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Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma:A case report and review of literature

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World Journal of Clinical Cases 2020年第24期8卷 6456-6464页

作者： Juan-Juan Li bing-chen chen Jie Dong You-Wei chen Yuan chen Department of Intensive Care Unit and Comprehensive Support Wang-Jiang-Shan Branch of Zhejiang Provincial People's HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Colorectal Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin lymphoma that is mainly involved in the gastrointestinal tract. Thesynchronous occurrence of colonic MALT lymphoma and adenocarcinoma in thesame patient is extremely rare. We here report a case of synchronous colonicMALT lymphoma found on surveillance colonoscopy five months after surgeryand chemotherapy for sigmoid *** SUMMARY A 67-year-old man was admitted because of hematochezia for two *** suggested a colonic tumor before hospitalization. Abdominalcomputed tomography (CT) revealed local thickening of the sigmoid colon. Thepatient underwent a left hemicolectomy with local lymph node dissection. Thehistopathology revealed moderately differentiated adenocarcinoma and partiallymucinous adenocarcinoma. The pTNM stage was T3N1Mx. The patient receivedchemotherapy with six cycles of mFOLFOX6 after surgery. Colonoscopy wasperformed five months later and revealed single, flat, polypoid lesions of thecolon 33 cm away from the anus. Subsequently, the patient underwent endoscopic mucosal resection for further diagnosis. The pathological diagnosis was MALTlymphoma. Positron emission tomography /CT suggested metastasis. The patientrefused further treatment and died ten months *** Colonic MALT lymphoma may occur after surgery and chemotherapy foradenocarcinoma as a synchronous malignancy. Regular surveillance colonoscopyand careful monitoring after surgery are critical.

关键词： Mucosa-associated lymphoid tissue lymphoma Adenocarcinoma Colon Synchronous malignancy Surgery Case report

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Femtosecond laser small incision lenticule extraction on binocularity for myopia with glasses-free 3D technique

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 125-131页

作者： bing-Jie chen Yu-chen Fan Yong-Chuan Liao Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Optometry and Visual Science West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To evaluate the effect of femtosecond laser small incision lenticule extraction(SMILE)on the binocular visual function in myopic patients with glasses-free threedimensional(3D)***:Totally 50 myopic patients(39 females and 11 males)with SMILE were enrolled in this prospective *** glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis,dynamic stereopsis,foveal suppression,and binocular balance point of signal to noise ratio(s/n ratio).All subjects received measurements in 1d before operation,and 1d,1wk,and 1mo ***:Both static and dynamic stereopsis showed no significant difference after *** foveal suppression improved significantly 1wk and 1mo after SMILE(P=0.005 and P=0.007 respectively).The binocular balance point of signal to noise ratio showed a significant improvement 1d,1wk and 1mo after SMILE for both eyes(P<0.001 for each eye respectively).CONCLUSION:Glasses-free 3D technique can be used to evaluate the effect of SMILE on the binocular visual function in myopic patients perceptively,and SMILE can improve both foveal suppression and binocular imbalance in these patients.

关键词： myopia small incision lenticule extraction foveal suppression binocular imbalance glasses-free threedimensional technique

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Mitochondrial dysfunction in the pathogenesis of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 76-83页

作者： Xia chen Rui Zhong bing Hu Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041China Department of Gastroenterology Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500China

The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as a key event in the pathophysiology of AP. Mitochondrial dysfunction is closely related to calcium (Ca^(2+)) overload, intracellular adenosine triphosphate depletion, mitochondrial permeability transition pore openings, loss of mitochondrial membrane potential, mitophagy damage and inflammatory responses. Mitochondrial dysfunction is an early triggering event in the initiation and development of AP,and this organelle damage may precede the release of inflammatory cytokines, intracellular trypsin activation and vacuole formation of pancreatic acinar cells. This review provides further insight into the role of mitochondria in both physiological and pathophysiological aspects of AP, aiming to improve our understanding of the underlying mechanism which may lead to the development of therapeutic and preventive strategies for AP.

关键词： Acute pancreatitis Autophagy Calcium Cell death Inflammation Mitochondria Mitophagy

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Investigation of magnesium phosphate cement on river dredged sludge with varying humic acid content and solidification mechanism

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 573-585页

作者： Xiaoyi Yuan Lei Peng bing chen Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai200240China

This paper investigated the use of magnesium phosphate cement (MPC) for solidifying sludge with different humic acid (HA) content (ranging from 0 to 4.5%) and explored the solidification mechanism. Fluidity, setting time, unconfined compressive strength (UCS), the strength formation mechanism, and the spontaneous imbibition process of solidified sludge (SS) were studied. The results indicate that MPC can be used as a low-alkalinity curing agent. As the HA content increases, fluidity and setting time also increase, while hydration temperature and strength decrease. Additionally, the failure mode of SS transitions from brittleness to ductility. The strength of SS is composed of the cementation strength provided by MPC hydration products, matric suction, osmotic suction, and the structural strength of the sludge. MPC reduces the structural strength caused by the shrinkage of pure sludge under the action of matric suction, but the incorporation of MPC significantly improved the strength when the sludge is eroded by water. X-ray diffraction (XRD) and scanning electron microscopy (SEM) show that the sludge and MPC can form a dense solid body, forming various hydration products, and synergistically improve the mechanical properties of the sludge.

