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cNPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes

World Journal of Diabetes 2024年第9期15卷 1932-1941页

作者： Yan-bin Yin Wei Ji Ying-Lan Liu Qian-hao Gao Dong-Dong He Shi-Lin Xu Jing-Xin Fan Li-Hai Zhang Department of General Surgery The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264199Shandong ProvinceChina Operating Room The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Anesthesiology Huazhong University of Science and Technology Union Jiangbei HospitalWuhan 430100Hubei ProvinceChina Department of Endocrinology The First Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND Diabetes mellitus type 2(T2DM)is formed by defective insulin secretion with the addition of peripheral tissue resistance of insulin *** has been affecting over 400 million people all over the *** To explore the pathogenesis of T2DM and to develop and implement new prevention and treatment strategies for *** Receiver operating characteristic(ROC)curve analysis was used to conduct diagnostic *** expression level of genes was determined by reverse transcription-PCR as well as Western *** proliferation assays were performed by cell counting kit-8(CCK-8)*** last,T2DM mice underwent Roux-en-Y gastric bypass *** We found that NPAS2 was significantly up-regulated in isletβcell apoptosis of *** ROC curve revealed that NPAS2 was capable of accurately diagnosing ***2 overexpression did increase the level of *** addition,the CCK-8 test revealed knocking down NPAS2 and KANK1 increased the proliferation of MIN6 *** last,we found that gastric bypass may treat type 2 diabetes by down-regulating NPAS2 and *** This study demonstrated that NPAS2 inducedβcell dysfunction by regulating KANK1 expression in type 2 diabetes,and it may be an underlying therapy target of T2DM.

关键词： Diabetes mellitus type 2 KANK1 NPAS2 Gastric bypass

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Portable fluorogenic probe for monitoring of volatile amine vapour and food spoilage

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Chinese Chemical Letters 2024年第3期35卷 257-261页

作者： Jian-hao Zhao Wen-Xing Xu bin Li Wei Xu Wu-Kun Zhang Ming-Shuai Yuan Hui-Zi Li Qing-Guo He Xiang Ma Jian-Gong Cheng Yan-Yan Fu State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of the Chinese Academy of SciencesBeijing 100039China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

There are urgent needs of volatile amine gas sensors with high-performance in food quality control,disease monitoring and environmental ***-film fluorescent probe is suitable for amine vapour sensing due to its high sensitivity,high selectivity,and no polluting ***,a novel fluorescent probe based on indacenodithiophene structure withπconjugated system was designed and *** experimental results show that the films prepared by this material exhibit rapid and distinct fluorescence quenching after being exposed to saturated vapours of primary amine,secondary amine and tertiary amine represented by n-propylamine,diethylamine and trimethylamine,*** quenching of fluorescence is 84%,87%and 96%,respectively,within 10 *** detection mechanism of probe for primary amine is based on specific chemical reaction,while the detection mechanism for secondary amine and tertiary amine is intramolecular charge *** experiments show that the detection limit of the fluorescent probe for trimethylamine,an important marker of food spoilage,could reach 4.610 ***-site detection based on spoilage of small yellow croaker suggests the material possesses the potential for food freshness *** simple fluorogenic probe is an original approach to simplify real-time visual monitoring of volatile amine vapour.

关键词： Fluorescent probe Volatile amine Gas sensing Trimethylamine Food spoilage

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Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-hao Zhang Yue-bin Zhang Duo-Te Cai Tao Pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei Huang Qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm tobin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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Enrichment characteristics of normal-pressure marine shale gas in the complex tectonic zone: a case study of the Lower Cambrian Niutitang Formation in northern Guizhou

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Journal of Earth Science 2024年

作者： Wenjibin Sun Zhonghu Wu Yujun Zuo Chao Pan hao Liu Baofeng Lan Jianyun Lin bin Chen Qinggang Chen Guizhou Energy Industry Research Institute Co.， Ltd Mining College， Guizhou University College of Resource and Environmental Engineering， Guizhou University College of Civil Engineering， Guizhou University

