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Tailoring Variant Pairing to Enhance Impact Toughness in High-Strength Low-Alloy Steels via Trace Carbon Addition

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Acta Metallurgica Sinica(English Letters) 2021年第6期34卷 755-764页

作者： Yi-Shuang Yu Zhi-Quan Wang bin-bin wu Jing-Xiao Zhao Xue-Lin Wang Hui Guo Cheng-Jia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114021China

Alloying can make conventional metals reach ultra-high strength,but this usually comes at dramatic loss of *** this work,a desirable strength–toughness combination in high-strength low-alloy steel achieved via trace carbon *** significance of carbon in tailoring variant pairing and tuning impact toughness was elucidated from the perspective of crystallography and *** the carbon content increases,the packets and blocks are refined,and the-40 impact toughness *** enhancement of impact toughness results from the higher density of block boundaries,and the fracture mode shifts from brittle fracture to ductile–brittle combined fractures,then to ductile fracture due to the increased *** the carbon content would lower the martensite start temperature(M_S)temperature and driving force for martensitic transformation,and increase the strength of austenite matrix,which in turn contributes to producing more V1/V2 variant pairs to accommodate the transformation strain.

关键词： High-strength low-alloy steel Carbon Impact toughness Variant pairing Phase transformation

Evidence for a New Extended Solid of Nitrogen

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Chinese Physics Letters 2020年第6期37卷 103-106页

作者： Li Lei Qi-Qi Tang Feng Zhang Shan Liu bin-bin wu Chun-Yin Zhou Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China Key Laboratory of High Energy Density Physics and Technology(Ministry of Education) Sichuan UniversityChengdu 610064China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

A new extended solid nitrogen,referred to as post-layered-polymeric nitrogen(PLP-N,or Panda-N),was observed by further heating the layered-polymeric nitrogen(LP-N)to above 2300 K at 161 *** new phase is found to be very optically transparent and exhibits ultra-large d-spacings ranging from 2.8 to 4.9 A at 172 GPa,suggesting a lower-symmetry large-unit-cell 2D chain-like or OD cluster-type structure with wide ***,the observed x-ray diffraction pattern and Raman scattering data cannot match any predicted structures in the published *** finding further complicates the phase diagram of nitrogen and also highlights the path dependence of the high-pressure dissociative transition in *** addition,the phase transition from cubic gauche nitrogen(cg-N)to LP-N is observed at 157 GPa and 2000K.

关键词： layered symmetry spacing

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苯并菲盘状侧链液晶聚合物的大分子工程

高分子学报 2017年第10期27卷 1574-1590页

作者：慕斌吴斌谌东中南京大学化学化工学院生命化学协同创新中心高性能高分子材料与技术教育部重点实验室南京210023

盘状液晶聚合物兼具盘状液晶的光电性能和聚合物的柔韧性以及优异的成膜加工性能,有望发展成为新一代先进有机聚合物柔性光电功能材料.本文介绍苯并菲盘状侧链液晶聚合物的研究进展,主要结合我们研究组的工作,重点评述采用受控/活性自... 详细信息

盘状液晶聚合物兼具盘状液晶的光电性能和聚合物的柔韧性以及优异的成膜加工性能,有望发展成为新一代先进有机聚合物柔性光电功能材料.本文介绍苯并菲盘状侧链液晶聚合物的研究进展,主要结合我们研究组的工作,重点评述采用受控/活性自由基聚合方法可控合成这类侧链液晶聚合物以及对分子量效应和间隔基长度影响等基本问题的阐明.我们采用可逆加成-断裂链转移(RAFT)聚合第一次成功实现了分子量窄分布的苯并菲聚丙烯酸酯侧链盘状液晶聚合物的可控制备.首先提出盘单元局部簇集的分立短柱堆积(DCS)模型,合理解释了聚合度20左右出现的显著分子量效应,尤其揭示并提出了盘状侧链液晶聚合物的正耦合效应(PCE)理论,即短间隔基的较强耦合作用更有利于其有序柱状相的形成,与棒状侧链液晶聚合物经典的柔性长间隔基去耦合理论形成鲜明对照,补充了缺失的理论短板.基于这些原则,我们设计合成的丁氧基苯并菲聚丙烯酸酯侧链盘状液晶聚合物,经飞行时间谱(TOF)测试,表现出比文献报道值高1~2个数量级的载流子迁移率.进一步在手性客体分子掺杂诱导组装形成单手性螺旋结构聚合物复合物,以及拓扑受限环状聚合物和嵌段共聚物的受控制备等方面开展了比较系统的大分子工程实践.盘状侧链液晶聚合物的可控制备及其显著不同于棒状液晶聚合物体系的一些基本特征的阐明,为这类重要有机聚合物半导体材料的理性设计与可控合成提供理论指导,也为加速推进其光电器件化应用奠定基础.

