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Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion

International Journal of Ophthalmology(English edition) 2017年第4期10卷 605-612页

作者： bin mo Hai-Ying Zhou Xuan Jiao Feng Zhang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory

AIM：To evaluate the potential role of hyperreflective foci（HF） as a prognostic indicator of visual outcome in patients with macular edema（ME） due to retinal vein occlusion（RVO）.METHODS：We retrospectively reviewed 50 eyes of 50 patients with ME due to ischemic central retinal vein occlusion（CRVO）,non-ischemic CRVO and branch retinal vein occlusion（BRVO） who were treated with anti-vascular endothelial growth factor（anti-VEGF） at Beijing Tongren Eye Center from January 2013 to July *** patients underwent best-corrected visual acuity（BCVA）,spectral domain optical coherence tomography（SD-OCT） at baseline and *** factors were evaluated and compared among three groups as baseline and final BCVA,central retinal thickness（CRT）,external limiting membrane（ELM） status and the numbers of HF in different *** linear regression analysis was employed to analyze the relationship between baseline HF and final *** of HF before and after treatment were evaluated ***：Among three groups,HF could be located in each retinal layers,as well as in vitreous *** mean HF in outer retinal layer（ORL） at baseline was 5.29±8.48 in ischemic CRVO with intact ELM,1.93±2.76 in non-ischemic CRVO,and 1.75±2.05 in *** disrupted ELM,the mean HF in ORL *** was statistically difference of HF in ORL between intact and disrupted *** numbers of HF in ORL were associated with poor visual outcome among three ***,HF in inner retinal layer（IRL） and vitreous cavity were not associated with poor visual ***,the baseline HF in ORL and vitreous cavity reduced significantly in nonischemic CRVO and BRVO after anti-VEGF ***：The numbers of HF in ORL are prognostic factors associated with the final BCVA in patients with ME due to RVO after anti-VEGF treatment.

关键词： hyperreflective foci retinal vein occlusion treatment optical coherence tomography

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Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells

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World Journal of Gastroenterology 2010年第5期16卷 618-624页

作者： Liang, Xue-Song Zhou, Ying Li, Chen-Zhong Wan, mo-bin Second Mil Med Univ Changhai Hosp Dept Infect Dis Shanghai 200433 Peoples R China Second Mil Med Univ Dept Biochem & Mol Biol Shanghai 200433 Peoples R China

AIM:To investigate if and how programmed death type-1(PD-1)expression affects the natural course of hepatitis B virus(HBV)infection. METHODS:Sixty-four patients in different natural stages of chronic HBV infection were enrolled in this ***-1 expression in total T cells was detected by flow *** of total CD8+T cell responses and proliferation in relation to PD-1 expression levels were analyzed with intracellular staining and PD-1/ PD-L1 blockage. RESULTS:The PD-1 expression in T cells was dynamically changed during the natural course of chronic HBV infection,did not significantly increase in the immune tolerance phase,and returned to normal in the inactive virus carrier *** of the PD-1/PD-L1 pathway could not affect the T-cell response in the immune tolerance and inactive virus carrier stages of chronic HBV ***,it could significantly restore the T-cell response in the immune clearance stage of chronic HBV ***,the PD-1 expression level in T cells was associated with the alanine aminotransferase level during the immune clearance stage of chronic HBV infection. CONCLUSION:The PD-l/PD-L1 pathway plays a different role in T-cell response during the natural course of chronic HBV infection.

关键词： Programmed death type-1 Hepatitis B virus Chronic hepatitis B Natural stage CD8+T cell Serum viral load Programmed death ligand T cell response

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ANALYSIS OF STRESS AND TEMPERATURE IN THE CONFORM FORMING PROCESS--FOUNDATION THEORY

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Journal of Central South University 1996年第2期8卷 50-55页

作者： Peng Yuelin Hu Jian mo bin Department of Applied Mathematics and Applied Software Central South University of TechnologyChangsha 410083China

The change of stress and temperature in the conform forming process has been studied. On the basis of the law of momentum, the law of momantum moment and the law of energy conservation, the governmental differential equations of stress and temperature in the conform metal forming process have been derived, whose definite conditions are given by material mechanics, elastic machanics and plastic mechanics. The analytic solution of these equations has been successfully obtained and as a result, the solid foundations and scientific guide for the further development of this prospective metal processing techique have been established.

