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中国药理通讯 2005年第4期22卷 48-49页

作者： Wu Ning Su Rui - bin Liu yin Li Jin Beijing Institute of Pharmacology and Toxicology Beijing 100850

Surface diffraction beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 47-57页

作者： Yue-Liang Gu Xu Zheng Xing-Min Zhang bin Zhao Guang-Zhi yin Da-Ming Zhu Yuan-He Sun Xing-Yu Gao Xiao-Long Li Shanghai Advanced Research Institute Chinese Academy of Sciences239 Zhangheng RoadPudong DistrictShanghai201204China

BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5×10^(12) photons/s at 10 keV and a beam size of 160µm×80µm at the sample *** is dedicated to studying surfaces(solid-vacuum,solid-gas)and interfaces(solid-solid,solid-liquid,and liquid-liquid)in nanoscience,condensed matter,and soft matter systems using various surface scattering techniques over an energy range of 4.8-28 keV with transmission and reflection ***,BL02U2 has a high energy resolution,high angular resolution,and low beam divergence,which can provide excellent properties for X-ray diffraction experiments,such as grazing incident X-ray diffraction,X-ray reflectivity,crystal truncation rods,and liquid X-ray *** of in situ environments can also be provided for the samples *** paper describes the setup of the new beamline and its applications in various fields.

关键词： Surface and interface Beamline Surface diffraction Microstructure

Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain

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Journal of Genetics and Genomics 2017年第3期44卷 171-174页

作者： Liyuan Zhu Xiaochao Tan Wei Liu Fengbiao Mao Chao Wu Junjie Zhou Xiao Liu Shuaiyao Lu Kaili Ma bin yin Jianjun Luo Jiangang Yuan Boqin Qiang Runsheng Chen State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience Center Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing 100005 China Beijing Institutes of Life Science Chinese Academy of Sciences Belting 100101 China Institute of Medical Biology Chinese Academy of Medical Sciences CAMS ＆ PUMC Kunming 650118 China Medical Primate Research Center Chinese Academy of Medical Science and Peking Union Medical College Beijing 100005 China Bioinformatics Laboratory and CAS Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Although only about 2%of the human genome has proved to be protein-coding genes,recent advances in genome wide analysis have revealed that the majority of the genome is transcribed,mainly from noncoding segments that were once considered＂junk sequences＂or＂dark matters＂（Liu et al.,2011a;Zhang et al.,2014b）. In addition to the well-characterized housekeeping non- coding RNAs （ncRNAs）（tRNA, rRNA, small nuclear RNA and small nucleolar RNAs） and some small regulatory ncRNAs （microRNAs and small interfering RNAs）, the transcriptome of mammals could also pervasively have been transcribed long noncoding RNAs （lncRNAs, at least 200 nt）（Rinn and Chang, 2012; Xie et al., 2012）.

关键词： RNA Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain

MIRE: A GRAPHICAL R PACKAGE FOR MICRORNARELATED ANALYSIS

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Chinese Medical Sciences Journal 2008年第4期23卷 202-204页

作者： Xing-qi Yan Kang Tu Lu Xie Yi-xue Li bin yin Yan-hua Gong Jian-gang Yuan Bo-qin Qiang Xiao-zhong Peng National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 Bioinformatics Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 Shanghai Center for Bioinformation Technology Shanghai 200235

Objective To provide a set of useful analysis tools for the researchers to explore the microRNA data. Methods The R language was used for generating the Graphical Users Interface and implementing most functions. Some Practical Extraction and Report Language (Perl) scripts were used for parsing source files. Results We developed a graphical R package named miRE, which was designated for the analysis of microRNA functions, genomic organization, etc. This package provided effective and convenient tools for molecular biologists to deal with routine analyses in microRNA-related research. With its help, the users would be able to build a desktop- centered microRNA research environment quite easily and effectively. miRE is freely available at http://www. ***/~kanghu/WorkPresentation/miRE/***. A detailed user manual and tutorials with example code and image are also available. Conclusion miRE is a tool providing an open-source, user-friendly, integrated interface for microRNA-related analysis. With its help, researchers can perform microRNA-related analysis more efficiently.

关键词： microRNA mRNA expression profiles

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氨基酸的手性与蛋白质生物合成

中国生物化学与分子生物学报 2015年第11期31卷 1152-1157页

作者：何超尹斌苏州大学医学部唐仲英血液学研究中心江苏苏州215123

生命体中行使生物学功能的重要大分子蛋白质,由其基本单位氨基酸组成.除甘氨酸外,其余19种常见氨基酸均具有手性,且均为L-构型,称为氨基酸的纯手性(homochirality,或称同手性).这个现象长久以来困扰着科学家们.本文简要综述了目前对纯... 详细信息

生命体中行使生物学功能的重要大分子蛋白质,由其基本单位氨基酸组成.除甘氨酸外,其余19种常见氨基酸均具有手性,且均为L-构型,称为氨基酸的纯手性(homochirality,或称同手性).这个现象长久以来困扰着科学家们.本文简要综述了目前对纯手性起源的一些假说,D-氨基酸在生命体中的存在和可能的作用,以及D-氨基酸在蛋白质合成这个重要过程中的特性,包括D-氨基酸的氨酰化和在新生肽链的掺入.D-氨基酸的研究,让人们对生命有了更深入的认识,为疾病、制药等领域提供了新的思路,也为生命科学的基础研究提供了新的理论支撑和研究方向.

