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Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3335-3336页

作者： bin lu Jianpin Ye The Second Affiliated Hospital Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China Protein Quality Control and Diseases Laboratory School of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou 450000China

Proteostasis(protein homeostasis) ensures precise adjustment of cellular demand to proteins in the stress conditions, which is essential in the maintenance of health environment inside cells and is indispensable for t... 详细信息

关键词： Proteostasis Protein degradation Drug discovery Autophagy E3 ligase Ubiquitination Drug resistance Off-target effect Tissue specificity

An Improved Model of the Jovian Magnetosphere

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Chinese Physics Letters 2014年第3期31卷 184-186页

作者： lu bin CHEN Chu-Xin Key Laboratory of Geospace Environment Department of Geophysics and Planetary Sciences School of Earth and Space Sciences University of Science and Technology of China Hefei 230026

The Jovian magnetosphere is modulated by the solar wind and centrifugal force. The configuration of the magnetic field in the previous model of the magnetosphere including the centrifugal force is consistent with the observations at low magnetic latitude （Λ〈50°）, while there is a substantial difference between the results of the model and the observations at high magnetic latitude （Λ≥50°）, especially in the distant magnetotail. Based on the previous model, a new configuration of the Jovian magnetosphere in the night side is suggested by a three-step transformation in this study. The new magnetosphere obtained by the transformation method is flattened in the z-direction and stretched in the x-direction in distant magnetotail, which agree with general knowledge.

关键词： Magnetosphere

Single-factor analysis and interaction terms on the mechanical and microscopic properties of cemented aeolian sand backfill

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International Journal of Minerals,Metallurgy and Materials 2023年第8期30卷 1584-1595页

作者： Shushuai Wang Renshu Yang Yongliang Li bin Xu bin lu School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Energy and Mining Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The use of aeolian sand(AS)as an aggregate to prepare coal mine cemented filling materials can resolve the problems of gangue shortage and excessive AS *** to the lack of research on the mechanism of cemented AS backfill(CASB),the response surface method(RSM)was adopted in this study to analyze the influence of ordinary Portland cement(PO)content(x_(1)),fly ash(FA)-AS(FA-AS)ratio(x_(2)),and concentration(x_(3))on the mechanical and microscopic properties of the *** hydration characteristics and internal pore structure of the backfill were assessed through thermogravimetric/derivative thermogravimetric analysis,mercury intrusion porosimetry,and scanning electron *** RSM results show that the influence of each factor and interaction term on the response values is extremely significant(except x_(1)x_(3),which had no obvious effect on the 28 d strength).The uniaxial compressive strength(UCS)increased with the PO content,FA-AS ratio,and *** interaction effects of x_(1)x_(2),x_(1)x_(3),and x_(2)x_(3) on the UCS at 3,7,and 28 d were *** terms of the influence of interaction items,an improvement in one factor promoted the strengthening effect of another *** enhancement mechanism of the curing time,PO content,and FA-AS ratio on the backfill was reflected in the increase in hydration products and pore structure *** contrast,the enhancement mechanism of the concentration was mainly the pore structure *** UCS was positively correlated with weight loss and micropore content but negatively correlated with the total *** R^(2) value of the fitting function of the strength and weight loss,micropore content,and total porosity exceeded 0.9,which improved the characterization of the enhancement mechanism of the UCS based on the thermogravimetric analysis and pore *** work obtained that the influence rules and mechanisms of the PO,FA-AS,concentration,and interaction terms on the mechanic

关键词： cemented aeolian sand backfill response surface method mechanical properties microscopic properties influence mechanism

A Modeling Language Based on UML for Modeling Simulation Testing System of Avionic Software

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Chinese Journal of Aeronautics 2011年第2期24卷 181-194页

作者： WANG Lize LIU bin lu Minyan Department of Project Systems Engineering Beihang University Beij ing 100191 China

With direct expression of individual application domain patterns and ideas,domain-specific modeling language（DSML） is more and more frequently used to build models instead of using a combination of one or more general *** on the profile mechanism of unified modeling language（UML） 2.2,a kind of DSML is presented to model simulation testing systems of avionic software（STSAS）.To define the syntax,semantics and notions of the DSML,the domain model of the STSAS from which we generalize the domain concepts and relationships among these concepts is given,and then,the domain model is mapped into a UML meta-model,named UML-STSAS *** a flight control system（FCS） as system under test（SUT）,we design the relevant *** results indicate that extending UML to the simulation testing domain can effectively and precisely model STSAS.

关键词： avionics hardware-in-the-loop test facilities meta-model UML profile domain-specific modeling language abstract state machine

Application of Extended Projective Riccati Equation Method to(2+1)-Dimensional Broer-Kaup-Kupershmidt System

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Communications in Theoretical Physics 2008年第10期50卷 814-820页

作者： lu bin ZHANG Hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116023 China

In this paper, extended projective Riccati equation method is presented for constructing more new exact solutions of nonlinear differential equations in mathematical physics, which is direct and more powerful than projective Riccati equation method. In order to illustrate the effect of the method, Broer Kaup Kupershmidt system is employed and Jacobi doubly periodic solutions are obtained. This algorithm can also be applied to other nonlinear differential equations.

