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Journal of Traditional Chinese Medicine 2024年第3期44卷 478-488页

作者： CHU Mengzhen WANG Yu LIN Zhijian lyu Jintao ZHANG Xiaomeng ZHANG bing Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese Medicine

OBJECTIVE: To explore the pharmacodynamic effects and potential mechanisms of Shuangling extract against ulcerative colitis(UC). METHODS: The bioinformatics method was used to predict the active ingredients and action targets of Shuangling extract against UC in mice. And the biological experiments such as serum biochemical indexes and histopathological staining were used to verify the pharmacological effect and mechanism of Shuangling extract against UC in mice. RESULTS: The Shuangling extract reduced the levels of seruminterleukin-1β(IL-1β), tumor necrosis factor-α(TNF-N), interleukin-6(IL-6) and other inflammatory factors in UC mice and inhibited the inflammatory response. AKT Serine/threonine Kinase 1 and IL-6 may be the main targets of the anti-UC action of Shuangling extract, and the TNF signaling pathway, Forkhead box O signaling pathway and T-cell receptor signaling pathway may be the main signaling pathways. CONCLUSION: The Shuangling extract could inhibit the inflammatory response induced by UC and regulate intestinal immune function through multiple targets and multiple channels, which provided a new option and theoretical basis for anti-UC.

关键词： Shuangling extract colitis, ulcerative molecular docking simulation network pharmacology pharmacodynamic study

Characterizing the Exposome of Food Contamination and China Total Diet Study: Project for Improving Food Safety Risk Assessment in China

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China CDC weekly 2022年第9期4卷 157-160,I0001页

作者： bing lyu Jingguang Li Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Sciences Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina

Over the past 30 years,China,as a developing country with a huge population and large geographical heterogeneity,has made a big leap from a shortage of food to basically the elimination of hunger.However,there has been a challenge moving from traditional agriculture and farming practices with numerous small food businesses and short supply chains to larger scale production and longer supply chains.Ensuring an adequate supply of safe,nutritious,high-quality food requires regulatory oversight based on scientific evidence.With the global distribution of human food and ingredients,this is a shared challenge internationally.The only way to steadily improve the food safety situation globally and in China is to follow the risk analysis framework with the joint efforts of all stakeholders(1).Since 2009,the Chinese risk assessment system has been developed in accordance with the Food Safety Law of the People’s Republic of China.

关键词： chains globally farming

Pre-combustion mercury removal with co-production of hydrogen via coal electrolysis

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Journal of Environmental Sciences 2024年第2期136卷 382-389页

作者： Xiang lyu Runming Tao Tianyu Zhang Chemical and Biomolecular Engineering Department Ohio University165 Stocker CenterAthensOH45701USA Electrification and Energy Infrastructures Division Oak Ridge National LaboratoryOak RidgeTN37831USA Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

Pre-combustion mercury removal via coal electrolysis was performed and investigated on a bench-scale coal electrolytic cell(CEC)systemically,and factorial design was used to determine the effect of different operating conditions(coal particle size,operating temperature,operating cell voltage,and flow rate of slurry)on the percentage of mercury removal,percentage of ash removal,and dry heating value change.The results showed that the operating cell voltage,as well as the interaction between operating cell voltage and coal particle size,are significant factors in the percentage of mercury removal.There is no significant factor in the percentage of ash removal and the dry heating value change,but the coal could be purified while keeping the dry heating value almost constant after electrolysis.A co-product of hydrogen could be produced during coal electrolysis with 50%lower energy consumption compared with water electrolysis.Meanwhile,a mechanism for mercury removal in coal was proposed.The facts indicate that coal electrolysis is a promising method for precombustion mercury removal.