关键词：纯手性 D-氨基酸蛋白质生物合成

Controlled Synthesis of Proton-Conductive Porous Organic Polymer Gels via Electrostatically Stabilized Colloidal Formation

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CCS Chemistry 2024年第7期6卷 1767-1775页

作者： bin Chen Yifeng Kuang Lu Liu Linkun Cai Zaoming Wang Panchao yin Liangbin Huang Cheng Gu State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhou 510640 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065 Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641 South China Advanced Institute for Soft Matter Science and Technology South China University of TechnologyGuangzhou 510640 Institute for Integrated Cell-Material Sciences Institute for Advanced StudyKyoto UniversityKyoto 606-8501

Porous organic polymers(POPs)have attracted extensive interest due to their structural diversity and predesigned ***,the majority of POPs are synthesized as insoluble and unprocessable powders,which greatly impede their advanced applications because of limited mass transport and inadaptation for device ***,we report a controlled synthetic strategy of macroscopic POP gels by a cation-stabilized colloidal formation mechanism,which is widely adaptable to a large variety of tetra-/tri-amino build blocks for the synthesis of Tröger’s base-linked POP gels,aerogels,and ionic *** POP gels combined the integrated advantages of hierarchically porous structures and tailorable mechanical stiffness,whereas they could load substantial amounts of phosphoric acids and construct unimpeded transport pathways for proton conduction,exhibiting unprecedented proton conductivity at subzero *** strategy offers a new solution to the intractable processing issues of POPs toward device applications with cutting-edge performances.

关键词： porous organic polymers Tröger’s base linkage gels superprotonic conduction subzero temperatures

基于复杂地表初至层析地震静校正技术研究及数值模拟

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中国有色金属学报 2013年第9期23卷 2471-2478页

作者：张胤彬田忠斌温建亮中南大学地球科学与信息物理学院长沙100083 山西省煤炭地质物探测绘院晋中030600

采用初至层析静校正方法,解决地表起伏大、纵横向速度变化剧烈的复杂地区的折射静校正效果不好的问题。介绍初至层析静校正原理,并根据需要建立横向速度变化大且基岩裸露的地震模型进行理论试算,分析层析静校正的特点及适用条件,指出层... 详细信息

采用初至层析静校正方法,解决地表起伏大、纵横向速度变化剧烈的复杂地区的折射静校正效果不好的问题。介绍初至层析静校正原理,并根据需要建立横向速度变化大且基岩裸露的地震模型进行理论试算,分析层析静校正的特点及适用条件,指出层析静校正应注意的关键问题。利用数值模拟手段研究初至层析静校正的适用条件和应用效果,为复杂地表煤层气地震资料静校正提供参考依据。结果表明:层析静校正更适合复杂地表煤层气地震资料的处理,能够很好地解决地表起伏问题和速度横向变化问题,对提高煤层气勘探精度具有重要意义。

关键词：复杂地表煤层气地震勘探静校正层析反演

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整合性学习观的动物行为模型探索

心理学报 2020年第11期52卷 1278-1287,I0001-I0009页

作者：尹彬武晓睿连榕福建师范大学心理学院福州350108

我国当下的学习观以渐进性学习为主。研究尝试提出“整合性学习”的学习观,以40只SD大鼠为被试,采用2(学习方式:整合/渐进)×2(性别:雄/雌)组间设计,运用14单元组合T迷宫进行五阶段的动物行为建模。结果显示,1)学习错误次数上,整合少于... 详细信息

我国当下的学习观以渐进性学习为主。研究尝试提出“整合性学习”的学习观,以40只SD大鼠为被试,采用2(学习方式:整合/渐进)×2(性别:雄/雌)组间设计,运用14单元组合T迷宫进行五阶段的动物行为建模。结果显示,1)学习错误次数上,整合少于渐进、雄性少于雌性;2)整合较渐进学习效果的迁移性更好;3)各组皆出现对第一段原正确路径的固着。由此得出:整合性学习更长效,习得的知识具有整体性、组块化、范畴化的可迁移的特征。

关键词：整合性学习观动物行为模型迷宫测试

Clinical and cost analysis of an ultra-rapid metagenomic sequencing test for pathogen detection in adult patients with sepsis

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中华医学杂志(英文版) 2024年第15期137卷 1882-1884页

作者： yin Yuyao Shen Jiawei Du Zhenshan Wang bin Wang Guangjie Chen Hongbin Wang Jun An Youzhong Liu Chao Wang Hui Department of Clinical Laboratory Peking University People’s Hospital Beijing China Department of Critical Care Medicine Peking University People’s Hospital Beijing China Medical Department Hangzhou Matridx Biotechnology Co. Ltd. Hangzhou Zhejiang China

Metallaphotoredox-Catalyzed Three-Component Couplings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： Ernest Koranteng Zhen-Cao Shu Yi-yin Liu Qian Yang bin Shi Qiang-Xian Wu Fen Tan Liang-Qiu Lu Wen-Jing Xiao Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries Co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and Technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen ***,it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds,especially unsymmetrical ***,we have disclosed novel and highly efficient three-component coupling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical *** reaction features simple and safe operations,broad substrate scopes,and product *** allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild conditions(27 examples,36%—98%yields).In addition,this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-coupling Nickel Photoredox catalysis Three-component reaction Ureas Carbamates