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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang Xiao-Jun Liu Xue-bin peng Xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Fast method for spreading sequence estimation of DSSS signal based on maximum likelihood function

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Journal of Systems Engineering and Electronics 2010年第6期21卷 948-953页

作者： Yanhua peng bin Tang Ming Lv College of Electronic Engineering University of Electronic Science and Technology of China Chengdu 610054 E R. China

To estimate the spreading sequence of the direct sequence spread spectrum (DSSS) signal, a fast algorithm based on maximum likelihood function is proposed, and the theoretical derivation of the algorithm is provided. By simplifying the objective function of maximum likelihood estimation, the algorithm can realize sequence synchronization and sequence estimation via adaptive iteration and sliding window. Since it avoids the correlation matrix computation, the algorithm significantly reduces the storage requirement and the computation complexity. Simulations show that it is a fast convergent algorithm, and can perform well in low signal to noise ratio (SNR).

关键词： direct sequence spread spectrum (DSSS) signal spreading sequence maximum likelihood estimation (MLE).

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Estimation of glacier ice storage in western China constrained by field ground-penetrating Radar surveys

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Advances in Climate Change Research 2022年第3期13卷 359-374页

作者： peng-bin LIANG Li-De TIAN Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Kunming 650091China

Recent decades have witnessed the accelerated retreat of alpine glaciers,which likely portends a decline in the glacial ice melt on which large downstream populations rely for ***,estimating water storage in alpine glaciers is critical for predicting the trend of glacier *** study compiled a rich set of ice thickness observations for glaciers of varying sizes in western *** here presented a first-order assessment of the various errors involved in interpreting ice thickness from ground-penetrating radar(GPR)*** empirical Bayesian kriging(EBK)method was used for ice thickness interpolation and volume *** then established a new volume-scaling law specific to western China glaciers based on these 36 volume-area *** together with the Second Chinese Glacier Inventory(SCGI),we obtain a regional volume estimate of 4451±298 km^(3).By comparison,we believed that this result is the most reliable estimate of the total ice storage in western China and more reliably predicts gross glacier ***,our results show that the method of glacier division can strongly affect the total volume estimation,which previous studies *** emphasizes the need for more surveyed glaciers data and more accurate glacier inventory to improve the evaluation of the climate impact on glacier melting water resources and to help ensure the future survival of these alpine glaciers.

关键词： Ground-penetrating radar Glacier thickness survey Glacier volume volume-area scaling law Distributed model Western China

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Operation Strategy and Matching of Supply and Demand of CCHP System with Various Building Types

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Journal of Thermal Science 2024年第6期33卷 2203-2220页

作者： LI Yaohong WANG pengxiang peng bin BIAN Xiaoyang School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou 730050China

The important indications for assessing CCHP(combined cooling,heating and power)systems are their supply-demand matching characteristics between the user demand side and the energy supply *** characteristics are primarily influenced by different building types and operating *** view of the energy redundancy of the following electric load(FEL)and following thermal load(FTL)operation strategies and the energy deficiency of the following hybrid electric-heating load(FHL)operation strategy,this paper proposes an improved following balanced heat-electrical load(IFBL)operation strategy based on the following balanced heat-electrical load(FBL)operation *** on the energy utilization rate as the objective function,this paper optimizes the installed capacity of CCHP systems in different buildings and proposes an energy factor for evaluating the supply-demand matching characteristics of the *** results show that the energy utilization rate and energy factor of the system under IFBL are optimal relative to the other operation ***,the hotel building has the highest energy utilization rate and the lowest energy factor;on the contrary,the office building has the lowest energy utilization rate and the highest energy ***,the analysis of supply-demand matching for different building types under multiple operating strategies shows that the hospital and hotel systems exhibit optimal supply-demand matching performance under the IFBL strategy,with values of 0.945 and 0.938,respectively;on the contrary,the office system has an optimal supply-demand matching of 0.935 under the FEL *** the FTL strategy,the systems of all three buildings exhibit poor matching performance.

关键词： combined cooling,heating and power system(CCHP) operation strategy energy utilization energyfactor matching supply and demand

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Organic Matter Enrichment and Aggregate Stabilization in a Severely Degraded Ultisol After Reforestation

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Pedosphere 2006年第6期16卷 699-706页

作者： ZHANG bin peng Xin-Hua Institute of Soil Science Chinese Academy of Sciences Nanjing 210008China

Three types of soils： an eroded barren soil under continuous fallow, an eroded soil transplanted with Lespedeza shrubs （Lespedeza bieolor）, and an eroded soil transplanted with camphor tree （Cinnaraomum camphora） were investigated to quantify organic matter pools and aggregates in reforested soils using physical fractionation techniques and to determine aggregate stability in relation to the enrichment of soil organic carbon （SOC）. Soil organic matter （SOM） was physically fractionalized into free particulate organic matter （fPOM）, occluded particulate organic matter （oPOM）, and mineralassociated organic matter （mOM）. The SOM was concentrated on the surface soil （0 5 cm）, with an average C sequestration rate of 20-25 g C m^-2 year^-1 over 14 years. As compared to the eroded barren land, organic C content of fPOM, oPOM, and mOM fractions of the soil under Lespedeza and under camphor tree increased 12-15, 45-54, and 3.1-3.5 times, respectively. A linear relationship was found between aggregate stability and organic C （r^2 = 0.45, P 〈 0.01）, oPOM （r^2 = 0.34, P 〈 0.05）, and roOM （r^2 = 0.46, P 〈 0.01） of aggregates. The enrichment of organic C improved aggregate stability of the soil under Lespedeza but not that under camphor tree. However, further research is needed on the physical and biological processes involved in the interaction of soil aggregation and SOC sequestration in ecosystem.

关键词： aggregate stability reforestation organic matter fractions soil C sequestration

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Bound lipase:an important form of lipase in rice bran (Oryza sativa)

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Food Science and Human Wellness 2023年第5期12卷 1779-1787页

作者： Chengwei Yu bin peng Ting Luo Zeyuan Deng State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China School of Health Jiangxi Normal UniversityNanchang 330022China Department of Food Science and Technology National University of SingaporeSingapore 117542Singapore National Research and Development Center of Freshwater Fish Processing Jiangxi Normal UniversityNanchang 330022China

Rice bran residue possessed a steady lipase activity((26.68 ± 3.69)%)after its endogenous lipase was extracted continuously by phosphate buffer solution(PBS)for 24 h. T herefore, the aim of this research was to explore whether there exist any bound lipases in rice bran(Oryza sativa). Three physical treatments(grinding, homogenizing and ultrasound crush)and 6 enzymatic treatments(cellulase, hemicellulase, pectinase, complex cellulase, glucoamylase and α-amylase)were applied to rice bran in order to investigate this bound lipase. The relative catalytic activities of extraction supernatant and residue for pectinase group were(437.63 ± 22.54)% and(159.26 ± 2.12)%, respectively, which were significantly higher(P bine with pectin. Molecular simulation proved that pectin could combine with two rice bran lipases(lipase 315 and lipase 308)and cover the catalytic centers so as to prevent the lipases from encountering the substrate and inhibiting their catalytic activities. During combination, pectin could make the lipases more compact and reduce the solvent accessible surface area of lipases, which would make the lipases inactive to molecular interaction. In summary, part of rice bran lipase was proved to exist in bound form and combined with the pectin.

关键词： Rice bran Bound lipase Pectin Catalytic activity

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Association between large artery atherosclerosis and cerebral microbleeds:a systematic review and meta-analysis

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Stroke & Vascular Neurology 2017年第1期2卷 7-14页

作者： Lingling Ding Yuehui Hong bin peng Department of Neurology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)BeijingChina

Objective:The aim of this systematic review and meta-analysis was to provide evidence that biomarkers of large artery atherosclerosis,including arterial stenosis and greater carotid intima-media thickness(cIMT),may serve as clinical markers of subclinical haemorrhage-prone cerebral small vessel disease,reflected by cerebral microbleeds(CMBs).Methods:We searched PubMed,MEDLINE,Web of Science,EMBASE and the Cochrane Library to identify relevant studies published before 1 July *** association between arterial stenosis and CMBs was estimated by the OR and 95%*** association of cIMT and CMBs was calculated using the standardised mean difference(SMD).Heterogeneity and publication bias were ***:8 studies including a total of 7160 participants were pooled in the meta-analysis.6 of the included studies were cross-sectional,except that 2 were *** found a significant association between arterial stenosis>50%and the presence of CMBs(OR 1.95,95%CI 1.13 to 3.36,I2=56.1%).A fixed-effects model suggested that patients with CMBs were more likely to have a greater cIMT(SMD 0.20,95%CI 0.11 to 0.28,I2=24.7%).Conclusions:This systematic review and metaanalysis found that there is a relationship between large artery atherosclerosis and *** studies are needed to confirm the impact of atherosclerosis on the CMBs,which may have potential therapeutic implications.

