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Anti-apoptotic effects of aspirin following cerebral ischemia-reperfusion injury in rats

Neural Regeneration Research 2008年第9期3卷 979-984页

作者： Liying qiu bin Du Ying Li Hongbin Fan Zhiyong Yang Department of Biopharmaceutical Sciences Medicine and Pharmaceutics School of Jiangnan University Wuxi 214122 Jiangsu ProvinceChina

BACKGROUND： The pharmacological effects of aspirin on apoptosis are complex. The underlying mechanisms have not been properly defined. OBJECTIVE： To observe the effect of different doses of aspirin on brain cell apoptosis following focal cerebral iscbemia-reperfusion injury （CIRI） in rats. DESING, TIME AND SETTING： A randomized, controlled, animal experiment, performed at the School of Medicine and Pharmaceutics, Jiangnan University between June and October 2006. MATERIALS： Twenty-six male, adult, Sprague Dawley rats （grade Ⅱ）, weighing 240-290 g, were obtained from Shanghai Experimental Animal Center, Chinese Academy of Sciences. Aspirin was provided by Sigma （USA）. METHODS： The rats were randomly divided into four groups： sham-operation （SO）, CIRI ＋ vehicle, CIRI ＋ aspirin （6 mg/kg）, and CIRI ＋ aspirin （60 mg/kg）. Rats in the lesion groups were intragastrically administrated saline, aspirin （6 mg/kg）, or aspirin （60 mg/kg）, respectively. MAIN OUTCOME MEASURES： The number of pyramidal neurons with normal appearance in the cerebral cortex at 24 mm from the midline; apoptotic cell death as measured by TUNEL; Bcl-2 and Bax protein localization was determined by immunohistochemistry; malondialdehyde （MDA） and super oxidation （SOD） content were determined by biochemistry method; adenosine triphosphate （ATP） content measured by capillary electrophoresis. RESULTS： Following CIRI, the following parameters were altered compared with sham-operated animals： the number of neurons with normal appearance was significantly reduced in the cerebral cortex; the number of apoptotic cells increased; Bax protein expression was enhanced; and the ratio between Bcl-2 and Bax decreased. In addition, MDA content increased significantly, whereas ATP content decreased （P 〈 0.01）. Aspirin ameliorated the loss of healthy pyramidal neurons. Both 6 and 60 mg/kg aspirin increased the ratio between Bcl-2 and Bax, with no significant difference between the treatment groups. In addition, 60 mg/kg asp

关键词： aspirin Bax Bcl-2 cerebral ischemia-reperfusion injury cell apoptosis

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THE HARDWARE IMPLEMENTATION OF A GENERIC FUZZY RULE PROCESSOR

THE HARDWARE IMPLEMENTATION OF A GENERIC FUZZY RULE PROCESSO...

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1998 Fourth International Conference Signal Processing

作者： bin qiu Pak L Woon School of Computer Science and Software Engineering Monash University

＜正＞In this paper,the hardware design and implementation of a generic fuzzy processor is *** processor allows the user to choose from a larger range of inference and defuzzification *** number of inputs and outputs was limited to 3,with a width of 8-bits for each. Rule base size and the number of inferences that can be performed per second were not a critical factor as larger and faster specifications will simply increase the end cost. Design and simulation using Altera’s Max+plus2 programmable logic development software was then conducted,and verified correct *** generic fuzzy processor was ultimately realised via construction using Altera FLEX 8000 FPGAs

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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture

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World Journal of Psychiatry 2024年第6期14卷 838-847页

作者： Wen-Hui Fu Zhi-Long Hu Yuan-Jun Liao Ri-Jiang Chen Jian-bin qiu Wu-Tang Que Wan-Tao Wang Wei-Hua Li Wei-bin Lan Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 361000Fujian ProvinceChina

BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress *** hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is *** speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological *** To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with *** In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were *** analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris *** Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,*** sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,*** specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,***,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consid

关键词： Psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis Correlation

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Modified Liangfu granule exhibits anti-cancer effects in gastric cancer by regulating apoptosis-related proteins and genes

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Journal of Traditional Chinese Medical Sciences 2019年第4期6卷 325-330页

作者： Ya Li Lingqun Zhu Fengqin Shi Ruibai Li Xinyi Chen Zhi Zheng bin qiu Li Hou Department of Oncology and Hematology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Key Laboratory of Chinese Internal Medicine of Educational Ministry and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Environmental Health Sciences Yale School of Public HealthYale UniversityNew HavenCT 06520USA Department of Internal Medicine 5th Division Jiangxi Cancer HospitalJiangxi Cancer CenterNanchang 330029China Department of Pharmacology Yale School of MedicineYale UniversityNew HavenCT 06520USA

