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High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis

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Chinese Medical Journal 2017年第14期130卷 1662-1669页

作者： Qian An Meng Sun Rui-Qun Qi Li Zhang Jin-Long Zhai Yu-Xiao Hong bing song Hong-Duo Chen Xing-Hua Gao Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Shenyang Children&#39 s Hospital Shenyang Liaoning 110032 China Department of Regenerative Medicine Cardiff Institute of Tissue Engineering and Repair School of Dentistry Cardiff University CF10 3AT UK

Background：Seborrheic dermatitis （SD） is a common inflammatory skin *** etiology is unclear,although overgrowth of Malassezia on the skin has been suggested to cause *** study investigated whether colonization with Staphylococcus plays a role in facial SD,which was not well addressed ***：The study was conducted from September 1,2011 to February 20,2012 in the First Hospital of China Medical *** the first phase,the study evaluated the level of transepidennal water loss （TEWL） and the number of colony-forming units （CFU） of Staphylococcus in defined skin areas of SD patients who were human immunodeficiency virus （HIV） seropositive （HIV [＋] SD [＋] group,n =13）,classical SD （HIV [-] SD [＋] group,n =24） patients,H IV seropositive-non-SD （HIV [＋] SD [-] group,n =16） patients,and healthy volunteers （HIV [-] SD [-] group,n 16）.In the second phase,we enrolled another cohort of HIV （-） SD （＋） patients who applied topical fusidic acid （n =15）,tacrolimus （n =16）,or moisturizer （n =12）.Changes in the Seborrheic Dermatitis Area Severity Index （SDASI）,TEWL,and Staphylococcus density were evaluated 2 weeks *** of each index were performed using analysis of variance （ANOVA） and least significant difference ***：The level of TEWL was greater through lesional sites in the HIV （＋） SD （＋） group than that in HIV （＋） SD （-） and HIV （） SD （-） groups （95% confidence interval [CI]：18.873-47.071,P 〈 0.001 and 95% CI：28.755-55.936,P 〈 0.001,respectively）.The number of CFU of Staphylococcus was greater in the HIV （＋） SD （＋） group than that in HIV （＋） SD （-） and HIV （-） SD （-） groups （95% CI：37.487-142.744,P =0.001 and 95% CI：54.936-156.400,P 〈 0.001,respectively）.TEWL was significantly more improved in patients treated with tacrolimus and fusidic acid than that in those treated with moisturizers （95% CI：7.560 38.987,P =0.004 and 95% CI：4.659-37.619,P =0.01 1,respectively）.Topical tacrolimus and fusidic acid were significantly associ

关键词： Human lmmunodeficiency Virus Seborrheic Dermatitis Staphylococcus

Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking

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Food Science and Human Wellness 2024年

作者： Junyu Liu Zhengyang song Haihong Chen Wen Zeng Guirong Han Wei Li bing Xu Yuan Lu Canyang Zhang Zhenglian Xue Bin Lü Chong Zhang song Yang Yi Wang Xinhui Xing Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory MOE Key Laboratory for Industrial Biocatalysis Centre for Synthetic and Systems Biology Department of Chemical Engineering Tsinghua University Shenzhen International Graduate School Tsinghua University Shandong Province Key Laboratory of Applied Mycology Qingdao International Center on Microbes Utilizing Biogas School of Life Sciences Qingdao Agricultural University Anhui University of Technology Yunnan Shujian Tea Co. Ltd.

Pu-erh tea， a traditional Chinese beverage， performs an anti-obesity function， but the correlation between its components and efficacy remains unknown. Here， we screened two Pu-erh teas with significant anti-obesity efficacies from 11 teas. In vitro experiments revealed that lipid accumulation in L02 cells and lipid synthesis in 3T3-L1 cells were significantly better inhibited by Tea-B than Tea-A. Further in vivo experiments using model mice revealed that the differences in chemical components generated two pathways in the anti-obesity efficacy and mechanism of Pu-erh teas. Tea-A changes the histomorphology of brown adipose tissue (BAT) and increases the abundance of Coriobacteriaceae＿UCG＿002 and cyclic AMP in guts through high chemical contents of cyclopentasiloxane， decamethyl， tridecane and 1，2，3-trimethoxybenzene， eventually increasing BAT activation and fat browning gene expression; the high content of hexadecane and 1，2-dimethoxy-benzene in Tea-B reduces white adipose tissue (WAT) accumulation and the process of fatty liver， increases the abundance of Odoribacter and sphinganine 1-phosphate， inhibits the expression of lipid synthesis and transport genes. These mechanistic findings on the association of the representative bioactive components in Pu-erh teas with the anti-obesity phenotypes， gut microbes， gut metabolite structure and anti-obesity pathways， which were obtained for the first time， provide foundations for developing functional Pu-erh tea.

