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Advance care planning readiness for Chinese older people:An integrative review and conceptual framework

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Frontiers of Nursing 2023年第1期10卷 43-49页

作者： Kalok Wong Hao-bin yuan Wipada Kunaviktikul Faculty of Health Sciences and Sports Macao Polytechnic UniversityMacao SAR 999078China Centro Hospitalar Conde de São Januário Macao SAR 99078China School of Nursing Panyapiwat Institute of ManagementBang TalatNonthaburi 11120Thailand

Advance care planning is a process of discussion in which patients can communicate their end-of-life care preferences to family members and health care providers for *** for advance care planning is a patient's preparedness to engage in advance care *** review aims to develop the conceptual framework for advance care planning readiness for Chinese older *** current knowledge from the published studies was identified and synthesized by an integrative *** conceptual framework was developed based on the social-ecological model and the theory of planned *** factors from the social environment/community,health care professionals,and individual/family layers were *** factors may influence an individual's medical decision-making,which in turn triggers individual behavioral mechanisms that arise from interactions between motivations,attitudes,and *** factors should be considered when assessing the behavior of personnel engaged in advance care planning or formulating appropriate intervention measures to improve advance care planning par ticipation in *** framework can be used to guide studies that explore how the social/familial/individual factors predict the readiness for advance care planning among Chinese older people,and to design intervention studies to test the effect of family function on the readiness for advance care planning.

关键词： advance care planning Chinese culture older people readiness

Flow characteristic of polymer solutions in porous media:Influence of the molecular weight and concentration

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Petroleum 2023年第2期9卷 214-222页

作者： Yingjie Dai Jia Li Li Li Yifei Liu yuan Li Xiangyu Wang Xuguang Song Caili Dai bin yuan Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum East China)Ministry of EducationQingdao 266580China Shandong Key Laboratory of Oilfield Chemistry(China University of Petroleum East China)Qingdao 266580China Nanchong Vocational and Technical College Nanchong 637131China Oil&Gas Technology Research Institute of Changqing Oilfield Company Xi'an 710000China Sinopec Research Institute of Petroleum Engineering Fracturing&Acidizing and Natural Gas Production Research InstituteDongying 257000China Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada

The polymer solution flow in porous media is a central research topic related to hydraulic fracturing measures,formation damage and fracture *** by molecular weights and concentrations,various flow patterns of polymer in pores are presented,resulting in different filtration *** this work,the effectiveness of various polymer solutions for filtration loss was assessed by utilizing the core flooding experiment *** result shows that lesser filtration loss normally is inextricably linked to solutions with high molecular weight and ***,the flow behaviors of polymer solutions investigated by designed micro pore-throat structure and micro-particle image velocimetry(m-PIV)further confirmed the above *** was found that the central convergent flow pattern benefiting from higher viscous force loss and less filtration loss was observed at high flow rates(0.5 mL/h),and higher molecular weight and concentration were more prone to convergent flow *** viscosity force loss increases by about 4 times varying the molecular weight of polymer from 5×10^(6)to 18×10^(6)g/mol or the concentration from 0.05 to 0.3%.It interprets higher molecular weight and concentration in core studies and field observations with decreased filtration loss of *** work provides a theoretical foundation for the application of fracturing fluids as well as fresh perspectives on how to access the filtration loss of fracturing fluids.

