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老年人脑血管疾病处理方面的争议

前卫医学情报 1993年第3期9卷 90-91页

作者： biller,j 任国铨

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老年脑血管病的治疗必需个体化

国外医学（老年医学分册） 1993年第4期14卷 162-164页

作者： biller j 戴富林

本文用典型病例分析的方法,讨论了老年人几种常见脑血管病的处理原则,并对目前仍有争论的不同意见进行对比。作者认为,个体化治疗是老年脑血管病处理中最基本的原则。

关键词：脑血管疾病老年性个体化

ABNORMAL CEREBRAL VASCULAR AU- TOREGULATION IN GLAUCOMA

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国际眼科杂志 2003年第1期3卷 110-110页

作者： D.Zarfati j.biller C.W.Sheets E.Rechtman Indiana Universtiy School of Medicine IN USAIndiana Universtiy School of Medicine IN USAIndiana Universtiy School of Medicine IN USAIndiana Universtiy School of Medicine IN USA

Introduction: There is evidence that glaucoma patients may suffer from hemodynamic deficits beyond the ocular vasculature. We, therefore, compared the response of ocular and cerebral blood flow velocities to hyperoxia in glaucoma patients versus age-matched controls. Methods: Middle cerebral (MCA) and ophthalmic artery (OA) blood flow velocities were measured

关键词：青光眼病理疾病进展脑血流脑血管自动调节失常

Mechanism of Action of Low Dose Preparations from Coffea arabica, Gelsemiumand VeratrumBased on in Vivoand in VitroNeurophysiological Findings

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journal of Behavioral and Brain Science 2015年第9期5卷 368-380页

作者： Wilfried Dimpfel Andreas biller NeuroCode AG Wetzlar Germany Dr. Loges + Co. GmbH Winsen/Luhe Germany

Low dose remedies are widely administered in medicine. We used Tele-Stereo-EEG and the hippocampal slice preparation to measure physiological effects of orally given Coffea D6 (40 mg/kg), Gelsemium D4 (10 mg/kg) and Veratrum D6 (30 mg/kg) in rats. Adult rats were implanted with electrodes positioned stereotactically into four brain regions. Changes in field potentials were transmitted wirelessly. After frequency analysis data from 6 - 8 animals were averaged. For in vitro testing, preparations were superfused directly on hippocampal slices. Stimulation of Schaffer Collaterals by single stimuli (SS) or theta burst stimulation (TBS) resulted in stable population spike amplitudes. All three low dose preparations produced decreases of spectral power. Statistically significant changes were observed in delta, theta and alpha2 spectral power. In the hippocampal slice preparation Coffea facilitated signal transfer presumably by enhancing glutamate AMPA receptor transmission. Gelsemium showed a similar effect, but only after single shock stimulation. Opposite to this, attenuation of the electric pathway was recognized after theta burst stimulation due to AMPA receptor and glutamate metabotropic II receptor mediated transmission. Veratrum was able to attenuate glutamatergic due to receptor-mediated signalling sensitive to AMPA and NMDA. The results strongly speak in favour of the existence of biologically active molecules in these low dose preparations.

关键词： Neurophysiology Rat Gelsemium sempervirens Veratrum album Coffea arabica Electropharmacogram Hippocampus Slice

Psychophysiological Effects of Sideritis and Bacopa Extract and Three Combinations Thereof—A Quantitative EEG Study in Subjects Suffering from Mild Cognitive Impairment (MCI)

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Advances in Alzheimer's Disease 2016年第1期5卷 1-22页

作者： Wilfried Dimpfel Leonie Schombert Andreas biller justus-Liebig-University Giessen Giessen Germany Neuro Code AG Wetzlar Germany Dr. Loges GmbH Winsen Germany

Mild cognitive impairment (MCI) is regarded as a transitional stage during the development of Alzheimer’s disease. Diagnosis of MCI can be obtained by the questionnaire “DemTect” in German speaking countries. Quantitative assessment has been successfully performed using psychometric testing concomitantly with quantitative EEG recording. The present investigation aimed at the possible treatment of MCI with two botanicals, namely extracts from Sideritis scardica (500 mg) or Bacopa monnieri (320 mg) and three combinations thereof using this method in order to find a new treatment. The performance of the d2-test, an arithmetic calculation test (CPT) and a memory-test revealed better performance for the d2-test only in the presence of Sideritis extract or the combinations with Bacopa extract. Quantitative EEG assessment during the different experimental conditions showed massive differences between both extracts. Whereas Sideritis extract and its combination with a low amount of Bacopa extract (160 mg) induced increases of spectral power in fronto-temporal brain areas, Bacopa and the combination of Sideritis with high amounts of Bacopa extract produced attenuation of all waves except for delta in fronto-temporal brain areas. These differences were also documented by quantitative EEG maps in comparison to Placebo. A different action of both extracts was confirmed by discriminant analysis, where Sideritis extract and its combination with low Bacopa grouped together quite at distance to Bacopa and the combination of Sideritis with high Bacopa. A combination of Sideritis extract with a low amount of Bacopa should be tested with daily repetitive dosing for at least 4 weeks as a consequence.

关键词： DemTect Cognition Psychometry EEG Source density Mild Cognitive Impairment (MCI) Alzheimer’s Disease CATEEM Sideritis Bacopa

Psychophysiological Effects of a Combination of Sideritis and Bacopa Extract (memoLoges^®) in 32 Subjects Suffering from Mild Cognitive Impairment. A Double-Blind, Randomized, Placebo-Controlled, 2-Armed Study with Parallel Design

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Advances in Alzheimer's Disease 2016年第3期5卷 103-125页

作者： Wilfried Dimpfel Andreas biller Samir Suliman Gwladys N. Chiegoua Dipah justus-Liebig-University Giessen Germany Dr. Loges + Co. GmbH Winsen Germany NeuroCode AG Wetzlar Germany

Mild cognitive impairment (MCI) can be regarded as a non-demented transitional stage during the development of Alzheimer’s disease. Early recognition of this stage might increase the chance of prevention by early treatment. Within a pilot study, two plant-derived preparations and mixtures thereof were tested successfully in subjects suffering from MCI. A combination of Sideritis scardica and Bacopa monnieri extract (memoLoges®) was chosen now for a repetitive dosing during 4 weeks. Thirty-two subjects aged 50 to 80 years and suffering from MCI (having a DemTect questionnaire score between 8 and 13) were recruited for intake of 2 capsules of the preparation per day. Quantitative EEG recording during relaxation and concomitant performance of three 5 minutes lasting psychometric tests (d2-concentration test, arithmetic calculation test and memory test) was achieved at the first day and one day after the last repetitive intake. Seventeen channels of EEG and one channel EOG (for artefact rejection) were recorded. After frequency analysis (FFT) current source density was calculated as reported earlier. One, two and three hours after intake of the herbal extract or placebo the whole procedure was repeated. Brain imaging was achieved by conversion of numerical values of spectral EEG power into spectral colors and additive color mixture according to RGB as used in TV settings. Intake of memoLoges® induced a trend of improvement of performance in psychometric testing (all three tests). During relaxation quantitative assessment of EEG data revealed attenuation of delta and theta spectral power in frontal brain as likewise reported in the presence of the Alzheimer drug rivastigmine, bringing the spectrum back to “normality”. During mental work memoLoges® induced statistically significant increases of beta power. Since MCI subjects produce less beta power in comparison to healthy subjects, this increase must likewise be seen as a positive effect

关键词： Sideritis scardica Bacopa monnieri EEG Source Density Spectral Power Mild Cognitive Impairment memoLoges® Psychophysiology CATEEM®