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Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes

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World Journal of Diabetes 2025年第4期16卷 166-177页

作者： Rui Wang Yu-Xian Xu Feng Xu Chun-Hua Wang Li-Hua Zhao Li-Hua Wang Wei-Guan Chen Xue-Qin Wang Cheng-Wei Duan Jian-bin su Department of Endocrinology The Affiliated Hospital 2 of Nantong UniversityNantong First People’s HospitalNantong 226001Jiangsu ProvinceChina Department of Nursing The Affiliated Hospital 2 of Nantong UniversityNantong First People’s HospitalNantong 226001Jiangsu ProvinceChina Department of Rehabilitation The Affiliated Hospital 2 of Nantong UniversityNantong First People’s HospitalNantong 226001Jiangsu ProvinceChina Medical Research Center The Affiliated Hospital 2 of Nantong UniversityNantong First People’s HospitalNantong 226001Jiangsu ProvinceChina

BACKGROUND Increased blood urea nitrogen(BUN)levels have been demonstrated to be associated with broader metabolic disturbances and the incidence of type 2 diabetes(T2D),potentially playing a role in the development of diabetic complications,including diabetic peripheral *** To examine the relationship between BUN levels and peripheral nerve function in patients with *** This observational study involved the systematic recruitment of 585 patients with T2D for whom BUN levels and estimated glomerular filtration rate were *** was used to assess peripheral motor and sensory nerve function in all patients,and overall composite Z-scores were subsequently calculated for nerve latency,amplitude,and conduction velocity(NCV)across the median,ulnar,common peroneal,posterior tibial,superficial peroneal,and sural *** Across the quartiles of BUN levels,the overall composite Z-score for latency(F=38.996,P for trend<0.001)showed a significant increasing trend,whereas the overall composite Z-scores for amplitude(F=50.972,P for trend<0.001)and NCV(F=30.636,P for trend<0.001)exhibited a significant decreasing ***,the BUN levels were closely correlated with the latency,amplitude,and NCV of each peripheral ***,multivariate linear regression analysis revealed that elevated BUN levels were linked to a higher overall composite Z-score for latency(β=0.166,t=3.864,P<0.001)and lower overall composite Z-scores for amplitude(β=-0.184,t=-4.577,P<0.001)and NCV(β=-0.117,t=-2.787,P=0.006)independent of the estimated glomerular filtration rate and other clinical ***,when the analysis was restricted to sensory or motor nerves,elevated BUN levels remained associated with sensory or motor peripheral nerve *** Increased BUN levels were independently associated with compromised peripheral nerve function in patients with T2D.

关键词： Blood urea nitrogen Metabolic disturbance Peripheral nerve function Electromyography Type 2 diabetes

Protection of Large-scale Wind Power Integration

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电力系统自动化 2012年第8期36卷 132-135页

作者： Cai, Rong su, bin ABB China Corporate Research Center Beijing 100015 China

More and more large capacity wind power will be integrated into power system in the future,and certain technical challenges will emerge due to the fluctuation characteristics of wind power and the complex control of power electronic devices inside the wind turbines(e.g.,low voltage ride through(LVRT)).By comparing a wind power integration grid with a hydropower integration grid,the special transient phenomena caused by the wind power integration is studied and simulation results are ***,the potential impacts on the traditional protection are *** show that the special transient phenomena can decrease the sensitivity,reliability and operation speed of conventional protections.

关键词：风力发电常规保护一体化电力电子器件风力涡轮机电力系统波动特性仿真结果

Vertically ordered silica mesochannels as preconcentration materials for the electrochemical detection of methylene blue

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Science China Chemistry 2015年第10期58卷 1593-1599页

作者： Yayun He Longhua Ding bin su Institute of Microanalytical Systems Department of Chemistry Zhejiang University (Zijin’gang Campus)

Silica mesochannels(SMCs) vertically and regularly oriented to the surface of indium tin oxide(ITO) electrodes were prepared and utilized for preconcentration and detection of methylene blue(MB) in aqueous solution. The positively charged MB can be adsorbed to the SMCs by following the pseudo-first-order kinetic model. The negative value of ?G=?34.73 k J/mol derived from the Langmuir adsorption isotherm indicated the thermodynamic feasibility of the adsorption and the spontaneous nature of the process. Moreover, the adsorbed MB can undergo an electrochemical reaction on the ITO electrode at a suitable potential and the resulting electrical current can be utilized to quantify the MB in aqueous solution. A good analytical performance for MB with a linear range from 10 nmol/L to 1.0 ?mol/L and a detection limit at the nmol/L level was obtained. We believe that such a platform consisting of SMCs perpendicularly tethered to the underlying electrode surface simultaneously allows enrichment and electrochemical detection and can be extended for the detection of various charged dyes, as well as many other charged species.