关键词： Polymer solution Porous media Flow pattern m-PIV

祛风宁肺散辅助丙酸氟替卡松治疗儿童咳嗽变异性哮喘风邪犯肺证的效果

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中国药物滥用防治杂志 2024年第6期30卷 1101-1105页

作者：董文阁胡营杰付芸芸袁斌舞钢市人民医院儿科河南舞钢462500 河南省儿童医院中医科河南郑州450000

目的:研究祛风宁肺散辅助丙酸氟替卡松治疗儿童咳嗽变异性哮喘风邪犯肺证的效果。方法:回顾性选取2021年9月—2022年9月舞钢市人民医院收治的咳嗽变异性哮喘风邪犯肺证患儿92例,根据治疗方案不同分为观察组和对照组,各46例。对照组采用... 详细信息

目的:研究祛风宁肺散辅助丙酸氟替卡松治疗儿童咳嗽变异性哮喘风邪犯肺证的效果。方法:回顾性选取2021年9月—2022年9月舞钢市人民医院收治的咳嗽变异性哮喘风邪犯肺证患儿92例,根据治疗方案不同分为观察组和对照组,各46例。对照组采用丙酸氟替卡松治疗,观察组采用祛风宁肺散辅助丙酸氟替卡松治疗。比较两组临床疗效、中医证候积分、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、血清免疫球蛋白E(IgE)、转化生长因子-β_(1)(TGF-β_(1))、可溶性程序性死亡配体1(sPD-L1)、Toll样受体4(TLR4)水平、不良反应发生率。结果:观察组临床总有效率为96.65%,高于对照组的80.43%(P0.05)。结论:祛风宁肺散辅助治疗儿童咳嗽变异性哮喘风邪犯肺证疗效显著,可有效缓解临床症状,调节血气指标,促进病情恢复,且安全可行。

关键词：祛风宁肺散丙酸氟替卡松咳嗽变异性哮喘风邪犯肺证

深圳市一次强化减排措施下的VOCs组成和来源特征

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环境科学学报 2024年第1期44卷 124-134页

作者：陈冰娜程鹏梁永贤黄冠聪颜敏黄伟超廖艺佳陈钰彬李小兵袁斌暨南大学质谱仪器与大气环境研究所广州510632 广东省大气污染在线源解析系统工程技术研究中心广州510632 环境质量协同创新粤港澳联合实验室广州511443 深圳市环境科学研究院深圳518001 暨南大学环境与气候研究院广州511443

挥发性有机物(VOCs)是大气对流层中非常重要的痕量组分,对大气的氧化能力和区域环境问题都有重要影响.在当前我国颗粒物污染得到有效控制,而臭氧污染日趋突出的背景下,开展VOCs监测和研究具有很强的现实意义.本研究于2022年秋季在深圳... 详细信息

挥发性有机物(VOCs)是大气对流层中非常重要的痕量组分,对大气的氧化能力和区域环境问题都有重要影响.在当前我国颗粒物污染得到有效控制,而臭氧污染日趋突出的背景下,开展VOCs监测和研究具有很强的现实意义.本研究于2022年秋季在深圳市坪山区采用气相色谱-质谱/氢火焰离子化检测器(GC-MS/FID)对VOCs进行了近一个月的连续监测,在观测前半段,深圳市实施了大气污染强化减排措施,而在非减排期出现了一周的持续降水.对此,本研究主要针对强化减排期和非减排期(无降水),以及降水条件下VOCs污染特征和变化规律进行了分析,并采用PMF模型对不同时期的VOCs来源进行了比较.主要结论如下:观测期间VOCs总浓度均值为(31.85±26.07)×10^(-9),强化减排期浓度略高于非减排期(无降水).强化减排期以OVOCs组分贡献最大(30.21%),非减排期(无降水)以烷烃组分贡献最大(44.90%).强化减排期间高浓度物种大多具有更低的VOC/CO排放比,甲基环戊烷、2,2-二甲基丁烷、2,3-二甲基戊烷、环己烷、2-己酮的削减最为明显,但大部分物种在非减排期(无降水)的排放比更低.而在降水期间VOCs浓度出现反弹,主要以甲基环戊烷、2,2-二甲基丁烷、2,3-二甲基戊烷、环己烷、2-己酮为主.源解析结果表明,机动车尾气(27.70%)、餐厨废气+燃烧(20.44%)、油气挥发(19.76%)、溶剂使用(16.52%)、工业过程(12.91%)和植物源(2.67%)为该站点VOCs的主要来源.强化减排期间机动车尾气的削减效果最为显著,溶剂使用和油气挥发也有一定减少,体现了减排措施的有效性.但工业过程的浓度在强化减排期更高,说明减排措施对这一类排放源缺乏效果.此外,受降水过程影响,植物源的贡献较小,而餐厨废气+燃烧在两个时期的变化不大.总体上,深圳市强化减排措施对不同VOCs物种和来源的削减体现出选择性的特点.但受限于天气条件、区域传输等其他因素,减排效果的科学评估需要更多观测数据的支持.