关键词： Sludge solidification MPC Unsaturated spontaneous imbibition Strength mechanism Humic acid

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Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets

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Journal of Animal Science and Biotechnology 2025年第1期16卷 377-387页

作者： Junqiu Luo Xiu Wu Daiwen chen bing Yu Jun He Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of China Ministry of EducationSichuan Agricultural UniversityChengduSichuan 611130People’s Republic of China

Background Oxidative stress significantly impacts growth performance and liver function in *** acid(FA)works as an antioxidant,however,the role and mechanism of FA in the regulation of diquat-induced oxidative stress in piglets are less *** study was designed to investigate the effects of FA on growth performance and antioxi-dant capacity in piglets with diquat *** Thirty-two healthy DLY(Duroc×Landrace×Yorkshire)piglets(13.24±0.19 kg)were randomly divided into one of two diets including 0 or 4 g/kg FA for 14 *** d 15,all pigs were intraperitoneally injected diquat or sterile *** Dietary supplementation with ferulic acid(FA)significantly improved the average daily gain(ADG)and decreased feed-gain ratio(F/G)of ***,dietary FA supplementation reduced serum aspartate aminotrans-ferase(AST),alanine aminotransferase(ALT)activities in diquat challenged ***,diquat infusion increased reactive oxygen radicals(ROS)level in liver,decreased the activities of total superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC)and increased malondialdehyde(MDA)con-tent in the liver and *** with FA significantly increased T-AOC and T-SOD activities and decreased MDA and ROS *** down-regulated gene and protein expression of Keap1,and up-regulated protein expression of Nrf2 and HO-1 in the liver of piglets with diquat ***,diquat challenge increased the ratio of late apoptosis,increased serum levels of IL-1β,IL-18 and lactate dehydrogenase(LDH),and up-regulated pyroptosis-related genes in the *** supplementation reduced the ratio of late apoptosis and down-regulated mRNA expression of ***,FA addition reduced concentration of IL-1β,IL-18,and LDH under diquat *** Diquat-induced oxidative stress reduced growth performance and impaired liver function in *** FA supplementation enhanced the antiox

关键词： Antioxidant capacity Ferulic acid Hepatic pyroptosis Piglets

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Evaluation of the shear stability of aerobic granular sludge from a pilot-scale membrane bioreactor:Establishment of a quantitative method

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Journal of Environmental Sciences 2025年第2期148卷 579-590页

作者： Biao Yang bingduo Wang Liying Bin Weirui chen Xinyi chen Ping Li Shanglong Wen Shaosong Huang Zhiqi Zhang bing Tang School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China Guangdong Guangshen Environmental Protection Technology Co. Ltd.Guangzhou 510663China Guangdong Yuehai Water Investment Co. Ltd.Shenzhen 518000China

This work established a quantitative method to access the shear stability of aerobic granular sludge(AGS)and validated its feasibility by using the mature AGS from a pilot-scale(50 tons/day)membrane bioreactor(MBR)for treating real municipal *** results showed that the changing rate( S)of the peak area(S)of granule size distribution(GSD)exhibited an exponential relationship(R^(2)≥0.76)with the shear time(y=a−b·cx),which was a suitable indicative index to reflect the shear stability of different AGS *** limiting granule size(LGS)was defined and proposed to characterize the equilibrium size for AGS after being sheared for a period of time,whose value in terms of Dv50 showed high correlation(R^(2)=0.92)with the parameter *** free Ca^(2+)(28.44-34.21 mg/L)in the influent specifically interacted with polysaccharides(PS)in the granule’s extracellular polymeric substance(EPS)as a nucleation site,thereby inducing the formation of Ca precipitation to enhance its Young’s modulus,while Ca2+primarily interacted with PS in soluble metabolic product(SMP)during the initial granulation ***,the Young’s modulus significantly affected the parameter a related to shear stability(R^(2)=0.99).Since the parameter a was more closely related(R^(2)=1.00)to S than that of the parameter b or c,the excellent correlation(R^(2)=0.99)between the parameter a and the wet density further verified the feasibility of this method.

