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A full solid-state conceptual magnetocaloric refrigerator based on hybrid regeneration

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The Innovation 2024年第4期5卷 94-101,93页

作者： Yuan Lin jing Wang Wei Dai Kaiming Qiao Houbo Zhou Tongyun zhao Fengxia Hu Baogen Shen Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China

The environmental friendliness and high efficiency of magnetocaloric refrigeration make it a promising substitute for vapor compression ***,the common use of heat transfer fluid in conventional passive magnetic regenerators(PMRs)and active magnetic regenerators(AMRs)makes only partial materials contribute to the regeneration process,which produces large regeneration loss and greatly limits the regeneration effi-ciency and refrigeration performance at high ***,we propose a new conceptual hybrid magnetic regenerator(HMR)composed of multiple solid-state high thermal conductivity materials(HTCMs)and magnetocaloric materials(MCMs),in which both HTCM and MCM elements participate in the regeneration *** novel working mode could greatly reduce regeneration losses caused by dead volume,pressure losses,and temperature nonuniformity in heat transfer substances to markedly improve regeneration efficiency at high working *** the experimentally obtained adiabatic temperature change and magnetic work and with the help of finite element simulation,a maximum temperature of 26 K,a dramatically large cooling power of 8.3 kW/kg,and a maximum ideal exergy efficiency of 54.2%are achieved at the working frequency of 10 Hz for an ideal prototype device of a rotary HMR magnetocaloric refrigerator,which shows potential for achieving an integrative,advanced performance against current AMR/PMR systems.

关键词： solid state magnetic

Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu jing-Nan Chen bing-Han Jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

美拉德反应中间体2,3-二氢-3,5-二羟基-6-甲基-4(H)吡喃-4-酮的研究进展

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食品与发酵工业 2024年第5期50卷 326-333页

作者：白冰何静杨静赵明林王清福陈芝飞王秋领郑州轻工业大学食品与生物工程学院河南郑州450000 河南中烟工业有限责任公司技术中心河南郑州450000

2,3-二氢-3,5-二羟基-6-甲基-4(H)吡喃-4-酮(2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one,DDMP),是美拉德反应关键中间体之一,在美拉德反应产物调控中起到重要作用。DDMP属于烯醇酮类化合物,广泛存在于天然尤其是热加工食品,具有抗氧化、抗菌、心脏保护等作用。当前,随着对食品安全、风味和活性功能关注度的不断提升,学者对DDMP进行了广泛而深入的研究。该文基于近年来相关文献,对DDMP的存在、形成及降解、生物活性及感官特性等方面的研究进展进行全面系统的总结,旨在为DDMP在食品、医药、香料领域的基础和应用研究提供参考。

关键词：二氢-3,5-二羟基-6-甲基-4(H)吡喃-4-酮热加工食品抗氧化降解香味

Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu Ru Feng Wenyu Li Yin Xiao Xinxiu Liu Yu Chen Xiaoxiao Wang bing bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen baitian zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

纸坊沟小流域近80年来土地利用变化及其土壤保持效应

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水土保持研究 2024年第3期31卷 90-100页

作者：王静王兵张智键白洁西北农林科技大学水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 中国科学院大学北京100049

[目的]小流域综合治理驱动的土地利用变化可显著影响流域产沙过程,探究纸坊沟小流域不同治理阶段土地利用动态变化特征及土壤保持效应,为黄土高原生态服务功能的改善提供科学支撑。[方法]基于CSLE模型,系统评估纸流域近80年5个治理时段... 详细信息

[目的]小流域综合治理驱动的土地利用变化可显著影响流域产沙过程,探究纸坊沟小流域不同治理阶段土地利用动态变化特征及土壤保持效应,为黄土高原生态服务功能的改善提供科学支撑。[方法]基于CSLE模型,系统评估纸流域近80年5个治理时段土地利用变化及其土壤保持效应的时空特征。[结果](1) 1938年植被破坏前流域林草植被占88.55%,植被破坏后1958年林草植被占比降为32%,林地、草地和耕地比例为1∶244∶433,1978年土地利用变化平缓;小流域综合治理实施后,1999年和2020年林草植被占比分别为64.73%和86.55%,2020年林草植被占比与1938年破坏前基本持平,但林地占比还是略小,草地略高,林地、草地和耕地比例为7.6∶5∶1。(2)流域5个时期土壤保持量分别为24.85万t, 18.86万t, 22.88万t, 23.62万t, 24.60万t,植被破坏后土壤保持量有所下降,小流域综合治理后土壤保持量有所增加,由于林地面积仍低于破坏前,2020年土壤保持量仍低于1938年0.01%。(3)受土地流转驱动,不同时期林地、草地和耕地土壤保持量分别较1938年增加或减少了-99.80%~-17.86%,23.90%~69.18%和-25.06%~664.66%,园地土壤保持量在1999年达到最大值,后于2020年降至7 511.14 t。[结论]纸坊沟小流域的植被覆盖已基本恢复至1938年破坏前的水平,说明黄土高原生态恢复在纸坊沟小流域取得了显著成效。

