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Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect

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Bioactive Materials 2024年第12期42卷 85-111页

作者： Qinfeng Yang guihua liu Guanghao chen Guo chen Keyu chen Lei Fan Yuesheng Tu Jialan chen Zhanjun Shi Chuan chen Shubo liu Geyang Deng Xiaoqian Deng Chunhan Sun Xiaoyang li Shuofei Yang Shaowei Zheng bin chen Division of Orthopaedics and Traumatology Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Division of Orthopaedic Surgery Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Institute of Orthopaedics Huizhou Central People’s HospitalHuizhouGuangdong516008China Department of Orthopaedics The Second Hospital of JiaxingThe Second Affiliated Hospital of Jiaxing UniversityJiaxingZhejiang314000China Department of Obstetrics and Gynecology Core Facility CenterThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230001China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong510060China Department of Vascular Surgery The Quzhou Affiliated Hospital of Wenzhou Medical UniversityQuzhou People’s HospitalQuzhouZhejiang324000China Department of Vascular Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200127China Department of Sports Medicine and Rehabilitation Peking University Shenzhen HospitalShenzhenChina State Key Laboratory of Quality Research in Chinese Medicines Laboratory of Drug Discovery from Natural Resources and IndustrializationSchool of PharmacyMacao University of Science and TechnologyMacao999078China

Hemophilic articular cartilage damage presents a significant challenge for surgeons,characterized by recurrent intraarticular bleeding,a severe inflammatory microenvironment,and limited self-repair capability of cartilage ***,there is a lack of tissue engineering-based integrated therapies that address both early hemostasis,anti-inflammation,and long-lasting chondrogenesis for hemophilic articular cartilage ***,we developed an adhesive hydrogel using oxidized chondroitin sulfate and gelatin,loaded with exosomes derived from bone marrow stem cells(BMSCs)(Hydrogel-Exos).This hydrogel demonstrated favorable injectability,self-healing,biocompatibility,biodegradability,swelling,frictional and mechanical properties,providing a comprehensive approach to treating hemophilic articular cartilage *** adhesive hydrogel,featuring dynamic Schiff base bonds and hydrogen bonds,exhibited excellent wet tissue adhesiveness and hemostatic *** a pig model,the hydrogel could be smoothly injected into the knee joint cartilage defect site and gelled in situ under fluid-irrigated arthroscopic *** in vitro and in vivo experiments confirmed that the sustained release of exosomes yielded anti-inflammatory effects by modulating macrophage M2 polarization through the NF-κB *** immunoregulatory effect,coupled with the extracellular matrix components provided by the adhesive hydrogel,enhanced chondrogenesis,promoted the cartilage repair and joint function restoration after hemophilic articular cartilage *** conclusion,our results highlight the significant application potential of Hydrogel-Exos for early hemostasis,immunoregulation,and long-term chondrogenesis in hemophilic patients with cartilage *** innovative approach is well-suited for application during arthroscopic procedures,offering a promising solution for addressing the complex challenges associated with hemophilic articular cartilage damage.

关键词： Hemophilic articular cartilage defect Adhesive hydrogel Exosomes Anti-inflammation Chondrogenesis

The Source and Observation System of binchuan Earthquake Signal Transmitting Seismic Station and Its Preliminary Observation Results

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Earthquake Research in China 2016年第3期30卷 316-325页

作者： Wang bin li xiaobin liu Zifeng Yang Jun Yang Runhai Wang Baoshan Yang Wei Earthquake Administration of Yunnan Province Kunming 650224 China Institute of Geophysics CEA Beijing 100051 China

This paper summarizes the basic situation of the binchuan Transmitting Seismic Station and the geophysical observations of the area where it is located,with a focus on the constitution of the observation system of the transmitting seismic station,the excitation characteristics and propagation distance of signals excited by the airgun source in the reservoir and well. The paper also summarizes and discusses on the results of the observations and problems encountered since the Transmitting Seismic Station was ***,this paper proposes the main research to be carried out on the basis of the project aims.