The Lower Cambrian Niutitang Formation is a crucial stratum for the exploration of normal-pressure marine shale gas in southern China， with great development potential. To research the normal-pressure shale gas accumulation of the Niutitang Formation in the complex tectonic zone， the shale cores in northern Guizhou were subjected to X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) observation， and tests were conducted to determine total organic content (TOC)， bitumen reflectance， and nitrogen isotopes. The results indicate that the equivalent vitrinite reflectance of cores varies from 2.30% to 3.73%， and the TOC content of cores varies from 3.8% to 7.8%. The total gas content of three wells in northern Guizhou is 0.5 m3/t， 0.3 m3/t， and 1.4 m3/t， respectively. The TOC content of the shale in the syncline structure is higher than that of the shale in the anticline structure. Nitrogen in shale gas originates primarily from the thermal ammoniation of organic matter， the atmosphere， and the deep crust. Shale gas preservation is favourable in regions with a large range of lifting， and small lifting differences. The syncline is broad and gentle with few faults have better gas accumulation conditions. The Niutitang Formation in the residual syncline of the study area has better gas content than that of other structures. Exploration of shale gas accumulation sweet spots in northern Guizhou should focus on the broad-gentle synclines with minimal changes in stratigraphic lifting， few faults， and no hydrothermal activity at the edges of paleo-uplifts.

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太阳高能粒子强度与日冕物质抛射及其Ⅱ型射电暴的关系

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物理学报 2024年第7期73卷 368-381页

作者：严豪丁留贯封莉顾斌南京信息工程大学大气物理学院南京210044 无锡学院大气与遥感学院无锡214105 中国科学院紫金山天文台南京210008 南京信息工程大学物理与光电工程学院南京210044

本文选取了第24太阳活动周2010年1月至2014年9月期间的快速、大角宽日冕物质抛射(CME)事件,结合不同约束条件下Richardson(2014)太阳高能粒子(SEP)强度经验模型输出结果,分析了CME属性、先行CME(pre-CME)、Ⅱ型射电暴等观测特征对SEP强... 详细信息

本文选取了第24太阳活动周2010年1月至2014年9月期间的快速、大角宽日冕物质抛射(CME)事件,结合不同约束条件下Richardson(2014)太阳高能粒子(SEP)强度经验模型输出结果,分析了CME属性、先行CME(pre-CME)、Ⅱ型射电暴等观测特征对SEP强度的影响,探讨了SEP事件的产生及其强度与这些特征的关系.主要结论如下:1)快速CME前13 h内是否存在pre-CME对模型预测效果和快速CME是否产生SEP事件有明显影响,但pre-CME的数量对模型输出结果没有明显改善.2)相比于无Ⅱ型射电暴伴随的快速CME而言,伴随Ⅱ型射电暴的CME爆发产生SEP事件的误报占比明显更低(42%),以此为约束条件,可更加突显大SEP事件(如峰值≥0.01 pfu/Me V)的模型预测值与观测值的关联;如果考虑射电增强,则SEP事件的误报占比可进一步下降至29.4%,模型预测效果显著提升.3)Ⅱ型射电暴的起始频率和结束频率对误报占比的影响不大,以此作为条件约束对模型预测效果提升不明显.4)如考虑Ⅱ型射电暴的细分类型作为模型约束条件,伴随多波段Ⅱ型射电暴的CME比单一波段事件具有更好的模型预测效果,如m-DH-kmⅡ型射电暴事件,具有较低的误报占比(35.4%),准确率较高.研究结果显示,除了CME的速度和角宽参数外,pre-CME、Ⅱ型射电暴及其增强、多波段类型等特征作为CME产生SEP事件的约束条件,SEP预测强度与观测强度具有较好的一致性,可以获得较优的模型预测效果.这也进一步表明了伴随有pre-CME、多波段Ⅱ型射电暴及其增强的快速大角宽CME更容易产生SEP事件,这些特征可作为SEP-rich类CME的辨别信号.

