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Carbon dots prepared for fluorescence and chemiluminescence sensing

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Science China Chemistry 2019年第8期62卷 968-981页

作者： Meng-Li Liu bin-bin chen Chun-Mei Li cheng-Zhi Huang Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Biomedical Analysis (Southwest University) Chongqing Science & Technology CommissionCollege of Pharmaceutical ScienceSouthwest UniversityChongqing 400715China

Carbon dots(CDs) have attracted considerable research interest in recent years due to their unique optical properties, chemical inertness, facile synthesis from a wide range of starting materials, and advantages over classic quantum dots and organic *** methods have been developed for preparing the CDs, including chemical oxidation, hydro/solvothermal method,electrochemical method, microwave-assisted synthesis, and direct carbonization method. Importantly, the superior electronic properties of CDs including efficient light harvesting and prominent photoinduced electron transfer have aroused considerable attention in fluorescence(FL) and chemiluminescence(CL) sensing field. In this review, we aim to demonstrate the recent progress of CDs in the synthesis, FL and CL sensing applications. This review gives new insights into how to use different synthetic methods to tune the structure of the CDs, with the major focus on FL and CL sensing.

关键词： carbon dots synthesis approach fluorescence sensing chemiluminescence sensing detection mechanism

Learning the Effective Spin Hamiltonian of a Quantum Magnet

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Chinese Physics Letters 2021年第9期38卷 101-107页

作者： Sizhuo Yu Yuan Gao bin-bin chen Wei Li School of Physics Beihang UniversityBeijing 100191China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

To understand the intriguing many-body states and effects in the correlated quantum materials,inference of the microscopic effective Hamiltonian from experiments constitutes an important yet very challenging inverse *** we propose an unbiased and efficient approach learning the effective Hamiltonian through the many-body analysis of the measured thermal *** approach combines the strategies including the automatic gradient and Bayesian optimization with the thermodynamics many-body solvers including the exact diagonalization and the tensor renormalization group *** showcase the accuracy and powerfulness of the Hamiltonian learning by applying it firstly to the thermal data generated from a given spin model,and then to realistic experimental data measured in the spin-chain compound copper nitrate and triangular-lattice magnet TmMgGaO_(4).The present automatic approach constitutes a unified framework of many-body thermal data analysis in the studies of quantum magnets and strongly correlated materials in general.

关键词： Hamiltonian quantum thermodynamics

Design and applications of carbon dots-based ratiometric fluorescent probes:A review

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Nano Research 2023年第1期16卷 1064-1083页

作者： bin-bin chen Meng-Li Liu Ya-Ting Gao Shuai Chang Ruo-Can Qian Da-Wei Li Key Laboratory for Advanced Materials Shanghai Key Laboratory of Functional Materials ChemistryFrontiers Science Center for Materiobiology&Dynamic ChemistrySchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenShenzhen 518172China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of PolymersCollege of Chemistry and MaterialsFudan UniversityShanghai 200433China

Ratiometric fluorescence(FL)probes can eliminate the background interference and provide more accurate detection results than single emission intensity-based ***,carbon dots(CDs)-based ratiometric FL probes have received extensive research attention due to their excellent biocompatibility,water solubility,and multi-emission *** this review,we firstly summarize the construction strategies of CDs-based ratiometric FL probes,including physical mixing,nanohybrid,and dual-emitting CDs ***,we classify the sensing types of CDs-based ratiometric FL probes into five categories according to the difference in spectral variation caused by analytes:“single-response-ON”,“single-response-OFF”,“doubleresponses-ON”,“double-responses-OFF”,and“double-responses-Reverse”***,a thorough overview of CDs-based ratiometric FL probe applications in ions,molecules,pH,and temperature sensing is *** believe this review can show the latest research progress of CDs-based ratiometric FL sensing fields and provide perspectives on future developments for the construction of CDs-based ratiometric FL probes and their potential applications.

关键词： carbon dots ratiometric fluorescent probes construction strategy sensing type a review

Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 606-610页

作者： bin-bin chen Feng-Wei Song Zhao-Hui Sun Yi Yang Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College

AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function *** was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow ***:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P<0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P<0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P<0.001).The more severity of amblyopia,the poorer levels of contrast *** pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously ***:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.

关键词： anisometropia amblyopia area under the log contrast senility function fusion stereopsis

Network-Initialized Monte Carlo Based on Generative Neural Networks

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Chinese Physics Letters 2022年第5期39卷 23-28页

作者： Hongyu Lu Chuhao Li bin-bin chen Wei Li Yang Qi Zi Yang Meng Department of Physics and HKU-UCAS Joint Institute of Theoretical and Computational Physics The University of Hong KongHong KongChina Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China School of Physics Beihang UniversityBeijing 100191China State Key Laboratory of Surface Physics Fudan UniversityShanghai 200438China Center for Field Theory and Particle Physics Department of PhysicsFudan UniversityShanghai 200433China

We design generative neural networks that generate Monte Carlo configurations with complete absence of autocorrelation from which only short Markov chains are needed before making measurements for physical observables,irrespective of the system locating at the classical critical point,fermionic Mott insulator,Dirac semimetal,or quantum critical *** further propose a network-initialized Monte Carlo scheme based on such neural networks,which provides independent samplings and can accelerate the Monte Carlo simulations by significantly reducing the thermalization *** demonstrate the performance of our approach on the two-dimensional Ising and fermion Hubbard models,expect that it can systematically speed up the Monte Carlo simulations especially for the very challenging many-electron problems.

