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Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice

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Neuroscience Bulletin 2022年第1期38卷 16-28页

作者： Shou-He Huang Wei-Zhu Liu Xia Qin Chen-Yi Guo Qing-Cheng Xiong Yu Wang Ping Hu bing-Xing pan Wen-Hua Zhang Laboratory of Fear and Anxiety Disorders Institutes of Life ScienceNanchang UniversityNanchang330031China Institute of Translational Medicine Nanchang UniversityNanchang330001China

Chronic stress leads to many psychiatric disorders,including social and anxiety disorders that are associated with over-activation of neurons in the basolateral amygdala(BLA).However,not all individuals develop psychiatric diseases,many showing considerable resilience against stress *** BLA neuronal activity is involved in regulating an individual’s vulnerability to stress remains *** this study,using a mouse model of chronic social defeat stress(CSDS),we divided the mice into susceptible and resilient subgroups based on their social interaction *** in vivo fiber photometry and in vitro patch-clamp recording,we showed that CSDS persistently(after 20 days of recovery from stress)increased BLA neuronal activity in all the mice regardless of their susceptible or resilient nature,although impaired social interaction behavior was only observed in susceptible *** anxiety-like behavior,on the other hand,was evident in both ***,the CSDS-induced increase of BLA neuronal activity correlated well with the heightened anxiety-like but not the social avoidance behavior in *** findings provide new insight to our understanding of the role of neuronal activity in the amygdala in mediating stress-related psychiatric disorders.

关键词： Chronic stress Amygdala Stress vulnerability Anxiety Fiber photometry Neuronal activity

Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2009年第38期15卷 4844-4848页

作者： Hai-Qing Ma Xiao-Ting Liang Jing-Jing Zhao Hui Wang Jian-Cong Sun Yi-bing Chen Ke pan Jian-Chuan Xia Key Laboratory of Oncology in Southern China and Departmentof Experimental Research Sun Yat-sen University Cancer CenterGuangzhou 510060 Guangdong Province China

AIM： To investigate the expression of Neurensin-2 （NRSN2） in hepatocellular carcinoma （HCC） and its prognostic values in predicting survival. METHODS： The expression and prognostic significance of NRSN2 in HCC was examined by performing immunohistochemical analysis using a total of 110 HCC clinical tissue samples, and Western blotting analysis to further confirm the result. RESULTS： Decreased NRSN2 expression was shown in 70.9% cases. Loss of NRSN2 expression in HCC was significantly related to tumor size （P = 0.006）. Larger tumor size was related to negative expression of NRSN2. Patients showing negative NRSN2 expression had a significantly shorter overall survival than those with positive expression （P = 0.008）. Multivariate Cox regression analysis indicated that NRSN2 expression level was an independent factor of survival （P = 0.013）. Western blotting analysis further confirmed decreased expression of NRSN2 in tumor tissues compared with non-tumorous tissues. CONCLUSION： Our study indicated that NRSIV2 could be a tumor suppressor gene for HCC and a candidate biomarker for long-term survival in HCC.

关键词： Neurensin-2 Hepatocellular carcinoma Expression Immunohistochemical analysis Prognosis

Correlation between molecular biomarkers and risk factors for the clinical progression of benign prostatic hyperplasia using tissue microarray immunostaining

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Chinese Medical Journal 2014年第23期127卷 4031-4035页

作者： Ma Ding Yang bing Zhou Zhe pan Dongliang Zhang Xianghua Department of Urology Peking University Shougang Hospital Beijing 100144 China

Background The pathogenesis of benign prostatic hyperplasia （BPH） has been widely studied,and several biomarkers are known to play roles in its *** study aimed to investigate the possible role of cysteine-rich protein 61 （CYR61）,vascular endothelial growth factor （VEGF）,androgen receptor （AR）,interleukin-6 （IL-6）,cytochrome c,caspase-3,and proliferating cell nuclear antigen （PCNA） in the clinical progression of *** Tissue specimens from 96 BPH cases who underwent transurethral resection of the prostate were processed and transferred to tissue *** age,prostate volume,serum prostate-specific antigen （PSA） level,and International Prostate Symptom Score （IPSS） of all BPH cases were collected before *** expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA was examined by immunostaining in the BPH specimens,and any possible correlation between the different biomarkers and risk factors for BPH clinical progression was *** The expression of CYR61,VEGF,AR,IL-6,cytochrome c,caspase-3,and PCNA in the BPH cases was 68.8％（66/96）,77.1％（74/96）,43.8％（42/96）,31.3％（30/96）,35.4％（34/96）,56.3％（54/96）,and 29.2％（28/96）,*** expression of both CYR61 and VEGF was positively correlated with patient age,prostate volume,and serum PSA level （P ＜0.05）.Furthermore,cytochrome c and caspase-3 expression were inversely related to prostate volume （P ＜0.05）,and AR expression was positively related to serum PSA level （P ＜0.05）.Conclusion CYR61 and VEGF expression might serve as biomarkers for predicting the clinical progression of BPH due to effects on stromal cell proliferation and angiogenesis.

