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RNF187 governs the maintenance of mouse GC-2.cell development by facilitating histone H3 ubiquitination at K57/80

Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： bing-Ya Xu Xiang-Ling Yu Wen-Xin Gao Ting-Ting Gao hao-Yue Hu Tian-Tian Wu Cong Shen Xiao-Yan Huang Bo Zheng Yi-Bo Wu Human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2.cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2.***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2.cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2.cell histone H3 RNF187 ubiquitination

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-bing Xiao Hai-Tao Cao Rui Xue Jin-Ting Cai Ge-Ge Wang Marina Manganaro Shao-Hua Zhang Zhi-hao Ouyang Li-Ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+2..35,Ton 599,B2.42.+32.and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+2.,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+2.,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+2.,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+2..35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

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Surface engineering on MnO_(2.nanorods by La single atoms to accelerate oxygen reduction kinetics

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Rare Metals 2024年第9期43卷 4302-4311页

作者： Zhang-Long He Liu-Qi Wang Min Jiang Jia-Nan Xie Shan Liu Jin-Can Ren Rui Sun Wen-Bin Lv Wei-Bin Guo Yu-Ling Liu bing Li Qi Liu hao He School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410000China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics City University of Hong KongHong Kong 999077China

Surface engineering,which modulates the electronic structure and adsorption/desorption properties of electrocatalysts,is one of the key strategies for improving the catalytic ***,we demonstrate a facile solid-phase reaction for surface engineering of MnO_(2.to boost the oxygen reduction *** reaction with surface hydroxy groups,La single atoms with loading amount up to 2.7 wt%are anchored onto a-MnO_(2.*** surface engineering,the oxygen reduction reaction(ORR)kinetics is significantly improved with the half-wave potential from 0.70 to 0.84 V,the number of transferred electrons from 2.5 to 3.9 and the limiting current density from 4.8 to 6.0 mA·cm^(-2..In addition,the catalyst delivers superior discharge performance in both alkaline and neutral metal–air *** functional theory(DFT)calculations reveal that atomic La modulates the surface electronic configuration of MnO_(2.,reduces its d-band center and thus lowers the OOH*and O*reaction energy *** work provides a new route for rational design of highly active electrocatalyst and holds great potential for application in various catalytic reactions.

关键词： Surface engineering Single atoms Electron injection Oxygen reduction reaction Metal-air batteries

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Evidence for reversible oxygen ion movement during electrical pulsing:enabler of emerging ferroelectricity in binary oxides

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Materials Futures 2024年第3期3卷 195-205页

作者： Huan Liu Fei Yu bing Chen Zheng-Dong Luo Jiajia Chen Yong Zhang Ze Feng Hong Dong Xiao Yu Yan Liu Genquan Han Yue hao State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi’an 710071People’s Republic of China Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311121People’s Republic of China Engineering Research Center of Thin Film Optoelectronics Technology Ministry of EducationNankai UniversityTianjin 300350People’s Republic of China

Ferroelectric HfO_(2.-based materials and devices show promising potential for applications in information technology but face challenges with inadequate electrostatic control,degraded reliability,and serious variation in effective oxide thickness *** demonstrate a novel interface-type switching strategy to realize ferroelectric characteristics in atomic-scale amorphous binary oxide films,which are formed in oxygen-deficient conditions by atomic layer deposition at low *** approach can avoid the shortcomings of reliability degradation and gate leakage increment in scaling polycrystalline doped HfO_(2.-based *** theoretical modeling and experimental characterization,we show the following.(1)Emerging ferroelectricity exists in ultrathin oxide systems as a result of microscopic ion migration during the switching process.(2.These ferroelectric binary oxide films are governed by an interface-limited switching mechanism,which can be attributed to oxygen vacancy migration and surface defects related to electron(de)trapping.(3)Transistors featuring ultrathin amorphous dielectrics,used for non-volatile memory applications with an operating voltage reduced to±1 V,have also been experimentally *** findings suggest that this strategy is a promising approach to realizing next-generation complementary metal-oxide semiconductors with scalable ferroelectric materials.

