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矿业安全与环保 2010年第S1期37卷 71-72,75页

作者：石银斌神华宁夏煤业集团汝箕沟煤矿宁夏平罗753404

按《防治煤与瓦斯突出规定》要求,突出煤层的区域突出危险性预测采用单项指标(二指标法),但由于煤与瓦斯突出机理的复杂性,汝箕沟煤矿在实际应用过程中采用多种指标共同预测,结果互相参考印证,可以提高突出危险性预测的准确性。

关键词：煤与瓦斯突出危险性区域划分

Can yin-Chai-Xiao-Du decoction be useful of COVID-19?the mechanism research based on network pharmacology

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Traditional Medicine Research 2020年第4期5卷 188-200页

作者： Lu Yang Ning Li Hai-Bo Hu bin yin Guo-Jing Zhao Feng-Chan Wang Xu-Hui Wang Hong-Wu Wang Xue-Chao Lu Huan-Tian Cui Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China First Clinical Hospital Shandong University of Traditional Chinese MedicineJinan 250000China Department of Pulmonary Disease in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266700China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250000China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China

Background:In this study,we preliminarily investigated the mechanism of yin-Chai-Xiao-Du decoction for the treatment of COVID-19 by the method of network ***:The potential targets and pathways of yin-Chai-Xiao-Du decoction for the treatment of COVID-19 were examined using network pharmacology;the ingredient and active targets of yin-Chai-Xiao-Du decoction were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper databases;the COVID-19-related targets were obtained from the online Mendelian inheritance in man,GeneCards,and GeneMANIA databases;the STRING database and Cytoscape were used to build a protein-protein interaction network,and a Network Analyzer tool was used to perform topology analysis to screen for the key ingredients and targets;the ClueGO and KOBAS 3.0 databases were for the enrichment analysis of gene function(Gene Oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes);the herb-ingredient-target-pathway network diagram was constructed by ***:The core herbs screened by the network pharmacological analysis were Jinyinhua(Lonicerae japonicae flos),Lianqiao(Forsythia suspensa),Chaihu(Bupleuri radix),Huangqin(Scutellariae radix),yinchen(Herba Artemisiae Scopariae),Guanghuoxiang(Pogostemonis herba),Roudoukou(Semen myristicae)and Qinghao(Artemisiae annuae herba).A total of 293 active ingredients were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the key ingredients were quercetin,kaempferol,isorhamnetin,stigmasterol,beta-sitosterol,and ***-Chai-Xiao-Du decoction has 138 COVID-19-related targets,and the key targets were mitogen-activated protein kinase 3,interleukin-6,tumor necrosis factor,vascular endothelial growth factor A,and CC motif ligand *** Encyclopedia of Genes and Genomes analysis revealed 120 enriched gene pathways,and the key pathways were signaling by interleukins,immune system,c

关键词： Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6

Filter Rod Pressure Drop Prediction Based on PSO-BP Neural Network

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Filter Rod Pressure Drop Prediction Based on PSO-BP Neural N...

Mutation at Paired box gene 9 is associated with nonsyndromic cleft lip only from Western Han Chinese population

第43届中国控制会议

作者： Junhan Wen Qingna Duan Qian Cheng bin yin He Leng bing Liu Hongyun Honghe Tobacco (Group) Co.Ltd.

Filter rod pressure drop is a crucial parameter in filter rod production,which directly affects the quality of filter rod and the tasting experience,and the pressure drop is affected by many factors in the filter rod production *** this study,we aim to solve the pressure drop prediction problem,and use BP neural network technology to predict the pressure drop of filter rods,optimize it by using particle swarm optimization(PSO),and construct a PSO-BP neural network *** this study,an in-depth study on the relationship between pressure drop and multiple influencing factors was carried out,and a PSO-BP neural network-based model was established to explore the complex interaction between the pressure drop and different features in order to predict the trend of the pressure drop of the filter *** methodological steps include data collection and processing,feature selection,model training,and optimization of the *** results of the study show that the proposed method exhibits significant accuracy and practicality in predicting the filter rod pressure *** results of the study show that the PSO-BP neural network is able to accurately predict the filter rod pressure drop in different cases,and it also performs well in terms of the mean relative error,the mean absolute error,the root-mean-square error,and the coefficient of determination of the samples,which provides a higher prediction accuracy.

关键词： PSO-BP neural network model Filter rod pressure drop Prediction

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Mutation at Paired box gene 9 is associated with nonsyndromi...