关键词：挥发性有机物污染特征来源解析

阿兹夫定片在健康成年及老年受试者中单次和多次给药的药代动力学研究

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中国临床药理学杂志 2024年第9期40卷 1316-1320页

作者：张宇刘小健鞠浩爽何斌源万元浩柴立维任乐阳吕敏贾亚强张微徐萍天津市第五中心医院Ⅰ期临床试验研究室天津300450 河南真实生物科技有限公司河南平顶山467000 有济(天津)医药科技有限公司天津300000 天津洛必塔医学研究有限公司天津300000

目的评价单次口服和多次口服阿兹夫定片在中国健康成年及老年受试者中的药代动力学特征及安全性。方法本研究采取开放、平行方案设计。试验分为2个试验组:健康成年受试者组和健康老年受试者组,分别入组12例受试者。入组的受试者首先进... 详细信息

目的评价单次口服和多次口服阿兹夫定片在中国健康成年及老年受试者中的药代动力学特征及安全性。方法本研究采取开放、平行方案设计。试验分为2个试验组:健康成年受试者组和健康老年受试者组,分别入组12例受试者。入组的受试者首先进行单次给药,空腹口服阿兹夫定片5 mg,经3 d清洗期后进入多次给药阶段,空腹口服阿兹夫定片5 mg·d^(-1),连续给药7 d。结果单次给予阿兹夫定片5 mg后,健康成年受试者C_(max),AUC_(0-∞)分别为(4.76±2.12)ng·mL^(-1),(6.53±2.20)ng·mL^(-1)·h,T_(max),t_(1/2)的中位数分别为0.75,1.87 h;健康老年受试者平均C_(max),AUC_(0-∞)分别为(6.40±3.25)ng·mL^(-1),(9.50±3.70)ng·mL^(-1)·h,T_(max),t_(1/2)的中位数分别为0.63,2.66 h。连续7 d给予阿兹夫定片5 mg后,健康成年受试者C_(max,ss),AUC_(0-∞,ss)分别为(3.26±1.61)ng·mL^(-1),(5.38±2.19)ng·mL^(-1)·h,T_(max,ss),t_(1/2,ss)的中位数分别为0.88,2.13 h;健康老年受试者平均C_(max,ss),AUC_(0-∞,ss)分别为(3.97±2.09)ng·mL^(-1),(6.71±3.26)ng·mL^(-1)·h,T_(max,ss),t_(1/2,ss)的中位数分别为0.75,2.56 h。单次给药后,健康老年人和健康成年人C_(max)、AUC_(0-t)和AUC_(0-∞)的几何均数比值及其90%置信区间分别为128.37%(88.23%~186.76%)、139.93%(105.42%~185.72%)、140.03%(106.33%~184.41%)。连续7 d给予阿兹夫定片5 mg,健康老年人和健康成年人C_(max,ss)、AUC_(0-t,ss)和AUC_(0-∞,ss)的几何均数比值及其90%置信区间分别为118.66%(80.83%~174.20%)、118.41%(83.60%~167.69%),118.95%(84.78%~166.89%)。结论单次及多次口服阿兹夫定片后,健康老年人与健康成年人相比,系统暴露均有所提高。健康老年人服用阿兹夫定片后,其不良事件和药物不良反应发生的种类、严重程度和发生率与健康成年人相比无明显差异,安全性耐受性良好。