关键词： biomarkers risk factors benign prostatic hyperplasia clinical progression tissue microarray

Chronic stress causes projection-specific adaptation of amygdala neurons via SK channel downregulation

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Chronic stress causes projection-specific adaptation of amyg...

数字图像相关中基于位移场局部最小二乘拟合的全场应变测量

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：张文华 bing-Xing pan Nanchang University

The role of the amygdala in mediating stress-coping has been long ***,basolateral amygdala projection neurons (BLA PNs) are organized into discrete outputs circuits and it remains unclear whether stress differentially impacts these *** were exposed to acute or chronic restraint stress (CRS) and c-fos expression was measured, as a proxy for neuronl activation, in (Retrobead retrogradely-labeled) dorsomedial

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光学学报 2007年第11期27卷 1980-1986页

作者：潘兵谢惠民清华大学工程力学系北京100084

为了从含噪声的位移场中计算得到可靠的应变场,提出一种基于位移场局部最小二乘拟合的全场应变求解方法。介绍了数字图像相关方法的原理,阐述了基于位移场局部最小二乘拟合的全场应变求解方法,并讨论了计算区域边界、孔洞及裂纹附近区... 详细信息

为了从含噪声的位移场中计算得到可靠的应变场,提出一种基于位移场局部最小二乘拟合的全场应变求解方法。介绍了数字图像相关方法的原理,阐述了基于位移场局部最小二乘拟合的全场应变求解方法,并讨论了计算区域边界、孔洞及裂纹附近区域等情况下的应变计算。对均匀变形和中心带圆孔的薄铝板拉伸实验的计算结果表明,该方法能有效地从原始位移场数据中提取全场应变信息。在均匀变形情况下应选择大的应变计算窗口,计算结果更逼近真值;在非均匀变形情况下,如果位移场中包含较强的噪声,则应选择较大的应变计算窗口,而位移场精度很高时可选择更小的应变计算窗口。

关键词：光学测量数字图像相关最小二乘拟合应变

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氧化层对渗氮动力学的影响

材料热处理学报 2005年第4期26卷 102-105页

作者：周潘兵周浪南昌大学材料科学与工程学院江西南昌330047

以纯铁为对象,采用增重测量、X射线衍射分析和扫描电镜显微分析方法就充分预氧化对渗氮的作用进行研究。结果表明,渗氮初期,预氧化纯铁表面发生Fe3O4氧化层向εFe3N相的转化;氮原子极易穿过Fe3O4氧化层渗入基体,并在氧化层之下的铁基体... 详细信息

以纯铁为对象,采用增重测量、X射线衍射分析和扫描电镜显微分析方法就充分预氧化对渗氮的作用进行研究。结果表明,渗氮初期,预氧化纯铁表面发生Fe3O4氧化层向εFe3N相的转化;氮原子极易穿过Fe3O4氧化层渗入基体,并在氧化层之下的铁基体形成γ′氮化物;γ′氮化物呈指状延伸生长,使得纯铁渗氮时的化合物层平直界面失稳。渗氮后,与未预氧化试样相比,扣除氧化层本身氮化带来的贡献,预氧化试样的催渗增重达45%,证实较厚的Fe3O4氧化层不仅不会阻碍渗氮,反而具有明显的催渗作用,并提出了两种可能的催渗机理。

关键词：气体渗氮预氧化纯铁催渗

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单相机高温三维数字图像相关方法

航空学报 2022年第6期43卷 285-296页

作者：俞立平潘兵北京航空航天大学固体力学所北京100083

高超声速飞行器热防护材料和结构在地面考核试验中高温变形的准确测量一直是困扰相关工程技术人员的测试技术难题之一。建立了基于单个普通相机/紫外相机和组合式平面反射镜相结合的单相机高温三维数字图像相关(3D-DIC)测量系统,该系统... 详细信息