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The Redemption of Zhejiang Shipping Industry Under the Crisis

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中国船检 2011年第10期 126-127页

作者： Chen Jieyue & song bing

The autumn is approaching and the chill is being felt, which is the general feeling of the shipping industry. Since the first quarter of 2011 till now, the coastal shipping market in Zhejiang has been vibrating at the... 详细信息

关键词： The Redemption of Zhejiang Shipping Industry Under the Crisis

To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 529-538页

作者： Ling-Hou Meng Xian-Wei Mo bing-Yu Yang Hai-Quan Qin Qing-Zhou song Xin-Xin He Qiang Li Zheng Wang Chang-Lin Mo Guo-Hai Yang Department of Gastrointestinal Surgery Guangxi Clinical Research Center for Colorectal CancerGuangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal and Anal Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina First Department of Chemotherapy Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving *** current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of *** To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of *** We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS *** In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of *** comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation *** was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.

关键词： Anterior resection syndrome Colorectal cancer Diagnostic evaluation system Magnetic resonance imaging defecography Pathogenesis

Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival

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Chinese Journal of Cancer 2011年第9期30卷 627-637页

作者： Wen-Ting Liao Yan Feng Men-Lin Li Guang-Lin Liu Man-Zhi Li Mu-Sheng Zeng Li-bing song State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department ol Pathology School of Basic Medical Sciences Southern Medical University Guangdong Provincial Key Laboratory of Molecular Tumor Pathology Guangzhou Guangdong 510515 P. R. China.

Breast cancer is one of the leading causes of cancer death *** study aimed to analyze the expression of centromere protein H(CENP-H) in breast cancer and to correlate it with clinicopathologic data,including patient *** reverse transcription-polymerase chain reaction and Western blotting to detect the expression of CENP-H in normal mammary epithelial cells,immortalized mammary epithelial cell lines,and breast cancer cell lines,we observed that the mRNA and protein levels of CENP-H were higher in breast cancer cell lines and in immortalized mammary epithelial cells than in normal mammary epithelial *** next examined CENP-H expression in 307 paraffin-embedded archived samples of clinicopathologically characterized breast cancer using immunohistochemistry,and detected high CENP-H expression in 134(43.6%) *** analysis showed that CENP-H expression was related with clinical stage(P = 0.001),T classification(P = 0.032),N classification(P = 0.018),and Ki-67(P < 0.001).Patients with high CENP-H expression had short overall *** analysis showed that CENP-H expression was an independent prognostic indicator for patient *** results suggest that CENP-H protein is a valuable marker of breast cancer progression and prognosis.

关键词：着丝粒蛋白乳腺癌过度表达 Western印迹法乳腺上皮细胞细胞永生化聚合酶链反应临床病理

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桩-岩摩擦黏着特性的试验与分析

岩土力学 2011年第8期32卷 2313-2317页

作者：宋兵蔡健华南理工大学土木工程系广州510063 广州市建筑科学研究院广州510440

研究桩与岩石的侧摩阻力组成及影响因素,有助于准确地把握桩与岩石的侧摩阻力取值原则。在对桩与岩层的摩擦黏着机制分析的基础上,指出界面力与岩层抗剪力的区别,并提出岩层的极限侧摩阻力由界面强度及岩石强度两者较弱一方决定的观点... 详细信息

研究桩与岩石的侧摩阻力组成及影响因素,有助于准确地把握桩与岩石的侧摩阻力取值原则。在对桩与岩层的摩擦黏着机制分析的基础上,指出界面力与岩层抗剪力的区别,并提出岩层的极限侧摩阻力由界面强度及岩石强度两者较弱一方决定的观点。进行了中风化岩中4组混凝土短桩的抗压及抗拔极限摩阻力对比试验,获得了相应的极限侧摩阻力值以及抗拔与抗压极限侧摩阻力值的比值。抗拔时由于上部岩层对桩侧岩层的约束作用较弱,会使侧摩阻力相对抗压时有较大降低。通过有限元计算及其与试验值的比较分析,研究短桩与岩层的界面强度条件,发现岩层和混凝土灌注桩间的侧摩阻力中界面黏着力占很大比例。

关键词：桩桩-岩侧摩阻力黏着力摩擦力有限元分析

HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients:ten-year experience

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 149-153页

作者： Chun-Hui Yuan Dian-Rong Xiu Bin Jiang Zhi-Fei Li Lei Li Shi-bing song Tong-Lin Zhang Department of General Surgery Peking University Third Hospital

BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation. METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group) The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared. RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P0.05). CONCLUSION: Compared with lamivudine monotherapy combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation.

