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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang bin Zhang Haobang liang Bei Hu Longlong Ren Yanjuan liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng li Xin li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy

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Chronic Diseases and Translational Medicine 2019年第3期5卷 155-169页

作者： bin-bin li Bo Wang Cheng-Ming Zhu Di Tang Jun Pang Jing Zhao Chun-Hui Sun Miao-Juan Qiu Zhi-Rong Qian School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China Equipe Communication Intercellulaire et Infections Microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)College de FranceParis 75005France

Current cancer therapies have encountered adverse response due to poor therapeutic efficiency,severe side effects and acquired resistance to multiple ***,there are urgent needs for finding new cancer-targeted pharmacological *** this review,we summarized the current understanding with THZ1,a covalent inhibitor of cyclin-dependent kinase 7(CDK7),which demonstrated promising anti-tumor activity against different cancer *** introducing the anti-tumor behaviors and the potential targets for different cancers,this review aims to provide more effective approaches to CDK7 inhibitor-based therapeutic agents and deeper insight into the diverse tumor proliferation mechanisms.

关键词： THZ1 Cyclin-dependent kinase 7 Cancer therapy Transcription Super-enhancer

The role of Fusobacteriu mnucleatum in colorectal cancer:from carcinogenesis to clinical management

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Chronic Diseases and Translational Medicine 2019年第3期5卷 178-187页

作者： Chun-Hui Sun bin-bin li Bo Wang Jing Zhao Xiao-Ying Zhang Ting-Ting li Wen-bing li Di Tang Miao-Juan Qiu Xin-Cheng Wang Cheng-Ming Zhu Zhi-Rong Qian Equipe Communication Intercellulaire et Infections Microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)College de FranceParis 75005France Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China Health Management Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China Department of Gastroenterology The Second Medical Center of Chinese PLA General Hospital Beijing 100853China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of General Surgery The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China

Colorectal cancer(CRC)is a common malignant tumor that affects people *** analyses have shown an enrichment of Fusobacterium nucleatum(***)in colorectal carcinoma tissue;many studies have indicated that *** is closely related to the colorectal *** this review,we provide the latest information to reveal the related molecular *** known virulence factors of *** promote adhesion to intestinal epithelial cells via FadA and ***,Fap2 also binds to immune cells causing ***,*** recruits tumor-infiltrating immune cells,thus yielding a pro-inflammatory microenvironment,which promotes colorectal neoplasia *** was also found to potentiate CRC development through toll-like receptor 2(TLR2)/toll-like receptor 4(TLR4)signaling and microRNA(miRNA)-21 *** addition,*** increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA-18a*,miRNA-4802,and autophagy ***,viable *** was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive *** findings indicated that an increased number o f *** in the tissues is a biomarker for the diagnosis and prognosis of CRC,and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with ***-associaied CRC.

关键词： Fusobacterium nucleatum:Colorectal carcinoma Carcinogenesis Immune microenvironment Intervention therapy

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation

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Oncology Research 2025年第1期33卷 161-169页

作者： XIUWANG WEI JIANBO liANG HUANWEN HUANG DAMING YANG XINXIN WANG XIUJIA WANG CHANGSHENG CHEN KAIQIANG li TAISEN PANG bin HU FENGNING WU Department of Urology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China Department of Rehabilitation The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China

Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains *** and Methods:Short hairpin RNA was performed to repress TMED3 in prostate cancer cells(DU145 cells)and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in ***:In the present study,we found that TMED3 was highly expressed in prostate cancer *** vitro,shTMED3 treatment suppressed the proliferation,invasion,and migration and promoted the apoptosis of DU145 ***,the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed a strong correlation between TMED3 and forkhead box O transcription factor(FOXO)***,TMED3 inhibition efficiently decreased FOXO1a and FOXO3a *** vivo,TMED3 downregulation suppressed the apoptosis,growth,and metastasis of prostate cancer cells via FOXO1a and ***:The present findings show that TMED3 participates in the regulation of prostate cancer progression via FOXO1a and FOXO3a phosphorylation,thereby revealing a novel mechanism underlying prostate cancer development and suggesting that TMED3 inhibition may serve as a novel strategy for prostate cancer treatment.

关键词： Prostate cancer Transmembrane emp24 trafficking protein 3(TMED3) forkhead box O transcription factor(FOXO) Proliferation Apoptosis

专业市场与电子商务双渠道融合的微观机理与实证分析

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研究与发展管理 2017年第3期29卷 141-150页

作者：于斌斌陆立军浙江理工大学经济管理学院杭州310018 浙江师范大学经济与管理学院金华321000

通过构建电子商务环境下双渠道选择的供应链整合模型,分析了专业市场与电子商务相互融合的微观机理,并利用义乌小商品市场的问卷调查数据进行了相关的实证性检验与拓展性分析.微观机理研究发现,随着电子商务平台市场风险的增加,市场经... 详细信息