关键词： ferroelectric binary oxide mobile ion amorphous dielectric nonvolatile memory

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Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

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Journal of Pharmaceutical Analysis 2024年第1期14卷 86-99页

作者： Shengyou Li Xue Gao Yi Zheng Yujie Yang Jianbo Gao Dan Geng Lingli Guo Teng Ma Yiming hao Bin Wei Liangliang Huang Yitao Wei bing Xia Zhuojing Luo Jinghui Huang Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi'an710032China

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid peroxidation. However, the molecular mechanisms of ferroptosis in the context of PNI and nerve regeneration remain unclear. Ferroportin (Fpn), the only known mammalian nonheme iron export protein, plays a pivotal part in inhibiting ferroptosis by maintaining intracellular iron homeostasis. Here, we explored in vitro and in vivo the involvement of Fpn in neuronal ferroptosis. We first delineated that reactive oxygen species at the injury site induces neuronal ferroptosis by increasing intracellular iron via accelerated UBA52.driven ubiquitination and degradation of Fpn, and stimulation of lipid peroxidation. Early administration of the potent arterial vasodilator, hydralazine (HYD), decreases the ubiquitination of Fpn after PNI by binding to UBA52. leading to suppression of neuronal cell death and significant acceleration of axon regeneration and motor function recovery. HYD targeting of ferroptosis is a promising strategy for clinical management of PNI.

关键词： Ferroptosis UBA52 Ferroportin Ubiquitination Hydralazine Peripheral nerve injury

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Tracking algorithm of Siamese network based on parallel multiple appearance features

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Kongzhi yu Juece/Control and Decision 2024年第11期39卷 3628-3636页

作者： Chen, Zhi-Wang Sun, Ze-bing Lv, Chang-hao Cao, Suo-Hang Peng, Yong Engineering Research Center of The Ministry of Education for Intelligent Control System and Intelligent Equipment Yanshan University Qinhuangdao 066004 China Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University Qinhuangdao 066004 China Key Lab of Power Electronics for Energy Conservation and Motor Drive of Hebei Province Yanshan University Qinhuangdao 066004 China School of Electrical Engineering Yanshan University Qinhuangdao 066004 China

Target tracking usually only uses the appearance information of the first frame of the video to obtain the appearance characteristics of the target online, and predict the position and size of the target in subsequent frames. However, the appearance of the target changes all the time during the tracking process, and the appearance of subsequent targets is not be accurately described by the first frame alone. Focusing on the above problems, this paper proposes a Siamese network target tracking algorithm based on parallel multi-appearance features. First, dynamic template frames containing information about the recent appearance of the target are introduced. At the same time, three methods of multi-appearance, parallel appearance and parallel multi-appearance are proposed, which make dynamic template frames for target tracking. Second, either the evaluation strategy of information entropy or the evaluation method of the neural network in the evaluation module is applied to score the obtained multiple predictions separately, and the prediction result with the highest score is selected as the final prediction result. Finally, an update module is proposed to analyse the scores obtained from the evaluation module. If the score meets the update conditions set by the update module, the final prediction result is used to update the dynamic template frame, and the new appearance information is used to guide the tracking of the next frame. The experimental results show that the algorithm achieves good results on standard datasets such as GOT-10k, OTB100, which verif the effectiveness of the proposed algorithm. © 2.2. Northeast University. All rights reserved.

关键词： Neural networks

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Quantitative analysis of the protective performance of bicycle helmet with multidirection impact protection system in oblique impact tests

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Chinese Journal of Traumatology 2024年第4期27卷 226-234页

作者： Yong Han hao Yang He Wu Di Pan bing-Yu Wang School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024Fujian provinceChina Fujian Key Laboratory of Bus Advanced Design and Manufacturing Xiamen361024Fujian provinceChina School of Aerospace Engineering Xiamen UniversityXiamen361005Fujian provinceChina

Purpose:The current study aimed to assess the protective performance of helmets equipped with multidirectional impact protection system(MIPS)under various oblique impact ***:Initially,a finite element model of a bicycle helmet with MIPS was developed based on thescanned geometric parameters of an actual bicycle ***,the validity of model wasconfirmed using the KASK WG11 oblique impact test *** different impact angles(30°,45°,and 60°)and 2.varying impact speeds(5 m/s and 8 m/s)were employed in oblique tests to evaluateprotective performance of MIPS in helmets,focusing on injury assessment parameters such as peaklinear acceleration(PLA)and peak angular acceleration(PAA)of the ***:The results demonstrated that in all impact simulations,both assessment parameters werelower during impact for helmets equipped with MIPS compared to those *** PAA wasconsistently lower in the MIPS helmet group,whereas the difference in PLA was not significant in the noMIPS helmet *** instance,at an impact velocity of 8 m/s and a 30°inclined anvil,the MIPS helmetgroup exhibited a PAA of 32.5 rad/s^(2. and a PLA of 2.1 *** contrast,the no-MIPS helmet group displayeda PAA of 82.3 rad/s^(2. and a PLA of 2.2.***,both PAA and PLA parameters decreased with theincrease of anvil *** a 60°anvil angles,PAA and PLA values were 664 rad/s^(2. and 2..7 g,respectively,reaching their ***:The findings indicated that helmets incorporating MIPS offer enhanced protection againstvarious oblique impact *** assessing helmets for oblique impacts,the utilization of larger angleanvils and rear impacts might not adequately evaluate protective performance during an impact *** findings will guide advancements in helmet design and the refinement of oblique impact testprotocols.