关键词： hepatitis B virus recurrence lamivudine hepatitis B immunoglobulin liver transplantation

基于瞬时幅值的光伏系统电流传感器微小故障检测及估计

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控制与决策 2022年第3期37卷 583-592页

作者：许水清陶松兵柴毅黄大荣程庭莉合肥工业大学电气与自动化工程学院合肥230009 重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044 重庆交通大学信息科学与工程学院重庆400000

电流传感器是光伏系统中用于系统控制和状态监测的重要元件,然而受运行环境影响,电流传感器易出现性能退化,影响系统运行安全.为了准确检测和估计出电流传感器微小故障,提出基于瞬时幅值的传感器微小故障检测和估计方法.首先,建立基于... 详细信息

电流传感器是光伏系统中用于系统控制和状态监测的重要元件,然而受运行环境影响,电流传感器易出现性能退化,影响系统运行安全.为了准确检测和估计出电流传感器微小故障,提出基于瞬时幅值的传感器微小故障检测和估计方法.首先,建立基于瞬时幅值的电流传感器微小故障模型,利用Hilbert变换(HT)估计相电流瞬时幅值将测量的三相正弦电流转换为相互独立的三维直流信号分量;其次,利用快速移动窗主成分分析(FWMPCA)对三维直流信号组成的数据矩阵进行特征提取,获得主元和残差子空间向量的概率密度分布函数;然后,利用Kullback-Leibler(KL)距离定量度量实际运行数据相对于无故障运行数据的微小变化,在此基础上,设置故障检测阈值,构建故障幅值估计模型,实现电流传感器微小故障检测和估计;最后,利用RT-LAB实验平台验证所提方法的有效性.

关键词：微小故障瞬时幅值快速移动窗主成分分析 KL距离光伏发电系统

基于双子空间并行回归的化工过程质量相关故障检测方法

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化工学报 2023年第11期74卷 4600-4610页

作者：宋冰郭涛侍洪波谭帅陶阳马浴阳华东理工大学能源化工过程智能制造教育部重点实验室上海200237 中铁十四局集团有限公司山东济南250000

邻域保持嵌入(neighborhood preserving embedding,NPE)是一种常用的无监督学习方法,在故障检测领域得到了广泛应用。由于NPE提取的数据特征无法解释输入数据和输出数据之间的关系,因此在化工过程质量相关故障检测方面存在局限性。另外,... 详细信息

邻域保持嵌入(neighborhood preserving embedding,NPE)是一种常用的无监督学习方法,在故障检测领域得到了广泛应用。由于NPE提取的数据特征无法解释输入数据和输出数据之间的关系,因此在化工过程质量相关故障检测方面存在局限性。另外,NPE在提取数据流形结构时忽略了动态信息的表征。为了解决上述问题,基于NPE和慢特征分析(slow feature analysis,SFA)算法提出了一种名为双子空间并行回归(twin-space parallel regression,TSPR)的质量相关故障检测方法,该方法能够同时提取数据的流形特征和变化速度信息。首先,通过基于互信息的策略将原始过程空间分为序列相关子空间和序列无关子空间,以应对变量在时间序列相关性的差异。其次,在两个子空间中分别应用提出的邻域保持-慢特征嵌入算法(neighborhood preserving-slow feature embedding regression,NP-SFE)和NPE算法提取数据的有效结构特征,并同时用最小二乘回归在两个特征子空间中构建过程变量与质量变量的回归关系。随后,通过对回归系数的协方差矩阵分解,得到质量相关子空间和质量无关子空间,进而在相应子空间建立统计量并估计其控制限。最后,将所提方法在典型案例上进行测试验证,以说明所提方法的有效性和合理性。

关键词：邻域保持嵌入慢特征分析质量相关最小二乘回归故障检测

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