关键词： Shear stability Quantitative evaluation Aerobic granular sludge Membrane bioreactor Pilot-scale study Municipal wastewater

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Umbilical cord-derived mesenchymal stromal cells:Promising therapy for heart failure

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World Journal of Cardiology 2025年第1期17卷 15-21页

作者： Ya-Lun Li En-Guo chen bing-bing Ren Department of Pulmonary and Critical Care Medicine Regional Medical Center for National Institute of Respiratory DiseaseSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Medical College Zhejiang UniversityHangzhou 310063Zhejiang ProvinceChina

Heart failure(HF)is a complex syndrome characterized by the reduced capacity of the heart to adequately fill or eject ***,HF remains a leading cause of morbidity and mortality worldwide,imposing a substantial burden on global healthcare *** advancements have highlighted the therapeutic potential of mesenchymal stromal cells(MSCs)in managing ***,umbilical cord-derived MSCs(UC-MSCs)have demonstrated superior clinical potential compared to traditional bone marrow-derived MSCs;this is evident in their non-invasive collection process,higher proliferation efficacy,and lower immunogenicity and tumorigenicity,as substantiated by preclinical *** the feasibility and safety of UC-MSCs have been tested in animal models,the application of UC-MSCs in HF treatment remains challenged by issues such as inaccurate targeted migration and low survival rates of ***,further research and clinical trials are imperative to advance the clinical application of UC-MSCs.

关键词： Umbilical cord-derived mesenchymal stromal cells Bone marrow-derived mesenchymal stromal cells Cell therapy Heart failure Cardiovascular diseases

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Statistical Research on Megahertz-peaked Spectra Pulsars

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Research in Astronomy and Astrophysics 2025年第1期25卷 116-134页

作者： Hong-bing Cai Li chen Shi-Dang Li Kai Wang Hang Liu JSNU SPBPU Institute of Engineering & SINO RUSSIAN Institute Jiangsu Normal University School of Physics and Electronic Engineering Jiangsu Normal University

Megahertz-peaked spectra(MPS) pulsars are referred as cases whose radio spectra turn over around 100 MHz. We identified 53 MPS pulsars based on the spectral data from the literature, and statistically analyzed the spatial location distribution, the magnetic field-period distribution, peak frequencies, spectral indices, and dispersion measures of these MPS pulsars. We found that there is a strong positive correlation between the dispersion measures and the peak frequencies of MPS pulsars, and negative correlations of the dispersion measures with spectral indices and the ages are also found. Such correlations suggest that the interstellar medium is an important factor that affects observational properties of MPS pulsars.

关键词： (stars:) pulsars: general ISM: general radio continuum: general

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Improved reference-frame-independent quantum key distribution with intensity fluctuations

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Chinese Physics B 2025年第2期34卷 48-52页

作者： Zi-Qi chen Hao-bing Sun Ming-Shuo Sun Qin Wang Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Broadband Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China

Reference-frame-independent quantum key distribution(RFI-QKD) can avoid real-time calibration operation of reference frames and improve the efficiency of the communication process. However, due to imperfections of optical devices,there will inevitably exist intensity fluctuations in the source side of the QKD system, which will affect the final secure key rate. To reduce the influence of intensity fluctuations, an improved 3-intensity RFI-QKD scheme is proposed in this *** considering statistical fluctuations and implementing global parameter optimization, we conduct corresponding simulation analysis. The results show that our present work can present both higher key rate and a farther transmission distance than the standard method.

关键词： quantum key distribution intensity fluctuations decoy-state method

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Research progress on secondary formation,photosensitive reaction mechanism and human health effects of chromophoric brown carbon

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Journal of Environmental Sciences 2025年第5期151卷 310-330页

作者： Baihang chen Jiangyao chen Guiying Li Taicheng An Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment Engineering Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Brown carbon(BrC)has attracted widespread attention because of its strong absorption of solar radiation in the ultraviolet-visible wavelength range,which causes adverse impacts on human ***,BrC was a physically defined class of ***,current research has gradually shifted towards the identification of its chemical groups,because its light-absorbing capability,chemical properties and health effects mainly depend on the chemical composition of its ***,this review mainly focuses on the chemical understanding of BrC based on chromophores,and the secondary formation mechanism of chromophores,photosensitized reactions,and human health effects of BrC were detailly ***,BrC chromophores are divided into five categories:nitrogen-heterocycles,nitrogen-chain,aromatic species,oligomers and sulfur-containing organic *** chromophore precursor species exhibit variations,and their formation mechanisms are also ***,BrC can trigger the production of secondary organic aerosol(SOA)precursors or cause SOA growth because BrC is an important component of light-absorbing particles formed during incomplete combustion of biomass and fossil fuels,potentially exerting adverse effects on human ***,developing sufficiently separated methods for BrC and refining algorithms and machine learning can lead to a more effective understanding of the chemical composition of chromophores,thus enabling better evaluation of the atmospheric effects and health impacts of *** all,this review provides new insights into the categories of BrC chromophores and new advance in secondary formation mechanisms,photosensitized reactions,and human health effects on the basis of chemical structures.

关键词： Brown carbon Constituent characteristics Secondary formation mechanism Photosensitive Human health effects

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