关键词：阿兹夫定片老年受试者健康成年受试者药代动力学

Resource investment for DDoS attack resistant SDN: a practical assessment

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Science China(Information Sciences) 2023年第7期66卷 112-129页

作者： bin yuan Fan ZHANG Jun WAN Huan ZHAO Shui YU Deqing ZOU Qiangsheng HUA Hai JIN School of Cyber Science and Engineering Huazhong University of Science and Technology National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Hubei Engineering Research Center on Big Data Security Shenzhen Huazhong University of Science and Technology Research Institute School of Computer Science and Technology Huazhong University of Science and Technology Cluster and Grid Computing Lab School of Computer Science University of Technology Sydney

Software-defined networks(SDNs) present a novel network architecture that is widely used in various datacenters. However, SDNs also suffer from many types of security threats, among which a distributed denial of service(DDoS) attack, which aims to drain the resources of SDN switches and controllers,is one of the most common. Once the switch or controller is damaged, the network services can be *** defense schemes against DDoS attacks have been proposed from the perspective of attack detection;however, such defense schemes are known to suffer from a time consuming and unpromising accuracy, which could result in an unavailable network service before specific countermeasures are taken. To address this issue through a systematic investigation, we propose an elaborate resource-management mechanism against DDoS attacks in an SDN. Specifically, by considering the SDN topology, we leverage the M/M/c queuing model to measure the resistance of an SDN to DDoS attacks. Network administrators can therefore invest a reasonable number of resources into SDN switches and SDN controllers to defend against DDoS attacks while guaranteeing the quality of service(QoS). Comprehensive analyses and empirical data-based experiments demonstrate the effectiveness of the proposed approach.

关键词： SDN security DDoS attacks resource management queueing theory QoS

Inter-comparisons of VOC oxidation mechanisms based on box model:A focus on OH reactivity

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Journal of Environmental Sciences 2022年第4期34卷 286-296页

作者： Xiaoyun Yang bin yuan Zhe Peng Yuwen Peng Caihong Wu Suxia Yang Jin Li Min Shao Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511443China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 511443China Department of Chemistry and Cooperative Institute for Research in Environmental Sciences University of ColoradoBoulderCO 80309USA

Volatile organic compounds(VOCs)oxidation processes play a very important role in atmospheric chemistry,and the chemical reactions are expressed in various manners in chemical *** gain an improved understanding of VOCs evolution during oxidation processes and evaluate the discrepancies of VOCs oxidation schemes among different mechanisms,we used the total VOC reactivity as a diagnostic and evaluated tool to explore the differences for six widely used chemical *** compared the total VOC reactivity evolution under high-NO_(x)xconditions for several sets of precursors,including n-pentane,toluene,ethene,isoprene and a mixture of 57 Photochemical Assessment Monitoring Stations(PAMS)species in a 0-D photochemical box ***-comparison of total VOC reactivity of individual precursor simulations showed discrepancies to different extent of the oxidation schemes among the studied mechanisms,which are mainly attributed to the different lumping approaches for organic *** PAMS simulation showed smaller discrepancy than individual precursor cases in terms of total VOC ***07 and RACM2 performances are found to better match the MCM for simulation of total VOC *** suggest that the performance in simulating secondary organic products,OH concentrations and NO_(x)concentrations are related to the OH reactivity discrepancies among various chemical *** in this study can be used in selection of chemical mechanisms to better model OH reactivity in different *** results in this study also provide directions to further improve the ability in modelling total VOC reactivity with the chemical mechanisms.