通过构建电子商务环境下双渠道选择的供应链整合模型,分析了专业市场与电子商务相互融合的微观机理,并利用义乌小商品市场的问卷调查数据进行了相关的实证性检验与拓展性分析.微观机理研究发现,随着电子商务平台市场风险的增加,市场经营户和采购商都倾向于降低批发价格,但只有采购商能从中获得更高的预期收益,而经营户的预期收益会减少.实证研究也证实:专业市场的价格优势虽能提高双渠道融合程度,却只能给采购商带来显著的融合绩效.同时,经营户和采购商都期望通过增加电子商务运营投入来扩大网络市场规模,以此从双渠道融合过程中获得规模报酬递增的预期收益.市场交易效率、金融支持和政策优势与双渠道融合显著正相关,而实体运营成本增加、采购规模扩张以及传统业务与电子商务冲突等因素会使双渠道融合产生负向效应.

关键词：专业市场电子商务双渠道融合微观机理

农民收入结构变化对吉林省畜牧业生产的影响分析

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中国畜牧杂志 2016年第18期52卷 17-22页

作者：杨宁宫斌斌张守莉吉林农业大学经济管理学院吉林长春130118

为分析吉林省农民收入结构变化对吉林省畜牧业生产的影响,本文运用定性分析与定量分析相结合的方法,采用灰色关联分析理论,构造农民收入结构变动率指标,着重研究农民收入结构变化与吉林省畜牧业之间的关联程度。结果表明:收入结构变动... 详细信息

为分析吉林省农民收入结构变化对吉林省畜牧业生产的影响,本文运用定性分析与定量分析相结合的方法,采用灰色关联分析理论,构造农民收入结构变动率指标,着重研究农民收入结构变化与吉林省畜牧业之间的关联程度。结果表明:收入结构变动率和工资性收入占比变动率均与畜牧业总产值占比变动率具有很强的关联度,说明农民收入结构性变化对畜牧业生产影响显著。据此提出优化吉林省畜牧业生产结构、推动现代畜牧业发展的对策建议。

关键词：收入结构变动率畜牧业生产灰色关联分析吉林省

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国际海事卫星地面终端天线阵单元的设计

上海交通大学学报 2004年第5期38卷 722-724页

作者：张亚斌黎滨洪刘毅军上海交通大学电子工程系上海200030

提供了一个详细的国际海事卫星地面终端天线阵单元的设计,该设计采用单馈点圆极化口径耦合的多层微带天线形式,使用低价格、低介电常数的泡沫塑料,以降低成本和拓宽天线的阻抗带宽.测量结果表明,天线的阻抗带宽(电压驻波比,VSWR≤2)和... 详细信息

提供了一个详细的国际海事卫星地面终端天线阵单元的设计,该设计采用单馈点圆极化口径耦合的多层微带天线形式,使用低价格、低介电常数的泡沫塑料,以降低成本和拓宽天线的阻抗带宽.测量结果表明,天线的阻抗带宽(电压驻波比,VSWR≤2)和圆极化带宽(轴比AR≤3dB)分别达到18.8%和12.3%.同时,天线在1593MHz的增益达到9.4dBi.

关键词：天线阵单元口径耦合圆极化微带天线

康柏西普不同给药方案治疗有临床意义的糖尿病性黄斑水肿疗效比较

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国际眼科杂志 2022年第1期22卷 130-134页

作者：李彬彬谭美华殷章亮中国江西省赣州市人民医院眼科 341000

目的:观察康柏西普不同给药方案治疗有临床意义的糖尿病性黄斑水肿(CSME)的疗效。方法:选取2019-01/2020-01赣州市人民医院眼科收治的糖尿病伴有CSME患者65例为研究对象,采用随机数字表法将其分为观察组(33例,采用康柏西普5+PRN方案治疗... 详细信息

目的:观察康柏西普不同给药方案治疗有临床意义的糖尿病性黄斑水肿(CSME)的疗效。方法:选取2019-01/2020-01赣州市人民医院眼科收治的糖尿病伴有CSME患者65例为研究对象,采用随机数字表法将其分为观察组(33例,采用康柏西普5+PRN方案治疗)、对照组(32例,康柏西普3+PRN方案治疗),治疗后1、2、3、6、9、12mo进行视力、光相干断层扫描(OCT)检查,对比两组治疗前后最佳矫正视力(BCVA,LogMAR)、黄斑中心视网膜厚度(CMT)变化,记录两组平均注射次数、并发症发生情况。结果:两组治疗后1、2、3、6、9、12mo BCVA均较治疗前改善,CMT变薄(P0.05);观察组平均注射次数5.81±0.54次,较对照组4.19±0.41次多(P0.05),两组均未见其他严重并发症。结论:康柏西普3+PRN或5+PRN方案治疗糖尿病伴CSME均有较好疗效,可提高视力,降低CMT,两种方案的改善效果相当,5+PRN方案可能增加注射次数,但不良反应可耐受,安全可靠。

关键词：康柏西普给药方案糖尿病有临床意义的糖尿病性黄斑水肿