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HIV抗体检测替代策略在全人群中推广应用的可行性研究

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中国艾滋病性病 2017年第1期23卷 17-19页

作者：戴洁陈会超冯瑞琳杨朝军董莉娟胡斌廖斌陈敏金晓媚马艳玲云南省疾病预防控制中心昆明650022 昆明市疾病预防控制中心昆明650228

目的评价艾滋病病毒(HIV)抗体检测替代策略在各类人群中检测HIV抗体的可靠性,探讨HIV抗体替代策略在全人群中推广的可行性。方法对1 040份筛查阳性的样本,用6种不同的快速试剂、1种酶联免疫吸附试验(ELISA)试剂及蛋白印迹法(WB)同时进... 详细信息

目的评价艾滋病病毒(HIV)抗体检测替代策略在各类人群中检测HIV抗体的可靠性,探讨HIV抗体替代策略在全人群中推广的可行性。方法对1 040份筛查阳性的样本,用6种不同的快速试剂、1种酶联免疫吸附试验(ELISA)试剂及蛋白印迹法(WB)同时进行检测,对WB不确定样本做病毒载量(VL)检测,对检测结果进行比较。结果 1 040份筛查阳性样本中,WB检测结果为阳性的有1 007份,当2种快速试剂检测结果为阳性,ELISA试剂检测结果 S/CO≥1时,一致性为100%;WB检测结果为不确定,且VL检测结果为阳性的有20份,当2种快速试剂检测结果为阳性,ELISA试剂检测结果 S/CO≥6时,一致性为100%;以上结果在各类人群中均一致。结论当2种快速试剂检测结果为阳性,且ELISA试剂检测结果 S/CO≥6时,与WB或VL检测结果一致性达到100%,可以替代WB确证检测。在保证检测试剂质量的情况下,将HIV抗体检测替代策略向全人群推广应用是可行的。

关键词：艾滋病病毒抗体检测替代策略

颈椎术后并发脊髓半切综合征：三例报告并文献复习

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颈椎术后并发脊髓半切综合征：三例报告并文献复习

Holographic Entanglement Entropy: A Topical Review

2019楚天骨科高峰论坛暨第二十六届中国中西医结合骨伤科学术年会

作者：王润生黄承军王继杨嘉薛鸿夏子茗 Ke-ya MAO Jian-heng LIU Rui ZHONG Wei JIANG Yi-hao LIU bin-bin chen Department of Orthopedics Chinese peoples Liberation Army General Hospital 广西中医药大学第三附属医院脊柱一科

目的总结颈椎术后并发脊髓半切综合征临床特点及康复规律。方法回顾分析2017年9月至2018年5月颈椎术后并发脊髓半切综合征3例,分析临床、影像特点,根据随访结果总结康复规律,3例中男性2例,女性1例,平均年龄47岁,术前诊断为脊髓型颈椎病... 详细信息

目的总结颈椎术后并发脊髓半切综合征临床特点及康复规律。方法回顾分析2017年9月至2018年5月颈椎术后并发脊髓半切综合征3例,分析临床、影像特点,根据随访结果总结康复规律,3例中男性2例,女性1例,平均年龄47岁,术前诊断为脊髓型颈椎病或神经根型颈椎病,伴有颈椎管狭窄、后纵韧带骨化症,平均病程8.3月。颈前路2例,1例行颈前路椎间盘摘除减压融合术(anterior cervical discectomy and fusion,ACDF)术式,1例行ACDF联合颈前路椎体次全切减压植骨融合术(anterior cervical corpectomy and fusion,ACDF)术式,颈椎后路1例,行颈椎后路椎板切除、椎管减压、侧块螺钉固定融合术。结果:3例术后并发脊髓半切综合征,其中1例伴霍纳综合征,2例病例随访6月以上,1例随访2月,影像学资料分析提示3例术前影像学均有椎间盘突出、椎管狭窄偏于1侧,颈髓受压严重,T2WI呈高信号,且均伴有严重后纵韧带骨化,表现为局灶型或连续型。2例颈前路术后麻醉复苏后患侧关键肌肌力1级以上者,术后6月内患侧关键肌肌力可恢复至4-5级,肌力恢复先近端后远端,患侧上肢远端肌力恢复较慢。1例颈后路术后麻醉复苏后患侧下肢关键肌肌力均为0级者,术后2月随访患侧下肢肌力恢复至3-4级。对侧痛温觉和患侧本体感觉均获得部分恢复,痛温觉恢复早于本体感觉,但均未能完全康复。结论颈椎术后并发脊髓半切综合征多为严重旁中央型椎间盘突出、椎管狭窄,且伴有后纵韧带骨化,经保守治疗恢复良好。

