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From basic liver immunology to therapeutic opportunities for liver diseases

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Cellular & Molecular Immunology 2021年第1期18卷 1-3页

作者： Dechun Feng bin gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA

Five years ago,we launched a special issue in the Cellular&Molecular Immunology with a focus on basic liver immunology,which included eight review articles covering the knowledge about immunological features of the liver.1 To date,these articles have been cited more than 1200 times according to the Google *** the past 5 years,enormous progress has been made in the understanding of liver immunology and the identification of various therapeutic strategies targeting inflammatory mediators for the diagnosis and treatment of liver ***,we are honored and excited to present another follow-up special issue to discuss the updated knowledge of translational liver immunology and the therapeutic targets based on the knowledge we learned from the studies of liver immunology.

关键词： therapeutic diagnosis Immunology

The Complement System in Liver Diseases

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Cellular & Molecular Immunology 2006年第5期3卷 333-340页

作者： Xuebin Qin bin gao Laboratory for Translational Research Harvard Medical School Cambridge MA 02139 USA Section on Liver Biology Laboratory of Physiologic Studies National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD 20892 USA Laboratory for Translational Research Harvard Medical School One Kendall Square Building 600 3rd Floor Cambridge MA 02139 USA.

The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver （mainly hepatocytes） is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety of complement receptors. Recent evidence from several studies suggests that the complement system is also involved in the pathogenesis of a variety of liver disorders including liver injury and repair, fibrosis, viral hepatitis, alcoholic liver disease, and liver ischemia/reperfusion injury. In this review, we will discuss the potential role of the complement system in the pathogenesis of liver diseases. Cellular ＆ Molecular Immunology.

关键词： immunity complement liver disease

Associative learning of a three-terminal memristor network for digits recognition

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Science China(Information Sciences) 2023年第2期66卷 209-218页

作者： Yiming REN Bobo TIAN Mengge YAN Guangdi FENG bin gao Fangyu YUE Hui PENG Xiaodong TANG Qiuxiang ZHU Junhao CHU Chungang DUAN Key Laboratory of Polar Materials and Devices (MOE) Ministry of Education Department of ElectronicsEast China Normal University Zhejiang Lab Institute of Microelectronics Beijing Innovation Center for Future Chips (ICFC) Tsinghua University Collaborative Innovation Center of Extreme Optics Shanxi University

Imitating the associative intelligence of the biological brain is attractive but is poorly achieved in hardware because the complex tunable connection in neural networks is difficult to reproduce. We develop a circuit composed of a three-terminal memristor network to reproduce the biological conditioning process artificially. The synaptic weight between co-firing neurons is strengthened simultaneously by generating a feedback signal from the integrate-and-fire neuron to the gate of the synaptic memristor. The network allows the multi-associative capacity of recalling more than one digit in one circuit. Both single and multi-associative learning for recalling digital images are achieved. Furthermore, all 10 digital images from “0” to “9” are successfully recalled in an associative network with such paralleling circuits. Assisted by this associative layer, a typical classification network effectively improves the recognition rate for fragmentary digital *** work sheds light on brain-inspired artificial associative memory and provides a strategy for applications,such as object recognition with partial features and similar scenes.

关键词： artificial intelligence associative learning memristor classification network

Bowel inflammatory presentations on computed tomography in adult patients with severe aplastic anemia during flared inflammatory episodes

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World Journal of Clinical Cases 2023年第3期11卷 576-597页

