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Realization of low-energy type-Ⅱ Dirac fermions in(Ir_(1-x)Pt_x)Te_2 superconductors

Chinese Physics B 2019年第3期28卷 71-76页

作者： bin-bin fu Chang-Jiang Yi Zhi-Jun Wang Meng Yang Bai-Qing Lv Xin Gao Man Li Yao-Bo Huang Hong-Ming Weng You-Guo Shi Tian Qian Hong Ding Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China Department of Physics and Beijing Key Laboratory of Opto-electronic functional Materials&Micro-nano Devices Renmin University of ChinaBeijing 100872China Songshan Lake Materials Laboratory Dongguan 523808China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

Topological Dirac semimetals(DSMs) present a kind of topologically nontrivial quantum state of matter, which has massless Dirac fermions in the bulk and topologically protected states on certain surfaces. In superconducting DSMs, the effects of their nontrivial topology on superconducting pairing could realize topological superconductivity in the bulk or on the surface. As superconducting pairing takes place at the Fermi level E_F, to make the effects possible, the Dirac points should lie in the vicinity of E_F so that the topological electronic states can participate in the superconducting paring. Here,we show using angle-resolved photoelectron spectroscopy that in a series of(Ir_(1-x)Pt_x)Te_2 compounds, the type-Ⅱ Dirac points reside around E_F in the superconducting region, in which the bulk superconductivity has a maximum T_c of ～ 3 *** realization of the coexistence of bulk superconductivity and low-energy Dirac fermions in(Ir_(1-x)Pt_x)Te_2 paves the way for studying the effects of the nontrivial topology in DSMs on the superconducting state.

关键词： type-Ⅱ Dirac semimetal superconductor topological superconducting angle-resolved photoemission spectroscopy(ARPES) substitution

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Differential expression of microRNAs in tumor bearing mice subjected to intermittent hypoxia: a next-generation sequence analysis

Differential expression of microRNAs in tumor bearing mice s...

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中国睡眠研究会第十届全国学术年会

作者： Xiao-bin Zhang Yi-Ming Zeng Yan-Ting Lai Ying Wu bin-bin fu Hui-Qing Zeng Yan-Ping Du Department of Respiratory Medicine Zhongshan HospitalXiamen UniversityTeaching Hospital of Fujian Medical University Second Clinical Medical College Fujian Medical University

Objective: Obstructive sleep apnea（OSA） is associated with tumor incidence and mortality,and the underlying mechanism remains poorly ***（miRNAs） are confirmed to be involved in tumor *** miRNAs had differential expression in OSA population needs to be *** aim of the present study was to determine the alterations of miRNAs in tumor bearing mice exposed to chronic intermittent hypoxia（CIH）,a hallmark of *** and methods: Next generation sequence was applied to screen the miRNAs in tumor mice exposed to CIH or normoxia *** differentially expressed miRNAs were verified by *** ontology（GO） and Kyoto encyclopedia of genes and genomes（KEGG） pathway were performed to reveal functional enrichment of target genes regulated by the ***: A total of 485 miRNAs,including 259 novel miRNAs and 226 known miRNAs,were differentially expressed between CIH and normoxia *** them,331 miRNAs were upregulated and 154 miRNAs were *** top 5 differential expressed known and novel miRNAs were validated by *** addition,GO and KEGG pathway analysis demonstrated that predicted target genes regulated by differentially expressed miRNAs were markedly enriched in related biological processes and pathways,including biological processes,cell metabolic and biosynthetic processes,and molecular ***: The differential expressed miRNAs in CIH condition indicates that those miRNAs might be involved in the mechanism of OSA promoting tumor progression.

关键词： sleep apnea intermittent hypoxia miRNAs next generation sequence tumor

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Application of micro PET-CT to evaluate the anti-tumor effect of endostatin in a mouse mode of sleep apnea

Application of micro PET-CT to evaluate the anti-tumor effec...

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中国睡眠研究会第十届全国学术年会

作者： Xiao-bin Zhang Xu-An Huang Hui-Qing Zeng bin-bin fu Yan-Ping Du Li-Da Chen Yan-Ting Lai Ying Wu Department of Respiratory Medicine Zhongshan HospitalXiamen UniversityTeaching Hospital of Fujian Medical University Medical College of Xiamen University Department of Respiratory Medicine Zhangzhou Affiliated Hospital of Fujian Medical University

＜正＞Background:Obstructive sleep apnea （OSA） is associated with cancer incidence and mortality. The potential mechanism is unknown. The aim of this study was to evaluate the influence of intermittent hypoxia （IH...