关键词： Pre-combustion mercury removal Coal electrolysis Ash removal Dry heating value Hydrogen production

Challenges and opportunities in rare cancer research in China

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Science China(Life Sciences) 2024年第2期67卷 274-285页

作者： Jianxin Xue Qunyan lyu Division of Thoracic Tumor Multimodality Treatment Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China National Natural Science Foundation of China Beijing 100085China

Cancer is one of the major public health challenges in China.Rare cancers collectively account for a considerable proportion of all malignancies.The lack of awareness of rare cancers among healthcare professionals and the general public,the typically complex and delayed diagnosis,and limited access to clinical trials are key challenges.Recent years have witnessed an increase in funding for research related to rare cancers in China.In this review,we provide a comprehensive overview of rare cancers and summarize the status of research on rare cancers in China and overseas,including the trends of funding and publications.We also highlight the challenges and perspectives regarding rare cancers in China.

关键词： rare cancers basic research clinical research preclinical model funding scheme

Simplified liver imaging reporting and data system for the diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2439-2448页

作者： Rong lyu Wei-Juan Hu Di Wang Jiao Wang Yu-bing Ye Ke-Feng Jia Department of Radiology Tianjin Third Central HospitalTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin 300170China

BACKGROUND The liver imaging reporting and data system(LI-RADS)diagnostic table has 15 cells and is too complex.The diagnostic performance of LI-RADS for hepatocellular carcinoma(HCC)is not satisfactory on gadoxetic acid-enhanced magnetic resonance imaging(EOB-MRI).AIM To evaluate the ability of the simplified LI-RADS(sLI-RADS)to diagnose HCC on EOB-MRI.METHODS A total of 331 patients with 356 hepatic observations were retrospectively analysed.The diagnostic performance of sLI-RADS A-D using a single threshold was evaluated and compared with LI-RADS v2018 to determine the optimal sLIRADS.The algorithms of sLI-RADS A-D are as follows:The single threshold for sLI-RADS A and B was 10 mm,that is,classified observations≥10mm using an algorithm of 10-19 mm observations(sLI-RADS A)and≥20 mm observations(sLI-RADS B)in the diagnosis table of LI-RADS v2018,respectively,while the classification algorithm remained unchanged for observations0.999).With HBP hypointensity as an MF,the sensitivity of F-sLI-RADS was greater than that of LI-RADS v2018(93.0%vs 87.0%,P<0.001)and sLI-RADS D(93.0%vs 89.8%,P=0.016),without a lower specificity(86.5%vs 90.1%,P=0.062;86.5%vs 89.4%,P=0.125).Compared with that of LI-RADS v2018,the time to classify lesions according to FsLI-RADS was shorter(51±

关键词： Hepatocellular carcinoma Magnetic resonance imaging Liver Diagnosis Contrast agent

Exposure to Bisphenolic Analogues in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 180-184,I0006-I0008页

作者： Jing Zhang Kai Yao Jie Yin bing lyu Yunfeng Zhao Jingguang Li bing Shao Yongning Wu Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijingChina NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina

Summary What is already known about this topic?Bisphenol A(BPA)and other bisphenolic compounds(BPs)are proved to pose potential endocrine disrupting properties.The primary source of BP exposure is the diet.European Food Safety Authority(EFSA)established a temporary tolerable daily intake(t-TDI)of BPA 4μg/kg body weight per day.What is added by this report?BPs were detected in composite food samples from the Sixth China Total Diet Study(TDS)at percentages of 27.1%-78.5%.The estimated dietary exposure of BPA and bisphenol S(BPS)for an average adult were 18.1 ng/kg body weight per day and 22.2 ng/kg body weight per day,respectively.The main dietary contributors for BPs were cereals,water and beverage,meat as well as vegetables.What are the implications for public health practices?BP dietary intake poses low risks on the Chinese general population based on the t-TDI set by EFSA.BPS presented a higher exposure level than BPA,which highlights the need to strengthen the surveillance of BP alternatives in foodstuffs.

