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Synthesis of N-Alkylperfluorooctanesulfonamides and Its Derivatives

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有机化学 2003年第Z1期23卷 118-119页

作者： LI Yan chen Zhi-Qi ZHOU Ye-bing chen Zu-xing LIU Zhao-Jie Faculty of Chemisty and Material Science Hubei University Wuhan 430062 Institute of Organic Synthesis Central China Normal University Wuhan 430079 Faculty of Chemisty and Material Science Hubei University Wuhan 430062 Faculty of Chemisty and Material Science Hubei University Wuhan 430062 Faculty of Chemisty and Material Science Hubei University Wuhan 430062 Institute of Organic Synthesis Central China Normal University Wuhan 430079

　　N-Alkylperfluorooctanesulfonamide compounds are special fine chemicals, and have been applied in many fields, such as vulcanizing agents for fluoro rubbers, smooth and friction reducing for coatings, fire extinguisher, anticorrosive agents for metals, water- and oil-repellents for leather, textiles and paper, photographic emulsion.[1]……

关键词： vulcanizing agents

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing chen Jiafu Ji Xiaofang xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution

Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1

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Chinese Medical Journal 2018年第1期131卷 82-87页

作者： Ying-chen Xu Jing Cui Li-Jun Zhang Dong-Xin Zhang bing-chen xing Xiong-Wei-Ye Huang Ji-Xiang Wu Chao-Jie Liang Guang-Ming Li Department of Hepatobiliary Surgery Surgical Laboratory Beijing Tong Ren Hospital Capital Medical University Beijing 100730 China Department of Pathology Capital Medical University Beijing 100069 China

Background： Decoy receptor 3 （DcR3） is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression was found to be related to the clinical stage, the invasion, and tile metastasis of the tumor. This in vitro study aimed to investigate the effect ofdownregulated expression of DcR3 on cell viability, cell apoptosis, and cell cycle in cholangiocarcinoma cell line TFK-1. Methods： Three different cell lines were cultured： human cholangiocarcinoma TFK-I, human biliary epithelial carcinoma HuCCT-1, and human cholangiocarcinoma RBE. The cholangiocarcinoma cell line with the highest expression of DcR3 was selected for further investigation. The expression of DcR3 was silenced/knocked down by transfection with DcR3-siRNA in the selected cell line. Various biological phenotype parameters such as cell viability, apoptosis, and cell cycle were observed. Results： The mRNA and protein levels of DcR3 were measured in the three cell lines, and TFK-1 was selected. After the treatment with DcR3-siRNA for 48 h, DcR3 mRNA and protein expression in the treatment group were 38.45% （P 〈 0.01 ） and 48.03% （P 〈 0.05） of that of＇the control, respectively. It was found that the cell viability decreased to 61.87% of the control group （P 〈 0.01 ） after the downregulation of DcR3 in cholangiocarcinoma cell line TFK- 1 by transfection with DcR3-siRNA, while tile percentage ofapoptotic cells was 2.98 times as compared with the control group （P 〈 0.05）. Compared with the control group the ratio of G0/G1 increased, and the ratio of G2/M dccreased in the treatment group. However, the differences were not statistically significant. Conclusions： The effect of DcR3 on the growth and apoptosis ofcholangiocarcinoma has been demonstrated. DcR3 is not only a predictive marker for malignant tumor but it is also likely to be a potential target for cancer gene therap

关键词： Apoptosis: Cell Cycle: Cholangiocarcinoma Decoy Receptor 3 TFK-1

基于表情子空间多分类器集成的非特定人人脸表情识别

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计算机应用 2011年第3期31卷 736-740页

作者：胡步发陈炳兴黄银成福州大学机械工程及自动化学院福州350108

针对非特定人人脸表情平均识别率普遍不高(约65%)的问题,提出了一种基于表情子空间和多分类器集成的人脸表情识别新方法。通过局部二进制模式(LBP)与高阶奇异值分解(HOSVD)方法对训练集1中的人脸图像的全脸、眼睛(包括眉毛)和嘴巴三个... 详细信息

针对非特定人人脸表情平均识别率普遍不高(约65%)的问题,提出了一种基于表情子空间和多分类器集成的人脸表情识别新方法。通过局部二进制模式(LBP)与高阶奇异值分解(HOSVD)方法对训练集1中的人脸图像的全脸、眼睛(包括眉毛)和嘴巴三个区域进行特征提取与分解,建立相应的表情子空间;利用支持向量机(SVM)方法对训练集2中的人脸图像在表情子空间训练,得到模糊系统参数;最后结合表情子空间与多分类器集成,对测试集中的图像进行表情分类识别。在JAFFE人脸表情库中实验,获得了71.43%的平均识别率。实验结果表明,该方法有效地减少了人脸外观特征和表情表现方式所带来的影响,具有更好的识别效果。

