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Rolling-induced microstructure change in Zr_(65)Al_(7.5)Ni_(10)Cu_(12.5)Ag_5 bulk metallic glass

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Chinese Science Bulletin 2011年第36期56卷 3948-3951页

作者： ZHOU Wei lu binfeng KONG LingTi LI JinFu ZHOU YaoHe State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai200240 China

The microstructures and free-volume evolutions of as-cast and pre-annealed Zr65Al7.5Ni10Cu12.5Ag5 bulk metallic glasses during rolling deformation have been investigated. No phase transformation is detected in the as-cast/rolled specimen. However,the structural stability of the glass against plastic deformation is worse after pre-annealing,indicated by nanocrystallization in preannealed/rolled specimens with large deformation degrees. Moreover,with increasing deformation degree,the free-volume content in a pre-annealed/rolled specimen increases at a lower average rate than that in an as-cast/rolled specimen.

关键词：大块金属玻璃微观结构诱导滚动自由体积塑性变形平均增长率轧制过程

Prognostic value of IL-6R mRNA in lung adenocarcinoma and squamous cell carcinoma

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Prognostic value of IL-6R mRNA in lung adenocarcinoma and sq...

第十三届全国免疫学学术大会

作者： Bin Xu Qu Chen Cuihua Yue binfeng lu Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow University Jiangsu Engineering Research Center for Tumor Immunotherapy the Third Affiliated Hospital of Soochow University Department of Immunology University of Pittsburgh School of Medicine

Evidence has shown that IL-6/IL-6R signaling pathway contributes to the pathogenesis of lung *** adenocarcinoma(luAD) and lung squamous cell carcinoma(luSC) are the major two pathological subtypesof non-small cell lung cancer(NSCLC).This study is aimed to elucidate potential clinical prognosis and biological function of IL-6R mRNA expression in luAD and *** used the Keywords: "lung cancer" and searched through GEO *** luAD and luSC datasets in TCGA database, totally 8 luAD and 6 luSC datasets were included for this *** found that ahigher expression level of IL-6R mRNA in tumor tissues was a positive prognostic factor for overall survival in luAD(pooled HR = 0.48, PluSC(pooled HR = 1.59, P=0.062 in univariate analysis;pooled HR=1.58, P=0.079 in multivariate analysis).Correlation analysis showed that IL-6 and IL-6R were negatively correlated in luAD while positively correlated in ***-6R and its most correlated genes are mainly involved in cell cycle progression in luAD and are mostly involved in tumor angiogenesis, invasion and metastasis in *** analyses suggest a possible role of tumoral expression of IL-6R in luAD and can potentially be used as a prognostic marker for this type of cancer.

关键词： lung adenocarcinoma lung squamous cell carcinoma IL-6R overall survival enrichment analysis

Eomes Impedes Durable Response to Tumor Immunotherapy by Inhibiting Stemness,Tissue Residency,and Promoting the Dysfunctional State of Intratumoral CD8+T Cells

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Eomes Impedes Durable Response to Tumor Immunotherapy by Inh...

第十四届全国免疫学学术大会

作者： Runzi Sun Jingting Jiang binfeng lu Yibei Zhu Department of Tumor Biological Treatment The Third Affiliated Hospital of Soochow University 匹兹堡大学医学院免疫系苏州大学基础医学与生物科学学院

Sustaining efficacious T cell-mediated antitumor immune responses in the tumor tissues is the key to the success of cancer *** strategies leverage altering the signals T cells sense in the tumor microenvironment(TME).Checkpoint inhibitor-based approaches block inhibitory signals such as PD-1 whereas cytokine-based therapies increase the level of immune-stimulatory cytokines such as *** extrinsic signals,the genetic circuit within T cells also participates in determining the nature and trajectory of antitumor immune ***,we showed that efficacy of the IL33-based tumor immunotherapy was greatly enhanced in mice with T cellspecific Eomes ***,we demonstrated that Eomes deficient mice had diminished proportions of exhausted/dysfunctional CD8

关键词： tumor immunotherapy tissue residency T cell dysfunction stem-like T cell tumor microenvironment

Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors

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Evaluation of tumor response to cytokine-induced killer cell...

第九届全国免疫学学术大会

作者： Xiao-Dong Li binfeng lu Changping Wu Jingting Jiang Department of Tumor Biological Treatment The Third Affiliated Hospital of Soochow University Department of Immunology University of Pittsburgh School of Medicine

CIK cells therapy has been evaluated as an adoptive cell immunotherapy for cancer patients,but there still have not been any standardized systems for evaluating the antitumor efficacy *** WHO and RECIST criteria have already been established for a few years but not sufficient to fully characterize the activity of *** on these two criteria,the irRC was proposed for evaluating the efficacy of immunotherapy.A variety of bioassays for immune monitoring including the specific and non-specific methods,have been *** recommend detect levels of various immunocytes,immune molecules and soluble molecules to find the correlations among them and clinicopathological characteristics to establish criteria for immunological *** also recommend a paradigm shift for the oncologists in the evaluation of immune therapies to ensure assessment of activity based on clinically relevant criteria and time points.

关键词： CIK cells therapy tumor response evaluation system

Function and mechanism of IL-36β on promoting antitumor immune response through activating CD8+T cells

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Function and mechanism of IL-36β on promoting antitumor imm...

第十届全国免疫学学术大会

作者： Xuefeng Wang Xin Zhao Yibei Zhu Xueguang Zhang binfeng lu Department of Biochemistry and Molecular Biology School of Biology and Basic Medical SciencesSoochow University Department of Immunology University of Pittsburgh School of Medicine 200 Lothrop Street Department of Immunology Institute of Medical Biotechnology School of Biology and Basic Medical Sciences Soochow University Department of General Surgery The First Affiliated Hospital of Soochow University

Background:Cytokines play a pivotal role in breaking immune tolerance of tumor antigens and increase response rates to ***-36/IL-36R signal has been demonstrated to have an effective function on promoting Th1 immune ***,the impact of IL-36βon tumor immunity is not ***:In the current study,we aim to reveal the function and mechanism of IL-36βin promoting CD8+T cell activation as well as antitumor immune ***:In vitro,the activation,proliferation and cytokine production of CD8+cells were determined by using flow cytometry,CFSE labeling,cell counting and ELISA assaying *** cytometry was also adopted to analyze the infiltrating *** data were analyzed with Graph Pad 6.0 software Result:It was found that IL-36βpromoted nave CD8+T cell activation and expansion at early ***,IL-36βcould stimulate m TORC1 activation dependent on My D88 and IKK ***,IL-36βwas identified to inhibit tumor progression,transformed the immunogenic tumor microenvironment and enhanced tumor antigen-specific CD8+T cell ***:Here we reveal the function and mechanism of IL-36βin promoting CD8+activation and ***,our work shows IL-36βcan break immune tolerance against tumor antigens.

关键词： interleukin-36β tumor microenvironment CD8+T cells m TORC1 My D88

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非晶合金微观结构的不均匀性与塑性

稀有金属材料与工程 2011年第7期40卷 1305-1310页

作者：卢斌峰李金富周尧和上海交通大学金属基复合材料国家重点实验室上海200240

块体非晶合金用于工程结构材料的优势在于其高强度和高弹性应变,瓶颈在于其缺乏塑性。近期的研究进展表明,在非晶合金中引入微观结构的不均匀性,可以获得良好的室温塑性。本文综述了块体非晶合金中各种微观结构不均匀性的形成条件、表... 详细信息

块体非晶合金用于工程结构材料的优势在于其高强度和高弹性应变,瓶颈在于其缺乏塑性。近期的研究进展表明,在非晶合金中引入微观结构的不均匀性,可以获得良好的室温塑性。本文综述了块体非晶合金中各种微观结构不均匀性的形成条件、表征手段以及微观结构不均匀性与剪切带行为和塑性的关系,讨论了制备条件和合金成分对非晶合金微观结构和塑性的影响,并提出了非晶领域未来需要解决的几个重要问题。

