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Laparoscopic liver resection for hepatocellular carcinoma complicated with significant portal hypertension:A propensity score-matched survival analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 358-365页

作者： Zhang-You Guo Yuan Hong bing tu Yao Cheng Xiao-Mei Wang Department of Minimally Invasive Interventional Therapy Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer CenterKunming 650118China Medical Laboratory The First Affiliated Hospital of Kunming Medical UniversityInstitute of Experimental Diagnostics of Yunnan ProvinceKey Laboratory of Laboratory Medicine of Yunnan ProvinceKunming 650032China Department of Hepatobiliary Surgery The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicated with SPH after LLR.

关键词： Hepatocellular carcinoma Significant portal hypertension Laparoscopic liver resection Propensity score matching analysis

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China stroke surveillance report 2021

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Military Medical Research 2024年第3期11卷 374-399页

作者： Wen-Jun tu Long-De Wang 无 Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China School of Public Health Peking UniversityBeijing 100191China Special Writing Group of China Stroke Surveillance Report

Since 2015,stroke has become the leading cause of death and disability in China,posing a significant threat to the health of its citizens as a major chronic non-communicable disease.According to the China Stroke High-risk Population Screening and Intervention Program,an estimated 17.8 million[95%confidence interval(CI)17.6–18.0million]adults in China had experienced a stroke in 2020,with 3.4 million(95%CI 3.3–3.5 million)experiencing their first-ever stroke and another 2.3 million(95%CI 2.2–2.4 million)dying as a result.Additionally,approximately 12.5%(95%CI 12.4%–12.5%)of stroke survivors were left disabled,as defined by a modified Rankin Scale score greater than 1,equating to 2.2 million(95%CI 2.1–2.2 million)stroke-related disabilities in 2020.As the population ages and the prevalence of risk factors like diabetes,hypertension,and hyperlipidemia continues to rise and remains poorly controlled,the burden of stroke in China is also increasing.A large national epidemiological survey initiated by the China Hypertension League in 2017 showed that the prevalence of hypertension was 24.7%;the awareness,treatment,and control rates in hypertensive patients were:60.1%,42.5%,and 25.4%,respectively.A nationally representative sample of the Chinese mainland population showed that the weighted prevalence of total diabetes diagnosed by the American Diabetes Association criteria was 12.8%,suggesting there are 120 million adults with diabetes in China,and the awareness,treatment,and control rates in diabetic patients were:43.3%,49.0%,and 49.4%,respectively.The“Sixth National Health Service Statistical Survey Report in 2018”showed that the proportion of the obese population in China was 37.4%,an increase of 7.2 points from 2013.Data from 1599 hospitals in the Hospital Quality Monitoring System and Bigdata Observatory Platform for Stroke of China(BOSC)showed that a total of 3,418,432 stroke cases[mean age±standard error(SE)was(65.700±0.006)years,and 59.1%were male]were admitted during 2020.Of those,over 80.0%(81.9%)were ischemic

关键词： Stroke Epidemiological characteristics Treatment Prognosis China

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Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

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Journal of Animal Science and Biotechnology 2024年第1期15卷 396-411页

作者： Shengyang Xu Chong Jiao Qiyu Diao Yan tu Beijing Key Laboratory for Dairy Cow Nutrition Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081People’s Republic of China

Background Rumen bacterial groups can affect growth performance,such as average daily gain(ADG),feed intake,and efficiency.The study aimed to investigate the inter-relationship of rumen bacterial composition,rumen fermentation indicators,serum indicators,and growth performance of Holstein heifer calves with different ADG.Twelve calves were chosen from a trail with 60 calves and divided into higher ADG(HADG,high pre-and post-weaning ADG,n=6)and lower ADG(LADG,low pre-and post-weaning ADG,n=6)groups to investigate differences in bacterial composition and functions and host phenotype.Results During the preweaning period,the relative abundances of propionate producers,including g_norank_f_Butyricicoccaceae,g_Pyramidobacter,and g_norank_f_norank_o_Clostridia_vadin BB60_group,were higher in HADG calves(LDA>2,Ptudy revealed that the preweaning period is the window of opportunity for rumen bacteria to regulate the ADG of calves.

关键词： Average daily gain Calves Preweaning period Rumen microbiota

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Towards efficient generative AI and beyond-AI computing:New trends on ISSCC 2024 machine learning accelerators

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Journal of Semiconductors 2024年第4期45卷 12-15页

作者： Bohan Yang Jia Chen Fengbin tu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina AI Chip Center for Emerging Smart Systems The Hong Kong University of Science and TechnologyHong KongChina School of the Gifted Young University of Science and Technology of ChinaHefei 230026Chin

Compared to the last decade when the convolution neu-ral network(CNN)dominated the research field,machine learn-ing(ML)algorithms have reached a pivotal moment called the generative artificial intelligence(AI)era.With the emer-gence of large-scale foundation models[1],such as large multi-modal model(LMM)GPT-4[2]and text-to-image generative model DALL·E[3].