关键词： conform stress temperature differential equations

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Spillover and quantile linkage between oil price shocks and stock returns: new evidence from G7 countries

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Financial Innovation 2020年第1期6卷 912-939页

作者： Yonghong Jiang Gengyu Tian bin mo Institute of Finance Jinan UniversityGuangzhouChina Institute of Finance Guangzhou UniversityGuangzhouChina

The link between crude oil price and stock returns of the Group of Seven(G7)countries(Canada,France,Germany,Italy,Japan,the United Kingdom,and the United States)was analyzed in this study using monthly data from January 1999 to March *** adopt a similar approach to Kilian(Am Econ Rev 99(3):1053–1069,2009)and construct a structural vector autoregression framework to decompose crude oil price shocks into oil supply shock,oil aggregate demand shock,and oil-specific demand *** then explore the distinct effects of different kinds of oil price shocks from various *** on the decomposed oil price shocks,we apply the connectedness approach and QQ regression to find time-varying co-movements and tail dependence between oil price shocks and G7 stock *** is no general correlation between the decomposed oil prices and stock returns in these *** effects of oil price shocks on stock returns across different stock market conditions appear to be *** supply shock appears to be a net transmitter of spillover effects for all G7 countries within the sample period.

关键词： Oil supply shock Oil aggregate demand shock Oil specific demand shock Stock market Spillover effect Quantile-on-quantile

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A Distinctive Pattern for Substituent Effects on Transition Metal Centers:Enhanced Electron-Donating Capacity of Cationic Palladium Species

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CCS Chemistry 2023年第5期5卷 1163-1175页

作者： Jun-Yan Wu bin-Rui mo Jin-Dong Yang Jin-Pei Cheng Department of Chemistry Tsinghua UniversityBeijing 100084 College of Chemistry Nankai UniversityTianjin 300071 Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192

Electronic and bonding situations at reaction centers are often detected by the remote substituent *** nonorganometallic reactions,this effect is conventionally described by the well-known Hammett-type substituent ***,for most transition metal(TM)-involved systems,no analogous numeral descriptors reflecting the intrinsic differences between metallic and nonmetallic bonding have been rigorously established till ***,we report a Pd(II)–O bond heterolysis energyΔG_(het)(Pd–O)study of the archetypal palladium complexes to represent the thermodynamics of the essential bond-breaking step in Pd-mediated *** we furnish the new substituent constantsσPd^(+)s and therefrom facilitate linear free-energy relationship(LFER)analysis for Pd-catalyzed ***,this led us to find an unexpected electron-donating ability of Pd(II)cation,which provided a gifted experimental support,with the aid of computation,to attribute the frustrating observation of a much scattered curvature in theΔG_(het)(Pd–O)-σ+correlation to the electrondonating capacity of the cationic palladium through back-donation of its *** of LFER analysis withσPd^(+)to predict the redox behavior of the palladium complex and in a kinetics *** study of transmetalation added further credence to their applicability to TM systems.

关键词： bond dissociation energy substituent effects palladium complexes thermodynamics structure–reactivity relationship

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Inhibition of choroidal neovascularization by lentivirusmediated PEDF gene transfer in rats

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1112-1120页

作者： Ya-Jie Yu bin mo Lu Liu Yan-Kun Yue Chang-Li Yue Wu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Department of Ophthalmology Fuxing Hospital Capital Medical University Department of Pathology Beijing Tongren Hospital Capital Medical University