作者： Xi-Chen Zhao Cheng-Jiang Xue Hui Song bin-Han gao Fu-Shen Han Shu-Xin Xiao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Neurosurgery The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Radiology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Pneumology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Patients with severe aplastic anemia(SAA)frequently present with inflammatory episodes,and during flared inflammatory episodes,hematopoietic function is further *** gastrointestinal tract is the most common site for infectious and inflammatory diseases,and its structural and functional features confer on it the most potent capacity to affect hematopoietic and immune *** tomography(CT)is a readily accessible approach to provide highly useful information in detecting morphological changes and guiding further *** To explore CT imaging presentations of gut inflammatory damage in adult SAA patients during inflammatory *** We retrospectively evaluated the abdominal CT imaging presentations of 17hospitalized adult patients with SAA in search of the inflammatory niche when they presented with systemic inflammatory stress and exacerbated hematopoietic *** this descriptive manuscript,the characteristic images that suggested the presence of gastrointestinal inflammatory damage and related imaging presentations of individual patients were enumerated,analyzed and *** All eligible patients with SAA had CT imaging abnormalities that suggested the presence of an impaired intestinal barrier and increased epithelial *** inflammatory damages were concurrently present in the small intestine,the ileocecal region and the large *** readily identified imaging signs,such as bowel wall thickening with mural stratification(“water holo sign”,“fat holo sign”,intramural gas and subserosal pneumatosis)and mesenteric fat proliferation(fat stranding and“creeping fat sign”),fibrotic bowel wall thickening,“balloon sign”,rugged colonic configuration,heterogeneity in the bowel wall texture,and adhered and clustered small bowel loop(including various patterns of“abdominal cocoon”),occurred at a high incidence,which suggested that the damaged gastrointestinal tract is a common inflammatory niche res

关键词： Aplastic anemia Computed tomography Bowel inflammatory damage Fat holo sign Balloon sign Abdominal cocoon

Basic liver immunology

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Cellular & Molecular Immunology 2016年第3期13卷 265-266页

作者： bin gao Laboratory of Liver Diseases National Institute onAlcohol Abuse and Alcoholism (NIAAA) NationalInstitutes of Health (NIH) Bethesda MD 20892USA

The liver is the largest solid organ in the body and has many unique immunological properties, including induction of immune tolerance, strong innate immunity, poor adaptive immune response versus overreactive autoimmunity and hematopoiesis in the fetal liver. Thus, the liver has been proposed as ＇an immunological organ＇. Although the primary functions of the liver are not traditionally considered to be immunological, the liver also performs many essential immune tasks. For example, hepatocytes are responsible for the production of 80-90% of the circulating innate immunity proteins in the body,

关键词： CELLS

Synergistic effect of Zr and Mo on precipitation and high-temperature properties of Al-Si-Cu-Mg alloys

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China Foundry 2024年第1期21卷 71-81页

作者： Chao gao bing-rong Zhang Yin-ming Li Zhi-ming Wang Xiang-bin Meng Faculty of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Hebei Ounai Machinery Mould Co.Ltd. Xingtai 054500HebeiChina

This study focuses on finding a solution to the sharp decline in mechanical properties of Al-Si-Cu-Mg alloys due to rapid coarsening of traditional intermediate phases at high temperature.A new type of modified al oy,to be used in automobile engines at high temperatures,was prepared by adding Zr and Mo into Al-Si-Cu-Mg *** synergistic effects of Zr and Mo on the microstructure evolution and high-temperature mechanical properties were *** show that the addition of Zr and Mo generates a series of intermetallic phases dispersed in the *** can improve the strength of the alloy by hindering dislocation movement and crack *** addition,some nano-strengthened phases show coherent interfaces with the matrix and improve grain *** addition of Mo greatly improves the heat resistance of the *** extremely low diffusivity of Mo enables it to improve the thermal stability of the intermetallic phases,inhibit precipitation during aging,reduce the size of the precipitates,and improve the heat resistance of the alloy.

