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LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance

Genes & Diseases 2023年第5期10卷 2082-2096页

作者： Xiangyu Zhai Zhijia Xia Gang Du Xinlu Zhang Tong Xia Delin Ma Xiaosong Li bin jin Hao Zhang Department of Hepatobiliary Surgery The Second Hospital of Shandong UniversityJinanShandong 250033China Department of General Visceraland Transplant SurgeryLudwig-Maximilians-University MunichMunich 81377Germany Department of Reproductive Medicine Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China Organ Transplant Department Qilu Hospital of Shandong UniversityJinanShandong 250012China Clinical Molecular Medicine Testing Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Accumulating evidence supports the association of somatic mutations with tumor occurrence and development.We aimed to identify somatic mutations with important implications in hepatocellular carcinoma(HCC)and explore their possible mechanisms.The gene mutation profiles of HCC patients were assessed,and the tumor mutation burden was calculated.Gene mutations closely associated with tumor mutation burden and patient overall survival were identified.In vivo and in vitro experiments were performed to verify the effects of putative genes on proliferation,invasion,drug resistance,and other malignant biological behaviors of tumor cells.Fourteen genes with a high mutation frequency were identified.The mutation status of 12 of these genes was closely related to the mutation burden.Among these 12 genes,LRP1B mutation was closely associated with patient prognosis.Nine genes were associated with immune cell infiltration.The results of in vivo and in vitro experiments showed that the knockdown of LRP1B promotes tumor cell proliferation and migration and enhances the resistance of tumor cells to liposomal doxorubicin.LRP1B could directly bind to NCSTN and affect its protein expression level,thereby regulating the PI3K/AKT pathway.Our mutational analysis revealed complex and orchestrated liposomal alterations linked to doxorubicin resistance that may also render cancers less susceptible to immunotherapy and also provides new treatment alternatives.

关键词： Doxorubicin Hepatocellular carcinoma LRP1B PI3K/AKT pathway Tumor mutation burden

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Solitary hyoid plasmacytoma with unicentric Castleman disease:A case report and review of literature

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World Journal of Clinical Cases 2022年第36期10卷 13364-13372页

作者： Yan-Hui Zhang Yi-Feng He Hao Yue Yue-Ni Zhang Lei Shi bin jin Pin Dong Department of Otolaryngology-Head and Neck Surgery Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Pathology Shanghai Cancer CenterFudan UniversityShanghai 200032China NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150028Heilongjiang ProvinceChina

BACKGROUND Solitary plasmacytoma and unicentric Castleman disease(UCD)are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes,respectively.CASE SUMMARY A 48-year-old Han Chinese man presented to our department with a neck mass and progressive foreign body sensation in his throat.18F-FDG positron emission tomography revealed focally increased radioactivity centered around the hyoid,and computed tomography(CT)revealed osteolytic lesions.Histopathology revealed Castleman-like features and CD138/CD38-positive mature plasma cells.Systemic work-up ruled out the possibility of POEMS syndrome,lymphoma,and multiple myeloma,leading to a final diagnosis of solitary hyoid plasmacytoma with UCD.The patient underwent partial hyoid resection and selective neck dissection,followed by intensity-modulated radiotherapy.99mTc-MDP singlephoton emission computed tomography/CT reevaluation showed neither local recurrence nor distant bone metastasis at the 40-mo follow-up.CONCLUSION The diagnostic process and differential diagnosis of this rare case provided valuable educational information to clinicians.

关键词： 18F-FDG Positron emission tomography/computed tomography Plasmacytoma Hyoid bone Castleman disease Case report

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Mitigated reaction kinetics between lithium metal anodes and electrolytes by alloying lithium metal with low-content magnesium

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Journal of Energy Chemistry 2024年第8期95卷 644-650页

作者： Yang-Yang Wang Ya-Nan Wang Nan Yao Shu-Yu Sun Xiao-Qing Ding Chen-Xi Bi Qian-Kui Zhang Zhao Zheng Cheng-bin jin Bo-Quan Li Xue-Qiang Zhang Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of Technology Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University College of Materials and Chemistry China Jiliang University

Lithium（Li） metal is regarded as a promising anode candidate for high-energy-density rechargeable batteries. Nevertheless, Li metal is highly reactive against electrolytes, leading to rapid decay of active Li metal reservoir. Here, alloying Li metal with low-content magnesium（Mg） is proposed to mitigate the reaction kinetics between Li metal anodes and electrolytes. Mg atoms enter the lattice of Li atoms, forming solid solution due to the low amount（5 wt%） of Mg. Mg atoms mainly concentrate near the surface of Mg-alloyed Li metal anodes. The reactivity of Mg-alloyed Li metal is mitigated kinetically, which results from the electron transfer from Li to Mg atoms due to the electronegativity difference. Based on quantitative experimental analysis, the consumption rate of active Li and electrolytes is decreased by using Mgalloyed Li metal anodes, which increases the cycle life of Li metal batteries under demanding conditions.Further, a pouch cell（1.25 Ah） with Mg-alloyed Li metal anodes delivers an energy density of 340 Wh kg-1and a cycle life of 100 cycles. This work inspires the strategy of modifying Li metal anodes to kinetically mitigate the side reactions with electrolytes.