关键词： Oblique impact Multi-direction impact protection system WG11 oblique impact test Angular acceleration

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Giant retroperitoneal hemolymphangioma:A case report and review of literature

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World Journal of Clinical Cases 2024年第22期12卷 5258-5262页

作者： Yi-Kai Wang Ying-hao Liu Wei-bing Shuang Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Hemolymphangioma is a very rare benign tumor in clinical practice caused by abnormalities of the *** clinical features are often atypical,and it is easy to miss and *** the time of nuclear magnetic T1 is significantly reduced,the diagnosis of hemangioma should be ***,we report this case in the hope of raising clinicians'awareness of the *** SUMMARY A 37-year-old man presented with a giant retroperitoneal *** tomography and magnetic resonance imaging indicated the possibility of a large perirenal lymphatic *** postoperative pathological diagnosis is retroperitoneal *** patient underwent surgical excision after adequate *** postoperative recovery was smooth and there were no *** was no recurrence during half a year of *** This case reiterates that large retroperitoneal cystic masses with significantly shortened nuclear T1 time should be considered *** clinical basis and experience for the diagnosis and treatment of these diseases is necessary.

关键词： Hemolymphangioma Retroperitoneal tumor Surgical excision Magnetic resonance imaging Case report

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Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology,molecular docking,and in vitro validation

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3539-3558页

作者： Cheng-Lei Wang bing-Wei Yang Xin-Yan Wang Xue Chen Wei-Dong Li hao-Yu Zhai Ying Wu Mu-YaoCui Jia-He Wu Qing-Hui Meng Nan Zhang Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Scientific Research Management Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China School of Clinical Medicine Qinghai University Xining 810000Qinghai ProvinceChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Herba Patriniae and Coix seed(HC)constitute a widely utilized drug combination in the clinical management of colorectal cancer(CRC)that is known for its diuretic,anti-inflammatory,and swelling-reducing *** its efficacy has been demonstrated in a clinical setting,the active compounds and their mechanisms of action in CRC treatment remain to be fully *** To identify the active,CRC-targeting components of HC and to elucidate the mechanisms of action *** Active HC components were identified and screened using *** for each component were ***-related targets were obtained from human gene *** targets between HC and CRC were identified.A“drug-ingredient-target”network was created to identify the core components and targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were conducted to elucidate the key pathways *** docking between core targets and key components was *** vitro experiments validated core *** Nineteen active components of HC were identified,with acacetin as the primary active *** predictive analysis identified 454 targets of the active compounds in *** mapping with 2.85 CRC-related targets yielded 171 intervention targets,including 30 core *** and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase(PI3K)/Akt signaling *** docking showed that acacetin exhibited an optimal interaction with AKT1,identifying PI3K,AKT,and P53 as key genes likely targeted by HC during CRC *** inhibited HT-2. cell proliferation and migration,as well as promoted apoptosis,in *** blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K,p-Akt,and survivin,which likely contributed to CRC *** Acacetin,the principal active compound in the HC pair,inhibited the proliferati

关键词： Colorectal cancer Baijiangcao(Herba Patriniae) Yiyiren(Coix seed) Acacetin Proliferation Migration Apoptosis Network pharmacology

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基于功率谱熵的无线电引信目标与干扰信号分类方法

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北京航空航天大学学报 2024年第3期50卷 913-919页

作者：刘冰郝新红蔡鑫北京理工大学机电动态控制重点实验室北京100081

无线电调频引信在战场环境容易受到干扰信号的干扰导致早炸,丧失打击能力。为提升无线电调频引信抗干扰能力,准确识别引信目标与干扰信号,提出一种基于功率谱熵特征的无线电调频引信目标与干扰信号分类识别方法。利用实测采集的无线电... 详细信息

无线电调频引信在战场环境容易受到干扰信号的干扰导致早炸,丧失打击能力。为提升无线电调频引信抗干扰能力,准确识别引信目标与干扰信号,提出一种基于功率谱熵特征的无线电调频引信目标与干扰信号分类识别方法。利用实测采集的无线电引信检波端输出信号,通过提取目标和干扰信号的功率谱指数熵和Renyi熵特征构成特征向量,作为K邻近(KNN)分类器的输入进行目标和干扰信号分类识别,并利用5-折交叉检验方法对其进行验证。结果表明:目标和干扰信号的功率指数熵和Renyi熵具有显著差异性,使用KNN分类器对其进行分类识别时,最高的识别准确率可达99.47%。

关键词：无线电调频引信抗干扰功率谱熵特征目标分类 KNN算法

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