关键词： Transmitting Seismic Station Active source Observation system

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氧化铝熟料溶出过程二次反应的热力学讨论

北京化工大学学报（自然科学版） 2007年第2期34卷 189-192,195页

作者：陈滨李小斌徐华军彭志宏刘桂华周秋生中南大学冶金科学与工程学院湖南长沙410083

对氧化铝熟料溶出过程涉及的二次反应进行了热力学计算和讨论。对原硅酸钙在铝酸钠溶液中的稳定性、硅酸钙与铝酸钠溶液的反应、水化石榴石与NaOH和Na2CO3作用和原硅酸钙水化反应分别进行了热力学分析。结果表明,原硅酸钙、硅酸钙在NaOH... 详细信息

对氧化铝熟料溶出过程涉及的二次反应进行了热力学计算和讨论。对原硅酸钙在铝酸钠溶液中的稳定性、硅酸钙与铝酸钠溶液的反应、水化石榴石与NaOH和Na2CO3作用和原硅酸钙水化反应分别进行了热力学分析。结果表明,原硅酸钙、硅酸钙在NaOH、Na2CO3和NaAl(OH)4这3种溶液成分中的稳定性是不同的;温度升高,NaOH、Na2CO3溶液分解水化石榴石的趋势变大,饱和系数较大的水化石榴石稳定性好于饱和系数较小的,水化石榴石在NaOH中的稳定性强于在Na2CO3溶液中的;低温下原硅酸钙最有可能水化成***2.1.17H2O和4CaO.3SiO2.1.5H2O。

关键词：熟料溶出二次反应机理热力学分析

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淀粉水热还原铬酸钠过程动力学研究

北京化工大学学报（自然科学版） 2009年第4期36卷 33-37页

作者：徐文彬李斌李小斌彭志宏刘桂华周秋生中南大学冶金科学与工程学院湖南长沙410083 中国铝业股份公司山东分公司山东淄博255051

为避免传统氧化铬工艺所产生的含铬副产物对环境的污染,本文提出了用淀粉水热还原铬酸钠生产氧化铬的新工艺。在对水热还原过程的反应规律及反应机理进行分析的基础上,对淀粉水热还原铬酸钠过程的动力学进行了研究,调查了影响六价铬还... 详细信息

为避免传统氧化铬工艺所产生的含铬副产物对环境的污染,本文提出了用淀粉水热还原铬酸钠生产氧化铬的新工艺。在对水热还原过程的反应规律及反应机理进行分析的基础上,对淀粉水热还原铬酸钠过程的动力学进行了研究,调查了影响六价铬还原转化率的因素。结果表明,反应温度、反应物浓度和反应时间是主要因素。选择等温、恒容、不可逆反应动力学模型来描述其反应过程,其动力学方程为:r=-d[Cr(Ⅵ)]/dt=1.367×1013 e(-100.566×1000)/RT[Cr(Ⅵ)][St],即指前因子、表观活化能和总反应级数分别为1.367×1013L/(mol·h)、100.566kJ/mol和二级或拟二级。该反应属化学反应控制,对Cr(Ⅵ)和淀粉均表现为一级或拟一级。

关键词：淀粉铬酸钠水热还原六价铬氧化铬动力学

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高比表面积氧化铝微粉从碱性废水中除氟

材料导报 2020年第4期34卷 20-24,55页

作者：张婷刘桂华陈斌斌齐天贵周秋生彭志宏李小斌中南大学冶金与环境学院

以合成的活性氧化铝微粉为吸附剂,研究了碱性含氟废水中pH值、初始氟浓度、吸附时间、氧化铝添加量等对除氟率和吸附容量的影响,讨论了其吸附机理。以铝酸钠溶液为原料,经氢氧化铝、丝钠铝石、碳酸铝铵和氧化铝等物相转化,制备了比表面... 详细信息