关键词： Al-Si-Cu-Mg alloy high-temperature properties Zr-Mo-rich intermetallics nano-strengthening phases

Current progress of research on heat -resistant Mg alloys: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1406-1425页

作者： Hong Yang Wenlong Xie Jiangfeng Song Zhihua Dong Yuyang gao bin Jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

With the increasing attention received by lightweight metals,numerous essential fields have increased requirements for mag-nesium(Mg)alloys with good room-temperature and high-temperature mechanical ***,the high-temperature mechanic-al properties of commonly used commercial Mg alloys,such as AZ91D,deteriorate considerably with increasing *** the past several decades,extensive efforts have been devoted to developing heat-resistant Mg *** approaches either inhibit the gen-eration of thermally unstable phases or promote the formation of thermally stable precipitates/phases in matrices through solid solution or precipitation *** this review,numerous studies are systematically introduced and *** alloy systems,includ-ing those based on Mg–Al,Mg–Zn,and Mg–rare earth,are carefully classified and compared to reveal their mechanical properties and strengthening *** emphasis,limitations,and future prospects of these heat-resistant Mg alloys are also pointed out and dis-cussed to develop heat-resistant Mg alloys and broaden their potential application areas in the future.

关键词： magnesium alloys mechanical properties heat resistance microstructures high temperatures strengthening mechanisms

Dynamic Analysis of a 10 MW Floating Offshore Wind Turbine Considering the Tower and Platform Flexibility

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Journal of Ocean University of China 2024年第2期23卷 358-370页

作者： gao Shan ZHANG Lixian SHI Wei WANG Wenhua WANG bin LI Xin Key Laboratory of Far-Shore Wind Power Technology of Zhejiang Province Hangzhou 311122China State Key Laboratory of Coastal and Offshore Engineering Deepwater Engineering Research CenterDalian University of TechnologyDalian 116024China Powerchina Huadong Engineering Corporation Limited Hangzhou 311122China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315000China

Recently,semisubmersible floating offshore wind turbine technologies have received considerable *** the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic *** dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed *** simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is *** effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are *** results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind *** the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid ***,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and ***,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.

关键词： floating offshore wind turbine TripleSpar semisubmersible platform rigidity and flexibility platform coupled simulation

Catch organism assemblages along artificial reefs area and adjacent waters in Haizhou Bay

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Acta Oceanologica Sinica 2024年第2期43卷 34-42页

作者： Shike gao bin Xie Chengyu Huang Xiao Zhang Shuo Zhang Wenwen Yu College of Marine Living Resource Sciences and Management Shanghai Ocean UniversityShanghai 201306China Jiangsu Research Institute of Marine Fisheries Nantong 226007China Third Institute of Oceanography Ministry of Natural ResourcesXiamen361005China Joint Laboratory for Monitoring and Conservation of Aquatic Living Resources In the Yangtze Estuary Shanghai 200000China

To better understand the community patterns mediated by connectivity in artificial reefs of coastal areas, it is necessary to understand the distribution and coexistence of organisms with artificial reefs area and adjacent waters. This study was conducted to examine main catches assemblages collected by trawls in Haizhou Bay,which included five habitats: the artificial reef area(AR), aquaculture area(AA), natural area(NA), estuary area(EA) and comprehensive effect area(CEA). The result shows that the total abundances of species in the five habitats were highly different(univariate PERMANOVA: P = 0.001, n = 24), but some species were also unique in their habitat(e.g. Scapharca subcrenata and Glossaulax didyma in AA). The body size distribution of specific species between habitats are different. For Collichthys lucidus, their body size in AR(14.63 cm ± 1.64 cm) and EA(14.3 cm ± 0.85 cm) is higher than that in NA(10.65 cm ± 1.64 cm), CEA(11.28 cm ± 1.85 cm) and AA(12.1 cm ±0.43 cm), which indicates the potential connection from AR to EA mediated by their adult population. We concluded that artificial reefs in AR can be considered key components that have the ability to support species assemblages in adjacent habitats. This study has implications for the conservation and monitoring of species assemblages in coastal areas in terms of that artificial reefs can be applied in different stages of habitat protection implementation and in different combinations of scenarios.

关键词： assemblage artificial reefs adjacent water Haizhou Bay