转录组分析氧化胁迫对毛白杨悬浮细胞生长发育的影响

2020年中华口腔医学会口腔遗传病与罕见病专业委员会第二次学术年会

作者： Cheng-wei Yang bin yin Jiayu-Shi bing Shi Zhong-Lin Jia State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept.of cleft lip and palate West China Hospital of Stomatology Sichuan University Division of Growth and Development and Section of Orthodontics School of Dentistry University of California

Objectives:This study aimed to initially screen more susceptible variations at PAX9gene in non-syndromic cleft palate only cases and then test their associations in independent non-syndromic orofacial cleft subtypes f...

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北京林业大学学报 2019年第9期41卷 90-98页

作者：尹玢陆海北京林业大学生物科学与技术学院

【目的】毛白杨是多年生木本植物,由于其固着的生长模式,毛白杨存在长期承受胁迫的可能性。氧化胁迫是常见的非生物胁迫方式,在多个物种中均有不同程度的研究,然而以毛白杨为材料在转录水平的研究目前鲜有报道。通过转录组数据探明活性... 详细信息

【目的】毛白杨是多年生木本植物,由于其固着的生长模式,毛白杨存在长期承受胁迫的可能性。氧化胁迫是常见的非生物胁迫方式,在多个物种中均有不同程度的研究,然而以毛白杨为材料在转录水平的研究目前鲜有报道。通过转录组数据探明活性氧平衡的打破对毛白杨悬浮细胞生长发育的影响。【方法】本研究对毛白杨悬浮细胞系进行H2O2胁迫处理,通过激光共聚焦显微镜和转录组测序技术(RNA-Seq),观察、分析了线粒体的形态学和基因表达量的差异。【结果】通过对转录组数据的分析得到了806个显著差异基因(P 1),其中449个差异基因下调,357个差异基因上调。这些差异基因涉及细胞分裂、细胞分裂素的激活、赤霉素调控以及磷酸化途径。通过线粒体特异性染料并使用激光共聚焦显微镜观察氧化胁迫条件下毛白杨线粒体的形态学,结果表明氧化胁迫下线粒体以蠕虫状为主。【结论】通过分析氧化胁迫条件下细胞转录组数据,在RNA水平揭示了氧化胁迫对植物细胞生长发育的影响,为植物的应激反应和生长发育研究提供了理论基础。

关键词：毛白杨活性氧悬浮细胞生长发育转录组测序

Microstructural evolution,flow stress and constitutive modeling of Al−1.88Mg−0.18Sc−0.084Er alloy during hot compression

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Transactions of Nonferrous Metals Society of China 2021年第1期31卷 53-73页

作者： Fu-rong CAO bin yin Si-yuan LIU Lu SHI Shun-cheng WANG Jing-lin WEN School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Lightweight Structural Materials of Liaoning Province Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Wuhu Cowin Automobile Co. Ltd.Wuhu 241000China Institute of Materials Processing and Forming Technology Guangdong General Research Institute of Industrial TechnologyGuangzhou 510650China

To explore the hot compression behavior and microstructural evolution,fine-grained Al−1.88Mg−0.18Sc−0.084Er(wt.%)aluminum alloy wires were fabricated with Castex(continuous casting−extrusion)and ECAP-Conform,and their hot compression behavior was investigated at temperatures of 673−793 K and strain rates of 0.001−10 s−1;the microstructures were characterized by optical microscope,X-ray diffractometer,transmission electron microscope,and electron backscattered diffractometer,and the flow stresses were obtained by thermal compression *** evolution and flow curves reveal that dynamic recovery is the dominant softening *** dynamic recrystallization followed by dynamic grain growth takes place at a temperature of 773 K and a strain rate of 0.001 s−1;the yielding drop phenomenon was *** sine constitutive equation incorporating dislocation variables was presented,and a power law constitutive equation was *** stress exponent is 3.262,and the activation energy for deformation is 154.465 kJ/mol,indicating that dislocation viscous glide is the dominant deformation mechanism.

关键词： Al−Mg alloy ECAP-Conform hot compression microstructure flow stress constitutive equation

Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements

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Journal of Genetics and Genomics 2018年第12期45卷 673-676页

作者： Pan Chen Xiangbin Ruan Yongqiang Chen Shilong Chu Kunlun Mo Chao Wu Wei Liu bin yin Junjie Zhou Liang Li Lin Hou Jiangang Yuan Boqin Qiang Jiekai Chen Pengcheng Shu Xiaozhong Peng State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience CenterChinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College CAS Key Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Department of Anatomy and Histology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Institute of Medical Biology Chinese Academy of Medical Sciences Chinese Academy of Medical Science and Peking Union Medical College

The striatum, as the primary input nucleus in the basal ganglion,plays an important role in neural circuits crucial for the control of critical motivation, motor planning and procedural learning(Kreitzer and Malenka, 2008). Most cells in the striatum are GABAergic, including a large population (90%-95%) of medium spiny neurons (MSNs) and a small population of interneurons.