以合成的活性氧化铝微粉为吸附剂,研究了碱性含氟废水中pH值、初始氟浓度、吸附时间、氧化铝添加量等对除氟率和吸附容量的影响,讨论了其吸附机理。以铝酸钠溶液为原料,经氢氧化铝、丝钠铝石、碳酸铝铵和氧化铝等物相转化,制备了比表面积为409.03 m^2·g^-1的介孔氧化铝微粉。当pH值为7.0~9.4时,氧化铝微粉的除氟率较高。延长吸附时间、降低氟浓度或提高微粉加入量有利于提高除氟率。Zeta电位随溶液pH值的增大而减小,等电点为9.77。当pH值为8.1时,高比表面积、静电吸引、多层吸附是碱性条件下氧化铝微粉吸附容量大(9.28 mg·g^-1)、除氟率高(94.20%)的主要原因。同时,吸附也符合拟二级动力学模型,对氟的吸附受化学吸附控制。

关键词：活性氧化铝比表面积氟碱性溶液脱除

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均匀沉淀法制备单分散颗粒研究进展

无机盐工业 2006年第3期38卷 9-12页

作者：陈滨李小斌冯港涛彭志宏刘桂华周秋生中南大学冶金科学与工程学院湖南长沙410083

均匀沉淀法在制备单分散粒子的研究中占有重要的地位。首先分析了均匀沉淀反应的反应原理,然后综述了国内外该方法在制备单分散颗粒领域取得的进展,包括沉淀剂的选择、反应物料浓度及配比、反应时间、反应温度、表面活性剂等,最后还就... 详细信息

均匀沉淀法在制备单分散粒子的研究中占有重要的地位。首先分析了均匀沉淀反应的反应原理,然后综述了国内外该方法在制备单分散颗粒领域取得的进展,包括沉淀剂的选择、反应物料浓度及配比、反应时间、反应温度、表面活性剂等,最后还就该方法的优点和目前该领域存在的问题进行了阐述。

关键词：均匀沉淀法单分散颗粒沉淀剂

β-arrestin-2通过上调PI3K/Akt信号抑制自噬以减轻小鼠肝脏缺血-再灌注损伤

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器官移植 2020年第6期11卷 692-697页

作者：王励谌小龙刘慧玲周静杨逸冬李慧陈浩琦程道柔吴斌陈规划汪根树中山大学附属第三医院肝脏外科暨肝移植中心广州510630 中山大学附属第三医院消化内科广州510630 中山大学附属第三医院病理科广州510630

目的验证β-arrestin-2是否通过上调PI3K/Akt信号抑制自噬对小鼠肝脏缺血-再灌注损伤(IRI)发挥保护作用。方法将C57BL/6背景的β-arrestin-2基因敲除(KO)及野生型(WT)小鼠各12只,随机分为KO小鼠假手术组(KO+sham组),KO小鼠IRI组(KO+IRI... 详细信息

目的验证β-arrestin-2是否通过上调PI3K/Akt信号抑制自噬对小鼠肝脏缺血-再灌注损伤(IRI)发挥保护作用。方法将C57BL/6背景的β-arrestin-2基因敲除(KO)及野生型(WT)小鼠各12只,随机分为KO小鼠假手术组(KO+sham组),KO小鼠IRI组(KO+IRI组),WT小鼠假手术组(WT+sham组)和WT小鼠IRI组(WT+IRI组),每组各6只。分别建立70%肝脏IRI模型或进行假手术处理,于肝脏再灌注或手术后6 h进行相关研究。采用免疫组织化学(免疫组化)染色检测凋亡信号蛋白裂解半胱氨酸天冬氨酸蛋白酶3(cleaved Caspase-3)、增殖信号蛋白Ki-67及PI3K/Akt通路信号蛋白p-Akt的表达。结果免疫组化染色结果显示,与相应的sham组比较,KO+IRI组和WT+IRI组小鼠肝组织中的cleaved Caspase-3、Ki-67和p-Akt阳性细胞计数均增加(均为P<0.01);与WT+IRI组比较,KO+IRI组小鼠肝组织中cleaved Caspase-3阳性细胞计数增加,Ki-67和p-Akt阳性细胞计数均减少(均为P<0.05)。结论β-arrestin-2可减轻小鼠IRI后肝细胞凋亡、促进其损伤修复,其通过上调PI3K/Akt信号抑制自噬来减轻小鼠肝脏IRI。

