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Journal of Environmental Sciences 2024年第5期139卷 543-555页

作者： Kai Xu Yunyu Guo Chenghua Xing Ronglong Fu bin zou Rongchuan Liu Luyi Cai Jianfang Yan Xi-Lin Wu Miaozhen Cai College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Agriculture Jinhua PolytechnicJinhua 321007China

Cadmium(Cd)pollution poses a serious threat to plant growth and *** have shown great application potential for alleviation of Cd toxicity to *** this study,we applied graphitic carbon nitride nanosheets(g-C_(3)N_(4)NSs)for alleviation of Cd-toxicity to soybean(Glycine max L.).The g-C_(3)N_(4)NSs supplementation significantly improved plant growth and reduced oxidative damage in the Cd-toxicated soybean seedlings through hydroponic ***,the g-C_(3)N_(4)NSs dynamically regulated the root cell wall(RCW)components by increasing pectin content and modifying its demethylation via enhancing pectin methylesterase(PME)activity,therefore greatly enhanced stronger RCW-Cd retention(up to 82.8%)and reduced Cd migration to the ***,the g-C_(3)N_(4)NSs reversed the Cd-induced chlorosis,increased photosynthetic efficiency because of enhancement in F_v/F_mration,Y(Ⅱ)and sugars *** results provide new insights into the alleviation of Cd toxicity to plants by g-C_(3)N_(4)NSs,and shed light on the application of low-cost and environmental-friendly carbon-based NMs for alleviating heavy metal toxicity to plants.

关键词： Cadmium Carbon nitride nanosheets Cell wall Pectin Pectin methylesterase Soybean

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Postoperativeinte rictalepil eptiform discharges predict seizure recurrence after antiepileptic drug withdrawal regardless of concordance with surgical site

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World Journal of Pediatric Surgery 2024年第1期7卷 33-41页

作者： Yuxin Wu ZaiYu Zhang Ping Liang Lusheng Li bin zou Difei Wang Xinyu Dong Haotian Tang Hanli Qiu Xuan Zhai Department of Neurosurgery Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqingChina

Objective The study aimed to explore the association between the site of interictal epileptic discharges(IEDs)on postoperative electroencephalogram(EEG)and seizure recurrence after antiepileptic drug(AED)*** study hypothesizes that the concordance of IED sites with surgical sites indicates incomplete resection of epileptic focus,while non-concordance of IED sites with surgical sites indicates postoperative changes or cortical *** former has a higher risk of seizure *** We retrospectively analyzed the postoperative EEG pattern of 182 consecutive children who underwent resection *** identify the risk factors for seizure recurrence,we compared the attributes of seizure recurred and seizure-free groups by univariate and multivariate *** tapering was standardized,involving a 25% reduction in the dose of a single type of AED every 2 weeks,independent of the presurgical AED *** We attempted AED withdrawal in 116(63.7%)***-eight(24.1%)children experienced seizure recurrence during or after AED withdrawal.A greater number of AEDs used at the time of surgery(p=0.005),incomplete resection(p=0.001),and presence of IED on postoperative EEG(p=0.011)are predictors of *** resectionand seizure recurrence after AED withdrawal were related to the presence of IED on the EEG,but not to the concordance of IED with surgical *** For children with abnormal EEG,the decision to discontinue AED should be made more cautiously,regardless of the relative location of the discharge site and the surgical site.

关键词： surgical seizure epileptic

Effect of dapagliflozin on uric acid in patients with chronic heart failure and hyperuricemia

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World Journal of Clinical Cases 2024年第18期12卷 3468-3475页

作者： Meng-Jiao Lin Shu-bin zou Bai-Xiang Zhu Three departments of cardiovascular medicine Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina

BACKGROUND Patients with chronic heart failure(CHF)frequently develop hyperuricemia,an elevated serum uric acid level,associated with adverse ***,a sodium-glucose cotransporter-2 inhibitor,demonstrates reduction in cardiovascular mortality and hospitalization in patients with CHF and ejection fraction(HFrEF),irrespective of ***,dapagliflozin’s effect on the uric acid levels in patients with CHF and hyperuricemia remain *** To investigate the effects of dapagliflozin on uric acid levels in CHF patients with *** We conducted a randomized,double-blind,placebo-controlled trial in 200 patients with CHF and hyperuricemia,with HFrEF and serum uric acid levels≥7 mg/dL(≥416μmol/L).The participants were randomly assigned to receive a daily dose of 10 mg dapagliflozin or placebo for 24 *** primary endpoint was the change in serum uric acid level from baseline to 24 *** endpoints included changes in left ventricular ejection fraction(LVEF),Nterminal pro-B-type natriuretic peptide(NT-proBNP),and quality of life(QoL)scores,as well as the incidence of cardiovascular death and hospitalization for heart *** At 24 months,dapagliflozin significantly reduced serum uric acid levels by 1.2 mg/dL(71μmol/L)compared with placebo(95%CI:-1.5 to-0.9;P<0.001).Dapagliflozin also significantly improved LVEF by 3.5%(95%CI:2.1-4.9;P<0.001),NT-proBNP by 25%(95%CI:18-32;P<0.001),and QoL scores by 10 points(95%CI:7-13;P<0.001)and reduced the risk of cardiovascular death and hospitalization for heart failure by 35%(95%CI:15–50;P=0.002)compared with the *** events were similar between the two groups,except for a higher rate of genital infections in the dapagliflozin group(10%vs 2%,P=0.01).CONCLUSION Dapagliflozin significantly lowered serum uric acid levels and improved the clinical outcomes in patients with CHF and ***,dapagliflozin may be a useful therapeutic option for this high-r

关键词： Dapagliflozin Hyperuricemia Chronic heart failure Sodium-glucose cotransporter-2 inhibitor Uric acid levels Cardiovascular mortality

Study on the hybrid energy storage for industrial park energy systems:Advantages,current status,and challenges

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National Science Open 2024年第3期 110-145页

作者： Jiacheng Guo Jinqing Peng Yimo Luo bin zou Zhengyi Luo College of Civil Engineering Hunan University Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education

In order to increase the renewable energy penetration for building and industrial energy use in industrial parks,the energy supply system requires transforming from a centralized energy supply mode to a distributed+centralized energy supply *** application of a hybrid energy storage system can effectively solve the problem of low renewable energy utilization levels caused by a spatiotemporal mismatch between the energy source and *** study summarized the advantages and limitations of common energy storage technologies in industrial parks from the aspects of service life,response time,cycle efficiency and energy storage density,*** advantages of the hybrid energy storage system in industrial parks were also discussed in terms of sustainable development,climate change mitigation,social impact, and other *** typical frameworks of hybrid energy storage were summarized,and the advantages,disadvantages,and application scenarios of each typical framework were *** current status of hybrid energy storage systems was summarized from the aspects of system modeling,hybrid energy storage mechanisms,design optimization,and operation *** the same time,the key challenges in modeling,regulation,and optimization of hybrid energy storage systems were *** discussion leads to proposals for the direction of future *** optimization methods and processes for designing and operating hybrid energy storage systems were proposed based on theoretical frameworks and *** is hoped that this review can provide some guidance and serve as a reference for developing and applying hybrid energy storage systems in industrial parks.

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Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma

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International Journal of Oral Science 2024年第2期16卷 251-264页

作者： Gan Xiong Nan Xie Min Nie Rongsong Ling Bokai Yun Jiaxiang Xie Linlin Ren Yaqi Huang Wenjin Wang Chen Yi Ming Zhang Xiuyun Xu Caihua Zhang bin zou Leitao Zhang Xiqiang Liu Hongzhang Huang Demeng Chen Wei Cao Cheng Wang Hospital of Stomatology Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Stomatology Sun Yat-sen UniversityGuangzhouChina Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhouChina Department of Periodontics Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Center for Translational Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouChina Department of Oral and Maxillofacial Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Oral and Maxillofacial&Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina National Center for Stomatology National Clinical Research Center for Oral diseasesShanghai Key Laboratory of StomatologyShanghaiChina

Ameloblastoma is a benign tumor characterized by locally invasive phenotypes,leading to facial bone destruction and a high recurrence ***,the mechanisms governing tumor initiation and recurrence are poorly ***,we uncovered cellular landscapes and mechanisms that underlie tumor recurrence in ameloblastoma at single-cell *** results revealed that ameloblastoma exhibits five tumor subpopulations varying with respect to immune response(IR),bone remodeling(BR),tooth development(TD),epithelial development(ED),and cell cycle(CC)*** note,we found that CC ameloblastoma cells were endowed with stemness and contributed to tumor recurrence,which was dominated by the EZH2-mediated *** EZH2 effectively eliminated CC ameloblastoma cells and inhibited tumor growth in ameloblastoma patient-derived *** data described the tumor subpopulation and clarified the identity,function,and regulatory mechanism of CC ameloblastoma cells,providing a potential therapeutic target for ameloblastoma.

关键词： inhibited cycling eliminated

基于移相控制统一模型的双有源桥DC-DC变换器基波环流优化控制策略

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电力自动化设备 2024年第4期44卷 74-81页

作者：曾进辉张长威曹斌余雪萍兰征邹彬王婷曹洋湖南工业大学电气与信息工程学院湖南株洲412007 国网湖南省电力有限公司长沙供电分公司湖南长沙410118 株洲变流技术国家工程研究中心有限公司湖南株洲412007

为充分利用双有源桥DC-DC变换器的容量,减小无功功率,提升工作效率,提出一种基于变换器移相控制统一模型的基波环流优化控制策略。通过引入基波移相比对变换器的所有移相控制方式进行统一描述,并采用傅里叶分解法建立全桥交流电压及电... 详细信息

为充分利用双有源桥DC-DC变换器的容量,减小无功功率,提升工作效率,提出一种基于变换器移相控制统一模型的基波环流优化控制策略。通过引入基波移相比对变换器的所有移相控制方式进行统一描述,并采用傅里叶分解法建立全桥交流电压及电感电流的统一模型。该统一模型降低了多控制变量下变换器多模态分析的复杂性,适用于不同移相控制的所有工作模式,具有普适性。基于频域分析法和功率因数角,构建变换器传输功率及无功功率的统一数学模型。在此基础上,提出考虑无功基波分量的环流优化控制策略,并对传导损耗进行建模与分析。该策略简单有效,能够很好地减小变换器无功功率和改善系统效率,更有利于工程实际的应用。搭建了实验平台,对比了所提基波环流优化控制策略与传统移相控制方式下变换器的功率因数及变换效率,仿真和实验结果验证了理论分析的正确性和所提控制策略的可行性。

关键词：双有源桥 DC-DC变换器统一模型基波优化功率因数传输效率

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贝伐珠单抗靶向治疗联合FOLFOX6化疗治疗直肠癌的效果及其对患者免疫功能的影响

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首都食品与医药 2024年第10期31卷 51-53页

作者：邹彬南华大学附属长沙中心医院湖南长沙410004

目的研究分析贝伐珠单抗靶向治疗联合FOLFOX6化疗治疗直肠癌的效果及其对患者免疫功能的影响。方法选取南华大学附属长沙中心医院在2022年1月-2023年6月期间收治的72例直肠癌患者以随机抽签法分为观察组(n=36,采取贝伐珠单抗靶向治疗联... 详细信息

目的研究分析贝伐珠单抗靶向治疗联合FOLFOX6化疗治疗直肠癌的效果及其对患者免疫功能的影响。方法选取南华大学附属长沙中心医院在2022年1月-2023年6月期间收治的72例直肠癌患者以随机抽签法分为观察组(n=36,采取贝伐珠单抗靶向治疗联合FOLFOX6化疗)和对照组(n=36,采取FOLFOX6化疗)。对比两组的临床疗效。结果两组治疗前的血清CEA、CA199、IGF-1、VEGF、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,无明显差异(P>0.05),治疗后的上述指标均发生变化,观察组治疗后的CEA、CA199、IGF-1、VEGF、CD8^(+)均要低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)则要高于对照组(P0.05)。结论与单一FOLFOX6化疗治疗相比较,联合贝伐珠单抗靶向治疗直肠癌有着更加确切的疗效,能够降低肿瘤标志物与生长因子水平,改善机体治疗期间的免疫功能,且具有较高的安全性。

关键词：贝伐珠单抗靶向治疗 FOLFOX6化疗直肠癌免疫功能

奥沙利铂联合卡培他滨应用于进展期胃癌患者临床治疗效果研究

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首都食品与医药 2024年第12期31卷 59-62页

作者：邹彬南华大学附属长沙中心医院湖南长沙410004

目的分析进展期胃癌患者治疗中应用奥沙利铂联合卡培他滨方案治疗的临床效果。方法选取2020年5月-2023年4月期间南华大学附属长沙中心医院收治的80例进展期胃癌患者,随机均分为对照组、观察组,予以氟尿嘧啶联合奥沙利铂治疗的40例患者... 详细信息

目的分析进展期胃癌患者治疗中应用奥沙利铂联合卡培他滨方案治疗的临床效果。方法选取2020年5月-2023年4月期间南华大学附属长沙中心医院收治的80例进展期胃癌患者,随机均分为对照组、观察组,予以氟尿嘧啶联合奥沙利铂治疗的40例患者为对照组,实施卡培他滨联合奥沙利铂治疗的40例为观察组,评价两组患者的临床效果。结果与对照组相比,观察组治疗总有效率较高,差异有统计学意义(P0.05),在化疗开始后,两组患者的CA19-9、CA125、CA242、CEA水平均持续降低,且与对照组相比,在化疗后3-9周,观察组的CA19-9、CA125、CA242、CEA更低,差异有统计学意义(P<0.05)。结论进展期胃癌应用奥沙利铂联合卡培他滨可提供较佳的治疗效果,且不良反应相对较低,有助于减轻患者在化疗中的损伤,降低患者的化疗风险,具有显著应用价值。

关键词：进展期胃癌奥沙利铂卡培他滨免疫肿瘤标志物

急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合进行治疗的效果与安全性

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首都食品与医药 2024年第14期31卷 70-72页

作者：邹彬南华大学附属长沙中心医院湖南长沙410004

目的分析急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合进行治疗的效果与安全性。方法以南华大学附属长沙中心医院2020年1月-12月内收治的80例急性粘连性肠梗阻患者为此次研究对象,并以治疗方案分为常规组(40例,常规内科治疗)和观察... 详细信息

目的分析急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合进行治疗的效果与安全性。方法以南华大学附属长沙中心医院2020年1月-12月内收治的80例急性粘连性肠梗阻患者为此次研究对象,并以治疗方案分为常规组(40例,常规内科治疗)和观察组(40例,常规内科+生长抑素+丙氨酰谷氨酰胺联合治疗),对比分析两组患者的临床症状缓解时间、转手术率、不良反应发生率及未采取手术患者治疗前后的血生化指标、白细胞计数、肛肠压力水平。结果①组间对比,观察组患者腹痛/腹胀持续时间、肛门排气时间、禁饮食时长及转手术率均显著低于常规组(P0.05);②观察组患者用药治疗后PCT、CRP、白细胞计数及直肠最大静息压均显著低于常规组(P<0.05),肛管最大静息压、肛管最大收缩压均显著高于常规组(P<0.05)。结论急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合治疗,安全性好且疗效显著。

关键词：急性粘连性肠梗阻生长抑素丙氨酰谷氨酰胺

定量评估气候变化对长江中下游地区植被GPPGS变化的影响

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环境科学 2024年第3期45卷 1615-1628页

作者：徐勇盘钰春邹滨郑志威郭振东桂林理工大学测绘地理信息学院桂林541006 中南大学地球科学与信息物理学院长沙410083

在区域和植被类型尺度上定量厘定气候因子对长江中下游地区生长季植被GPP(GPP_(GS))的直接、间接和综合影响,可为全球气候变化背景下区域植被资源管理与恢复提供科学依据.利用MODIS GPP数据、气象数据和植被类型数据,结合Theil-Sen Med... 详细信息

在区域和植被类型尺度上定量厘定气候因子对长江中下游地区生长季植被GPP(GPP_(GS))的直接、间接和综合影响,可为全球气候变化背景下区域植被资源管理与恢复提供科学依据.利用MODIS GPP数据、气象数据和植被类型数据,结合Theil-Sen Median趋势分析和Mann-Kendall显著性检验探究长江中下游地区植被GPP_(GS)时空变化特征,并通过通径分析揭示气候因子对长江中下游地区整体和不同类型植被GPP_(GS)变化的直接影响、间接影响和综合影响.结果表明:(1)2000~2021年长江中下游地区植被GPP_(GS)呈波动上升趋势,上升速率(以C计,下同)为2.70 g·(m^(2)·a)^(-1)(P<0.01).不同类型植被GPP_(GS)均呈极显著上升趋势(P<0.01),其中,灌丛上升速率最高,为3.31 g·(m^(2)·a)^(-1),栽培植被上升速率最低,为2.54 g·(m^(2)·a)^(-1).(2)长江中下游地区GPP_(GS)呈上升趋势的面积占比为88.11%.不同类型植被GPP_(GS)呈上升趋势的面积占比均大于84%.(3)通径分析结果表明,降水和最高气温对植被GPP_(GS)的直接影响呈显著正向影响(P<0.05),而太阳辐射呈不显著正向影响(P≥0.05).最高气温、降水和太阳辐射对植被GPP_(GS)的间接影响均呈非显著负向影响(P≥0.05).在直接影响和间接影响的综合作用下,降水和最高气温对植被GPP_(GS)呈不显著正向影响(P≥0.05),而太阳辐射对植被GPP_(GS)呈不显著负向影响(P≥0.05);不同植被类型上,降水是影响栽培植被GPP_(GS)变化的主要气候因子,最高气温是影响针叶林、阔叶林、灌丛和草丛GPP_(GS)变化的主要气候因子.(4)长江中下游地区植被GPP_(GS)变化主要受最高气温、降水和太阳辐射的直接影响,降水的直接影响对植被GPP_(GS)变化的主导区域占56.72%.研究结果可为量化长江中下游地区植被固碳潜力和全球气候变化背景下制定因地制宜的生态恢复治理政策提供参考.

关键词：总初级生产力(GPP) 不同类型植被生长季通径分析气候因子直接影响间接影响

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