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Arsenic trioxide induces apoptosis of human gastrointestinal cancer cells

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World Journal of Gastroenterology 2014年第18期20卷 5505-5510页

作者： Zhi-bin ma Hong-Yu Xu Miao Jiang You-Lin Yang Lian-Xin Liu Ying-Hua Li Department of Gastroenterology First Affiliated Hospital of Harbin Medical University Department of Hematology First Affiliated Hospital of Harbin Medical University

AIM: To investigate the changes in apoptosis in gastrointestinal cancer cells from patients with gastrointestinal cancers treated with arsenic trioxide (As2O3); and to study the possible molecular mechanisms of such c... 详细信息

关键词： Gastrointestinal cancer Arsenic trioxide Apoptosis p53 Bcl-2

一种用于变压器局部放电在线监测的光纤声发射传感器实验研究

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光谱学与光谱分析 2017年第7期37卷 2273-2277页

作者：马宾徐健齐鲁工业大学信息学院山东济南250023 山东财经大学计算机信息与工程学院山东济南250002

提出了一种光纤声发射传感器并构建传感系统实现变压器局部放电在线监测,利用传感光栅体积小,重量轻,灵敏度高和抗电磁干扰的特点,将传感器置于变压器内部实现局部放电声发射信号的测量。研究了传感光栅实现声发射应力波测量的机理,声... 详细信息

提出了一种光纤声发射传感器并构建传感系统实现变压器局部放电在线监测,利用传感光栅体积小,重量轻,灵敏度高和抗电磁干扰的特点,将传感器置于变压器内部实现局部放电声发射信号的测量。研究了传感光栅实现声发射应力波测量的机理,声发射信号引起传感光栅反射光谱发生漂移,导致特定频点处反射光强发生变化,通过反射光强的变化实现声发射信号的测量。构建声发射传感系统实验模型并提出了一种系统性能优化策略,使系统工作在传感光栅反射光谱上升或下降沿的半峰值频点处,从而保障传感系统具有良好的线性输出特性;研究传感系统工作点稳定技术,设计信号反馈回路自动跟踪反射光谱的漂移,保证系统稳定工作在传感光栅半峰值频点处,消除温度变化对传感系统测量精度的影响。将封装好的传感器用于变压器局部放电现场检测,结果表明,光纤光栅声发射传感器与压电传感器相比具有灵敏度高、动态范围宽等优点,可以实现变压器局部放电在线监测。

关键词：声发射光纤光栅变压器局部放电传感器

Measurement of S-Wave Scattering Length between 6Li and 88Sr Atoms Using Interspecies Thermalization in an Optical Dipole Trap

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Chinese Physics Letters 2019年第7期36卷 27-30页

作者： Xiao-bin ma Zhu-Xiong Ye Li-Yang Xie Zhen Guo Li You Meng Khoon Tey State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Beijing 100084 Collaborative Innovation Center of Quantum matter Beijing 100084

We report the creation of the first mixture of ^6Li and ^88Sr atoms in an optical dipole trap. Using this mixture,a measurement of the interspecies thermalization process is carried out and the previously unknown interspecies s-wave scattering length between ^6Li and ^88Sr atoms is extracted to be |a6 Li-88 Sr|=(380-100^+160)a0 with a0 being the Bohr radius from the rate of interspecies thermalization.

关键词： We report the creation optical dipole trap

Randomized,double-blind,parallel-controlled clinical trial on correspondence of prescriptions and Traditional Chinese Medicine syndrome of ischemic stroke

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Journal of Traditional Chinese Medicine 2012年第3期32卷 335-342页

作者： Ying Gao Haizhen Zhong bin ma Yue Huang Department of Neurology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700 China National Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing100700 China

OBJECTIVE:To investigate the effect of correspondence of prescriptions and the traditional Chinese medicine(TCM) syndrome of ischemic ***:Based on standard syndrome diagnosis and a series of effective formulas,a randomized,double-blind,parallel-controlled clinical trial on correspondence of prescriptions and the TCM syndrome of ischemic stroke was *** formulas were dynamically changed according to the patient's TCM ***:The treatment was composed of a series of formulas changed daily according to the TCM *** which were composed of a series of formulas had similar short-term(1 month after onset) effects in improving mild and moderate neurological deficits compared with treatments composed of only one ***,patients treated with a series of formulas showed improved subjective symptoms in the short-term and a decreased risk of stroke recurrence within three months after ***:Complete(series of formulas) and incomplete(only one formula) correspondence of prescriptions and TCM syndrome have similar effects on the central clinical manifestation of ischemic stroke,such as neurological deficit and activities in daily ***,they have significant differences regarding individual dysfunctions,such as subjective symptoms.