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Effects of sodium tanshinone IIA sulfonate on oxidative stress and apoptosis in a mouse model of tumor and sleep apnea

Effects of sodium tanshinone IIA sulfonate on oxidative stre...

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中国睡眠研究会第十届全国学术年会

作者： Xiao-bin Zhang Mao-Hong Huang Mu-Yun Guo Hui-Qing Zeng Yi-Ming Zeng bin-bin fu Ying Wu Yan-Ping Du Li-Da Chen Xiongbdiao Luo Department of Respiratory Medicine Zhongshan HospitalXiamen UniversityTeaching Hospital of Fujian Medical University Second Clinical Medical College of fujian Medical University Department of Respiratory and Critical Care Medicinethe Second Affiliated Hospital of Fujian Medical UniversityCenter of Respiratory Medicine of Fujian Province Department of Respiratory Medicine Zhangzhou Affiliated Hospital of Fujian Medical University Department of Computer Science Xiamen University

Background: Obstructive sleep apnea（OSA） is closely associated with cancer incidence and *** of oxidative stress and apoptosis were commonly seen both in cancer and OSA *** aim of the present study was to determine the effect of sodium tanshinone IIA sulfonate（TSA） on tumor oxidative stress and apoptosis in a mouse model of intermittent hypoxia（IH）,a novel feature of *** and methods: Forty-eight male C57 BL/6 J mice were randomly assigned to four groups: control（normoxia） group（CTL）,control plus TSA（CTL+TSA） group,IH group,and IH plus TSA（IH+TSA） *** in IH and IH+TSA groups were subjected to IH 8 hours/per day for 5 *** was intraperitoneally injected（10 mg/kg） daily after tumor grew to 200 mm3 in CTL+TSA and IH+TSA *** oxidative stress indexes,malondialdehyde（MDA） and superoxide dismutase（SOD）,were *** deoxynucleotidyl transferase dUTP nick-end labeling（TUNEL） assay and western blotting of Bax,Caspase-3 were conducted for evaluating ***: Compared with CTL group,mice exposed to IH had higher MDA and lower SOD levels,and the TUNEL-positive cell rate,Bax and Caspase-3 expression levels were decreased in IH *** treatment with TSA,the MDA levels were decreased while SOD levels were increased,and the TUNEL-positive cell rate,Bax and Caspase-3 protein levels were ***: The therapeutic effects of TSA were more significant under IH *** contributes to high oxidative stress and low apoptosis in tumor bearing *** appears to improve IH-induced oxidative stress and apoptosis.

关键词： intermittent hypoxia tumor sodium tanshinone IIA sulfonate oxidative stress apoptosis

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纳米花状MnO_2/PPS功能复合滤料的制备及其NH_3-SCR脱硝性能研究

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高分子学报 2017年第11期27卷 1806-1815页

作者：郑伟杰郑玉婴陈健邹海强付彬彬陈雪红福州大学材料科学与工程学院福州350108

首先采用表面活性剂十二烷基硫酸钠(SDS)对聚苯硫醚(PPS)滤料进行表面活化,由于SDS亲水基团(SO_4~–)与溶液中的H^+发生静电吸附作用,使得之后高锰酸钾在PPS滤料表面原位生成纳米花状二氧化锰,制得nf-MnO_2/PPS复合滤料;并通过探讨高锰... 详细信息

首先采用表面活性剂十二烷基硫酸钠(SDS)对聚苯硫醚(PPS)滤料进行表面活化,由于SDS亲水基团(SO_4~–)与溶液中的H^+发生静电吸附作用,使得之后高锰酸钾在PPS滤料表面原位生成纳米花状二氧化锰,制得nf-MnO_2/PPS复合滤料;并通过探讨高锰酸钾与滤料的质量比、反应时间对nf-MnO_2/PPS复合滤料结构及性能的影响,从而得到最佳制备条件.并利用场发扫描电子显微镜(FESEM)、透射电子显微镜(TEM)、X-射线光电子能谱(XPS)、脱硝活性测试等分析手段对该复合滤料的结构和性能进行了研究;在其基础上利用原位聚合法,在复合滤料表面形成聚吡咯包覆层,制得nf-MnO_2/PPy@PPS复合滤料,并通过多种测试分析手段对改性滤料的结构和性能进行了研究.最后,脱硝测试结果显示,由最佳条件制备出的nf-MnO_2/PPS表现出了最优异的脱硝活性,其在80~180℃时的NO转化率达到36%~100%,nf-MnO_2/PPy@PPS表现出了更好的结合强度和催化稳定性能,但脱硝活性有所下降.