关键词：土壤保持时空变化土地利用治理阶段

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氟取代对香豆素分子超快动力学过程的影响

光谱学与光谱分析 2024年第11期44卷 3128-3135页

作者：葛晶李智彪薛丙乾白西林山西师范大学物理与信息工程学院山西省光谱测量与分析重点实验室

设计具有高亮度、高光稳定性和环境友好型的荧光染料，是当前备受关注的前沿领域。研究发现，荧光染料的发光效率受到扭转分子内电荷转移(TICT)的影响。因此，有效地抑制TICT过程对于荧光标记物和探针的研究与开发具有至关重要的意义。... 详细信息

设计具有高亮度、高光稳定性和环境友好型的荧光染料，是当前备受关注的前沿领域。研究发现，荧光染料的发光效率受到扭转分子内电荷转移(TICT)的影响。因此，有效地抑制TICT过程对于荧光标记物和探针的研究与开发具有至关重要的意义。香豆素及其衍生物，尤其是具有高荧光产率和长荧光寿命的7-氨基香豆素染料，一直以来都广泛应用于不同体系中，作为荧光探针的重要组成部分。然而，以往的研究主要集中在探究不同溶剂对香豆素染料分子激发态动力学过程的影响，而忽略了染料分子结构对TICT过程的重要作用。采用了飞秒时间分辨瞬态吸收(TA)光谱和密度泛函理论(DFT)计算相结合的方法，深入研究香豆素染料C460和C481在不同溶剂中的激发态动力学。研究结果揭示，在具有高强供氢能力的高极性甲醇溶剂中，C481才显著发生TICT过程。此外，量子化学计算结果表明，氟取代效应会降低分子内扭转势垒，导致非辐射失活效应加速，从而引发更为明显的荧光猝灭现象。这一研究不仅有助于优化荧光染料性能时选择合适的溶剂，还可为荧光染料分子结构的设计提供重要的指导，具有深远的研究价值。

关键词：瞬态吸收光谱扭转分子内电荷转移密度泛函理论

多学科协作式延续性干预对老年神经胶质瘤患者术后并发症及生活质量的影响

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癌症进展 2024年第16期22卷 1766-1769,1797页

作者：赵静周欢白冰郑州大学第一附属医院神经外科一病区郑州450052 郑州大学第一附属医院介入手术室郑州450052

目的探讨多学科协作(MDT)式延续性干预对老年神经胶质瘤患者术后并发症及生活质量的影响。方法将106例老年神经胶质瘤患者根据干预方式的不同分为干预组(56例)和对照组(50例)。对照组患者接受常规术后干预,干预组患者接受MDT式延续性干... 详细信息

目的探讨多学科协作(MDT)式延续性干预对老年神经胶质瘤患者术后并发症及生活质量的影响。方法将106例老年神经胶质瘤患者根据干预方式的不同分为干预组(56例)和对照组(50例)。对照组患者接受常规术后干预,干预组患者接受MDT式延续性干预。比较两组患者的生活质量[日常生活活动量表(ADL)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)和简易精神状态量表(MMSE)]、神经肽[β-内啡肽(β-EP)、神经降压素(NT)和精氨酸升压素(AVP)]水平及术后并发症发生情况。结果干预后1个月,两组患者身体机能、心理状况、社会能力和整体生活质量评分均较干预前升高,且干预组患者身体机能、心理状况、社会能力和整体生活质量评分均高于对照组,差异均有统计学意义(P﹤0.05)。干预后1个月,两组患者NIHSS评分均较干预前降低,MMSE评分均较干预前升高,且干预组患者NIHSS评分低于对照组,MMSE评分高于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者β-EP、NT、AVP水平均较干预前升高,且干预组患者β-EP、NT、AVP水平均高于对照组,差异均有统计学意义(P﹤0.05)。干预组患者术后并发症总发生率低于对照组患者,差异有统计学意义(P﹤0.05)。结论MDT式延续性干预能够显著减少老年神经胶质瘤患者的术后并发症,提高生活质量,减轻炎症反应,促进神经功能恢复。