关键词： Stroke Classical prescriptions Symptom complex Multicenter study

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基于增强型边缘定向插值的运动自适应去隔行

高技术通讯 2010年第11期20卷 1190-1195页

作者：丁勇马斌浙江大学超大规模集成电路设计研究所杭州310027

为实现隔行扫描到逐行扫描的高质量视频格式转换,提出了一种基于边缘定向插值的运动自适应去隔行算法,主要包括空间加权边缘搜索、边缘定向插值、同极性场间的运动检测和运动自适应插值等。该算法通过增加对边缘的加权拟合和搜索消除伪... 详细信息

为实现隔行扫描到逐行扫描的高质量视频格式转换,提出了一种基于边缘定向插值的运动自适应去隔行算法,主要包括空间加权边缘搜索、边缘定向插值、同极性场间的运动检测和运动自适应插值等。该算法通过增加对边缘的加权拟合和搜索消除伪边缘插值,通过增加边缘方向的预判断抑制反向插值错误,通过边缘搜索的提前终止减小计算量,通过同极性运动检测消除运动检测错误。实验结果表明,基于边缘定向插值的运动自适应去隔行算法在处理图像和视频流时均表现出优异的性能。

关键词：去隔行运动自适应边缘搜索边缘定向

水垫塘异型构造底板缝隙水流脉动压力特性研究

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天津大学学报（自然科学与工程技术版） 2016年第1期49卷 96-102页

作者：马斌岳颖天津大学水利工程仿真与安全国家重点实验室天津300072

水垫塘作为保护下游河床的结构,其自身在高速水流冲击下的安全性是实现消能和防冲目的的关键所在.优化水垫塘底板的结构设计对于整体结构稳定性就具有一定的实际研究价值.以某水垫塘为背景,基于模型试验结果,研究了异型构造底板缝隙处... 详细信息

水垫塘作为保护下游河床的结构,其自身在高速水流冲击下的安全性是实现消能和防冲目的的关键所在.优化水垫塘底板的结构设计对于整体结构稳定性就具有一定的实际研究价值.以某水垫塘为背景,基于模型试验结果,研究了异型构造底板缝隙处水流脉动压力特性.分析了板块增设键槽前后下表面脉动压力的分布规律、概率特性以及互相关特性和频谱特性,进而从缝隙水流脉动压力的角度分析键槽的增设对底板稳定性的意义.研究表明:在水跃稳定区,带键槽板块间下表面脉动压强系数较不带键槽板块有明显减小趋势;带键槽板块可能产生的脉动上举力较小;增设键槽后,涡旋的保持性和平均尺度增加,板块间相互联系增加;脉动压强的功率谱密度曲线向更低频移动.

关键词：水利水电工程异型构造底板键槽模型试验脉动压力

Application of Preoperative CT/MRI Image Fusion in Target Positioning for Deep Brain Stimulation

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Chinese Medical Sciences Journal 2016年第3期31卷 161-167页

作者： Yu Wang Zi-yuan Liu Wan-chen Dou Wen-bin ma Ren-zhi Wang Yi Guo Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To explore the efficacy of target positioning by preoperative CT/MRI image fusion technique in deep brain *** We retrospectively analyzed the clinical data and images of 79 cases(68 with Parkinson's disease,11 with dystonia) who received preoperative CT/MRI image fusion in target positioning of subthalamic nucleus in deep brain *** of implanted electrodes from the target nucleus of each patient were *** evaluations of each patient before and after the treatment were performed and *** of the positioning and treatment were *** The mean deviations of the electrodes implanted on X,Y,and Z axis were 0.5 mm,0.6 mm,and 0.6 mm,*** neurologic evaluations scores of unified Parkinson's disease rating scale(UPDRS) for Parkinson's disease and Burke-Fahn-marsden Dystonia Rating Scale(BFMDRS) for dystonia patients improved significantly compared to the preoperative scores(Pmain side effects were dysarthria and *** Target positioning by preoperative CT/MRI image fusion technique in deep brain stimulation has high accuracy and good clinical outcomes.

关键词： deep brain stimulation image fusion magnetic resonance imaging computed tomography Parkinson's disease dystonia

Neural network-based computer-aided diagnosis in distinguishing malignant from benign solitary pulmonary nodules by computed tomography

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Chinese Medical Journal 2007年第14期120卷 1211-1215页

作者： CHEN Hui WANG Xiao-hua ma Da-qing ma bin-rong Institute of Biomedical Engineering Capital Medical University Beijing 100069 China Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100053 China

Background Computer-aided diagnosis （CAD） of lung cancer is the subject of many current researches. Statistical methods and artificial neural networks have been applied to more quantitatively characterize solitary pulmonary nodules （SPNs）. In this study, we developed a CAD scheme based on an artificial neural network to distinguish malignant from benign SPNs on thin-section computed tomography （CT） images, and investigated how the CAD scheme can help radiologists with different levels of experience make diagnostic decisions. Methods Two hundred thin-section CT images of SPNs with proven diagnoses （135 small peripheral lung cancers and 65 benign nodules） were analyzed. Three clinical features and nine CT signs of each case were studied by radiologists, and the indices of qualitative diagnosis were quantified. One hundred and forty nodules were selected randomly to form training samples, on which the neural network model was built. The remaining 60 nodules, forming test samples, were presented to 9 radiologists with 3-20 years of clinical experience, accompanied by standard reference images. The radiologists were asked to determine whether a nodule was malignant or benign first without and then with CAD output. Diagnostic performance was evaluated by receiver operating characteristic （ROC） analysis. Results CAD outputs on test samples had higher agreement with pathological diagnoses （Kappa=0.841, P〈0.001）. Compared with diagnostic results without CAD output, the average area under the ROC curve with CAD output was 0.96 （P〈0.001） for junior radiologists, 0.94 （P=0.014） for secondary radiologists and 0.96 （P=0.221） for senior radiologists, respectively. The differences in diagnostic performance with CAD output among the three levels of radiologists were not statistically significant （P=0.584, 0.920 and 0.707, respectively）. Conclusions This CAD scheme based on an artificial neural network could improve diagnostic performance and assist radiologists in distinguishi

关键词： diagnosis, computer-assisted neural networks (computer) solitary pulmonary nodules computed tomography ROC curve

Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer

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World Journal of Clinical Cases 2022年第14期10卷 4446-4459页

作者： Jin-Hua Tao Xiao-Tong Wang Wei Yuan Jia-Nan Chen Zhi-Jie Wang Yun-bin ma Fu-Qiang Zhao Liu-Yuan Zhang Jie ma Qian Liu Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Clinical Immunology CenterNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Abodominal Surgery Beijing Sanhuan Cancer HospitalBeijing 100122China

BACKGROUND Colorectal cancer(CRC)is a common malignant tumor of the gastrointestinal *** metabolism,as an important part of material and energy circulation,is well known to play a crucial role in *** To explore the relationship between serum lipids and CRC development and identify aberrantly expressed cholesterol metabolism genes in *** We retrospectively collected 843 patients who had confirmed CRC and received surgical resection from 2013 to 2015 at the Cancer Hospital of the Chinese Academy of Medical Sciences as our research *** levels of serum total cholesterol(TC),triglycerides,low-density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C),LDL-C/HDL-C and clinical features were collected and statistically analyzed by ***,we used the data from Oncomine to screen the differentially expressed genes(DEGs)of the cholesterol metabolism pathway in CRC and used Gene Expression Profiling Interactive Analysis to confirm the candidate *** was used to analyze the prognostic value of the DEGs,and Search Tool for the Retrieval of Interacting Genes was used to construct the protein-protein interaction network of *** The serum HDL-C level in CRC patients was significantly correlated with tumor size,and patients whose tumor size was more than 5 cm had a lower serum HDL-C level(1.18±0.41 mmol/L vs 1.25±0.35 mmol/L,P<0.01)than their *** addition,TC/HDL(4.19±1.33 vs 3.93±1.26,P<0.01)and LDL-C/HDL-C(2.83±1.10 vs 2.61±0.96,P<0.01)were higher in patients with larger *** levels of HDL-C(P<0.05),TC/HDL-C(P<0.01)and LDL-C/HDL-C(P<0.05)varied in different stages of CRC patients,and the differences were *** screened 14 differentially expressed genes(DEGs)of the cholesterol metabolism pathway in CRC and confirmed that lipoprotein receptor-related protein 8(LRP8),PCSK9,low-density lipoprotein receptor(LDLR),MBTPS2 and FDXR are upregulated,while ABCA1 and OSBPL1A are downregulated in

关键词： Colorectal cancer High-density lipoprotein cholesterol Cholesterol metabolism Prognosis