关键词：颈椎手术脊髓半切综合征脊髓损伤并发症

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Communications in Theoretical Physics 2019年第7期71卷 837-852页

作者： bin chen Department of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Collaborative Innovation Center of Quantum Matter Center for High Energy Physics Peking University

In this topic review,we introduce recent developments on holographic entanglement *** briefly reviewing the basic notions of entanglement in quantum information and quantum field theory,we introduce the RyuTakayanagi’s prescription of computing the entanglement entropy *** review the inequalities on the holographic entanglement entropy,and its derivation from Euclidean *** particular,we discuss its implications in semi-classical AdS3/CFT2 correspondence,and furthermore review the recent studies on the emergence of geometry and gravity from entanglement.

关键词： entanglement entropy gravity holography AdS-CFT correspondence

B-Spline Wavelet on Interval Finite Element Method for Static and Vibration Analysis of Stiffened Flexible Thin Plate

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Computers, Materials & Continua 2016年第4期52卷 53-71页

作者： Xing Wei Wen chen bin chen bin chen2 bin chen3 bin chen4 State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049PR China Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityCleveland Ohio 44106USA School of Instrument Science and Engineering Southeast UniversityNanjing 210096PR China

A new wavelet finite element method(WFEM)is constructed in this paper and two elements for bending and free vibration problems of a stiffened plate are *** means of generalized potential energy function and virtual work principle,the formulations of the bending and free vibration problems of the stiffened plate are derived ***,the scaling functions of the B-spline wavelet on the interval(BSWI)are introduced to discrete the solving field variables instead of conventional polynomial ***,the corresponding two problems can be resolved following the traditional finite element *** are some advantages of the constructed elements in structural *** to the excellent features of the wavelet,such as multi-scale and localization characteristics,and the excellent numerical approximation property of the BSWI,the precise and efficient analysis can be ***,transformation matrix is used to translate the meaningless wavelet coefficients into physical space,thus the resolving process is *** order to verify the superiority of the constructed method in stiffened plate analysis,several numerical examples are given in the end.

关键词： B-spline wavelet on the interval Wavelet finite element method Stiffened plate Bending analysis Vibration analysis

Robust bounded control for uncertain flight dynamics using disturbance observer

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Journal of Systems Engineering and Electronics 2014年第4期25卷 640-647页

作者： Mou chen bin Jiang College of Automation Engineering Nanjing University of Aeronautics and Astronautics

The robust bounded flight control scheme is developed for the uncertain longitudinal flight dynamics of the fighter with control input saturation invoking the backstepping technique. To enhance the disturbance rejection ability of the robust flight control for fighters, the sliding mode disturbance observer is designed to estimate the compounded disturbance including the unknown external disturbance and the effect of the control input saturation. Based on the backstepping technique and the compounded disturbance estimated output, the robust bounded flight control scheme is proposed for the fighter with the unknown external disturbance and the control input saturation. The closed-loop system stability under the developed robust bounded flight control scheme is rigorously proved using the Lyapunov method and the uniformly asymptotical convergences of all closed-loop signals are guaranteed. Finally, simulation results are presented to show the effectiveness of the proposed robust bounded flight control scheme for the uncertain longitudinal flight dynamics of the fighter.

关键词： flight dynamics bounded control robust control backstepping control disturbance observer.

