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Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3818-3836页

作者： Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng bing Liu Jie Lei bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Medical Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 510275PR China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023PR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080PR China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871PR China Department of Surgery and Cancer Imperial College LondonLondon W120NNUK Department of Breast Surgery Precision Cancer Medicine CenterFudan University Shanghai Cancer CenterShanghai 200032PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101PR China

Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains ***,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer *** of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE ***,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved *** activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial ***,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like *** findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.

关键词： Cancer neural architectures

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Long-term survival outcome of laparoscopic liver resection for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1110-1121页

作者： Shi lam Kai-Chi Cheng Department of Surgery Kwong Wah HospitalHong Kong999077China

Long-term survival is the most important outcome measurement of a curative oncological *** hepatocellular carcinoma(HCC),the long-term disease-free and overall survival of laparoscopic liver resection(LLR)is shown to be non-inferior to the current standard of open liver resection(OLR).Some studies have reported a superior long-term oncological outcome in LLR when compared to *** has been argued that improvement of visualization and instrumentation and reduced operative blood loss and perioperative blood transfusion may contribute to reduced risk of postoperative tumor *** the other hand,since most of the comparative studies of the oncological outcomes of LLR and OLR for HCC are non-randomized,it remained inconclusive as to whether LLR confers additional survival benefit compared to *** the paucity of level 1 evidence,the practice of LLR for HCC has gained wide-spread acceptance due to the reproducible improvements in the perioperative outcomes and non-inferior oncological outcomes demonstrated by large-scaled,matched comparative ***-analyses of the outcomes of these studies by multiple systematic reviews have also returned noncontradictory *** the basis of a theoretical advantage of LLR over OLR in preventing tumor recurrence,the current review aims to dissect from the current meta-analyses and comparative studies any evidence of such superiority.

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Liver resection Longterm outcome Overall survival Disease-free survival

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An update on the histological subtypes of hepatocellular carcinoma

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Hepatoma Research 2019年第11期5卷 17-23页

作者： Regina Cheuk-lam Lo Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)is one of the top-ranking cancers worldwide and in Southeast *** high propensity for tumor recurrence,distant metastasis and chemoresistance remain major hurdles in the treatment of *** advances on genetics and genomics research,molecular targeted therapies are emerging as a hope for better disease *** the histological perspective,microscopic review of clinical samples has led to subclassification of HCC and establishment of new *** this review,latest understanding on macrotrabecular-massive HCC,steatohepatitic HCC,lymphocyte-rich HCC,scirrhous HCC,fibrolamellar carcinoma and combined hepatocellular-cholangiocarcinoma will be discussed,emphasizing on the clinical relevance of these pathological *** delineation of the histological,immunohistochemical,molecular and biological phenotypes of primary liver cancer would to further enhance an integrated morphological-molecular classification that better predicts clinical outcome and guides clinical management.

关键词： Liver cancer subtype histology

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Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

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Journal of Genetics and Genomics 2020年第2期47卷 69-83页

作者： Raoxu Wang Bowen Li Sin Man lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology.Chinese Acadmy of SciencesBeijing.100101China University of Chinese Academy of Sciences Beijing100101China Lipidall Technologies Company Limited Changzhou213000China

Mass spectrometry(MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic *** metabolomes of cells,tissues,and organisms comprise a variety of molecules including lipids,amino acids,sugars,organic acids,and so *** mainly focus on the hydrophilic classes,while lipidomics has emerged as an independent omics owing to the complexities of the organismal *** potential roles of lipids and small metabolites in disease pathogenesis have been widely investigated in various human diseases,but system-level understanding is largely lacking,which could be partly attributed to the insufficiency in terms of metabolite coverage and quantitation accuracy in current analytical *** scientists are continuously striving to develop high-coverage omics approaches,integration of metabolomics and lipidomics is becoming an emerging approach to mechanistic *** of metabolome and lipidome offers a complete atlas of the metabolic landscape,enabling comprehensive network analysis to identify critical metabolic drivers in disease pathology,facilitating the study of interconnection between lipids and other metabolites in disease *** this review,we summarize omics-based findings on the roles of lipids and metabolites in the pathogenesis of selected major diseases threatening public *** also discuss the advantages of integrating lipidomics and metabolomics for in-depth understanding of molecular mechanism in disease pathogenesis.

关键词： Metabolomics Lipidomics Integration Disease progression

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Alcoholic ketoacidosis in two Chinese patients

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Chinese Medical Journal 2000年第11期113卷 91-93页

作者： Rossa WKChiu Hok-Leung Tai and Ching-Wan lam DepartmentofChemicalPathology TheChineseUniversityofHongKongPrinceofWalesHospitalHongKongChinaDepartmentofChemicalPathologyTheChineseUniversityofHongKongPrinceofWalesHospitalHongKongChina

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Complexity scalable control algorithm for intra coding in H.264 under energy constraints

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High Technology Letters 2010年第3期16卷 274-279页

作者： Gao Xuejun lam Kin Man ZhuoLi ShenLansun Signal and Information Processing Laboratory Beijing University of Technology Beijing 100124 P.R. China Centre for Signal Processing Department of Electronic and Information Engineering the Hong Kong Polytechnic University Kowloon Hong Kong P.R. China

In this paper, the complexity of intra coding is first analyzed so as to achieve a weight of complexity measurement for each intra mode. Then, a new complexity scalable control algorithm for intra coding in H. 264 is proposed, based on the rearrangement of the order of candidate modes and an efficient complexity allocation and control （CAAC） scheme at the macroblock （MB） level. The candidate modes of each MB are rearranged according to the local-edge information. Experimental results show that our proposed algorithm can make an appropriate cut-off point of the candidate modes sequence adaptively according to the current energy condition of a mobile device, so as to adjust the complexity at any level while maximizing the video quality, which can prolong the operational lifetime of the battery with minimum degradation in video quality.

关键词： complexity scalable control complexity allocation rearrangement of candidate modes intra coding H. 264 energy constraints

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Contribution of Genomics to Gene Discovery in Plant Abiotic Stress Responses

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Molecular Plant 2012年第6期5卷 1176-1178页

作者： Yun Ma Feng Qin lam-Son Phan Tran Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing100039Chlna Signaling Pathway Research Unit Plant Science CenterRIKEN Yokohama Institute1-7-22Suehiro-choTsurumiYokohama 230-0045Japan

Sustaining agricultural production under adverse environ- mental conditions, such as drought and high salinity, rep- resents a major challenge. The discovery of key genes and signal transduction pathways underlying plant responses to environmental stress will play an important role in devel- oping strategies for the genetic improvement of crops to address this challenge. Crop functional genomics has greatly contributed to the identification of abiotic stress-related genes. Current advances in genomic technologies now pro- vide effective and high-throughput methods for identifying stress-related genes at a genome-wide level, especially with the availability of the complete genomic sequence of several model and crop plant species. The development of genetic database resources has allowed bioinformatic approaches to identify stress-tolerant gene families across species based on homology and synteny. Additionally, genome-wide associa- tion studies （GWAS） for complex trait loci in crops have facili- tated the discovery of critical stress-related genes and their favorable alleles.

关键词： IN-SILICO ANALYSIS TRANSCRIPTION FACTORS DEHYDRATION STRESS PREDICTION

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Is engineered wood China’s way to carbon neutrality?

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Journal of Bioresources and Bioproducts 2022年第2期7卷 1-2页

作者： Christian Sonne Changlei Xia Su Shiung lam Department of Ecoscience Faculty of Technological SciencesAarhus UniversityRoskilde DK-4000Denmark Sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesUttarakhand 248007India Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

China emits more than 25%of the world’s carbon dioxide(https://***/co2-emissions),and in December 2021 the country’s daily carbon trading volume hits a new highest *** with the EU and USA,China bears a great responsibility to limit global warming to 2℃,and therefore recently launches a plan to be carbon-neutral be-fore 2060(https://***/co2-emissions).However,its rapid urbanization challenges this initiative as the boom-ing building and construction industry constitute more than 1/3 of the total energy consumption,which undesirably in-creases carbon emissions(IEA,2019;Duan et al.,2021).Although China has built five new nuclear power stations and closed down more than 1000 coal-fired power plants,it is still highly insufficient to meet the country’s goal to be carbon-neutral(https://***/countries/china/).

关键词： Climate change Engineered wood Carbon neutrality Building material China

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Responses in gas exchange and water status between drought-tolerant and-susceptible soybean genotypes with ABA application

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The Crop Journal 2015年第6期3卷 500-506页

作者： Md.Mokter Hossain Hon-Ming lam Jianhua Zhang School of Life Sciences and Center for Soybean Research of the State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong

The purpose of this study was to investigate the physiological responses of drought-tolerant and drought-susceptible soybean genotypes to exogenous abscisic acid(ABA) application during progressive soil drying at seedling stages. Five-day old soybean seedlings were transplanted into PVC tubes filled with soil mixture. Seedlings were watered daily with similar water volumes until second trifoliate leaves emerged, and thereafter soil drying with or without exogenous ABA application was imposed. Half of the seedlings of each genotype were left for regular watering as control plants. Soil water status declined significantly over seven days of withholding water supply for both genotypes. Leaf expansion rate, stomatal conductance(g_s), leaf water potential(ψ_w), and relative water content of leaves(%RWC) declined significantly under soil drying as well as soil drying with ABA application, compared to their values for well-watered soybean genotypes. However, a drought-tolerant genotype(C12) responded more rapidly than a drought-susceptible genotype(C08) after imposition of soil drying and soil drying with exogenous ABA. In addition, application of exogenous ABA to water-restricted soybeans resulted in higher %RWC and ψwin the drought-tolerant than in the drought-susceptible genotype. Compared to the drought-susceptible genotype, the drought-tolerant genotype was more responsive to exogenous ABA application, resulting in a higher root-to-shoot ratio.

关键词： Drought stress Exogenous ABA Leaf relative water content Stomatal conductance Soybean genotypes

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Impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes of liver disease

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World Journal of Gastroenterology 2021年第29期27卷 4831-4845页

作者： Tiffany Khoo Danielle lam John K Olynyk Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalup 6027Australia

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic *** treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by *** introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive *** the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence,the number of new *** treatments have decreased the rates of liver decompensation and as a result,lowered hospitalisation and mortality rates for both chronic hepatitis B and C *** quality of life of chronically infected patients has also been improved significantly by modern *** therapy has stopped the progression of liver disease to cirrhosis in certain patient cohorts and prevented ongoing hepatocellular damage in patients with existing *** term benefits of antiviral therapy include a reduced risk of developing hepatocellular carcinoma and decreased number of patients requiring liver *** review article assesses the literature and summarises the impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes from liver disease.

关键词： Hepatitis B Hepatitis C Nucleotide analogues Directly acting antiviral therapy Clinical outcomes Liver disease

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