AIM: To evaluate the effects of lentivirus-mediated pigment epithelium-derived factor (PEDF) gene transfer performed in treatment of rats with established choroidal neovascularization (CNV), and investigates the mechanism by which PEDF inhibits CNV in rats. METHODS: Brown Norway (BN) rats (n=204) were induced by exposure to a laser, and then randomly assigned to 3 groups: no treatment; treatments with intravitreal injection of lentivirus-PEDF-green fluorescent protein (GFP) or lentivirus-control GFP (free fluorescent protein). Following induction and treatment, the CNV tissue was assessed for form, size and vessel leakage by fluorescein fundus angiography (FFA), optical coherence tomography (OCT), histopathology, and examination of choroidal flat mounts. VEGF, Flk-1, and PEDF expression were evaluated by real-time polymerase chain reaction (PCR) and Western blot. RESULTS: A stable laser-induced rat model of CNV was successfully established, and used to demonstrate lentivirus-mediated REDO gene transfer by intravitreal injection. Expression of green fluorescence labelled PEDF was observed in the retina up to 28d after injection. An intravitreal injection of lentivirus-PEDF-GFP at 7d led to a significant reduction in the size, thickness and area of CNV showed by FFA, OCT and choroidal flat mounts. PEDF was up-regulated while VEGF and Flk-1 were down-regulated in the lentivirus-PEDF-GFP group. The differences in VEGF and Flk-1 expression in the control and lentivirus-PEDF groups at 7, 14, 21 and 28d after laser induction were all statistically significant. CONCLUSION: Lentivirus-mediated PEDF gene transfer is effective for use in treatment of laser-induced CNV, and PEDF exerts its therapeutic effects by inhibiting expression of VEGF and Flk-1.

关键词： pigment epithelium-derived factor choroidal neovascularization lentivirus vascular endothelial growth factor Flk-1

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Characterization of NDM-5-producing Enterobacteriaceae isolates from retail grass carp(Ctenopharyngodon idella) and evidence of blaNDM-5-bearing IncHI2 plasmid transfer between ducks and fish

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Zoological Research 2022年第2期43卷 255-264页

作者： Lu-Chao Lv Yao-Yao Lu Xun Gao Wan-Yun He Ming-Yi Gao Kai-bin mo Jian-Hua Liu College of Veterinary Medicine Key Laboratory of Zoonosis of Ministry of Agricultural and Rural AffairsNational Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in AnimalsGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety EvaluationSouth China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Laboratory for Lingnan modern Agriculture GuangzhouGuangdong 510642China

We aimed to characterize NDM-5-producing Enterobacteriaceae from aquatic products in Guangzhou,China.A total of 196 intestinal samples of grass carp collected in 2019 were screened for carbapenemase *** of bla_(NDM-5) positive isolates and plasmids was determined by antimicrobial susceptibility testing,conjugation experiments,Illumina HiSeq,and Nanopore *** Citrobacter freundii and six Escherichia coli strains recovered from seven intestinal samples were verified as bla_(NDM-5) carriers(3.57%,7/196).The bla_(NDM-5) genes were located on the lncX3(n=5),lncHI2(n=1),or lncHI2-lncF(n=1)*** bla_(NDM-5)-bearing plasmids were transferred by conjugation at frequencies of~10^(-4)-10^(-6).Based on sequence analysis,the lncHI2 plasmid pHNBYF33-1 was similar to other bla_(NDM-5)-carrying lncHI2 plasmids deposited in GenBank from Guangdong *** all lncHI2 plasmids,bla_(NDM-5)was embedded in a novel transposon,Tn7057(IS3000-△ISAba125-IS5-△ISAba125-bla_(NDM-5)-bleMBL-trpF-tat-△dct-IS26-△umuD-△ISKox3-IS3000),which was identical to the genetic structure surrounding bla_(NDM-5)found in some IncX3 *** lncHI2-lncF hybrid plasmid pHNTH9F11-1 was formed by homologous recombination of the bla_(NDM-5)-carrying lncHI2 plasmid and a heavy-metal-resistant IncF plasmid through△Tn1721 To the best of our knowledge,this is the first report on the characterization of bla_(NDM-5)-bearing plasmids in fish in *** lncHI2 plasmid pHNBYF33-1 may be transmitted from ducks,considering the common duck-fish freshwater aquaculture system in ***7051 is likely responsible for the transfer of bla_(NDM-5) from lncX3 to lncHI2 plasmids in Enterobacteriaceae,resulting in the expansion of transmission vectors of bla_(NDM-5).