关键词： Alloying Anode/electrolyte interface Lithium metal anodes Pouch cell Reaction kinetics

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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG jin-bin LI Long HE Zhen-fan HUANG Zhuo-jian LIU Zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU Heng-li MA Hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

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What is Discussed about COVID-19:A Multi-Modal Framework for Analyzing Microblogs from Sina Weibo without Human Labeling

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Computers, Materials & Continua 2020年第9期64卷 1453-1471页

作者： Hengyang Lu Yutong Lou bin jin Ming Xu School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China National Key Laboratory for Novel Software Technology Department of Computer Science and TechnologyNanjing UniversityNanjing210023China

Starting from late 2019,the new coronavirus disease(COVID-19)has become a global crisis.With the development of online social media,people prefer to express their opinions and discuss the latest news online.We have witnessed the positive influence of online social media,which helped citizens and governments track the development of this pandemic in time.It is necessary to apply artificial intelligence(AI)techniques to online social media and automatically discover and track public opinions posted online.In this paper,we take Sina Weibo,the most widely used online social media in China,for analysis and experiments.We collect multi-modal microblogs about COVID-19 from 2020/1/1 to 2020/3/31 with a web crawler,including texts and images posted by users.In order to effectively discover what is being discussed about COVID-19 without human labeling,we propose a unified multi-modal framework,including an unsupervised short-text topic model to discover and track bursty topics,and a self-supervised model to learn image features so that we can retrieve related images about COVID-19.Experimental results have shown the effectiveness and superiority of the proposed models,and also have shown the considerable application prospects for analyzing and tracking public opinions about COVID-19.

关键词： COVID-19 public opinion microblog topic model self-supervised learning

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Effect of Surface Mechanical Attrition Treatment on Tribological Behavior of the AZ31 Alloy

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Journal of Materials Science & Technology 2016年第12期32卷 1245-1252页

作者： Shuangwu Xia Yong Liu Dongming Fu bin jin Jian Lu Key Laboratory of Near Net Forming of Jiangxi Province Nanchang University Department of Mechanical and Biomedical Engineering City University of Hong Kong Centre for Advanced Structural Materials Shenzhen Research InstituteCity University of Hong Kong

By surface mechanical attrition treatment（SMAT）,a gradient nano structure（GNS） from the surface to center was generated in the AZ31 alloy sheet.The tribological behavior of AZ31 alloy with GNS was systematically investigated by using dry sliding tests,a 3D surface profile-meter and a scanning electron microscope equipped with an energy-dispersive spectrometer.The experimental results indicate that the Mg alloy with GNS exhibits better wear resistance comparing to the as-received sample,which is associated to the alteration of wear mechanism at different sliding speeds.The Mg alloy with GNS presents the wear mechanism of the abrasive wear at 0.05 m/s and the oxidative wear at 0.5 m/s,respectively.Moreover,the GNS can effectively promote the reaction between the oxygen and worn surface,which leads to a compact oxidation layer at 0.5 m/s.The effect of oxidation layer on the wear resistance of the Mg alloy was also discussed.

关键词： Magnesium alloy Surface mechanical attrition treatment Wear mechanism Oxidation layer

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Microstructure Evolution and Mechanical Properties of a SMATed Mg Alloy under In Situ SEM Tensile Testing

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Journal of Materials Science & Technology 2017年第3期33卷 224-230页

作者： Xiaowei Liu Yong Liu bin jin Yang Lu Jian Lu 1 CentreforAdvanced Structural Materials(CASM) Department of Mechanical and Biomedical EngineeringCity University ofHong KongKowloonHong KongChina Key Laboratory of Near Net Forming of Jiangxi Province Nanchang UniversityNanchang 330031China Shenzhen Research Institute City University of HongKongShenzhen 518057China