关键词： BAC Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements cis

Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients

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Translational Neurodegeneration 2022年第1期11卷 859-868页

作者： Gen Li Pei Huang Shi-Shuang Cui Yu-Yan Tan Ya-Chao He Xin Shen Qin-ying Jiang Ping Huang Gui-ying He bin-yin Li Yu-Xin Li Jin Xu Zheng Wang Sheng-Di Chen Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institute for Biological SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory for Bone and Joint Diseases Shanghai Institute of Orthopedics and TraumatologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200003China School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental HealthIDG/McGovern Institute for Brain ResearchPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China.

Background:Tai Chi has been shown to improve motor symptoms in Parkinson’s disease(PD),but its long-term effects and the related mechanisms remain to be *** this study,we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying ***:Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi(n=32),brisk walk-ing(n=31)and no-exercise(n=32)*** baseline,6 months and 12 months during one-year intervention,all participants underwent motor symptom evaluation by Berg balance scale(BBS),Unified PD rating-scale(UPDRS),Timed Up and Go test(TUG)and 3D gait analysis,functional magnetic resonance imaging(fMRI),plasma cytokine and metabolomics analysis,and blood Huntingtin interaction protein 2(HIP2)mRNA level *** self-changes were calculated using repeated measures ***(generalized estimating equations)was used to assess factors associated with the longitudinal data of rating *** rates were used for fMRI *** discovery rate correction was used for multiple ***:Participants in the Tai Chi group had better performance in BBS,UPDRS,TUG and step ***,Tai Chi was advantageous over brisk walking in improving BBS and step *** improved BBS was correlated with enhanced visual network function and downregulation of interleukin-1β.The improvements in UPDRS were asso-ciated with enhanced default mode network function,decreased L-malic acid and 3-phosphoglyceric acid,and increased adenosine and HIP2 mRNA *** addition,arginine biosynthesis,urea cycle,tricarboxylic acid cycle and beta oxidation of very-long-chain fatty acids were also improved by Tai Chi ***:Long-term Tai Chi training improves motor function,especially gait and balance,in *** underlying mechanisms may include enhanced brain network function,reduced inflammation,improved amino acid metabolism,energy metabolism and neurotransmitter metabo

关键词： Parkinson’s disease Tai Chi Motor symptoms Mechanism Brain network

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基于消息重要性的机会网络能量均衡路由算法

通信学报 2018年第12期39卷 91-101页

作者：陈志刚殷滨安吴嘉中南大学软件学院湖南长沙410075 "移动医疗"教育部-中国移动联合实验室湖南长沙410083

提出了基于消息重要性的能量均衡路由算法——MIEBR(message importance based energy balanced routing algorithm)。MIEBR对消息重要性进行度量,并根据消息转发收益确定消息的转发顺序和路由。在节点缓存空间不足时,MIEBR依据消息缓... 详细信息

提出了基于消息重要性的能量均衡路由算法——MIEBR(message importance based energy balanced routing algorithm)。MIEBR对消息重要性进行度量,并根据消息转发收益确定消息的转发顺序和路由。在节点缓存空间不足时,MIEBR依据消息缓存价值进行缓存替换。实验结果表明,在缓存空间和能量受限的机会网络中,MIEBR均衡节点的能量消耗,降低了重要消息的传输延时,在投递成功率和延时等方面优于其他算法。

关键词：机会网络路由算法消息重要性能量均衡

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由粗到精稳像方法的应用研究

计算机工程与应用 2011年第3期47卷 184-187页

作者：尹宾段会川山东师范大学信息科学与工程学院济南250014

视频稳像的精度和处理效率在视频稳像处理中非常关键。通过分析视频稳像的原理和常用的几种算法,提出一种基于灰度投影和块匹配相结合的算法。先使用灰度投影算法进行首次匹配工作和粗补偿,针对灰度投影提出一种快速搜索算法,可以有效... 详细信息

视频稳像的精度和处理效率在视频稳像处理中非常关键。通过分析视频稳像的原理和常用的几种算法,提出一种基于灰度投影和块匹配相结合的算法。先使用灰度投影算法进行首次匹配工作和粗补偿,针对灰度投影提出一种快速搜索算法,可以有效减少计算量。灰度投影算法的作用是为下一步的工作做铺垫。然后使用块匹配进行第二次匹配和精确补偿,其中菱形搜索(DS)策略的应用可以有效地提高算法效率。提出的算法体现了一种由粗到精的处理思路,灰度投影和块匹配算法可以很好地配合工作。实验结果表明,该算法在保持较高稳像精度的同时有效降低了计算复杂度。

关键词：视频稳像灰度投影块匹配快速搜索菱形搜索