关键词： bla_(NDM-5) Enterobacteriaceae Plasmid Fish Carbapenemase

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人在世界中的位置——卡姆拉对盖伦哲学人类学的批判

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自然辩证法研究 2018年第3期34卷 60-66页

作者：莫斌中国社会科学院中国社会科学杂志社北京100026

作为在世界之中的存在者,人所特有的存在方式是如何被揭示出来的?这是哲学人类学的基本话题之一。盖伦工作的显著特征是对周遭环境因素的考虑,并在"匮乏的生物体"意义上解释人的独特性的地位。卡姆拉认为盖伦夸大了人的自然属性,盖伦没... 详细信息

作为在世界之中的存在者,人所特有的存在方式是如何被揭示出来的?这是哲学人类学的基本话题之一。盖伦工作的显著特征是对周遭环境因素的考虑,并在"匮乏的生物体"意义上解释人的独特性的地位。卡姆拉认为盖伦夸大了人的自然属性,盖伦没有认识到,人作为唯一生物体拥有的不是"环境",而是"世界"。盖伦合理地揭示人类劳作与语言之间的相关性,但对于劳作中的语言问题并没有真正展开。卡姆拉指出了盖伦错误的实质:语言不应仅仅被视为人类的精神现象,而应该理解为具有语言的人类活生生的行为举止。通过对盖伦的批判,卡姆拉的建构主义哲学人类学获得三个向度:人的实际生存中的时间性维度;人的责任;语言的创制和使用。

关键词：哲学人类学环境语言时间性维度

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新时代的学术创新与哲学社会科学“三大体系”建设

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哲学动态 2022年第4期 15-21,126页

作者：莫斌中国社会科学院中国社会科学杂志社哲学部

新时代的学术创新以及哲学社会科学“三大体系”建设体现为建构自己的理论,彰显当代中国马克思主义的真理力量。立足中国实践的哲学社会科学研究,要在文明交融互鉴视域中坚持马克思主义基本原理同中国具体实际相结合、同中华优秀传统文... 详细信息

新时代的学术创新以及哲学社会科学“三大体系”建设体现为建构自己的理论,彰显当代中国马克思主义的真理力量。立足中国实践的哲学社会科学研究,要在文明交融互鉴视域中坚持马克思主义基本原理同中国具体实际相结合、同中华优秀传统文化相结合,推动中华优秀传统文化创造性转化、创新性发展,展现中国文化的综合实力和国际竞争力。新时代协同创新视域下的科研能力提升,需要学者们关注前沿学科和交叉学科,在跨学科视域中构建学术共同体。创新型国家方位下的学术创新要着力于重塑全球创新版图与重构全球知识结构,向世界展现新时代的思想中国。

关键词：新时代 “三大体系”建设世界性难题协同创新

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康德的多重面孔

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哲学分析 2024年第6期15卷 173-180页

作者：莫斌中国社会科学杂志社哲学编辑部

“每一个时代的哲学作为分工的一个特定的领域,都具有由它的先驱传给它而它便由此出发的特定的思想材料作为前提。因此,经济上落后的国家在哲学上仍然能够演奏第一小提琴:18世纪的法国对英国来说是如此(法国人是以英国哲学为依据的),后... 详细信息

“每一个时代的哲学作为分工的一个特定的领域,都具有由它的先驱传给它而它便由此出发的特定的思想材料作为前提。因此,经济上落后的国家在哲学上仍然能够演奏第一小提琴:18世纪的法国对英国来说是如此(法国人是以英国哲学为依据的),后来的德国对英法两国来说也是如此。”a康德因开启了哥白尼式的思想革命,成为现当代思想的引路人之一。他不但是德国古典哲学的创始人,也作为自然科学家闻名于世。今年是康德诞辰三百周年,学术界纷纷举行各种纪念活动。比如,2024年4月北京大学哲学系、北京大学外国哲学研究所与中华全国外国哲学史学会康德哲学专业委员会(中国康德学会)举办的纪念大会就以“我们时代的康德”为主旨。从今年国内外学术界举办纪念康德活动的议题,就可以管中窥豹,一睹康德思想无远弗届的影响力和生命力。

关键词：哥白尼式外国哲学史英国哲学康德哲学自然科学家无远弗届纪念活动德国古典哲学

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