关键词：侧链盘状液晶聚合物分子量效应正耦合效应可控合成高载流子迁移率

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石英毛细管椭球微气泡模式特性及传感技术

光子学报 2016年第11期45卷 167-172页

作者：刘彬斌张蒙吴根柱浙江师范大学信息光学研究所浙江省光信息检测与显示技术研究重点实验室浙江金华321004 浙江师范大学行知学院浙江金华321004

利用有限元数值分析方法研究了椭球状石英毛细管微气泡回音壁模式特性及其折射率传感性能.计算分析了不同半径与内壁厚度情况下空芯和液芯椭球形微气泡模式特征,包括品质因数、有效折射率和能量比等,并探讨了微气泡在高灵敏度和高分辨... 详细信息

利用有限元数值分析方法研究了椭球状石英毛细管微气泡回音壁模式特性及其折射率传感性能.计算分析了不同半径与内壁厚度情况下空芯和液芯椭球形微气泡模式特征,包括品质因数、有效折射率和能量比等,并探讨了微气泡在高灵敏度和高分辨率折射率传感方面的应用潜能.研究结果表明微气泡膨胀至350μm,且内壁厚度为1μm时分辨率和灵敏度最佳;在该厚度范围附近,微气泡分辨率不会因为半径尺寸的改变而发生太大变化;二阶径向模具有较高品质因数,其灵敏度略高于一阶基模,且使用二阶径向模可降低在制造时对结构壁厚控制精度的要求,可用于实际传感应用中.研究结果对微气泡的进一步实验研制具有理论参考价值.

关键词：光学传感回音壁模式品质因数有限元数值模拟椭球形微气泡灵敏度分辨率

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基于群密钥协商的无线传感器网络签名协议

吉林大学学报（工学版） 2017年第3期47卷 924-929页

作者：于斌斌武欣雨初剑峰胡亮吉林大学计算机科学与技术学院长春130012 北华大学信息技术与传媒学院吉林省吉林市132013

为确保信息在无线传感器网络安全传输,提出了一个新的基于群密钥的安全协议。通过离散对数和哈希链的使用,可确保信息不被攻击者伪造或窃取。同时,考虑到无线传感器网络是由大量能量有限的节点构成,其计算能力不高,生存周期较短的特性,... 详细信息

为确保信息在无线传感器网络安全传输,提出了一个新的基于群密钥的安全协议。通过离散对数和哈希链的使用,可确保信息不被攻击者伪造或窃取。同时,考虑到无线传感器网络是由大量能量有限的节点构成,其计算能力不高,生存周期较短的特性,为节省传感器电池能量,降低能源的消耗,在初始化阶段传感器节点发送数据前通过服务器来完成群密钥协商。经过实验和理论分析,所提出协议的安全和效率整体上优于其他协议。

关键词：计算机系统结构无线传感器网络群密钥哈希链离散对数数字签名

Phase saddle point transformation-enabled mode-adaptive detection of acoustic orbital angular momentum with high efficiency and low crosstalk

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Kai wu Yang Tan Jingjing Liu bin Liang Jianchun Cheng Collaborative Innovation Center of Advanced Microstructures and Key Laboratory of Modern Acoustics MOE Institute of AcousticsDepartment of Physics Nanjing University

Acoustic orbital angular momentum (OAM) provides an infinite set of orthogonal bases in Hilbert space and significantly boosts the link capacity and data transmission rate. High-capacity and low-crosstalk OAM detection within compact physical space is highly desired to effectively harness this spatial dimension of sound wave, but the existing mechanisms generally either operate only for finite OAMs with predetermined mode orders or rely on complicated active devices. Here, we propose a phase saddle point (PSP) transformation mechanism for distinguishing and demultiplexing acoustic OAM modes in a passive, mode-adaptive,high-efficiency, and high-accuracy paradigm. The phase mask characterized by a PSP in the specific area is created through the single-pass log-polar transformation without prior information of incident modes, whose interaction with incident vortex beams of different OAM modes will yield the translation of the stationary phase point and thereby generate the corresponding focused line spots at distinct lateral positions. We theoretically elucidate the mode-adaptive response of PSP transformation by deriving the quantitative relationship between the OAM order and line spot offset. This mode adaptability enables our mechanism to detect OAM of arbitrary mode orders and mode numbers with the inter-mode crosstalk being effectively suppressed, beyond attainable with the existing methods. The effectiveness of our proposed mechanism is validated by demonstrating several distinct examples of single-mode OAM sorting and multi-mode synthesized vortex beam demultiplexing. We anticipate this modeadaptive methodology, designed for compact dimensions and featuring with low crosstalk and uniform efficiency, will find important applications in OAM information processing.

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie wu Chenrui Liu Xingxing Fang Liangming Zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation

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Oncology Research 2025年第1期33卷 161-169页

作者： XIUWANG WEI JIANBO LIANG HUANWEN HUANG DAMING YANG XINXIN WANG XIUJIA WANG CHANGSHENG CHEN KAIQIANG LI TAISEN PANG bin HU FENGNING wu Department of Urology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China Department of Rehabilitation The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China

Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains *** and Methods:Short hairpin RNA was performed to repress TMED3 in prostate cancer cells(DU145 cells)and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in ***:In the present study,we found that TMED3 was highly expressed in prostate cancer *** vitro,shTMED3 treatment suppressed the proliferation,invasion,and migration and promoted the apoptosis of DU145 ***,the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed a strong correlation between TMED3 and forkhead box O transcription factor(FOXO)***,TMED3 inhibition efficiently decreased FOXO1a and FOXO3a *** vivo,TMED3 downregulation suppressed the apoptosis,growth,and metastasis of prostate cancer cells via FOXO1a and ***:The present findings show that TMED3 participates in the regulation of prostate cancer progression via FOXO1a and FOXO3a phosphorylation,thereby revealing a novel mechanism underlying prostate cancer development and suggesting that TMED3 inhibition may serve as a novel strategy for prostate cancer treatment.

关键词： Prostate cancer Transmembrane emp24 trafficking protein 3(TMED3) forkhead box O transcription factor(FOXO) Proliferation Apoptosis

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke