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Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1581-1591页

作者： Yan Jiang Di Gong Xiao-Hong chen Lin Yang Jing-Jing Xu Qi-Jie Wei bin-bin chen Yong-Jiang Cai Wen-Qun Xi Zhe Zhang Departments of Laboratory Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina Center of Health Management Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Visionary Intelligence Ltd. Beijing 100080China Ophthalmology Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To develop a deep learning-based model for automatic retinal vascular segmentation,analyzing and comparing parameters under diverse glucose metabolic status(normal,prediabetes,diabetes)and to assess the potential of artificial intelligence(AI)in image segmentation and retinal vascular parameters for predicting prediabetes and ***:Retinal fundus photos from 200 normal individuals,200 prediabetic patients,and 200 diabetic patients(600 eyes in total)were *** U-Net network served as the foundational architecture for retinal arteryvein *** automatic segmentation and evaluation system for retinal vascular parameters was trained,encompassing 26 ***:Significant differences were found in retinal vascular parameters across normal,prediabetes,and diabetes groups,including artery diameter(P=0.008),fractal dimension(P=0.000),vein curvature(P=0.003),C-zone artery branching vessel count(P=0.049),C-zone vein branching vessel count(P=0.041),artery branching angle(P=0.005),vein branching angle(P=0.001),artery angle asymmetry degree(P=0.003),vessel length density(P=0.000),and vessel area density(P=0.000),totaling 10 ***:The deep learning-based model facilitates retinal vascular parameter identification and quantification,revealing significant *** parameters exhibit potential as biomarkers for prediabetes and diabetes.

关键词： deep learning retinal vascular parameters segmentation model diabetes prediabetes

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Carbon dots prepared for fluorescence and chemiluminescence sensing

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Science China Chemistry 2019年第8期62卷 968-981页

作者： Meng-Li Liu bin-bin chen Chun-Mei Li cheng-Zhi Huang Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Biomedical Analysis (Southwest University) Chongqing Science & Technology CommissionCollege of Pharmaceutical ScienceSouthwest UniversityChongqing 400715China

Carbon dots(CDs) have attracted considerable research interest in recent years due to their unique optical properties, chemical inertness, facile synthesis from a wide range of starting materials, and advantages over classic quantum dots and organic *** methods have been developed for preparing the CDs, including chemical oxidation, hydro/solvothermal method,electrochemical method, microwave-assisted synthesis, and direct carbonization method. Importantly, the superior electronic properties of CDs including efficient light harvesting and prominent photoinduced electron transfer have aroused considerable attention in fluorescence(FL) and chemiluminescence(CL) sensing field. In this review, we aim to demonstrate the recent progress of CDs in the synthesis, FL and CL sensing applications. This review gives new insights into how to use different synthetic methods to tune the structure of the CDs, with the major focus on FL and CL sensing.

关键词： carbon dots synthesis approach fluorescence sensing chemiluminescence sensing detection mechanism

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An evolutionary life history approach to understanding mental health

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General Psychiatry 2020年第6期33卷 381-389页

作者： Wen Han bin-bin chen Department of Psychology Fudan UniversityShanghaiChina

In recent years,evolutionary life history theory has been used as a heuristic framework to understand mental *** article reviews the life history theory and its integration with mental disorders and then introduces representative research methods and related empirical studies in the field of evolutionary *** the end,this article concludes with future directions for further research examining and developing the evolutionary psychopathological framework.

关键词： evolutionary life has

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Learning the Effective Spin Hamiltonian of a Quantum Magnet

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Chinese Physics Letters 2021年第9期38卷 101-107页

作者： Sizhuo Yu Yuan Gao bin-bin chen Wei Li School of Physics Beihang UniversityBeijing 100191China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

To understand the intriguing many-body states and effects in the correlated quantum materials,inference of the microscopic effective Hamiltonian from experiments constitutes an important yet very challenging inverse *** we propose an unbiased and efficient approach learning the effective Hamiltonian through the many-body analysis of the measured thermal *** approach combines the strategies including the automatic gradient and Bayesian optimization with the thermodynamics many-body solvers including the exact diagonalization and the tensor renormalization group *** showcase the accuracy and powerfulness of the Hamiltonian learning by applying it firstly to the thermal data generated from a given spin model,and then to realistic experimental data measured in the spin-chain compound copper nitrate and triangular-lattice magnet TmMgGaO_(4).The present automatic approach constitutes a unified framework of many-body thermal data analysis in the studies of quantum magnets and strongly correlated materials in general.