关键词： methylene blue silica mesochannels preconcentration adsorption electrochemical detection

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基于模型预测控制的液压挖掘机回转控制系统

现代机械 2025年第1期 30-34页

作者：祝捷金忠苏宾广西柳工机械股份有限公司智能产品与应用研究院广西柳州545000

虽然PID控制算法易于实现且不需要建立数学模型,但是难以保证机构具有良好的动态和静态性能。对于不同的机器,PID参数需要重新标定,而且液压挖掘机系统模型结构复杂,耦合性较强,PID控制效果不太理想。为了提高无人挖掘机的自动控制精度... 详细信息

虽然PID控制算法易于实现且不需要建立数学模型,但是难以保证机构具有良好的动态和静态性能。对于不同的机器,PID参数需要重新标定,而且液压挖掘机系统模型结构复杂,耦合性较强,PID控制效果不太理想。为了提高无人挖掘机的自动控制精度,采用模型预测控制算法来设计跟踪控制器。以回转平台机构作为研究对象,建立回转平台的动力学方程,以泰勒级数展开方法对动力学方程解耦合,建立线性化的状态方程,并搭建模型预测控制的跟踪控制器,实现挖掘机回转平台的自动控制。采用的控制算法,将挖掘机回转的一些复杂的非线性问题转化为线性问题,简化了预测控制模型,且经过验证,该控制算法具有较高的控制精度。

关键词：液压挖掘机模型预测控制回转平台

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中国医药 2025年第03期20卷 370-375页

作者：苏斌罗成荀欣中国人民解放军联勤保障部队第九二〇医院肿瘤科

目的分析膜突蛋白、配对相关同源框蛋白1(PRRX1)在老年非小细胞肺癌(NSCLC)组织中表达及与奥希替尼靶向治疗效果的相关性。方法选取中国人民解放军联勤保障部队第九二〇医院2021年1月至2024年6月收治的60例老年NSCLC患者为研究对象。... 详细信息

目的分析膜突蛋白、配对相关同源框蛋白1(PRRX1)在老年非小细胞肺癌(NSCLC)组织中表达及与奥希替尼靶向治疗效果的相关性。方法选取中国人民解放军联勤保障部队第九二〇医院2021年1月至2024年6月收治的60例老年NSCLC患者为研究对象。收集手术切除的癌组织和癌旁组织标本，对组织中的膜突蛋白、PRRX1水平表达进行检测，分析二者表达变化与奥希替尼靶向治疗效果的相关性，并依据患者奥希替尼靶向治疗效果分为治疗有效组(42例)与治疗无效组(18例),比较2组膜突蛋白、PRRX1表达水平。分析膜突蛋白、PRRX1表达对老年NSCLC患者临床疗效的预测价值。结果癌组织中膜突蛋白、PRRX1的阳性表达率分别为70.0%(42/60)、83.3%(50/60),细胞染色区域扩大，染色强度较高。2组病理组织类型、肿瘤最大径、TNM分期、分化程度、淋巴结转移、被膜侵犯、膜突蛋白和PRRX1阳性表达、表皮生长因子受体基因突变发生率比较差异均有统计学意义(均P<0.05)。表皮生长因子受体(EGFR)基因野生型患者膜突蛋白阳性率高于EGFR突变型患者；PRRX1阳性表达率低于突变型患者(均P<0.05)。Spearman相关性分析结果显示膜突蛋白、PRRX1表达与临床疗效均呈正相关(r=0.339、0.558,均P<0.001)。多因素Logistic回归分析结果显示，病理组织类型、肿瘤最大径、TNM分期、分化程度、淋巴结转移、被膜侵犯、膜突蛋白、PRRX1表达均是影响患者奥希替尼靶向治疗效果的危险因素(均P<0.001)。受试者工作特征曲线分析结果显示，膜突蛋白、PRRX1联合检测对老年NSCLC患者临床疗效的预测价值高于膜突蛋白、PRRX1单独检测。结论在老年NSCLC患者中膜突蛋白、PRRX1表达对奥希替尼靶向治疗效果有关，可通过联合检测预测，从而为临床治疗方案调整提供参考。

关键词：非小细胞肺癌膜突蛋白配对相关同源框蛋白1 奥希替尼靶向治疗

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Editorial

Journal of Analysis and Testing 2020年第2期4卷 55-56页

作者： bin su Institute of Analytical Chemistry Department of ChemistryZhejiang UniversityHangzhou 310058China

Electrochemiluminescence(ECL)is a luminescent phenom-enon,in which the emissive excited-states are generated under dark conditions by electrochemical reactions involv-ing heterogeneous charge transfer between electrode(s)and emitters(and co-reactants)in *** has attracted tre-mendous research attention and been successfully applied in commercial immunodiagnostics for the quantitative deter-mination of a broad range of disease biomarkers,due to its remarkable features such as short detection time(less than 20 min),wide measuring range(over six orders of mag-nitude),low sample consumption(dozens of microliter),high on-board stability(highly stable reagents),excellent precision and sensitivity(near-zero background interfer-ence).Totally several billions of ECL immunodiagnostic tests are commercially run worldwide a *** addition to diagnostics applications,ECL has also been developed as a versatile and powerful technique for fundamental research in diverse fields,such as biosensing,nanocatalysis,environ-mental monitoring and so *** is why this special issue is organized by the editorial office of Journal of Analysis and Testing.