关键词： nonlinear- partial differential equations extended projective Riccati equation method exact solutions Broer- Kaup Kupershmidt system

Designing a Secure Round Function Based on Chaos

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China Communications 2020年第5期17卷 29-37页

作者： bin lu Xin Ge Fenlin Liu Zhengzhou Information Science and Technology Institute Zhengzhou 45000China Henan Key Laboratory of Network Cryptography Technology Zhengzhou 45000China

A round function based on chaos is designed combining Feistel structure’s pseudo-randomness, chaotic system’s parameter sensitivity and image data characteristics. The round function composes of two parts--data transformation based on Feistel(abbreviated as FST) and sampling output based on chaos(abbreviated as SMP). FST bases on Feistel structure and several efficient operations including bitwise xor, permutation and circulating shift. SMP is a chaos based pseudo-random sampling algorithm. It is from theoretical analysis that the round function is a pseudo-random function. The upper bounds of the average maximum differential probability and average maximum linear probability are p^2 and q^2 respectively. Finally, the good pseudo-randomness of the round function is examined with the NIST random test. The design of this round function provides an important cryptographic component for the design of chaotic image encryption algorithm.

关键词： image encryption round function chaos pseudo-random function

Stability margin of uncertain control systems

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控制理论与应用（英文版） 2009年第4期7卷 427-432页

作者： bin lu Qinghe WU Department of Automatic Control Beijing Institute of Technology Beijing 100081 China

Achieving stability is the essential issue in the control system design. In this paper, four approaches that can be used to calculate the stability margin of the interval plant family are summarized and compared. The μ approach gives the bounds of the stability margin, and good estimation can be obtained with the numerical method. The eigenvalue approach yields accurate value, and the MATLAB＇s function robuststab sometimes provides wrong results. Since the eigenvalue approach is both accurate and computationally efficient, it is recommended for the calculation of the stability margin, while utilization of the function robuststab should be avoided due to the unreliable results it gives.

关键词： Interval plant family Stability margin Stability radius MATLAB's function robuststab

Helicobacter pylori eradication for preventing gastric cancer

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World Journal of Gastroenterology 2014年第19期20卷 5660-5665页

作者： bin lu Meng Li Department of Gastroenterology the First Affiliated Hospital of Zhejiang Chinese Medical University

Helicobacter pylori(***)infection is a major riskfactor for gastric cancer(GC)development,which isone of the most challenging malignant diseases worldwide with limited *** the multistep pathogenesis of GC,*** infection slowly induces chronicactive gastritis,which progresses through the premalignant stages of atrophic gastritis,intestinal metaplasia,and dysplasia,and then finally to *** eradication of *** is a reasonable approach for the prevention of GC,there have been some contradictory reports,with only some long-term follow-up data showingefficacy of this *** inconsistencies are likely due to the insufficient number of participants,relatively short follow-up periods,poor quality of study designs,and the degree and extent of preneoplastic changes atthe time of *** *** review analyzesrecent high-quality studies to resolve the discrepancies regarding the eradication of *** for GC *** relationship between *** eradication and GC/precancerous lesions/metachronous GC is examined,and the cost-effectiveness of this strategy in the prevention of GC is *** it is assumed that eradication of *** has the potential to prevent GC,the feasibility and appropriate timing of this strategy for cancer prevention remain to be *** a result,additional well-designed trials with longer followup periods are needed to clarify this issue.

关键词： Helicobacter pylori Gastric cancer Cancer prevention

Production and characterization of highly transparent novel magneto-optical Ho_(2)Zr_(2)O_(7) ceramics with anion-deficient fluorite structures

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Journal of Materials Science & Technology 2023年第19期150卷 217-224页

作者： Liangbin Hu bin lu Bowen Xue Shixun Dai School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

Based on material design idea,we employ a co-precipitation strategy to obtain sinterable Ho_(2)Zr_(2)O_(7) flu-orite particles,successfully leading to novel transparent Ho_(2)Zr_(2)O_(7) ceramics with good optical/magneto-optical *** resulting precipitation precursor is identified to be hydrated basic carbonate upon calcination at the optimum temperature of 1250℃into near-spherical Ho_(2)Zr_(2)O_(7) nanopowder with an average size of~64 nm and unimodal narrow size *** crystal intrinsic oxygen defect in fluorite ceramic generally exists in the form of F+*** best bulk specimen achieved in this work exhibits a high refractive index of~2.1 and a high transparency of~74.4%at 1000 nm comparable with the corresponding defect-free single crystal(~76.4%in theory).In the Ho_(2)Zr_(2)O_(7) structure system,the elec-tronic polarizability of O_(2)-anion generally remains constant around 2.2?3 in the visible region and the corresponding optical basicity is approximately *** developed magneto-optical transparent Ho_(2)Zr_(2)O_(7) ceramic has Verdet constants of-180±3,-157±5,-87±2,-54±2,and-43±2 rad T^(-1) m^(-1) at 515,635,780,980,and 1064 nm,respectively,which are roughly 1.2-fold higher than the commercial TGG crystal.

关键词： Transparent ceramics Ho_(2)Zr_(2)O_(7) Magneto-optical ceramics Fluorite Optical properties