Objective:To investigate the anti-cancer effects and mechanism of modified Liangfu granule(MLFG)in BGC-823 gastric cancer ***:The drug serum was extracted from abdominal aorta of Wistar rats treated by cyclophosphamide,dioscin,MLFG(high-,medium-,and low-dose),*** assay was performed to detect the effect of different concentrations of MLFG and dioscin on cell *** effect of MLFG on cellular apoptosis was detected by flow *** blot was used to examine Bcl-2 and Akt in BGC-823 cells treated with *** real-time polymerase chain reaction assay was performed to determine the expression level of caspase-3,E2F1 and E2F3 genes in cells treated by MLFG-and dioscin-containing ***:MLFG-and dioscin-containing serum inhibited the cell proliferation of BGC-823 *** induced gastric carcinoma cell apoptosis and inhibited the expression of Bcl-2 and Akt in a dosedependent *** also significantly induced the gene expression of caspase-3 and downregulated E2F1 and E2F3 gene ***:The effect of MLFG and dioscin on inhibiting cell proliferation and induction of apoptosis of gastric cancer cells might be related to the regulation of Bcl-2 and Akt proteins and the expression of caspase-3,E2F1 and E2F3 genes.

关键词： Modified Liangfu granule Gastric cancer Caspase-3 E2F1 E2F3

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论乡村“善治”进路中的基层志愿服务--以浙江嵊州“村嫂”为讨论基础

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甘肃社会科学 2021年第3期 159-166页

作者：裘斌绍兴文理学院马克思主义学院浙江绍兴312000

志愿服务与乡村“善治”是乡村治理中的重要问题,从整体上考察对于乡村治理拓展和创新具有重要意义。当前,走向“善治”是提升乡村治理有效性的重要途径,有助于重塑乡村凝聚力,有助于培育村民群众的公共精神,有助于构建“乡政”“村治... 详细信息

志愿服务与乡村“善治”是乡村治理中的重要问题,从整体上考察对于乡村治理拓展和创新具有重要意义。当前,走向“善治”是提升乡村治理有效性的重要途径,有助于重塑乡村凝聚力,有助于培育村民群众的公共精神,有助于构建“乡政”“村治”良性互动关系。现阶段,志愿服务是推进乡村“善治”的题中之义和重要抓手。农村志愿服务内容的生活化优势契合乡村“善治”服务民生的内在要求,农村志愿服务过程的近距离优势契合乡村“善治”建立和谐政治关系的客观要求,农村志愿服务运作的低成本优势契合乡村“善治”效益最大化的本质诉求。农村基层志愿服务的拓展和振兴,更可为乡村“治理有效”夯实村民参与、乡风形塑、内生性资源基础。同时,研究表明,当前乡村“善治”视野下的基层志愿服务尚存在独立性不强、发展性较弱、专业性不足等诸问题,需要引起理论研究者和实务工作者的关注和重视。

关键词：志愿服务 “村嫂” 乡村治理 “善治” 拓展进路

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我国考试经济伦理问题初探

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湖南科技大学学报（社会科学版） 2017年第2期20卷 178-184页

作者：邱斌中南大学公共管理学院湖南长沙410012

考试经济是围绕考试而形成的各种经济活动或经济行为。作为考试的衍生物,考试经济给从业者带来了丰厚的回报,同时也产生了一些亟需规范的行为,造成了不良的社会影响,对公民道德诉求产生了一定的负面作用,对考试实施主体提出了新的伦理诉... 详细信息

考试经济是围绕考试而形成的各种经济活动或经济行为。作为考试的衍生物,考试经济给从业者带来了丰厚的回报,同时也产生了一些亟需规范的行为,造成了不良的社会影响,对公民道德诉求产生了一定的负面作用,对考试实施主体提出了新的伦理诉求,对考试经济从业者也提出了新的伦理规范。要推动考试经济规范化发展,其根源是要规范考试管理,理顺考试主体与客体的关系,优化考试措施,不断深化考试改革,并依法约束畸形考试经济行为,促进考试经济健康发展,驶入良性运行轨道。

关键词：伦理经济考试

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Research Progress on Acupuncture Therapy in Infertility: A Bibliometric Analysis from 2000 to 2021

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Chinese Medicine 2023年第3期14卷 181-207页

作者： Nuan Wen bin qiu Ping Wang Ran Li Department of Chinese Medicine Weifang Nursing Vocational College Weifang China Department of Chinese Medicine Weifang Weien Hospital Weifang China Department of Gynaecology and Obstetrics Weifang Weien Hospital Weifang China

