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Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

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World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan liu bai-Jin-tao Sun Chuan Zhang bing li Xiao-Xuan Yu Yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

Mechanism of local solidification time variations with melt rate during vacuum arc remelting process of 8Cr4Mo4V high-strength steel

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Journal of Iron and Steel Research(International) 2024年第2期31卷 377-388页

作者： tao Pan Hong-chun Zhu Zhou-hua Jiang Hua-bing li Rui Zhang Hao Feng School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

A 2D axisymmetric numerical model was established to investigate the variations of molten pool with different melt rates during the vacuum arc remelting of 8Cr4Mo4V high-strength steel,and the ingot growth was simulated by dynamic mesh *** results show that as the ingot grows,the molten pool profile changes from shallow and flat to V-shaped,and both the molten pool depth and the mushy width ***,the variation of both the molten pool shape and the mushy width melt rate is clarified by the thermal equilibrium *** melt rate increases,both the molten pool depth and the mushy width *** is caused by the increment in sensible heat stored in the ingot due to the limitation of the cooling capacity of the *** nonlinear increment in sensible heat leads to a nonlinear increase in the mushy *** addition,as melt rate increases,the local solidification time(LST)of ingot decreases obviously at first and then *** melt rate is controlled in a suitable range,LST is the lowest and the secondary dendrite arm spacing of the ingot is the smallest,which can effectively improve the compactness degree of 8Cr4Mo4V high-strength steel.

关键词： 8Cr4Mo4V high-strength steel Vacuum arc remelting process Melt rate Molten pool Local solidification time

Cobalt-catalyzed deoxygenative borylation of diaryl ketones

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Chinese Chemical Letters 2024年第3期35卷 277-281页

作者： Longqing liu bing Zhang Yu liu Jinbo Zhao tao li Wanxiang Zhao College of Chemistry and life Science Changchun University of TechnologyChangchun 130012China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Geminal diboronates and diarylmethyl boronates are versatile building blocks in synthetic *** here reported a highly efficient approach for the synthesis of gem-bisborylalkanes and diarylmethyl boronates via cobalt-catalyzed deoxygenative borylation of diaryl *** borylation protocol is compatible with a broad range of functionalized aryl groups,providing access to a wide array of boronic *** resulting boronic esters can be further transformed to various cross-coupling products and TPEs that represent important structural motifs in organic chemistry and materials science.

关键词： Bisborylalkanes Cobalt Deoxygenative borylation Ketones

Analysis of the Influence of Geometrical Parameters on the Performance of a Proton Exchange Membrane Fuel Cell

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Fluid Dynamics & Materials Processing 2024年第1期20卷 219-237页

作者： Guodong Zhang Huifang tao Da li Kewei Chen Guoxiang li Shuzhan bai Ke Sun School of Energy and Power Engineering Shandong UniversityJinan250061China Sinotruk Jinan Special Purpose Vehicle Co. Ltd.Jinan250117China

A suitable channel structure can lead to efficient gas distribution and significantly improve the power density of fuel *** this study,the influence of two channel design parameters is investigated,namely,the ratio of the channel width to the bipolar plate ridge width(i.e.,the channel ridge ratio)and the channel *** impact of these parameters is evaluated with respect to the flow pattern,the gas composition distribution,the temperature field and the fuel cell output *** results show that a decrease in the channel ridge ratio and an increase in the channel depth can effectively make the distributions of velocity,temperature and concentration more uniform in each channel and improve the output capability of the fuel *** increase in the channel ridge ratio and depth obviously reduces the flow resistance and improves the flow characteristics.

关键词： Hydrogen fuel cell bipolar plate flow channel multiphysics coupling

Milling degree affects the fermentation properties of rice:perspectives from the composition of nutrients and gut microbiota via in vitro fermentation

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Food Science and Human Wellness 2024年第3期13卷 1578-1588页

作者： Yu Zhang Fan li Shutong Pan bing bai Kai Huang Sen li Hongwei Cao Tian Xie Jian Xie Xiao Guan School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China National Grain Industry(Urban Grain and Oil Security)Technology Innovation Center Shanghai 200093China Nutrition&Health Research Institute Co.Ltd. COFCO CorporationBeijing 102209China China Grain Wuhan Scientific Research&Design Institute Co.Ltd. Wuhan 430079China

Fermentation substrates of rice with different milling degrees(MDs) were prepared and fermented with human feces to compare their fermentation properties and effects on gut *** 0s,MD 5s and MD 60s represented brown rice,moderately-milled rice and white rice,*** in vitro fermentation,the MD 5s group showed higher starch utilization,compared with the MD 0s and 60s groups evaluated by Fourier transform infrared spectrometer,and confocal laser scanning *** of fermentation substrates of rice with different MDs on gut microbiota were evaluated by 16S rDNA *** the sample groups reduced the pH and produced short-chain fatty acids(SCFAs) and branched-chain fatty *** MD 5s group exhibited higher α-diversity than the MD 0s and 60s *** of Phascolarctobacterium,Blautia and norank_f_Ruminococcaceae were higher in the MD 0s and 5s groups,compared with the MD 60s *** bacteria were also positively correlated with the SCFAs production via Spearman correlation *** vitro culture assay revealed that fermentation substrates of MD 0s and 5s promoted the growth of two probiotics(Akkermansia muciniphila and Bifidobacterium adolescentis).Our results showed that moderate milling might be an appropriate way to produce rice products with richer nutrients and better fermentation properties.