关键词：人脸表情非特定人多分类器集成高阶奇异值分解模糊规则

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《德意志意识形态》的理论价值

重庆与世界(学术版) 2016年第5期 27-30页

作者：陈炳杏华侨大学马克思主义学院

经实践检验和历史证明,《德意志意识形态》在马克思著作中地位举足轻重,它系统地阐述了马克思的重要理论的形成,完善了马克思主义理论体系的内容,标志着唯物主义的诞生和马克思世界观的形成,完成了哲学史上的变革,创立了科学的实践观点... 详细信息

经实践检验和历史证明,《德意志意识形态》在马克思著作中地位举足轻重,它系统地阐述了马克思的重要理论的形成,完善了马克思主义理论体系的内容,标志着唯物主义的诞生和马克思世界观的形成,完成了哲学史上的变革,创立了科学的实践观点,揭示了社会发展包括共产主义运动发展的一般规律,阐述了以生产力与生产关系的矛盾为核心的唯物史观基本原理。该著作是马克思主义学习者必修的经典著作。

关键词：德意志意识形态历史唯物主义市民社会交往意识形态

院前三维急救模式对急诊危重症患者抢救效果及预后的影响效果评价

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中外医疗 2020年第14期39卷 91-93页

作者：陈炳星福建省立医院急诊科/福建省急救中心/福建省急诊医学研究所福建福州350001

目的分析院前三维急救模式对急诊危重症患者抢救效果及预后的影响效果。方法研究观察方便选取的该院收治的70例急诊危重症患者,患者在2018年6月—2019年7月期间收治,按照入院的先后顺序分组,一组采取常规抢救流程,一组给与院前三维急救... 详细信息

目的分析院前三维急救模式对急诊危重症患者抢救效果及预后的影响效果。方法研究观察方便选取的该院收治的70例急诊危重症患者,患者在2018年6月—2019年7月期间收治,按照入院的先后顺序分组,一组采取常规抢救流程,一组给与院前三维急救模式,分别作为对照组和实验组,每组35例患者,比较两组患者的急救抢救效果。结果实验组患者急救应诊反应时间为(10.3±2.4)min,抢救时间为(15.7±3.8)min,护送检查时间为(8.4±1.2)min,其数据较对照组更低,差异有统计学意义(t=7.378、3.092、7.035,P<0.05);实验组患者致残率为5.71%(2例),并发症发生率为5.71%(2例),其数据较对照组低,差异有统计学意义(χ^2=4.200、4.519,P<0.05);实验组患者家属对抢救过程的满意度为94.29%(33例),其中非常满意17例,满意16例,其数据较对照组高,差异有统计学意义(P<0.05),患者未见死亡,病死亡率较对照组低,差异有统计学意义(P<0.05)。结论院前三维急救模式可显著降低急诊危重症患者抢救的时间消耗,并有效提升抢救质量,减少致残率和并发症,改善患者预后,值得使用。

关键词：院前三维急救模式急诊危重症抢救效果预后效果

Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao You Huiying Ouyang Ruixiang Deng Qiuqi Zhang Zhenzhong xing Xiaowu chen Qingliang Shan Jinshan Yang Shaoming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

E-PRedictor: an approach for early prediction of pull request acceptance

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Science China(Information Sciences) 2025年

作者： Kexing chen Lingfeng BAO xing HU Xin XIA Xiaohu YANG State Key Laboratory of Blockchain and Data Security Zhejiang University Software Engineering Application Technology Lab

A pull request (PR) is an event in Git where a contributor asks project maintainers to review code he/she wants to merge into a project. The PR mechanism greatly improves the efficiency of distributed software development in the opensource community. Nevertheless, the massive number of PRs in an open-source software (OSS) project increases the workload of developers. To reduce the burden on developers, many previous studies have investigated factors that affect the chance of PRs getting accepted and built prediction models based on these factors. However, most prediction models are built on the data after PRs are submitted for a while (e.g., comments on PRs), making them not useful in practice. Because integrators still need to spend a large amount of effort on inspecting PRs. In this study, we propose an approach named E-PRedictor (earlier PR predictor) to predict whether a PR will be merged when it is created. E-PRedictor combines three dimensions of manual statistic features (i.e., contributor profile, specific pull request, and project profile) and deep semantic features generated by BERT models based on the description and code changes of PRs. To evaluate the performance of E-PRedictor, we collect475192 PRs from 49 popular open-source projects on GitHub. The experiment results show that our proposed approach can effectively predict whether a PR will be merged or not. E-PRedictor outperforms the baseline models (e.g., Random Forest and VDCNN) built on manual features significantly. In terms of F1@Merge, F1@Reject, and AUC (area under the receiver operating characteristic curve), the performance of E-PRedictor is 90.1%, 60.5%, and 85.4%, respectively.

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury