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APACHE system is better than Ranson system in the prediction of severity of acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 294-299页

作者： Yuk Pang yeung billy yeung kit lam Andrew Wai Chun Yip Department ot Surgery Kwong Wah Hospital 25 Waterloo Road Kowloon Hong Kong China

BACKGROUND: It has been suggested that addition of obesity score to the APACHE-Ⅱ system can lead to more accurate prediction of severity of acute pancreatitis. However there is scanty information on the usefulness of the combined APACHE-O scoring system in Asian patients. This study aimed to compare the accuracy of Ranson, APACHE-Ⅱ and APACHE-O systems in assessing severity of acute pancreatitis in a local Chinese population. METHODS: One hundred and one consecutive patients with acute pancreatitis were prospectively studied. Body mass index (BMI) was measured on admission. Ranson score, APACHE-Ⅱ and APACHE-O scores were recorded on admission and at 48 hours. By adopting the cut-off levels and definitions advocated in the Atlanta consensus for severe disease, the diagnostic accuracy of the three scoring systems was compared by the area under the curve (AUC) under the receiver operator characteristic curve. RESULTS: Of the 101 patients, 12 (11.9%) patients suffered from severe pancreatitis. Obesity was uncommon and only two patients (2.0%) had BMI >30. Eighty-two (81.2%) patients were normal weight (BMI≤25) whereas 17 (16.8%) were overweight ( BMI 25-30 ). Overweight or obesity (BMI >25) was not associated with severe pancreatitis (P= 0.40). The AUC for admission scores of Ranson, APACHE-Ⅱ, and APACHE-O systems was 0. 549, 0. 904 and 0. 904, respectively. The AUC for 48-hour scores of Ranson, APACHE-Ⅱ and APACHE-O systems was 0.808, 0.955 and 0.951, respectively. CONCLUSIONS: The APACHE-Ⅱ scoring system is more accurate than the Ranson scoring system of the prediction of severity in acute pancreatitis. Addition of obesity score does not significantly improve the predictive accuracy of the APACHE-Ⅱ system in our local population with a low prevalence of obesity.

关键词： acute pancreatitis APACHE-Ⅱ score APACHE-O score disease severity Ranson score

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View-Aware Image Object Compositing and Synthesis from Multiple Sources

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Journal of Computer Science & Technology 2016年第3期31卷 463-478页

作者： Xiang Chen Wei-Wei Xu Sai-kit yeung Kun Zhou State Key Laboratory of Computer Aided Design and Computer Graphics Zhejiang University Hangzhou 310058 China Vision Graphics and Computational Design Group Singapore University of Technology and Design Singapore 487372 Singapore

Image compositing is widely used to combine visual elements from separate source images into a single image. Although recent image compositing techniques are capable of achieving smooth blending of the visual elements from different sources, most of them implicitly assume the source images are taken in the same viewpoint. In this paper, we present an approach to compositing novel image objects from multiple source images which have different viewpoints. Our key idea is to construct 3D proxies for meaningful components of the source image objects, and use these 3D component proxies to warp and seamlessly merge components together in the same viewpoint. To realize this idea, we introduce a coordinate- frame based single-view camera calibration algorithm to handle general types of image objects, a structure-aware cuboid optimization algorithm to get the cuboid proxies for image object components with correct structure relationship, and finally a 3D-proxy transformation guided image warping algorithm to stitch object components. We further describe a novel application based on this compositing approach to automatically synthesize a large number of image objects from a set of exemplars. Experimental results show that our compositing approach can be applied to a variety of image objects, such as chairs, cups, lamps, and robots, and the synthesis application can create novel image objects with significant shape and style variations from a small set of exemplars.

关键词： image cloning 3D proxy probabilistic modeling data-driven method

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Population Dynamics in an Advective Environment

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Communications on Applied Mathematics and Computation 2024年第1期6卷 399-430页

作者： King-yeung lam Ray Lee Yuan Lou Department of Mathematics The Ohio State UniversityColumbusOH43210USA School of Mathematical Sciences CMA-Shanghai and MOE-LSCShanghai Jiao Tong UniversityShanghai200240China

We consider a one-dimensional reaction-diffusion equation describing single-and two-species population dynamics in an advective environment,based on the modeling frameworks proposed by Lutscher et *** *** analyze the effect of rate of loss of individuals at both the upstream and downstream *** the single-species case,we prove the existence of the critical domain size and provide explicit formulas in terms of model *** further derive qualitative properties of the critical domain size and show that,in some cases,the critical domain size is either strictly decreasing over all diffusion rates,or monotonically increasing after first decreasing to a *** also consider competition between species differing only in their diffusion *** two species having large diffusion rates,we give a sufficient condition to determine whether the faster or slower diffuser wins the *** also briefly discuss applications of these results to competition in species whose spatial niche is affected by shifting isotherms caused by climate change.

关键词： Reaction-diffusion-advection Critical domain size Competition Climate change

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LARGE-EDDY SIMULATION OF FLOW AROUND CYLINDER ARRAYS AT A SUBCRITICAL REYNOLDS NUMBER

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Journal of Hydrodynamics 2008年第4期20卷 403-413页

作者： ZOU Lin LIN Yu-feng lam kit School of Mechanical and Electronic Engineering Wuhan University of Technology Wuhan 430070 China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China

The complex three-dimensional turbulent flows around a cylinder array with four cylinders in an in-line square configuration at a subcritical Reynolds number of 1.5 × 10^4 with the spacing ratio at L/D = 1.5 and 3.5 were investigated using the Large Eddy Simulation （LES）. The full field vorticity and velocity distributions as well as turbulent quantities were calculated in detail and the near wake structures were presented. The results show that the bi-stable flow nature was observed at L/D = 1.5 and distinct vortex shedding of the upstream cylinders occurred at L/D = 3.5 at Re = 1.5 × 10^4. The techniques of Laser Doppler Anemometry （LDA） and Digital Particle Image Velocimetry （DPIV） are also employed to validate the present LES method. The results show that the numerical predictions are in excellent agreement with the experimental measurements. Therefore, the full field instantaneous and mean quantities of the flow field, velocity field and vorticity field can be extracted from the LES results for further study of the complex flow characteristics.

关键词： four-cylinders array turbulent flow Large Eddy Simulation (LES) Laser Doppler Anemometry (LDA) Digital Particle Image Velocimetry (DPIV)

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Dipyridyl Azo Compound 4,4'-Azopyridine as a Potential Coating Material for Toilet Sanitizer

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Chemical Research in Chinese Universities 2023年第6期39卷 864-869页

作者： WANG Qiwei JIANG Lu lam Pik-Ling CHUI Chung-Hin WONG Wai-yeung Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsChengdu UniversityChengdu 610052P.R.China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong KongP.R.China Research and Development Division One Health International LimitedHong KongP.R.China

Good toilet hygiene can reduce the risk of pathogenic *** flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet *** coli(***)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet *** this study,we investigated the potential *** activity of some azobenzene *** them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on ***,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/*** 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular *** further examined the potential cytotoxicity of compound 2 to the human skin HaCaT *** 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/***,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of ***.

关键词： Antibacterial Azobenzene Escherichia coli Skin cytotoxicity Toilet seat

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Optimization and evaluation of reduced graphene oxide hydrogel composite as a demulsifier for heavy crude oil-in-water emulsion

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Chinese Journal of Chemical Engineering 2021年第5期34卷 297-305页

作者： Kin kit Fong Inn Shi Tan Henry Chee Yew Foo Man Kee lam Adrian Chiong Yuh Tiong Steven Lim Department of Petroleum Engineering Faculty of Engineering and ScienceCurtin UniversityCDT 25098009 MiriSarawakMalaysia Department of Chemical Engineering Faculty of Engineering and ScienceCurtin UniversityMiri 98009Malaysia Chemical Engineering Department Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingUniversiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanKajang 43000Malaysia Centre for Photonics and Advanced Materials Research Universiti Tunku Abdul RahmanKajang 43000Malaysia

The rising production of produced water from oilfields had been proven to bring detrimental environmental *** this study,an efficient,recyclable,and environmental-friendly reduced graphene oxide immobilizedκ-Carrageenan hydrogel composite(κCaGO)was fabricated as an alternative sorbent for crude oil-in-water ***(PEI)was employed to form a stable hydrogel *** conditions for the immobilization of graphene oxide(GO)on PEI-modifiedκ-Carrageenan(κC)beads were optimized *** immobilization yield of 77%was attained at 2%PEI,2 h immobilization activation time,and pH ***,the synthesizedκCaGO is capable of demulsification with an average demulsification efficiency of 70%.It was found that the demulsification efficiency increases with salinity andκCaGO dosage,and it deteriorates under alkaline *** phenomena can be attributed to the interfacial interactions betweenκCaGO and the ***,theκCaGO can be recycled to use for up to six cycles without significant leaching and *** such,the synthesizedκCaGO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water.

关键词： Graphene oxide κ-Carrageenan Adsorbents Demulsification Composites Waste water

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Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy

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Science China(Life Sciences) 2015年第6期58卷 521-530页

作者： LIU Jin yeung Patrick Ka kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim Department of Anatomy Li Ka Shing Faculty of Medicine The University of Hong Kong Department of Ophthalmology Li Ka Shing Faculty of Medicine The University of Hong Kong Research Centre of Heart Brain Hormone and Healthy Aging Li Ka Shing Faculty of Medicine The University of Hong Kong Division of Science and Technology United International College Zhuhai 519085 China State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong

Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac 1 and Epac2, are cAMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion （tMCAO） was performed on Epacl-deficient （Epacl-/- ） mice, Epac2-deficient （Epac2-/-） mice, and their wild type counter-parts （Epacl＋/＋ and Epac2＋/＋）. Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After tMCAO, the contralateral retinae displayed similar morphology between different genotypes. Neu-ronal loss, retinal edema and increase in immunoreactivity for aquaporin 4 （AQP4）, glial fibrillary acidic protein （GFAP）, peroxiredoxin 6 （Prx6） were observed in ipsilateral retinae. Epac2 / ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2＋/＋. However, Epacl-/- ipsilateral retinae displayed similar pathology as those in Epacl＋/＋ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury.

关键词： Epac retina ischemia retinopathy

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A cyanostilbene-based molecule with aggregation-induced emission properties: amplified spontaneous emission, protonation effect and electroluminescence

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Science China Chemistry 2019年第2期62卷 212-219页

作者： Yujie Dong Suqian Ma Xiaoyu Zhang Jingyu Qian Nianyong Zhu Bin Xu Cheuk-lam Ho Wenjing Tian Wai-yeung Wong Institute of Molecular Functional Materials and Department of Chemistry Hong Kong Baptist University State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology College of Chemical Engineering Zhejiang University of Technology State Key Laboratory of Supramolecular Structure and Materials Jilin University Department of Applied Biology & Chemical Technology The Hong Kong Polytechnic University

A terpyridine-substituted cyanostilbene derivative(Z)-2-(4′-([2,2′:6′,2″-terpyridin]-4′-yl)-[1,1′-biphenyl]-4-yl)-3-phenylacrylonitrile(CNSTPy) was synthesized and characterized. The compound exhibits remarkable aggregation-induced emission phenomenon and its single crystal shows a blue emission with fluorescent efficiency as high as 45%. Based on its aggregation state behavior, multiple applications towards exploring its lasing, fluorescence switching and electroluminescence properties were realized. Amplified spontaneous emission(ASE) was observed from the crystal and verified by the variable pump strip method, with a threshold value of ～1.5 m J cm^(-2). The protonation/deprotonation processes accompanied by the formation of different molecular aggregation structure result in the distinct blue and yellow emissions. Additionally, the molecule also shows a moderate electroluminescence performance.

关键词： aggregation-induced emission cyanostilbene amplified spontaneous emission protonation effect

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Chinese medicine practitioner turnover rate and the development of Chinese medicine in Hong Kong,China

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Journal of Traditional Chinese Medical Sciences 2021年第2期8卷 145-149页

作者： Ka-kit Chua Vivien Lau Wing-Yan Lee Chun-Pong lam School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Sin-Hua Herbalist's&Herb Dealer's Promotion Society Limited Hong KongChina Alumni Association of Full-time Chinese Medicine Undergraduate Hong Kong Baptist UniversityHong KongChina

Objective:To establish that the Hong Kong Special Administrative Region(HKSAR)government is actively promoting Chinese medicine(CM)and to examine turnover rate of Chinese medicine practitioners(CMPs)in Hong Kong,China in light of this governmental ***:This study covered two major areas:reviewing CM development in Hong Kong,and assessing the turnover rate of CMPs in Hong *** first part of the paper is a historical *** investigation of turnover rate had two *** 1,quantitative method,involved online questionnaires;Section 2,qualitative method comprised interviews with CMPs from different types of CM clinics to ascertain the reasons for the turnover among ***:A total of 123 online questionnaires were received in Section 1(55 from male CMPs;66 from female CMPs;2 respondents were unwilling to disclose their sex).The proportion of CMPs who had resigned in 2018e19 was 22.8%(28),of whom 5.7%(7)had resigned twice in one *** rates of resignation in 3 years and 5 years were up to 40.7%(50)and 56.9%(70),*** CMPs were interviewed in Section *** CMPs were more likely to resign than *** large gap between actual salary and expectations appeared to be the main reason for the high rate of ***:HKSAR government keenly desires to promote CM in Hong Kong,however,high turnover rate of CMPs was detected even under this positive governmental *** is an urgent need to conduct a more representative study of the reasons for the inclination of CMPs in Hong *** study highlights an important issue in CM development,and these results should remind different stakeholders in the CM industry and the government that CMPs need better career prospects and support in various areas.

关键词： Chinese medicine development Chinese Medicine Turnover rate Hong Kong SAR Career prospect Salary

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Appended corrole manganese complexes:Catalysis and axial-ligand effect

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Chinese Chemical Letters 2014年第4期25卷 571-574页

作者： Nga-Chun Ng Mian HR Mahmood Chi-K.Chang Hai-Yang Liu Fei Yam lam-Lung yeung Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis Hong Kong University of Science and Technology Department of Chemistry South China University of Technology Department of Chemistry Michigan State University Chi-K.Changa

A series of N-base appended corroles and their manganese complexes were synthesized and their binding constants with three different nitrogenous ligands, triethylamine, N-methylimidazole and pyridine, were evaluated by spectroscopy. Kinetic studies indicated that the presence of appended N- donor ligands may cause a significant enhancement of the rate of oxygen atom transfers （OAT） from （oxo）manganese（V） corrole to alkene, and the stronger axial ligand binding has impact on the rate of the oxidation reaction. Turnover frequency （TOF） for the catalytic oxidation of alkenes by appended manganese corroles varies with the following ligand order： acetamido 〈 pyridyl 〈 imidazolyl. The influence of the external axial ligands on the catalytic epoxidation was investigated by using appended acetamido manganese corrole as catalyst, with the results revealing that N-methylimidazole gave the best enhancement on the yields of total oxidation products among the investigated nitrogenous ligands.

关键词： Manganese Corrole Catalysis Axial-ligand Oxygen atom transfer

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