Objective: To investigate the research progress and new trend of acupuncture in the treatment of infertility from 2000 to 2021. Methods: The literature review was conducted on acupuncture and moxibustion treatment of infertility from 2000 to 2021 from the Web of Science core collection and PubMed. CiteSpace and VOSviewer were used to analyze the annual number of articles, countries, institutions, authors, journals, references and keywords. Statistical Analysis Toolkit for Informetrics 3.2 (SATI) and IBM SPSS Modeler 18.0 were employed to draw the maps of core acupoints and acupuncture approaches. Results: A total of 316 articles were included. From 2000 to 2021 the number of publications has been ever increased with certain fluctuations. The United States was the most productive country. Heilongjiang University of Chinese Medicine was the most active institution. Stener-Victorin E was the highest cited author. Fertility and Sterility was the most prolific journal. Paulus We, 2002 was the highest co-citation literature. SP6 (Sanyinjiao) was the most commonly used acupoint. Manual acupuncture was the most commonly used method. Conclusions: The study of acupuncture in the treatment of infertility is characterized by multinational, multi-institutional participation and close regional cooperation. Acupuncture is a potentially effective therapy for infertility. Due to a lack of research quality and difficulties in performing double-blind, high-quality clinical evidence is urgently required. A complete acupuncture therapy system for infertility should be gradually constructed.

关键词： Acupuncture Infertility Bibliometric Analysis CiteSpace VOSviewer

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Body Language between Chinese and English in Intercultural Communication

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海外英语 2017年第20期 219-220页

作者：邱彬中北大学人文社会科学学院

As the economy and culture developing and globalizing so quickly, people have more opportunities to communicate with others who come from different cultures than before. Human communication system includes two parts, one is language communication system and the other is nonverbal communication system. Some researches show that in human's daily communication, 93% information is transmitted by nonverbal communication, among which, 55% information is transmitted by facial, gesture and so on; 38% information is transmitted by tone. So nonverbal communication is the main part of body language. But body language and culture have an inseparable relationship, some body languages are similarly in different cultures, and some have their own unique culture connotation.

关键词： Chinese and English cultures body language intercultural communication

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Evaluation of bronchoscopic direct vision glottis anesthesia method in bronchoscopy

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World Journal of Clinical Cases 2023年第21期11卷 5108-5114页

作者： Jie Lang Zhi-Zhen Guo Shu-Shan Xing Jian Sun bin qiu Yu Shu Zhi-Qiang Wang Gui-Xiang Liu Department of Thoracic Surgery Tangshan People’s HospitalTangshan 063000Hebei ProvinceChina Department of Nephrology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Oncology Tangshan Central HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Fibrobronchoscopy is a common adjunct tool that requires anesthesia and is widely used in the diagnosis and treatment of various respiratory ***,current anesthesia methods,such as spray,nebulized inhalation,and cricothyroid membrane puncture,have their own advantages and ***,studies have shown that bronchoscopic direct-view glottis anesthesia is a simple and inexpensive method that shortens the examination time and provides excellent anesthetic *** To evaluate the effectiveness of bronchoscopic direct vision glottis anesthesia for *** The study included 100 patients who underwent bronchoscopy during thoracic surgery.A random number table method was used to divide the patients into control and observation groups(50 patients each).The control and observation groups were anesthetized using the nebulized inhalation and bronchoscopic direct vision glottis method,*** indices[systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),and oxygen saturation(SpO_(2))before(T1),5 min after anesthesia(T2),and at the end of the operation(T3)]serum stress hormone indices[norepinephrine(NE),epinephrine(E),adrenocorticotropic hormone(ACTH),and cortisol(Cor)before and after treatment]were compared between the 2 *** effects were also RESULTS At T2 and T3,SBP,DBP,and HR were lower in the observation group than the control group,whereas SpO_(2) was higher than the control group[(119.05±8.01)mmHg vs(127.05±7.83)mmHg,(119.35±6.66)mmHg vs(128.39±6.56)mmHg,(84.68±6.04)mmHg vs(92.42±5.57)mmHg,(84.53±4.97)mmHg compared to(92.57±6.02)mmHg,(74.25±5.18)beats/min compared to(88.32±5.72)beats/min,(74.38±5.31)beats/min compared to(88.42±5.69)beats/min,(97.36±2.21)%vs(94.35±2.16)%,(97.42±2.36)%vs(94.38±2.69%],with statistically significant differences(all P<0.05).After treatment,NE,E,ACTH,and Cor were significantly higher in both groups than before treatment,but were lower in the obser

关键词： Direct bronchoscopy Glottis anesthesia method Bronchoscopy Airway Sedation

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Genomic Evolution of Lung Cancer Metastasis:Current Status and Perspectives

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Cancer Communications 2021年第12期41卷 1252-1256页

作者： Wen-Fang Tang Rui Fu Yi Liang Jie-Shan Lin Zhen-bin qiu Yi-Long Wu Wen-Zhao Zhong Department of Cardiothoracic Surgery Zhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Nephrology Blood Purification CenterZhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

INTRODUCTION Lung cancer is one of the cancers with the highest morbidity and mortality *** the two past decades,although the treatment of non-small cell lung cancer(NSCLC)has been revolutionized by the use of tyrosine kinase inhibitor(TKI)and immune treatments,metastatic disease remains largely incurable and presents a 5-year survival rate of approximately 10%[1].

关键词： Lung mortality lung

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