关键词： process critical chains

Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 479-486页

作者： Feng-wei SONG bin-bin chen Zhao-hui SUN Li-ping WU Su-juan ZHAO Qi MIAO Xia-jing TANG Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College Department of Otolaryngology-Head and Neck Surgery the First Affiliated HospitalWenzhou Medical College

Objective:To screen mutations in FERM domain-containing protein 7(FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus(XLICN).Methods:Common ophthalmic data and peripheral blood of two Chinese XLICN families(families A and B) were collected after informed *** DNA was prepared from the peripheral blood of members of the two families and from 100 normal *** in the FRMD7 gene were determined by directly sequencing polymerase chain reaction(PCR) ***:We identified a novel mutation c.980_983delATTA compound with c.986C>A mutation in the 11th exon of FRMD7 in family B,and a previously reported splicing mutation c.782G>C(p.R261G) in family *** mutations were detected in patients and female carriers,while they were absent in other relatives or in the 100 normal ***:Our results expand the spectrum of FRMD7 mutations in association with XLICN,and further confirm that the mutations of FRMD7 are the underlying molecular mechanism for XLICN.

关键词： Mutation Idiopathic congenital nystagmus FERM domain-containing protein 7(FRMD7)

Research and Practice of Production Technology for High Performance Low Alloy Steels in WISCO

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Journal of Iron and Steel Research International 2011年第S1期18卷 99-103页

作者： FU Lian-chun,GUO Ai-ming,LIU Ji-bin,GUO bin,chen Yan-tang [Wuhan Iron and Steel (Group) Corporation,Wuhan 430080,Hubei,China] Wuhan Iron & Steel Grp Corp Wuhan 430080 Hubei Peoples R China

The product system of high strength low alloy steels (HSLA) produced by Wuhan Iron and Steel (Group) Corporation (WISCO) was presented.A series of high performance structural steels have been developed for important construction projects around the world in different areas,such as bridge,pressure vessel,pipe line,shipbuilding,architecture,machinery and railway *** order to promote the development of large heat input welding steel,high grade thick pipeline steel and long span bridge steel,a lot of advanced production technologies have been achieved through intensive investigation,such as the control of high purity,high homogenization and free defects in steel slabs,the rules of high melting point particle formation and distribution in micro and nano scale during steel production,and the TMCP technology for ultra low carbon bainite steel for medium and heavy *** will carry on research and application of economic and weather-resistant steels and promote the developing and producing technologies of HSLA steel.

关键词： WISCO high performance low alloy steels production technology

Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1581-1591页

作者： Yan Jiang Di Gong Xiao-Hong chen Lin Yang Jing-Jing Xu Qi-Jie Wei bin-bin chen Yong-Jiang Cai Wen-Qun Xi Zhe Zhang Departments of Laboratory Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina Center of Health Management Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Visionary Intelligence Ltd. Beijing 100080China Ophthalmology Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To develop a deep learning-based model for automatic retinal vascular segmentation,analyzing and comparing parameters under diverse glucose metabolic status(normal,prediabetes,diabetes)and to assess the potential of artificial intelligence(AI)in image segmentation and retinal vascular parameters for predicting prediabetes and ***:Retinal fundus photos from 200 normal individuals,200 prediabetic patients,and 200 diabetic patients(600 eyes in total)were *** U-Net network served as the foundational architecture for retinal arteryvein *** automatic segmentation and evaluation system for retinal vascular parameters was trained,encompassing 26 ***:Significant differences were found in retinal vascular parameters across normal,prediabetes,and diabetes groups,including artery diameter(P=0.008),fractal dimension(P=0.000),vein curvature(P=0.003),C-zone artery branching vessel count(P=0.049),C-zone vein branching vessel count(P=0.041),artery branching angle(P=0.005),vein branching angle(P=0.001),artery angle asymmetry degree(P=0.003),vessel length density(P=0.000),and vessel area density(P=0.000),totaling 10 ***:The deep learning-based model facilitates retinal vascular parameter identification and quantification,revealing significant *** parameters exhibit potential as biomarkers for prediabetes and diabetes.

关键词： deep learning retinal vascular parameters segmentation model diabetes prediabetes

Breeding of Silkworm Variety "Chuancan No.24" with Strong Vitality for Summer-Autumn Rearing

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Animal Husbandry and Feed Science 2010年第8期2卷 6-8,11页

作者： LIU Jun-feng LIU bin-bin chen Yi-an Sedcultural Research Institute Sichuan Academy of Agricultural Sciences Nanchong 637000 China

[ Objective] The aim was to introduce the breeding process of natural colorful cocoon silkworm variety, Chuancan No. 24. [ Method] By cross breeding and pedigree separation, the silkworm variety, Chuancan No. 24, with double sex-limited markings and strong vitality and for sum- mer-Autumn rearing was bred. [ Result] The results of laboratory identification and countryside test in Sichuan Province indicated that the Chuancan No. 24 was strong and could be reared easily. They had uniform development and excellent quality of cocoon and silk. In addition, their sexes could be identified by larval body color and markings. The main indexes are as follows： cocoon yield per 10 003 fourth instar larvae, 19.66 kg; filament length, 1 241.29 m; length of non-broken filament, 941.99 mm; reelability, 75.87% ; raw silk ratio of fresh cocoon, 17.07% ; and neatness, 94.03 points. The main economic features of new variety were better than those of the control. [ Conclusion] The Chuancan No. 24 has been approved by the Sichuan Silkworm Evaluation Commission, and it is suitable to rear this new variety in some regions of the Yangtze River drainage basin, such as Sichuan Province and Chongqing.

关键词： Bombyx mori Variety for summer-Autumn rearing Strong vitality Chuancan No. 24