关键词：太阳高能粒子日冕物质抛射 Ⅱ型射电暴

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Cervical cancer with transferrin receptor has a poor prognosis and is associated with immune infiltration, according to a comprehensive bioinformatics study

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Cancer Advances 2024年第6期7卷 1-9页

作者： Dong-Mei Han Cai-Hong Wu bin Ling hao Jin Center For Precision Cancer Medicine and Translation Research Tianjin Cancer Hospital Airport HospitalTianjin 300181China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Background:The molecular mechanism underlying the involvement of the Transferrin receptor(TFRC)in cervical cancer remains poorly *** study aims to elucidate the role of TFRC in cervical cancer by analyzing data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)***:TFRC protein expression was obtained from Human Protein Altas(HPA).All datas were collected from TCGA and *** this study,we analyzed the expression of TFRC in cervical cancer and its clinical *** Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene set enrichment analyses(GSEA),investigated the related molecular pathways of *** relationship between TFRC and immune infiltration was then *** prognosis of different immune cell subsets was then analyzed after dividing cervical cancer patients into high and low expression of TFRC ***:TFRC is highly expressed in various tumor tissues compared to control normal tissues,including cervical *** increased expression of TFRC was associated with higher Tumor(T)and Node(N)stage,as well as a higher clinical ***–Meier(KM)survival analysis investigated that higher TFRC expression patients have a poor overall survival(OS),disease specific survival(DSS)and progress free interval(PFI).Both KEGG and GSEA enriched signaling pathway by high TFRC and low TFRC *** was a significant negative linear correlation between TFRC expression and immune *** affects the prognosis of cervical cancer patients through immune ***:Cervical cancer patients with TFRC expression may have a worse prognosis.

关键词： cervical cancer prognosis immune infiltration transferrin receptor

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Flapping vortex dynamics of two coupled side-by-side flexible plates submerged in the wake of a square cylinder

International Journal of Fluid Engineering

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International Journal of Fluid Engineering 2024年第1期 40-55页

作者： bin Xu hao wang Weibin Zhang Yilin Deng Xi Shen Desheng Zhang B.P.M.(Bart) van Esch Research Center of Fluid Machinery Engineering and Technology Jiangsu University Key Laboratory of Fluid and Power Machinery(Xihua University) Ministry of Education Institute for Energy Research Jiangsu University Eindhoven University of Technology

The flapping vortex dynamics of two flexible plates submerged side-by-side in the wake of a square cylinder are investigated through a two-way fluid–structure interaction(FSI) simulation. The gap between the two plates can stabilize wakes, lengthen vortex formation,elongate vortices, suppress vortex shedding, and decrease hydrodynamic forces. The numerical results indicate that the two flexible plates can exhibit four distinct modes of coupled motion: out-of-phase flapping, in-phase flapping, transition flapping, and decoupled flapping,depending on the gap spacing. Additionally, it is discovered that each of the four coupling modes has a unique pattern of vortex development. The findings of this study should proved valuable in the design of FSI-based piezoelectric energy harvesters utilizing cylinder–plate systems.

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Ilizarov technique for treating elbow stiffness caused by myositis ossificans:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3144-3150页

作者： Ming-wang Zhou Peng-Wei Zhang An-Le Zhang Chang-hao Wei Yu-De Xu Wei Chen Zhi-bin Fu Department of Orthopedics Medicine Gansu Province Hospital of Chinese MedicineLanzhou 730050Gansu ProvinceChina Gansu University of Chinese Medicine Clinical College of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Myositis ossificans(MO)is a rare disease involving the formation of bone outside the musculoskeletal *** surgical intervention is the main treatment approach,preventing recurrence and standardized rehabilitation are also ***,we present a surgical strategy to prevent the recurrence of *** SUMMARY A 28-year-old female patient was admitted for the first time for a comminuted fracture of the left ***,incorrect postoperative rehabilitation resulted in the development of elbow joint stiffness with ectopic ossification,causing a loss of normal range of *** patient was diagnosed with MO based on physical examination,X-ray findings,and clinical *** devised a surgical strategy to remove MO,followed by fixation with an Ilizarov frame,and implemented a scientifically reasonable rehabilitation *** surgery lasted for 3 h with an estimated blood loss of 45 mL.A drainage tube was placed after surgery,and fluid was aspirated through ultrasound-guided *** patient experienced a significant reduction in joint stiffness after *** the final follow-up at 9 mouths,there was evident improvement in the range of motion of the elbow joint,and no other symptoms were *** The Ilizarov frame is an advantageous surgical technique for facilitating rehabilitation after MO *** offers benefits such as passive recovery,individualized treatment,and prompt recovery.

关键词： Myositis ossificans Ilizarov frame Rehabilitation strategy Stiffness Case report

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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU Zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting ZENG Xin hao Hua-bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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