关键词： Hamiltonian quantum thermodynamics

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Design and applications of carbon dots-based ratiometric fluorescent probes:A review

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Nano Research 2023年第1期16卷 1064-1083页

作者： bin-bin chen Meng-Li Liu Ya-Ting Gao Shuai Chang Ruo-Can Qian Da-Wei Li Key Laboratory for Advanced Materials Shanghai Key Laboratory of Functional Materials ChemistryFrontiers Science Center for Materiobiology&Dynamic ChemistrySchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenShenzhen 518172China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of PolymersCollege of Chemistry and MaterialsFudan UniversityShanghai 200433China

Ratiometric fluorescence(FL)probes can eliminate the background interference and provide more accurate detection results than single emission intensity-based ***,carbon dots(CDs)-based ratiometric FL probes have received extensive research attention due to their excellent biocompatibility,water solubility,and multi-emission *** this review,we firstly summarize the construction strategies of CDs-based ratiometric FL probes,including physical mixing,nanohybrid,and dual-emitting CDs ***,we classify the sensing types of CDs-based ratiometric FL probes into five categories according to the difference in spectral variation caused by analytes:“single-response-ON”,“single-response-OFF”,“doubleresponses-ON”,“double-responses-OFF”,and“double-responses-Reverse”***,a thorough overview of CDs-based ratiometric FL probe applications in ions,molecules,pH,and temperature sensing is *** believe this review can show the latest research progress of CDs-based ratiometric FL sensing fields and provide perspectives on future developments for the construction of CDs-based ratiometric FL probes and their potential applications.

关键词： carbon dots ratiometric fluorescent probes construction strategy sensing type a review

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Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 606-610页

作者： bin-bin chen Feng-Wei Song Zhao-Hui Sun Yi Yang Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College

AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function *** was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow ***:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P<0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P<0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P<0.001).The more severity of amblyopia,the poorer levels of contrast *** pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously ***:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.

关键词： anisometropia amblyopia area under the log contrast senility function fusion stereopsis

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Evaluation of frictional pressure drop correlations for air-water and air-oil two-phase flow in pipeline-riser system

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Petroleum Science 2024年第2期21卷 1305-1319页

作者： Nai-Liang Li bin chen School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049ShaanxiChina

Accurate prediction of the frictional pressure drop is important for the design and operation of subsea oil and gas transporting system considering the length of the pipeline. The applicability of the correlations to pipeline-riser flow needs evaluation since the flow condition in pipeline-riser is quite different from the original data where they were derived from. In the present study, a comprehensive evaluation of 24prevailing correlation in predicting frictional pressure drop is carried out based on experimentally measured data of air-water and air-oil two-phase flows in pipeline-riser. Experiments are performed in a system having different configuration of pipeline-riser with the inclination of the downcomer varied from-2°to-5°to investigated the effect of the elbow on the frictional pressure drop in the riser. The inlet gas velocity ranges from 0.03 to 6.2 m/s, and liquid velocity varies from 0.02 to 1.3 m/s. A total of885 experimental data points including 782 on air-water flows and 103 on air-oil flows are obtained and used to access the prediction ability of the correlations. Comparison of the predicted results with the measured data indicate that a majority of the investigated correlations under-predict the pressure drop on severe slugging. The result of this study highlights the requirement of new method considering the effect of pipe layout on the frictional pressure drop.