关键词： properties. Total intake

Exposure to Fipronil Insecticide in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 185-189,I0009-I0011页

作者： Zhibin Liu Dawei Chen bing lyu Jingguang Li Yunfeng Zhao Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina Nanchang Key Laboratory of Detection and Control of Food Safety Nanchang Inspection and Testing CenterNanchangJiangxi ProvinceChina

Summary What is already known about this topic?Fipronil is classified as a“possible human carcinogen”by the United States Environmental Protection Agency.Long-term exposure to fipronil may cause damage to liver,thyroid,and kidney.However,fipronil and its metabolites are ubiquitous in the environment and food.What is added by this report?The dietary intake of fipronil in China was within acceptable levels with low health risk.Eggs were the main dietary intake contributor of fipronil for Chinese adult populations(55.3%),followed by vegetables(30.7%),meats(5.90%),cereals(5.30%),and other food categories contributed less than 2%.What are the implications for public health practice?The study results will help health managers understand the health risk of fipronil,and help to better formulate monitoring plans in foods.It is still necessary to strengthen the monitoring of fipronil in foods,especially animal-derived foods.

关键词： cereal intake nil

Single transmembrane GPCR modulating proteins:neither single nor simple

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Protein & Cell 2024年第6期15卷 395-402页

作者： Meng Wang Jianjun lyu Chao Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co. LtdEast Lake High-Tech Development ZoneWuhan 430205China Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)Tongji UniversityShanghai 200092China

The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on the plasma membrane and impressionable downstream intracellular cascades.GPCR accessory proteins not only contribute to the proper folding and trafficking of receptors but also exhibit selectable receptor preferences.

关键词： specificity GPCR neither

Adaptation of Ocular Opponency Neurons Mediates Attention-Induced Ocular Dominance Plasticity

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Neuroscience Bulletin 2024年第3期40卷 339-349页

作者： Fangxing Song Lili lyu Min Bao CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing100101China Department of Psychology University of Chinese Academy of SciencesBeijing100049China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China

Previous research has shown that ocular dominance can be biased by prolonged attention to one eye.The ocular-opponency-neuron model of binocular rivalry has been proposed as a candidate account for this phenomenon.Yet direct neural evidence is still lacking.By manipulating the contrast of dichoptic testing gratings,here we measured the steady-state visually evoked potentials(SSVEPs)at the intermodulation frequencies to selectively track the activities of ocular-opponency-neurons before and after the“dichoptic-backward-movie”adaptation.One hour of adaptation caused a shift of perceptual and neural ocular dominance towards the unattended eye.More importantly,we found a decrease in the intermodulation SSVEP response after adaptation,which was significantly greater when high-contrast gratings were presented to the attended eye than when they were presented to the unattended eye.These results strongly support the view that the adaptation of ocular-opponency-neurons contributes to the ocular dominance plasticity induced by prolonged eye-based attention.

关键词： Attention Ocular dominance Opponency neuron Adaptation Steady-state visually evoked potential

The early Japanese books reorganization by combining image processing and deep learning

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CAAI Transactions on Intelligence Technology 2022年第4期7卷 627-643页

作者： bing lyu Hengyi Li Ami Tanaka Lin Meng Graduate School of Science and Engineering Ritsumeikan UniversityKusatsuShigaJapan College of Science and Engineering Ritsumeikan UniversityKusatsuShigaJapan

Many early Japanese books record a large amount of information,including historical politics,economics,culture,and so on,which are all valuable legacies.These books are waiting to be reorganized at the moment.However,a large amount of the books are described by Kuzushiji,a type of handwriting cursive script that is no longer in use today and only readable by a few experts.Therefore,researchers are trying to detect and recognise the characters from these books through modern techniques.Unfortunately,the characteristics of the Kuzushiji,such as Connect-Separate-characters and Manyvariation,hinder the modern technique assisted re-organisation.Connect-Separatecharacters refer to the case of some characters connecting each other or one character being separated into unconnected parts,which makes character detection hard.Manyvariation is one of the typical characteristics of Kuzushiji,defined as the case that the same character has several variations even if they are written by the same person in the same book at the same time,which increases the difficulty of character recognition.In this sense,this paper aims to construct an early Japanese book reorganisation system by combining image processing and deep learning techniques.The experimentation has been done by testing two early Japanese books.In terms of character detection,the final Recall,Precision and F-value reaches 79.8%,80.3%,and 80.0%,respectively.The deep learning based character recognition accuracy of Top3 reaches 69.52%,and the highest recognition rate reaches 82.57%,which verifies the effectiveness of our proposal.

关键词： character recognition deep learning image processing Japanese books reorganization Kuzushiji