关键词： ISSCC beyond AI

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Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus

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Neural Regeneration Research 2024年第6期19卷 1177-1178页

作者： Longlong tu Yanlin He Yong Xu Children's Nutrition Research Center Department of Pediatrics Baylor College of Medicine Department of Molecular and Cellular Biology Section of Endocrinology Diabetes and Metabolism Department of Medicine Baylor College of Medicine Brain Glycemic and Metabolism Control Department Pennington Biomedical Research Center Louisiana State University

Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological range.Certainly,the body necessitates a stable supply of energy mainly provided by glucose for various bodily functions.High or low blood glucose levels would impair the physiological functions of various organs of the body.Prolonged high blood glucose(i.e.,

关键词： HYPOGLYCEMIA

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Equivalence between the internal observability and equation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 89-97页

作者： LIU Wen-jun tu Zhi-yu School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

This paper is concerned with a third order in time linear Moore-Gibson-Thompson equation which describes the acoustic velocity potential in ultrasound wave program.Influenced by the work of Kaltenbacher,Lasiecka and Marchand(Control Cybernet.2011,40:971-988),we establish an observability inequality of the conservative problem,and then discuss the equivalence between the exponential stabilization of a dissipative system and the internal observational inequality of the corresponding conservative system.

关键词： Moore-Gibson-Thompson equation internal observability exponential stability

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Sobolev Mapping of the Bergman Projections on Generalized Hartogs Triangles

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Acta Mathematica Sinica,English Series 2024年第2期40卷 451-466页

作者： Hong Yan LIU Zhen Han tu School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we investigate Sobolev mapping properties of the Bergman projection.Th domain we focus on is defined byΩm/n:={(z,w)∈C^(1+N):|w1|<|z|m1/n1<1,…|wN|<|z|/m_(N)/n_(N)<1},where m=(m1,…mN)∈(Z^(+))^(N),n=(n1,…nN)∈(Z^(+))N,N∈Z^(+).Sobolev irregularity of the Bergman projections on 2 is shown.We also prove some Sobolev regularity results of the Bergman projections onΩm/n for m=(1,…1).

关键词： Bergman projections generalized Hartogs triangles Sobolev spaces

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Spectral‐spatial sequence characteristics‐based convolutional transformer for hyperspectral change detection

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1237-1257页

作者： Chengle Zhou Qian Shi Da He bing tu Haoyang Li Antonio Plaza School of Geography and Planning Sun Yat‐sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory for Urbanization and GeoSimulation Sun Yat‐sen UniversityGuangzhouChina Institute of Optics and Electronics Nanjing University of Information Science and TechnologyNanjingChina Hyperspectral Computing Laboratory Escuela PolitecnicaUniversity of ExtremaduraCaceresSpain

Recently,ground coverings change detection(CD)driven by bitemporal hyperspectral images(HSIs)has become a hot topic in the remote sensing community.There are two challenges in the HSI‐CD task:(1)attribute feature representation of pixel pairs and(2)feature extraction of attribute patterns of pixel pairs.To solve the above problems,a novel spectral‐spatial sequence characteristics‐based convolutional transformer(S3C‐CT)method is proposed for the HSI‐CD task.In the designed method,firstly,an eigenvalue extrema‐based band selection strategy is introduced to pick up spectral information with salient attribute patterns.Then,a 3D tensor with spectral‐spatial sequence characteristics is proposed to represent the attribute features of pixel pairs in the bitemporal HSIs.Next,a fusion framework of the convolutional neural network(CNN)and Transformer encoder(TE)is designed to extract high‐order sequence semantic features,taking into account both local context information and global sequence dependencies.Specifically,a spatial‐spectral attention mechanism is employed to prevent information reduction and enhance dimensional interactivity between the CNN and TE.Finally,the binary change map is determined according to the fully‐connected layer.Experimental results on real HSI datasets indicated that the proposed S3C‐CT method outperforms other well‐known and state‐of‐the‐art detection approaches in terms of detection performance.

关键词： change detection imageanalysis

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Random vibration analysis of FGM plates subjected to moving load using a refined stochastic finite element method

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Defence Technology（防务技术） 2024年第4期34卷 42-56页

作者： Ngoc-tu Do Trung Thanh Tran Faculty of Mechanical Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam

The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.

关键词： FGM Moving load R-FSDT Q4 element Monte Carlo simulation Random vibration

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A spaceborne advanced storage system for remote sensing microsatellites

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 600-615页

作者： Shilei tu Huiquan WANG Yue HUANG Zhonghe JIN Micro-Satellite Research Center Zhejiang UniversityHangzhou 310027China Key Laboratory of Micro-Nano Satellite Research Zhejiang ProvinceHangzhou 310027China

With the development of satellite miniaturization and remote sensing,the establishment of microsatellite constellations is an inevitable trend.Due to their limited size,weight,and power,spaceborne storage systems with excellent scalability,performance,and reliability are still one of the technical bottlenecks of remote sensing microsatellites.Based on the commercial off-the-shelf field-programmable gate array and memory devices,a spaceborne advanced storage system(SASS)is proposed in this paper.This work provides a dynamic programming,queue scheduling multiple-input multiple-output cache technique and a high-speed,high-reliability NAND flash controller for multiple microsatellite payload data.Experimental results show that SASS has outstanding scalability with a maximum write rate of 2429 Mb/s and preserves at least 78.53%of the performance when a single NAND flash fails.The scheduling technique effectively shortens the data scheduling time,and the data remapping method of the NAND flash controller can reduce the retention error by at least 50.73%and the program disturbance error by at least 37.80%.

关键词： Microsatellite Spaceborne advanced storage system(SASS) Scalability Performance Reliability

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