关键词：聚苯硫醚(PPS) 吡咯原位聚合法结合强度催化剂稳定性能

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MK表达载体的构建及在大肠杆菌中的表达

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生物化学与生物物理进展 1998年第1期25卷 56-60页

作者：薛泳涛黄文晋石斌陈镔复鞠躬第四军医大学神经科学研究所

ＭＫ是属于肝素结合因子家族的一种多肽，仅在胚胎中期和成年期肾脏表达，在某些肿瘤细胞中也有异常表达．ＭＫ能够促进细胞特别是神经细胞的生长和分化，并抑制某些肿瘤细胞的生长．通过ＲＴＰＣＲ从胚胎肾脏中获得了ＭＫ成熟肽ＤＮ... 详细信息

ＭＫ是属于肝素结合因子家族的一种多肽，仅在胚胎中期和成年期肾脏表达，在某些肿瘤细胞中也有异常表达．ＭＫ能够促进细胞特别是神经细胞的生长和分化，并抑制某些肿瘤细胞的生长．通过ＲＴＰＣＲ从胚胎肾脏中获得了ＭＫ成熟肽ＤＮＡ编码序列，克隆入载体ｐＢＶ２２１中，并转入大肠杆菌，建立了重组ＭＫ的高表达菌株．

关键词： Midkine 基因表达克隆载体表达载体

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu fu Lei Gu Xin Shao Qinqin Wang Xin Dong bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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260例中药不良反应文献分析

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中国新药与临床杂志 2003年第10期22卷 625-626页

作者：莫斌斌符成海中南大学湘雅二医院湖南长沙410011 湖南省药材公司湖南长沙410008

目的 :对中药引起的不良反应进行统计分析 ,为临床使用中药提供参考。方法 :对 1 998～2 0 0 2年间国内主要医药期刊报道的中药不良反应2 60例进行数据收集分析。结果 :中药引起的不良反应涉及的品种较广 ,ADR发生率以注射剂最多(占 60 ... 详细信息

目的 :对中药引起的不良反应进行统计分析 ,为临床使用中药提供参考。方法 :对 1 998～2 0 0 2年间国内主要医药期刊报道的中药不良反应2 60例进行数据收集分析。结果 :中药引起的不良反应涉及的品种较广 ,ADR发生率以注射剂最多(占 60 .4% ) ,过敏反应最为常见 (占 5 2 .7% )。结论 :加强中药ADR的宣传 ,合理使用中药 ,尽量避免或减少ADR的发生。

关键词：中草药数据库文献型数据收集药物不良反应

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Retrospective comparison of retroperitoneal laparoscopic versus open dismembered pyeloplasty for ureteropelvic junction obstruction

Retrospective comparison of retroperitoneal laparoscopic ver...

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第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： Zhang Xu, Li Hong-Zhao, Ma Xin, Zhang Jun, Lang bin, fu bin, Xu Kai, Zheng Tao, Wang Bao-Jun, Ju Zheng-Hua and Shi Tao-Ping From the Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China

Purpose: To evaluate the clinical value of retroperitoneal laparoscopic dismembered pyeloplasty for ureteropelvic junction obstruction as compared with open surgery. Materials and Methods: The clinical data of 56 pati... 详细信息

关键词： laparoscopy pyeloplasty kidney

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丝瓜种子萌芽及子叶生长过程中谷氨酰胺合成酶同工酶的变化

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武汉大学学报（理学版） 2004年第4期50卷 511-514页

作者：张吉王云华袁永泽周卫陆彬彬张楚富武汉大学生命科学学院发育生物学教育部重点实验室湖北武汉430072

测定了丝瓜种子萌芽及子叶不同生长阶段的谷氨酰胺合成酶(GS)的活性及其同工酶的变化.除了发育上的变化外,光和外源氮对GS活性及其同工酶影响也是显著的.无论外源氮(N)是否存在,GS活性在种子萌芽和子叶生长初期是逐渐升高的,于第6天达... 详细信息

测定了丝瓜种子萌芽及子叶不同生长阶段的谷氨酰胺合成酶(GS)的活性及其同工酶的变化.除了发育上的变化外,光和外源氮对GS活性及其同工酶影响也是显著的.无论外源氮(N)是否存在,GS活性在种子萌芽和子叶生长初期是逐渐升高的,于第6天达到最大,其后活性逐步降低.在光照下,外源氮对GS1诱导作用大于GS2;在无氮下,光对GS2的刺激大于GS1;在暗处,外源氮对GS1和GS2两者都有诱导作用.

关键词：谷氨酰胺合成酶同工酶萌发子叶丝瓜

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