关键词：非晶合金结构不均匀性剪切带塑性

电子束表面合金化合成(Cr,Fe)_7C_3复合层耐磨性

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焊接学报 2008年第11期29卷 77-80页

作者：陆斌锋芦凤桂唐新华姚舜上海交通大学上海市激光制造与材料改性重点实验室上海200240

以Fe/Cr/C粉末为添加原料,采用可控电子束旋转线扫描方式对低碳钢表面进行表面改性。通过电子束加热工艺和粉末配比的优化,在表面复合层中原位合成了(Cr,Fe)7C3。对表面复合层的显微组织及室温干滑动磨损性能进行了分析。结果表明,表面... 详细信息

以Fe/Cr/C粉末为添加原料,采用可控电子束旋转线扫描方式对低碳钢表面进行表面改性。通过电子束加热工艺和粉末配比的优化,在表面复合层中原位合成了(Cr,Fe)7C3。对表面复合层的显微组织及室温干滑动磨损性能进行了分析。结果表明,表面复合层中主要包含两种相,即少量的初生硬化相(Cr,Fe)7C3以及奥氏体与(Cr,Fe)7C3组成的共晶相,共晶碳化物弥散分布于奥氏体基体中,呈不连续网状组织。表面复合层与基体之间为完全冶金结合。复合层与GCr15钢球的磨损机理为磨料磨损,在室温干滑动磨损下具有优异的耐磨损性能。

关键词：表面复合层真空电子束扫描碳化铬耐磨性

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真空电子束原位合成碳化物技术

焊接学报 2007年第6期28卷 34-36页

作者：芦凤桂陆斌锋唐新华姚舜上海交通大学焊接研究所上海200030

通过真空电子束原位合成技术在低碳钢表面局部区域合成碳化物,用以改善金属表面的耐磨性能。在试验中将配比不同的Fe粉,Cr粉,C粉末均匀混合,直接涂敷或制备成试样放于低碳钢钢板表面,应用真空电子束作为热源,以旋转线扫描加热方式对金... 详细信息

通过真空电子束原位合成技术在低碳钢表面局部区域合成碳化物,用以改善金属表面的耐磨性能。在试验中将配比不同的Fe粉,Cr粉,C粉末均匀混合,直接涂敷或制备成试样放于低碳钢钢板表面,应用真空电子束作为热源,以旋转线扫描加热方式对金属粉末表面进行加热,使粉末发生化学反应。通过对生成的化合物进行X射线衍射分析发现在金属表面生成了碳化物Cr7C3,且金相分析也证明了表面有聚集成块的碳化物增强项。结果表明,试样表面由于生成了碳化物增强相使得表面的硬度远远大于其基体的硬度,从而可以改善金属表明的耐磨性能。原位合成技术被证明是可以实现金属表面改性的一种较好的方法。

关键词：真空电子束原位合成碳化物

Trajectory-Based Hand Gesture Recognition Using Kinect via Deterministic Learning

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Trajectory-Based Hand Gesture Recognition Using Kinect via D...

第37届中国控制会议

作者： Fenglin Liu Wei Zeng Chengzhi Yuan Qinghui Wang Ying Wang binfeng lu School of Mechanical & Electrical Engineering Longyan University Department of Mechanical Industrial & Systems EngineeringUniversity of Rhode Island

The aim of this study is to develop a new trajectory-based method for hand gesture recognition using Kinect via deterministic learning. The recognition approach consists of two stages: a training stage and a recognition stage. In the training stage, trajectory-based hand gesture features are derived from Kinect. Hand motion dynamics underlying motion patterns of different gestures which represent capital English alphabets（A-Z） are locally accurately modeled and approximated by radial basis function（RBF） neural networks. The obtained knowledge of approximated hand motion dynamics is stored in constant RBF networks. In the recognition stage, a bank of dynamical estimators is constructed for all the training patterns. Prior knowledge of hand motion dynamics represented by the constant RBF networks is embedded in the estimators. By comparing the set of estimators with a test gesture pattern to be recognized, a set of recognition errors are generated. Finally, experiments are carried out to demonstrate the recognition performance of the proposed method. By using the 2-fold and 10-fold cross-validation styles,the correct recognition rates are reported to be 93.3% and 94.7%, respectively.

关键词： Hand Gesture Recognition Deterministic Learning Kinect Trajectory RBF Neural Networks