关键词： Rice processing Milling Whole grains Gut microbiota

Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2631-2645页

作者： Yu-Xin liu Cheng-li Bin Lu Zhang Wen-tao Yang bai-Ping An Department of Oncology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Gynecology and Obstetrics Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Endocrine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Cardiovascular Chengdu Integrated TCM&Western Medicine HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Previous observational studies have shown that the prevalence of gastroesophageal reflux disease(GERD)and Barrett’s esophagus(BE)is associated with socioeconomic ***,due to the methodological limitations of traditional observational studies,it is challenging to definitively establish *** To explore the causal relationship between the prevalence of these conditions and socioeconomic status using Mendelian randomization(MR).METHODS We initially screened single nucleotide polymorphisms(SNPs)to serve as proxies for eight socioeconomic status phenotypes for univariate MR *** inverse variance weighted(IVW)method was used as the primary analytical method to estimate the causal relationship between the eight socioeconomic status phenotypes and the risk of GERD and *** then collected combinations of SNPs as composite proxies for the eight socioeconomic phenotypes to perform multivariate MR(MVMR)analyses based on the IVW MVMR ***,a two-step MR mediation analysis was used to examine the potential mediation of the associations by body mass index,major depressive disorder(MDD),smoking,alcohol consumption,and sleep *** The study identified three socioeconomic statuses that had a significant impact on *** included household income[odds ratio(OR):0.46;95% confidence interval(95%CI):0.31-0.70],education attainment(OR:0.23;95%CI:0.18-0.29),and the Townsend Deprivation Index at recruitment(OR:1.57;95%CI:1.04-2.37).These factors were found to independently and predominantly influence the genetic causal effect of ***,the mediating effect of educational attainment on GERD was found to be mediated by MDD(proportion mediated:10.83%).Similarly,the effect of educational attainment on BE was mediated by MDD(proportion mediated:10.58%)and the number of cigarettes smoked per day(proportion mediated:3.50%).Additionally,the mediating effect of household income on GERD was observed to be mediated by sleep dur

关键词： Socioeconomic status Gastroesophageal reflux disease Barrett’s esophagus Two-step Mendelian randomization Multivariate Mendelian randomization

Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin li Long‑Hui Ru Zhi‑Chao Zhang bing‑Feng Lv Ning‑tao Zhang Jin‑Long Zhang Chen‑Gui Lu bing‑Shui Gao Jun‑bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_2 at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

Acute suppurative terminal cholangitis:Clinical characteristics of a new subtype of acute cholangitis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 293-299页

作者： Rong-tao Zhu Ye li Chi-Xian Zhang Wei-Jie Wang Ruo-Peng liang Jian li Kai bai Yu-ling Sun Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Diseases Zhengzhou 450052China Institute of Hepatobiliary and Pancreatic Diseases Zhengzhou UniversityZhengzhou 450052China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Acute suppurative terminal cholangitis(ASTC)is rarer than acute obstructive cholangitis and is not well *** explore this subtype of acute cholangitis,we described our clinical experience with ***:We performed a retrospective review of patients with ASTC admitted to our center from September 2014 to August *** analyzed their clinical characteristics,including etiology,clinical manifestations,imaging features,treatment and ***:A total of 32 ASTC patients were included in the *** majority of the patients had a history of biliary operations,and clinical manifestations were occult and *** positive rate of bacterial culture was 46.9%.All the patients had typical imaging features on computed tomography and magnetic resonance *** with effective antibiotics was provided as soon as diagnosis was *** treatment,most patients had a good *** levels of total bilirubin,aspartate aminotransferase,procalcitonin and gamma-glutamyltransferase were the characteristics of critically ill patients and were associated with relatively poor ***:Our results demonstrated that ASTC should be recognized as a new subtype of acute cholangitis,and that earlier diagnosis and more personalized treatments are needed.

关键词： Acute suppurative terminal cholangitis Acute cholangitis Gram-negative bacterial infections Diagnosis Treatment

Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang tao Luo Fuyu li Yali Jiang Jinke Wang Weizhong Zhang Yunfei bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several ***,the heterogeneity of eccDNA is largely *** this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron *** discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization