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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal.of Gastrointestinal.oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang li-Ting Zhang Xiao-Jun liu Xue-bin Peng Xiao-Rong Mao The First School.of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGRoUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-l1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(Il-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that Il-17A participates in tumor progression by affe-cting the level.of immune checkpoint molecules in *** upregulation of PD-l1 expression in HCC cells by Il-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of Il-17A in immune evasion was explored through coculture of T cells and HCC *** effects of Il-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an Il-17A inhibitor and its synergistic effects with a PD-l1 inhibitor were studied in *** Il-17A upregulated PD-l1 expression in HCC cells in a dose-dependent manner,whereas Il-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-l1 expression induced by ***-17A enhanced the survival.of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after Il-17A treatment,whereas BAX expression *** combination of Il-17A and PD-l1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** Il-17A upregulates PD-l1 expression via the Il-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal.of Gastrointestinal.oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng Zhou Wei Yang Di Zhu Bi-Fei Wu Hai-bin Shi Sheng liu Wei-Zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGRoUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+Sl)compared to TACE with lenvatinib alone(TACE+l)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+Sl therapy in comparison to TACE+l therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival.oS),progression-free survival(PFS),and objective response rate(oRR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+Sl group and 27 in the TACE+l *** TACE+Sl group demonstrated significantly improved median PFS and oS compared to the TACE+l group(PFS:14.1 months vs 9.6 months,P=0.016;oS:22.4 months vs 14.1 months,P=0.039),along with a higher oRR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+Sl group again showing longer median PFS and a trend toward improved oS(PFS:14.6 months vs 9.2 months,P=0.012;oS:23.9 months vs 16.3 months,P=0.063),and a higher oRR(73.3%vs 53.3%).No severe adverse events were *** TACE+Sl demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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绿豆R2R3-MYB转录因子家族鉴定及其类黄酮合成调控基因的筛选

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作物学报 2025年第1期51卷 117-133页

作者：郭飞翔李春霞周爽郭彬彬张均马超河南科技大学农学院/河南省旱地农业工程技术研究中心河南洛阳471000

R2R3-MYB转录因子家族在植物次生代谢物合成、胁迫应答和生长发育等生命过程起着重要的调控作用。本研究基于生物信息学鉴定了绿豆(Vigna radiata l.)全基因组水平的R2R3-MYB转录因子,并对其理化性质、系统进化、染色体定位、启动子顺... 详细信息

R2R3-MYB转录因子家族在植物次生代谢物合成、胁迫应答和生长发育等生命过程起着重要的调控作用。本研究基于生物信息学鉴定了绿豆(Vigna radiata l.)全基因组水平的R2R3-MYB转录因子,并对其理化性质、系统进化、染色体定位、启动子顺式作用元件及基因结构做了预测分析;此外,转录组数据和实时荧光定量PCR(QuantitativeReal-timePCR,RT-PCR)分析该转录因子在不同组织、逆境胁迫下的表达模式;并基于相关分析及蛋白互作网络,筛选到可能参与调控绿豆类黄酮生物合成的R2R3-MYB成员。结果表明,共鉴定到168个R2R3-MYB成员,其中145个分布于11条染色体, 23个成员染色体信息未知;大多数R2R3-MYB含有3个外显子,编码99~1645个氨基酸,均为亲水性蛋白;系统进化将绿豆R2R3-MYB基因家族分为30个亚组(V1~V30),不同亚组成员的基因结构存在差异;共线性分析表明,片段复制事件均进行了纯化选择;启动子顺式作用元件分析表明,绿豆R2R3-MYB基因启动子区含有大量激素响应、胁迫响应及少量的类黄酮合成响应等元件;基因表达分析表明,在叶片、叶柄、下胚轴和籽粒种皮中表达量较高的成员分别占15.5%、16.1%、16.1%和10.7%。RT-PCR分析发现,几乎所有的R2R3-MYB家族成员在低温胁迫下的相对表达量显著下调,不同成员对逆境胁迫有不同的响应模式。蛋白互作与相关性分析可知,VrMYB6、VrMYB77、VrMYB93这3个基因可能参与了绿豆类黄酮生物合成的调控。

关键词：绿豆 R2R3-MYB转录因子转录因子家族分析类黄酮合成调控基因

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Hybrid uncertainties-based analysis and optimization design of powertrain mounting systems

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Science China(Technological Sciences) 2020年第5期63卷 838-850页

作者： CAI BoHao SHANGGUAN Wen-bin lÜHui Bo Tao School.of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641China

In this study,a hybrid uncertainties-based analysis and optimization method is presented for the designs of the powertrain mounting system(PMS)involving mixed *** the presented method,the PMS parameters with sufficient data are treated as random variables,while those with limited information are defined as interval ***,an uncertainty-based analysis method called as hybrid interval-random perturbation-central difference method(HIRP-CDM),is proposed to compute the hybrid interval-random outputs of the inherent characteristics of the PMS in concerned *** addition,the hybrid interval-random-Monte Carlo method(HIR-MCM)is developed to verify the computational accuracy of ***,an optimization model mixed uncertainties is built up for the PMS design based on HIRP-CDM,in which the hybrid intervalrandom outputs of the concerned inherent characteristics are adopted to construct the design objective and *** complex optimization problem can be effectively settled by means of *** effectiveness of the presented method is verified by a numerical example.

关键词： powertrain mounting system hybrid uncertainties uncertainty analysis optimization design

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From granulite fluids to quartz-carbonate megashear zones:The gold rush

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Geoscience Frontiers 2014年第5期5卷 747-758页

作者： bin Fu Jacques l.R.Touret Research School.of Earth Sciences The Australian National University Institut de Mineralogie.de Physique des Materiaux et de Cosmochimie(IMPMC) Sorbonne Universites UPMC Univ Paris 06.UMR CNRS 7590 Museum National d'Histoire Naturelle IRD UMR 206.4 Place Jussieu.F-75005 Paris.France

At peak granulite-facies metamorphic conditions, lower continental crust is arguably fluxed by large amounts of two key low water activity fluids：（i） high-density Co2 and/or （ii） concentrated saline so- lutions. These fluids are either internally-derived, generated by mineral reactions or dehydration melting or, notably for Co2, externally-derived, issued from the underlying mantle. Postmetamorphic evolution results in complete disappearance of these fluids, except for minute remnants preserved in minerals as fluid inclusions. Two major processes are involved：（i） at peak conditions, granitoid magmas form, migrate upward, and crystallize as shal.ow intrusions in the upper crust （mineralized porphyry types or reduced intrusions）; （ii） during the rapid decompression which al.ost systematically fol.ows a period of post-peak isobaric cooling, especially for ultrahigh-temperature granulites （anticlockwise P-T paths）, quartz-carbonate megashear zones are formed by repeated periods of seismic activity. Seismic activity may continue until all free fluids have disappeared, resulting in the ultramylonites and pseudotachylites that are found in many granulite domes. A great majority of vein-type Au deposits worldwide occur in the above-mentioned settings or nearby. We suggest that the Au has been scavenged by the granulite fluids, then redistributed and concentrated during the formation of veins and related phenomena.

关键词： Granulite Co2 BrinesMegashear zonesAu mineralization

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Effect of Tongxieyaofang decoction on colonic mucosal protein expression profiles in rats with visceral hypersensitivity

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Journal.of Traditional Chinese Medicine 2020年第2期40卷 245-252页

作者： lin Yongjun Ding Ying lü bin liu Nan Department of Intensive Care Unit Sir Run Run Shaw HospitalMedicine School of Zhejiang UniversityHangzhou 310016China Department of Intensive Care Unit Sir Run Run Shaw Hospital XiaSha CampusMedicine School of Zhejiang UniversityHangzhou 310018China Department of Gastroenterology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China

oBJECTIVE: To explore the underlying mechanism of action of Tongxieyaofang decoction in rats with visceral hypersensitivity using proteomics ***: Twenty-four female Sprague-Dawley rats were randomly divided into three groups: control group, irritable bowel syndrome(IBS) group and Tongxieyaofang treatment group. An IBS model, characterized as visceral hypersensitivity, was established using the odour of mothballs as conditional stimulation and colorectal distension combined with classic physical restraint as non-conditional stimulation. Rats were intragastrically treated with Tongxieyaofang(2 or 4 m l · kg^(-1)· d^(-1))for 4 weeks. on the 45 th day, the rats were dissected and the colonic mucosal proteins were extracted. Differential protein spots were screened by fl.orescent two-dimensional differential gel electrophoresis(2 D-DIGE), and identified by matrix-assisted laser desorption/ionisation time of flight mass spectrometry(MAlDI-ToF-MS). Western blotting experiments were performed to verify the changes observed in 2 D-DIGE and ***: It was found that the visceral sensitivity of rats in the Tongxieyaofang treatment group(4 m l/kg) was lower than that in the IBS group(P one protein spots were differentially expressed between the IBS group and the Tongxieyaofang treatment group. of these, 23 spots were upregulated in the Tongxieyaofang treatment group, while 38 spots were downregulated. Three specific proteins were successfully identified from the five protein spots with the most obvious changes. The two upregulated proteins were transgelin(TAGlN) and acetaldehyde dehydrogenase 2(Aldh2) and the downregulated protein was cytokeratin 8(CK8).CoNClUSIoN: Tongxieyaofang can dose-dependently amel.orate visceral hypersensitivity in rats and the mechanism of action may involve the upregulation of TAGlN and Aldh2 and the downregulation of CK8.

关键词： Irritable bowel syndrome Hypersensitivity Acetaldehyde dehydrogenase inhibitor Keratin-8 Tongxieyaofang

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Spacelike Mobius Hypersurfaces in Four Dimensional lorentzian Space Form

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Acta Mathematica Sinica,English Series 2019年第4期35卷 519-536页

作者： Yan bin lIN Ying lü Chang Ping WANG College of Mathematics and Informatics Fujian Normal University School.of Mathematical Sciences Xiamen University

In this paper, we first set up an alternative fundamental theory of M?bius geometry for any umbilic-free spacelike hypersurfaces in four dimensional lorentzian space form, and prove the hypersurfaces can be determined completely by a system consisting of a function W and a tangent frame {E_i}. Then we give a complete classification for spacelike M?bius homogeneous hypersurfaces in four dimensional lorentzian space form. They are either M?bius equivalent to spacelike Dupin hypersurfaces or to some cylinders constructed from logarithmic curves and hyperbolic logarithmic spirals. Some of them have parallel para-Blaschke tensors with non-vanishing M?bius form.

关键词： Mobius form Mobius metric para-Blaschke tensor Mobius homogeneous hypersurface hyperbolic logarithmic spiral Dupin hypersurface

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De-emulsification of 2-ethyl-1-hexanol/water emulsion using oil-wet narrow channel combined with low-speed rotation

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Chinese Journal.of Chemical Engineering 2018年第10期26卷 2048-2054页

作者： ling lü Kejing Wu You Tang Siyang Tang bin liang Multi-phases Mass Transfer and Reaction Engineering laboratory College of Chemical Engineering Sichuan University College of Chemical Engineering and Chemistry Technology Southwest Petroleum University

low-speed rotation of disc in an internal circulation of a novel de-emulsification with rotation-dise horizental contactor(RHC-D) realized de-emulsification for o/W emulsions due to repeated coalescence in oil-wet narrow channels at a low rotation speed. For three emulsions included ethanol/water/2-ethyl-1-hexanol, ethanol/water/2-ethyl-1-hexanol/SDS(Sodium Dodecyl Sul.onate) and 2-ethyl-1-hexanol/water/SDS emulsion, deemulsification ratios of oil phase could reach 1, 1 and 0.67 respectively at 170 r·min-1, and de-emulsification ratios increased obviously after agitating 10 min. De-emulsification experiment in the seam indicated that oil droplet sizes in o/W emulsion became larger after de-emulsification. The main de-emulsification mechanism in RHCD was the coalescence of oil droplets in oil-wet narrow channels. With increase of the rotation speed, oil droplets dispersed better in the aqueous phase. However, de-emulsification effect enhanced due to the increase of the coalescence rate at a bit higher rotation speed. In addition, internal circulation made those o/W emulsions to be broken repeatedly, consequently de-emulsification ratio increased. Repeated de-emulsification through internal circulation might make continuous extraction of ethanol come true at a low rotation speed.

关键词： De-emulsification oil-wet channel low rotation speed o/W emulsion Internal circulation

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Decomposition behavior of CaSo_4 during potassium extraction from a potash feldspar-CaSo_4 binary system by calcination

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Chinese Journal.of Chemical Engineering 2018年第4期26卷 838-844页

作者： li lü Chun li Guoquan Zhang Xiaowei Hu bin liang School.of Chemical Engineering Sichuan University

The extraction of potassium from a tablet mixture of K-feldspar ore and CaSo4by roasting was studied with a focus on the effects of the decomposition behavior of CaSo4on the potassium extraction *** roasted slags were characterized by X-ray diffraction（XRD）,scanning electron microscopy（SEM）,energy-dispersive X-ray spectroscopy,and thermogravimetric（TG）*** XRD analysis revealed that hydrosoluble mischcrystal K2Ca2（So4）3was obtained by ion exchange of Ca^2＋ in CaSo4 and K^＋ in ***,the intermediate product,Sio2,separated from KAl Si3o8and reacted with CaSo4to decompose *** SEM results showed that some blowholes emerged on the surface of the CaSo4particles when they reacted with Sio2at 1200℃,which indicates that So2and o2gases were released from *** TG curves displayed that pure CaSo4could not be decomposed below 1200℃,while the mixture of K-feldspar ore and CaSo4began to lose weight at 1000℃.The extraction rate of potassium and decomposition rate of CaSo4were 62%and 44%,respectively,at a mass ratio of CaSo4to K-feldspar ore of 3：1,temperature of 1200℃,tablet-forming pressure of6 MPa,and roasting time of 2 *** decomposition of CaSo4reduced the potassium extraction rate;therefore,the required amount of CaSo4was more than the theoretical ***,excess CaSo4was al.o undesirable for the potassium extraction reaction because a massive amount of So2and o2gas were derived from the decomposition of CaSo4,which provided poor contact between the *** So2released from CaSo4decomposition can be effectively recycled.

关键词： K-feldspar Calcium sulfate Potassium extraction Calcium sulfate decomposition Roasting

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The electromagnetic and gravitational-wave radiations of X-ray transient CDF-S XT2

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Research in Astronomy and Astrophysics 2021年第2期21卷 180-186页

作者： Hou-Jun lü Yong Yuan lin lan bin-bin Zhang Jin-Hang Zou En-Wei liang Guangxi Key laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School.of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210093China Space Science and Technology Hebei Normal UniversityShijiazhuang 050000China

binary neutron star(NS)mergers may result in remnants of supra-massive or even stable NS,which have been supported indirectly by observed X-ray plateau of some gamma-ray burst(GRB)***,Xue et al.(2019)discovered an X-ray transient CDF-S XT2 that is powered by a magnetar from merger of double NS via X-ray plateau and fol.owing stepper ***,the decay slope after the plateau emission is slightly larger than the theoretical value of spin-down in electromagnetic(EM)dominated by losing its rotation *** this paper,we assume that the feature of X-ray emission is caused by a supra-massive magnetar central engine for surviving thousands of seconds to collapse into a black *** this scenario,we present the comparisons of the X-ray plateau luminosity,break time,and the parameters of magnetar between CDF-S XT2 and other short GRBs with internal plateau *** adopting the collapse time to constrain the equation of state(EoS),we find that three EoSs(GM1,DD2,and DDME2)are consistent with the observational *** the other hand,if the most released rotation energy of magnetar is dominated by GW radiation,we al.o constrain the upper limit of ellipticity of NS for given EoS,and its range is[0.32-1.3]×10^(-3).Its GW signal cannot be detected by Advanced lIGo or even for more sensitive Einstein Telescope in the future.

关键词： stars magnetars

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