关键词： VOCs Box model Chemical mechanism Total VOC reactivity VOC oxidation

废机油残留物再生剂对老化沥青动态力学性能和组分迁移的影响

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材料导报 2024年第2期38卷 276-283页

作者：况栋梁马小军马晓燕袁斌侯俊鹏蔡军长安大学材料科学与工程学院西安710064 青海交通规划设计研究院有限公司西宁810000 甘肃路桥集团养护科技有限公司兰州730050 青海西互高速公路管理有限公司西宁810000

目前,再生沥青的研究主要集中在老化沥青性能的恢复上,而对老化后再生沥青性能变化的研究较少。本研究以自制的两种废机油残留物再生剂(REOB1、REOB2)对老化基质沥青进行再生,并对再生沥青进行短期老化(TFOT)和长期老化(PAV)。采用动态... 详细信息

目前,再生沥青的研究主要集中在老化沥青性能的恢复上,而对老化后再生沥青性能变化的研究较少。本研究以自制的两种废机油残留物再生剂(REOB1、REOB2)对老化基质沥青进行再生,并对再生沥青进行短期老化(TFOT)和长期老化(PAV)。采用动态剪切流变仪(DSR)和薄层棒状色谱仪(TLC-FID)分析再生沥青及其老化后的动态力学性能和化学组分变化情况。结果表明,两种REOB再生剂均能使老化基质沥青的性能恢复至原样沥青水平,并且REOB2再生剂与老化基质沥青的相容性优于REOB1再生剂;采用CAM模型对沥青复数模量、相位角主曲线进行拟合,并以原样沥青主曲线为参考,对老化与再生沥青拟合数据进行归一化处理,发现两种REOB再生剂均可以恢复老化基质沥青的复数模量和相位角。在二次老化过程中,RA+REOB再生沥青的归一化复模量指标(NCMI)在低频和中频范围内逐渐增大,即使经过长期老化,其复模量仍低于长期老化的基质沥青;而归一化相角指标(NPAI)在中频范围内的下降幅度明显大于低频范围和高频范围内的下降幅度,RA+REOB1再生沥青经过PAV老化后的NPAI低于长期老化后的基质沥青;随着老化程度的加深,RA+REOB再生沥青的化学组分从芳烃组分向胶质迁移,REOB1再生沥青经PAV老化后轻组分损失最大。

关键词：道路工程再生沥青再生剂二次老化动态力学性能化学组分

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非嗜酸性粒细胞哮喘诊治进展

重庆医科大学学报 2024年第1期49卷 1-7页

作者：张心悦邵子建练康吴德美袁斌吴芳唐兰芳浙江大学医学院附属儿童医院中医科、国家儿童健康与疾病临床医学研究中心杭州310005 南京中医药大学第一临床医学院、南京中医药大学附属医院儿科南京210028 浙江大学医学院附属儿童医院呼吸内科、国家儿童健康与疾病临床医学研究中心杭州310005

哮喘是全球最常见的慢性呼吸系统疾病之一,非嗜酸性粒细胞哮喘(non-eosinophilic asthma,NEA)是哮喘的一种特殊表型,其气道炎症的特征是细胞浸润以中性粒细胞为主,缺乏嗜酸性粒细胞。NEA发病与环境及宿主因素均有关,例如职业暴露、环境... 详细信息

哮喘是全球最常见的慢性呼吸系统疾病之一,非嗜酸性粒细胞哮喘(non-eosinophilic asthma,NEA)是哮喘的一种特殊表型,其气道炎症的特征是细胞浸润以中性粒细胞为主,缺乏嗜酸性粒细胞。NEA发病与环境及宿主因素均有关,例如职业暴露、环境污染、吸烟、感染和肥胖,上述风险因素单独或联合作用可以激活特定的细胞和分子途径,导致NEA发生。NEA的临床特征是对标准哮喘治疗的反应不佳,尤其是对吸入性皮质类固醇,导致疾病更严重和难以控制的哮喘。虽然NEA不是最普遍的哮喘表型,但重度哮喘患者中NEA比例高,其重要性不容忽视。本文就近年来NEA的流行病学现状、致病因素、发病机制和治疗现状作一综述。

关键词：哮喘非嗜酸性粒细胞型诊断治疗