关键词： atherosclerosis cerebral stenosis

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Molecular dynamics simulation of chip formation mechanism in single-crystal nickel nanomachining

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Science China(Technological Sciences) 2019年第11期62卷 1916-1929页

作者： ZHU ZongXiao peng bin FENG RuiCheng WANG LinJun JIAO Shi DONG Yun School of Mechanical and Electronical Engineering Lanzhou University of Technology

Nanometric machining simulations of single-crystal nickel were performed using molecular *** atomic displacement vector method was applied to study the relationship between defect displacement vectors and the crystal slip system during different deformation stages as well as the displacement trend characteristics of workpiece atoms under different *** arrangement characteristics of atoms in the machining region,relative density of atoms at different machining zones,and proportion of different atoms were investigated in *** addition,the atom shunt phenomenon was observed by studying the displacement trend of the atoms adjacent to the machining tool,and a method for determining the location of the shunt point was ***,direct evidence of crystal transition caused by temperature was *** effects of machining depth on workpiece damage,surface flatness,and workpiece temperature were *** increasing machining depth,the chip gradually changed from spherical to strip-shaped,the damage depth of workpiece gradually increased,but the atomic arrangement of the machined surface became ***,the dislocation reaction of subsurface defects was studied,and the rationality of the reaction was analyzed using an energy ***,the overall temperature of the workpiece increased,but the temperature of the chip part gradually decreased.

关键词： molecular dynamics simulation single crystal nickel atomic displacement vector crystal slip system shunt point

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Fluorescent silicon nanoparticle-based gene carriers featuring strong photostability and feeble cytotoxicity

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Nano Research 2016年第10期9卷 3027-3037页

作者： Jingyang Pang Yuanyuan Su Yiling Zhong Fei peng bin Song Yao He Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM)Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China

Safe fluorescent gene-transfection vectors are in great demand for basic biological applications and for gene-therapy research. Here, we introduce a new type of luminescent silicon nanoparticle （SiNP）-based gene carrier suitable for determining the intracellular fate of the gene vehicle in a long-term and real-time manner. The presented SiNP-based nanocarriers simultaneously feature strong and stable fluorescence, high DNA-loading capacity and gene-transfection efficienc35 as well as favorable biocompafibility. Taking advantage of these unique benefits, we were able to readily observe the behavior of the gene carriers in live cells （e.g. cellular uptake, intracellular trafficking, and endosomal escape） in a long-term and real- time manner. The results demonstrate the potential usability of these fluorescent SiNP-based gene vectors as powerful tools in the field of gene therapy, and provide invaluable information for understanding the intracellular behavior of gene carriers.

关键词： fluorescent silicon nanoparficles gene delivery biocompatibility long-term and real-time tracking

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Formation mechanism of asymmetric breather and rogue waves in pair-transition-coupled nonlinear Schr?dinger equations

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Chinese Physics B 2019年第1期28卷 283-289页

作者： Zai-Dong Li Yang-yang Wang peng-bin He Department of Applied Physics Hebei University of TechnologyTianjin 300401China Key Laboratory of Electronic Materials and Devices of Tianjin School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China School of Physics and Electronics Hunan UniversityChangsha 410082China

Based on the developed Darboux transformation, we investigate the exact asymmetric solutions of breather and rogue waves in pair-transition-coupled nonlinear Schr?dinger equations. As an example, some types of exact breather solutions are given analytically by adjusting the parameters. Moreover, the interesting fundamental problem is to clarify the formation mechanism of asymmetry breather solutions and how the particle number and energy exchange between the background and soliton ultimately form the breather solutions. Our results also show that the formation mechanism from breather to rogue wave arises from the transformation from the periodic total exchange into the temporal local property.

关键词： Akhmediev breather solution Kuznetsov–Ma breather solution rogue wave nonuniform exchange

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