Spectral-spatial classification for hyperspectral imagery: a novel combination method based on affinity scoring

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Science China(Information Sciences) 2016年第10期59卷 181-193页

作者： Zhao chen bin WANG State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Key Laboratory for Information Science of Electromagnetic Waves (Ministry of Education) Fudan University Research Center of Smart Networks and Systems School of Information Science and Technology Fudan University

Recently, a general framework for spectral-spatial classification has caught the attention of the hyperspectral imagery(HSI) society. It consists of three parts: classification, segmentation and combination of the former results to make a refined labeled map. Seeing the potentials of the last part, we derive a novel combination rule based on affinity scoring(CRAS). The core of the system is affinity score(AS), which is derived from fuzzy logic. Every AS measures the degree, i.e., the affinity, by which a pixel belongs to a class. The score is essentially decided by three factors: local spatial consistency, spectral similarity, and prior knowledge. The method is compatible with basic classification and segmentation tools, thus saving the trouble of designing complex techniques for the other parts in the framework. Experimental results show that CRAS excels several basic techniques as well as various state-of-the-art methods in the area of spectral-spatial classification.

关键词： hyperspectral imagery spectral-spatial classification affinity score local spatial consistency fuzzy superpixel

Functional knowledge integration of the design process

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Science China(Technological Sciences) 2017年第2期60卷 209-218页

作者： chen bin XIE YouBai State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240 China

Functional knowledge integration is the initial and core phase of a design process. It is the key phase to ensure that the functional requirement of the design product can be appropriately complied with, and its result is also the rudiment of the subsequent detailed design work. If this important phase can be supported by an increasingly distributed resource environment, and be automated such that its completion requires less manual work, the efficiency of the design process would be largely improved and its ability to promote innovation would be enhanced. Therefore, this study involved a detailed analysis of the functional knowledge integration of the design process, as well as the proposal of a corresponding running model. Based on the model, a computational algorithm and an evaluating method were established to automate functional knowledge integration. A corresponding computer program was developed to prove the feasibility of this approach, and it was used to design a solarpowered wiper blade.

关键词： functional knowledge integration design process running model computational algorithm evaluating method

First-Principles Study of Field Emission from Zigzag Graphene Nanoribbons Terminated with Ether Groups

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Chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： Xin chen bin Li Department of Physics University of Science and Technology of China Hefei 230026 China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 ChinaSynergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China Hefei 230026 China

Field emission properties of zigzag graphenenanoribbons terminated with C-O-C ether groups (including cyclic and alternative ether groups at edge, denoted as ZGNR-CE and ZGNR-AE) are studied by adopting a self-consistent method based on density functional theory calculation. The results show that the field emissions of these two nanoribbons are dominated by states around Brillouin zone center and close to Fermi level. Because of lower work function, the ZGNR-CE can produce much stronger emission current than reconstructed zigzag graphenenanoribbon. The ZGNR-AE has nearly completely spin-polarized emission current, although its emission current is not strong enough. It is also found that under the lower E-field, the uniaxial strain can effectively modulate their emission currents but the spin polarization of ZGNR-AE keeps unchanged with the varied strain. The underlying mechanisms are revealed by combining the analyses of their work functions and band structures with edge dipole model.

关键词： Field emission Nanoribbon Ether group Density functional theory

Coordinated motion of molecular motors on DNA chains with branch topology

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Acta Mechanica Sinica 2021年第10期37卷 1580-1588,I0004页

作者： Di Lu bin chen Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou310027China

Toward understanding the macroscopic mechanical behaviors of responsive deoxyribonucleic acid(DNA)hydrogels integrated with DNA motors,here we construct the state map for the translocation process of a single C-terminal translocase domain(FtsKC)on a single DNA chain at the molecular level and then investigate the movement of single or multiple FtsKC motors on DNA chains with varied branch *** studies indicate that multiple FtsKC motors can have coordinated motion,which is mainly due to the force responsive behavior of individual FtsKC *** further suggest the potential application of motors of FtsKC,together with DNA chains of specific branch topology,to serve as strain sensors in hydrogels.

关键词： DNA Molecular motor Coordinated motion Branch topology Strain sensor