高超声速飞行器热防护材料和结构在地面考核试验中高温变形的准确测量一直是困扰相关工程技术人员的测试技术难题之一。建立了基于单个普通相机/紫外相机和组合式平面反射镜相结合的单相机高温三维数字图像相关(3D-DIC)测量系统,该系统采用高亮度单色光照明(蓝光/紫外照明)和带通滤波成像(蓝色/紫外滤波片)相结合的主动光学成像技术克服高温测量过程中的热辐射干扰问题。首先,采用面内和离面平移实验验证了“主动成像”单相机3D-DIC系统的位移测量精度。然后,利用建立的蓝光单相机3D-DIC系统测量了不锈钢和氧化铝陶瓷试验件不同温度下非直接受热面(后表面)的全场变形,实验测得的材料热膨胀系数与航空材料手册参考值一致。最后,利用建立的紫外单相机3D-DIC系统测量了不锈钢材料直接受热面(前表面)的全场变形,测得材料热膨胀系数同样与参考值接近。

关键词：热变形数字图像相关方法单相机3D-DIC 主动成像紫外相机

Ultra-compact lithium niobate microcavity electro-optic modulator beyond 110 GHz

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Chip 2022年第4期1卷 29-36页

作者： bing-Cheng pan Hong-Xuan Liu Hao-Chen Xu Yi-Shu Huang Huan Li Ze-Jie Yu Liu Liu Yao-Cheng Shi Dao-Xin Dai State Key Laboratory for Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInterna-tional Research Center for Advanced PhotonicsZhejiang UniversityZijingang CampusHangzhou 310058China Ningbo Research Institute Zhejiang Uni-versityNingbo 315100China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China Intelligent Optics&Photonics Re-search Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China

A lithium-niobate-on-insulator(LNOI)electro-optic(EO)modulator based on a 2×2 FP-cavity was designed and realized with an ultra-compact footprint and an ultra-high bandwidth.A comprehensive analysis on the present LNOI FP-cavity modulator was conducted to reveal the dependence of modulation bandwidth and modulation effi-ciency on the cavity Q-factor and the operation wavelength detuning to the *** particular,the 2×2 FP cavity was designed to achieve an optimal Q factor by reducing the reflectivity of reflectors and the cavity length,thus reducing the photon lifetime in the *** ultra-short effective cavity length of only∼50μm was achieved for the designed LNOI FP-cavity modulator,with itsfootprint being as compact as∼4×500μm *** was demonstrated theoretically that the modulation bandwidth could be improved significantly to be over 200 GHz by utilizing the peaking enhancement *** fabricated device exhibited an excess loss of∼1 dB and an extinction ratio of∼20 dB in experiments,while the measured 3-dB bandwidth was higher than 110 GHz(beyond the maximal range of the facilities in experiments).Up till now,to our best knowledge,this has been the first LNOI microcavity modulator with a bandwidth higher than 110 ***,high-quality eye-diagrams of 100 Gbps on-off keying(OOK)and 140 Gbps 4-pulse amplitude modulation(PAM4)signals were demonstrated experimentally,and the energy consumption for the OOK signals was as low as 4.5 fJ/bit.

关键词： Lithium niobate Microcavity Electro-optic Modulator

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旋转弹引信用卫星定位接收信号旋转解调方法

北京理工大学学报 2018年第2期38卷 173-178页

作者：肖洪兵潘海北京工商大学计算机与信息工程学院北京100048

为解决旋转弹飞行中的高旋转、高动态条件会造成卫星定位接收系统无法正常定位的问题,针对旋转、动态环境开展了旋转弹卫星定位接收信号旋转解调方法的研究.详细分析了旋转条件对卫星定位信号接收的影响,并针对旋转特性设计了旋转跟踪... 详细信息

为解决旋转弹飞行中的高旋转、高动态条件会造成卫星定位接收系统无法正常定位的问题,针对旋转、动态环境开展了旋转弹卫星定位接收信号旋转解调方法的研究.详细分析了旋转条件对卫星定位信号接收的影响,并针对旋转特性设计了旋转跟踪解调环,用于对旋转的跟踪与解调,给出了旋转弹卫星定位信号接收系统的设计方案,基于Simulink实现了旋转弹卫星定位信号接收系统的仿真,并给出了相应的仿真与实验结果.结果表明,设计的以旋转跟踪环为核心的旋转弹卫星定位信号接收系统,在中心频率为200 Hz的情况下跟踪范围可达到±40Hz,较好地满足了转速在200转/s左右的旋转弹信号接收要求.

关键词：引信旋转解调全球卫星导航系统跟踪