关键词：肝脏缺血-再灌注损伤自噬 β-arrestin-2 基因敲除 PI3K/Akt信号免疫组织化学

Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists

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Intelligent Medicine 2022年第4期2卷 221-229页

作者： Longjiang Zhang Zhao Shi Min chen Yingmin chen Jingliang cheng li Fan Nan Hong Wenxiao Jia guihua Jiang Shenghong Ju Xiaogang li Xiuli li Changhong liang Weihua liao Shiyuan liu Zaiming Lu lin Ma Ke Ren Pengfei Rong bin Song Gang Sun Rongpin Wang Zhibo Wen Haibo Xu Kai Xu Fuhua Yan Yizhou Yu Yunfei Zha Fandong Zhang Minwen Zheng Zhen Zhou Wenzhen Zhu Guangming Lu Zhengyu Jin on behalf of Chinese Association of Radiologists Department of Radiology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002China Department of Radiology Beijing HospitalNational Center of GerontologyBeijing 100005China Department of Radiology Hebei General HospitalShijiazhuangHebei 050199China Department of Magnetic Resonance Imaging The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Medical Imaging and Nuclear Medicine Changzheng Hospital of Naval Medical UniversityShanghai 200072China Department of Radiology Peking University People’s HospitalBeijing 100044China Imaging Center First AffiliatedHospital of Xinjiang Medical UniversityUrumqiXinjiang Uygur Autonomous Region 830054China Department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhouGuangdong 510050China Department of Radiology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 211189China Department of Radiology General Hospital of Northern Theater CommandShenyangLiaoning 110011China DeepWise AI lab.Beijing 100089 China Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 519041China Department of Radiology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Radiology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Radiology Chinese PLA(People’s Liberation Army)General HospitalBeijing 100853China Department of Radiology Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361005China Department of Radiology Third Xiangya HospitalCentral South UniversityChangshaHunan 410013China Department of Radiology Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduSichuan 610044China Department of Nuclear Medicine 960 Hospital of PLAJi’nanShandong 250012China Department of Radiology Guizhou Provincial People’s Hosp

In recent years,with the development of artificial intelligence,especially deep learning technology,researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical ***,because of the complexity and flexibility of the deep learning algorithms,these researches have great variability on model building,validation process,performance description and results *** lack of a reliable,consistent,standardized design protocol has,to a certain extent,affected the progress of clinical translation and technology development of computer aided detection *** reviewing a large number of literatures and extensive discussion with domestic experts,this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular *** further research and application expansion,this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools.

关键词： Cerebrovascular diseases Deep learning Study design Medical imaging

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芳纶纸力学性能调控及应用研究进展

中国造纸 2024年第8期43卷 81-93页

作者：王舜柯李金鹏李永锋常小斌刘金科王斌王铁军陈克复广东工业大学轻工化工学院广东广州530001 华南理工大学轻工科学与工程学院制浆造纸国家重点实验室广东广州510640 赣州龙邦材料科技有限公司江西省芳纶材料科学与工程技术创新中心江西赣州341900

芳纶纸是一种具有优异耐热性、耐腐蚀性和耐磨性的新型高性能纸基材料,被广泛应用于航空航天、国防、信息技术、能源和环保等重要领域。本文综述了近年来芳纶纸的改性方法及芳纶纸力学性能调控技术,分析了不同改性方法对芳纶纸力学性能... 详细信息

芳纶纸是一种具有优异耐热性、耐腐蚀性和耐磨性的新型高性能纸基材料,被广泛应用于航空航天、国防、信息技术、能源和环保等重要领域。本文综述了近年来芳纶纸的改性方法及芳纶纸力学性能调控技术,分析了不同改性方法对芳纶纸力学性能的影响规律,总结了芳纶纸的增强增韧机制,旨在为芳纶纸力学性能优化研究提供参考。同时进一步介绍了芳纶纸的应用研究进展,并对芳纶纸未来发展趋势及面临的挑战进行了展望。

关键词：芳纶纸芳纶纤维力学性能调控应用

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