关键词：神经胶质瘤多学科协作延续性干预术后并发症生活质量

Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 51-65页

作者： Binzhong Wang Bin Wu Xueqing Liu Yacheng Hu Yao Ming Mingzhou bai Juanjuan Liu Kan Xiao Qingkai Zeng jing Yang Hongqi Wang baifu Guo Chun Tan Zixuan Hu Xun zhao Yanhong Li Zhen Yue Junpu Mei Wei Jiang Yuanjin Yang Zhiyuan Li Yong Gao Lei Chen Jianbo Jian Hejun Du Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes Yichang 443100China Chinese Sturgeon Research Institute China Three Gorges CorporationYichang 443100China Yangtze River Biodiversity Research Center China Three Gorges CorporationWuhan 430014China BGI-Shenzhen Shenzhen 518083China BGI Genomics BGI-ShenzhenShenzhen 518083China Department of Biotechnology and Biomedicine Technical University of DenmarkLyngby 2800Denmark River Basin Complex Administration Center China Three Gorges CorporationYichang 443100China BGI-Sanya BGI-ShenzhenSanya 572025China Yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

The order Acipenseriformes,which includes sturgeons and paddlefishes,represents“living fossils”with complex genomes that are good models for understanding whole-genome duplication(WGD)and ploidy evolution in ***,we sequenced and assembled the first high-quality chromosome-level genome for the complex octoploid Acipenser sinensis(Chinese sturgeon),a critically endangered species that also represents a poorly understood ploidy group in *** results show that *** is a complex autooctoploid species containing four kinds of octovalents(8n),a hexavalent(6n),two tetravalents(4n),and a divalent(2n).An analysis taking into account delayed rediploidization reveals that the octoploid genome composition of Chinese sturgeon results from two rounds of homologous WGDs,and further provides insights into the timing of its ploidy *** study provides the first octoploid genome resource of Acipenseriformes for understanding ploidy compositions and evolutionary trajectories of polyploid fishes.

关键词： Chinese sturgeon Whole-genome sequencing Autooctoploid Polyploidization and diploidization Whole-genome duplication

基于VMD的双通道构音障碍语音特征图谱提取算法

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东北大学学报（自然科学版） 2024年第6期45卷 793-801页

作者：薛珮芸白静张楠赵建星太原理工大学电子信息工程学院山西晋中030600 山西高等创新研究院博士后科研工作站山西太原030024 中北大学信息与通信工程学院山西太原030024

针对在提取构音障碍患者语音有效特征信息不足,导致语音识别率低的问题,提出一种基于变分模态分解(VMD)的多尺度双通道滤波器组(MBCFbank)特征图谱提取算法.首先,为了更好地提取符合人耳听觉结构特性的声学特征,提出一种双通道滤波器组(... 详细信息

针对在提取构音障碍患者语音有效特征信息不足,导致语音识别率低的问题,提出一种基于变分模态分解(VMD)的多尺度双通道滤波器组(MBCFbank)特征图谱提取算法.首先,为了更好地提取符合人耳听觉结构特性的声学特征,提出一种双通道滤波器组(BCFbank)特征提取算法,该算法采用Mel滤波后做对数变换,同时采用Gammatone滤波后作非线性响度变换;其次,采用VMD来优化BCFbank特征,对分解后的多个语音信号分量筛选出相关系数较高的3个,分别提取其BCFbank特征及其差分特征,同时对未分解的语音信号提取BCFbank特征,从而构成MBCFbank特征图谱;最后,在双路语音识别模型上进行训练和识别.实验结果表明,基于BCFbank特征、MBCFbank特征图谱的语音识别模型准确率最高分别达到了87.82%,94.34%,优于Fbank特征的识别效果.

关键词：构音障碍语音识别变分模态分解卷积神经网络 MBCFbank特征