关键词： solution. versatile excited

Packet track and traceback mechanism against denial of service attacks

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The Journal of China Universities of Posts and Telecommunications 2008年第3期15卷 51-58页

作者： LI Li SHEN su-bin Institute of Information Network Technology Nanjing University of Posts and Telecommunications Nanjing 210003 China

The denial of service attack is a main type of threat on the Internet today. On the basis of path identification （Pi） and Internet control message protocol （ICMP） traceback （iTrace） methods, a packet track and traceback mechanism is proposed, which features rapid response and high accuracy. In this scheme, routers apply packet marking scheme and send traceback messages, which enables the victim to design the path tree in peace time. During attack times the victim can trace attackers back within the path tree and perform rapid packet filtering using the marking in each packet. Traceback messages overcome Pi＇s limitation, wherein too much path information is lost in path identifiers; whereas path identifiers can be used to expedite the design of the path-tree, which reduces the high overhead in iTrace. Therefore, our scheme not only synthesizes the advantages but also compromises the disadvantages of the above two methods. Simulation results with NS-2 show the validity of our scheme.

关键词： denial of service (DoS) attack traceback packet marking Pi

The Effect of Ionic Strength on the Electrochemiluminescence Generation by Tris(2,2′-bipyridyl)ruthenium(II)/Tri-n-propylamine

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Chemical Research in Chinese Universities 2022年第3期38卷 816-822页

作者： HU Shifan WANG Yafeng su bin Institute of Analytical Chemistry Department of ChemistryKey Laboratory of Excited-State Materials of Zhejiang ProvinceZhejiang UniversityHangzhou310058P.R.China

Electrochemiluminescence(ECL)is a powerful transduction technique used in biosensing and in vitro diagnosis,while the mechanism of ECL generation is complicated and affected by various *** the effect of ionic strength on ECL generation by the classical tris(2,2′-bipyridyl)ruthenium(II)[Ru(bpy)_(3)^(2+)]/tri-n-propylamine(TPrA)system was *** is clear that the ECL intensity decreases significantly with the increase of ionic strength,most likely arising from the reduced deprotonation rate of TPrA^(+)·.We further combined microtube electrode(MTE)with ECL microscopy to unravel the evolution of ECL layer with the variation of ionic *** a low concentration of Ru(bpy)_(3)^(2+),the thickness of ECL layer(TEL)nearly kept unchanged with the ionic strength,indicating the surface-confined ECL generation is dominated by the oxidative-reduction *** at a high concentration of Ru(bpy)_(3)^(2+),ECL generation is dominated by the catalytic route and TEL increases remarkably with the increase of ionic strength,because of the extended diffusion length of Ru(bpy)_(3)^(3+) at a reduced concentration of TPrA·.

关键词： Electrochemiluminescence(ECL) ECL layer thickness ECL microscopy Ionic strength Reaction mechanism

Effect of Microdomain Structure on the Mechanical Behavior of binary Blends

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Chinese Journal of Polymer Science 2015年第7期33卷 964-975页

作者： bin su Yong-sheng Zhao 陈枫傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

The relationship between microphase structure and mechanical response of the binary blends consisting of polystyrene-block-polyisoprene-block-polystyrene copolymer and low molecular weight polystyrene has been investigated. Low molecular weight polystyrene was chosen to obtain uniformly solubilized nano-blends without macrophase separation. The specimens were solution-cast by adding different amounts of homo-polystyrene to acquire different microphase structures. Small angle X-ray scattering（SAXS）, transmission electron microscopy（TEM） and atom force microscopy（AFM） have been used to study the microdomain and grain structure. It is observed that the structural changes in d-spacing and grain size on account of different amounts of polystyrene alter the mechanical behavior in both monotonic tensile and cyclic tests. The elastic and the Mullins effects are strongly sensitive to the changes in d-spacing and grain sizes. Moreover, the sample with bi-continuous structure shows the largest tensile strength and Mullins effect. In addition, the Mooneye-Rivlin phenomenological model was used to evaluate and explore the relationship between the polymer topological networks and the rubber elasticity of these styrenic nano-blends.

关键词： Microphase Grain size d-Spacing Bi-continuous structure Elastic response