trigger time delayed by^1.7 s with respect to the merger time of the GW *** generally discuss the astrophysical origin of the delay time,Δt,of GW-GRB associations within the context of compact binary coalescence(CBC)-short GRB(sGRB)associations and GW burst-long GRB(lGRB)*** general,the delay time should include three terms,the time to launch a clean(relativistic)jet,Δtjet;the time for the jet to break out from the surrounding medium,Δtbo;and the time for the jet to reach the energy dissipation and GRB emission site,Δ*** CBC-sGRB associations,Δtjet andΔtbo are correlated,and the final delay can be from 10 ms to a few *** GWB-lGRB associations,Δtjet andΔtbo are *** latter is at least^10 s,so thatΔt of these associations is at least this *** certain jet launching mechanisms of lGRBs,Δt can be minutes or even hours long due to the extended engine waiting time to launch a *** discuss the cases of GW170817/GRB 170817A and GW150914/GW150914-GBM within this theoretical framework and suggest that the delay times of future GW/GRB associations will shed light into the jet launching mechanisms of GRBs.

关键词： gravitational waves gamma-ray bursts general

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THREE-DIMENSIONAL NUMERICAL SIMULATION OF WAVE SLAMMING ON AN OPEN STRUCTURE

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Journal of Hydrodynamics 2012年第4期24卷 526-534页

作者： DING Zhao-qiang WANG Guo-yu REN bing State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

The three-dimensional numerical simulation of wave slamming on an open structure in the splash zone is carried out based upon the Volume Of Fluid （VOF） method. A wave basin is established by solving the continuity equation and the Navier-Stoke equations. The linear wave-maker is placed on the left side of the basin, and the numerical sponge layer and the SRC are placed on the right side of the basin to damp the incident waves. The three-dimensional wave slamming boundary condition is adopted to model waves in contact with and separated from the underside of the structure. The numerical results of wave slamming on a foursquare structure for various parametric cases are verified by the experimental results. Meanwhile, the characteristics of the wave impact forces on the undersides of the rectangular structures with various length-breadth ratios are discussed.

关键词： wave slamming three-dimensional Volume Of Fluid (VOF)

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