Surface mechanical attrition treatment（SMAT） has been recently applied to bulk polycrystalline magnesium（Mg） alloys with gradient grain size distribution from the impact surface to inside matrix, hence effectively improving the alloys＇ mechanical performances. However, in-depth understanding of their mechanical property enhancement and grain size-dependent fracture mechanism remains unclear. Here,we demonstrated the use of in situ micro-tensile testing inside a high resolution scanning electron microscope（SEM） to characterize the microstructure evolution, in real time, of SMATed Mg alloy AZ31 samples with different grain sizes of ~10 μm（＇coarse-grain sample＇） and ~5 μm（＇fine-grain sample＇）, respectively, and compared the results with those of a raw Mg alloy AZ31. The quantitative tensile tests with in situ SEM imaging clearly showed that fracture of ‘fine-grain sample＇ was dominated by intergranular cracks,while both trans-granular and intergranular cracks led to the final failure of the ‘coarse-grain samples＇.It is expected that this in situ SEM characterization technique, coupled with quantitative tensile testing method, could be applicable for studying other grain-refined metals/alloys, allowing to optimize their mechanical performances by controlling the grain sizes and their gradient distribution.

关键词： Surface mechanical attrition treatment（SMAT） Mg alloy Mechanical property In situ SEM Microstructure characterization

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深入学习领会习近平总书记重要讲话精神为奋力实现中国式现代化成都图景提供机构编制保障

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中国机构编制 2024年第3期 22-25页

作者：敬斌成都市委组织部成都市委编办

习近平总书记在二十届中央机构编制委员会第一次会议上发表重要讲话,系统总结党的十八大以来机构编制工作取得的重大成就和宝贵经验,对新时代机构编制工作高质量发展作出了重要部署,为新时代机构编制工作指明了前进方向、提供了根本遵... 详细信息

习近平总书记在二十届中央机构编制委员会第一次会议上发表重要讲话,系统总结党的十八大以来机构编制工作取得的重大成就和宝贵经验,对新时代机构编制工作高质量发展作出了重要部署,为新时代机构编制工作指明了前进方向、提供了根本遵循。成都市把学习贯彻习近平总书记重要讲话精神作为当前和今后一个时期的首要政治任务,深入学习领会,准确把握领悟,立足城市发展,强化机构编制使命担当,切实为推动高质量发展、创造高品质生活、实现高效能治理提供体制机制服务保障。

关键词：机构编制中国式现代化习近平总书记重要讲话精神党的十八大以来根本遵循高品质生活学习领会使命担当

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基于市域一体化卫生人才引进的实践探索

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中国医疗管理科学 2024年第3期14卷 52-56页

作者：金斌苏州市卫生人力资源管理服务中心江苏省苏州市215008

整合优质资源,加强市县联动,开展市域一体化卫生人才引进是卫生健康引才工作高质量发展的必然要求。文章阐明了苏州市对卫生人力资源的渴求和推进市域一体化引才的必要性,对苏州市卫生人才引进现状进行了分析,对标先进城市做法,从建立... 详细信息

整合优质资源,加强市县联动,开展市域一体化卫生人才引进是卫生健康引才工作高质量发展的必然要求。文章阐明了苏州市对卫生人力资源的渴求和推进市域一体化引才的必要性,对苏州市卫生人才引进现状进行了分析,对标先进城市做法,从建立全域引才工作体系、搭设招才引智平台、营造人才发展环境等方面进行一系列的实践探索,逐步打造富有苏州卫生健康行业特色的引才品牌,取得了明显的引才聚才成效,并提出今后要进一步提高市域一体化引才参与度、品质度、精准度的发展思路。

关键词：市域一体化卫生人才引进医疗资源苏州

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多轴数控加工技术在汽车零部件加工中的运用分析

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现代制造技术与装备 2024年第5期60卷 187-189页

作者：靳斌兰州航空职业技术学院兰州730070 兰州航空工业技工学校兰州730070

随着汽车工业的发展,零部件加工精度的要求不断提高,传统数控加工技术已经不能满足需求。多轴数控加工技术通过增加机床的自由度,能够实现更加复杂的加工操作。基于此,介绍多轴数控加工技术的基本原理,明确汽车零部件加工中多轴数控加... 详细信息

随着汽车工业的发展,零部件加工精度的要求不断提高,传统数控加工技术已经不能满足需求。多轴数控加工技术通过增加机床的自由度,能够实现更加复杂的加工操作。基于此,介绍多轴数控加工技术的基本原理,明确汽车零部件加工中多轴数控加工技术要点,分析多轴数控加工技术在汽车零部件加工中的应用情况。经过实践证明,多轴数控加工技术在汽车零部件加工中具有显著的应用优势,能够提高加工效率,降低加工成本,满足高加工精度的要求。

关键词：多轴数控加工技术汽车零部件加工精度加工效率

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