关键词： Frictional pressure drop Pipeline-riser Gas-liquid two-phase flow Severe slugging Correlation

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Network-Initialized Monte Carlo Based on Generative Neural Networks

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Chinese Physics Letters 2022年第5期39卷 23-28页

作者： Hongyu Lu Chuhao Li bin-bin chen Wei Li Yang Qi Zi Yang Meng Department of Physics and HKU-UCAS Joint Institute of Theoretical and Computational Physics The University of Hong KongHong KongChina Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China School of Physics Beihang UniversityBeijing 100191China State Key Laboratory of Surface Physics Fudan UniversityShanghai 200438China Center for Field Theory and Particle Physics Department of PhysicsFudan UniversityShanghai 200433China

We design generative neural networks that generate Monte Carlo configurations with complete absence of autocorrelation from which only short Markov chains are needed before making measurements for physical observables,irrespective of the system locating at the classical critical point,fermionic Mott insulator,Dirac semimetal,or quantum critical *** further propose a network-initialized Monte Carlo scheme based on such neural networks,which provides independent samplings and can accelerate the Monte Carlo simulations by significantly reducing the thermalization *** demonstrate the performance of our approach on the two-dimensional Ising and fermion Hubbard models,expect that it can systematically speed up the Monte Carlo simulations especially for the very challenging many-electron problems.

关键词： process critical chains

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Controllable chemical redox reactions to couple microbial degradation for organic contaminated sites remediation:A review

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Journal of Environmental Sciences 2024年第5期139卷 428-445页

作者： bin chen Jiang Xu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Zhejiang UniversityHangzhou 310058China Zhejiang Agriculture&Forest University Lin'an 311300China

Global environmental concern over organic contaminated sites has been progressively conspicuous during the process of urbanization and industrial *** traditional physical or chemical remediation technologies may significantly destroy the soil structure and function,coupling moderate chemical degradation with microbial remediation becomes a potential way for the green,economic,and efficient remediation of contaminated ***,this work systematically elucidates why and how to couple chemical technology with microbial remediation,mainly focused on the controllable redox reactions of organic *** rational design of materials structure,selective generation of reactive oxygen species,and estimation of degradation pathway are described for chemical ***,current progress on efficient and selective reductions of organic contaminants(i.e.,dechlorination,defluorination,-NO_(2) reduction)is *** with the microbial remediation of contaminated sites,several consideration factors of how to couple chemical and microbial remediation are proposed based on both fundamental and practical points of *** review will advance the understanding and development of chemical-microbial coupled remediation for organic contaminated sites.

关键词： Soil remediation Groundwater remediation Rational design Reactive species Environmental nanotechnology

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Tuning mechanical behaviors of highly entangled hydrogels with the random distribution of mobile entanglements

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 277-294页

作者： Jinlong LIU Di LU bin chen Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Beijing System Design Institute of Electro-Mechanic Engineering Beijing 100854China Intelligent Robotic Research Center Zhejiang LaboratoryHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou 311100China

Highly entangled hydrogels exhibit excellent mechanical properties,including high toughness,high stretchability,and low *** considering the evolution of randomly distributed entanglements within the polymer network upon mechanical stretches,we develop a constitutive theory to describe the large stretch behaviors of these *** the theory,we utilize a representative volume element(RVE)in the shape of a cube,within which there exists an averaged chain segment along each edge and a mobile entanglement at each *** employing an explicit method,we decouple the elasticity of the hydrogels from the sliding motion of their entanglements,and derive the stress-stretch relations for these *** present theoretical analysis is in agreement with experiment,and highlights the significant influence of the entanglement distribution within the hydrogels on their *** also implement the present developed constitutive theory into a commercial finite element software,and the subsequent simulations demonstrate that the exact distribution of entanglements strongly affects the mechanical behaviors of the structures of these ***,the present theory provides valuable insights into the deformation mechanism of highly entangled hydrogels,and can aid in the design of these hydrogels with enhanced performance.

关键词： highly entangled hydrogel constitutive theory entanglement gamma distribution

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