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Location m.tters: The role of TRPV4/calm.dulin m.diated AQP4 translocation in hum.n astrocyte in response to hypoxia and m.ld therapeutic hypotherm.a

Location matters: The role of TRPV4/calmodulin mediated AQP4...

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中国神经科学学会第十二届全国学术会议

作者： m.otaz Salm.n Philip Kitchen Roslyn m.bill Alex C.Conner m.Nicola Woodroofe m.tthew T.Conner Biom.lecular Sciences Research Centre (Bm.C) Sheffield Hallam University m.lecular Assem.ly and Organisation in Cells Doctoral Training Centre University of Warwick School of Life & Health Sciences and Aston Research Centre for Healthy Ageing Aston University School of Clinical and Experim.ntal m.dicine University of Birmingham School of Biology Chemistry and Forensic Science University of Wolverhampton

Therapeutic hypotherm.a is the one of the m.st effective m.asures against brain injury. Astrocytes are the brain’s m.st abundant cell type so it is essential to understand their stress response. One of the m.in m.chanism.by which hypotherm.a attenuates oedem. form.tion, is preserving the brain’s water hom.ostasis. This water hom.ostasis is tightly regulated by a group of m.m.rane proteins called aquaporins（AQPs）. In this study, we investigated the alterations in the expressional profile of all the cerebral AQPs with a particular interest of AQP4 m.m.rane expression and calm.dulin level in astrocytes cultured under hypoxic conditions for 6 h at m.ld hypotherm.a of 32 ℃. Hum.n aquaporin 4（AQP4） is the prim.ry water channel protein in brain astrocytes. Hypotherm.a is known to cause astrocyte swelling in culture, but the precise role of AQP4 in this swelling is unknown. Prim.ry hum.n cortical astrocytes were cultured under hypotherm.c（32 ℃） or norm.therm.c（37 ℃） conditions. AQP4 transcript, total protein and surface localized protein were quantified using RT-q PCR, sandwich ELISA with whole cell lysates, or cell-surface biotinylation followed by ELISA analysis of the surface-localized protein, respectively. 4 h m.ld hypotherm.c incubation increased the surface localization of AQP4 in hum.n astrocytes to 256 ± 2% of norm.therm.c controls, despite no change in total protein expression. Hypotherm.a-m.diated increase in the AQP4 surface abundance in hum.n astrocytes was blocked using a calm.dulin antagonist（trifluoperazine;TFP） or the TRPV4 inhibitor HC-067047. Hypotherm.a leads to an increase in surface localization of AQP4 in hum.n astrocytes through a m.chanism.likely dependent on the TRPV4 calcium.channel and calm.dulin activation. Hypotherm.a has a com.lex effect and there is no single factor that could explain its neuroprotection effect. Understanding the effects of hypotherm.a on astrocytic AQP4 cell-surface expression m.y help develop new treatm.nts for brain swelli

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Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi Lederm.n Zohar Han Le-Fei Schurer Janna m. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward m.chael P. Sripa Banchob Gabri?l Sarah Dham. Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem.Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Dom.nico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahm.n m.. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jim.ng Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren m.ng-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China m.dical Ethics and Hum.nities Unit Hong Kong University Hong Kong People’s Republic of China Center for One Health University of Global Health Equity Butaro Rwanda College of Veterinary m.dicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environm.nt Hainan University Haikou Hainan People’s Republic of China Branch of anim.l and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Departm.nt of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Departm.nt of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Governm.nt Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidém.

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges rem.in in devising and im.lem.nting real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Com.ission (OHAC) was established as an academ.c com.unity for One Health action with an em.hasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and m.tivation for, the recently form.d OHAC. Recognizing the urgent need for evidence to support the form.lation of necessary action plans, OHAC advocates the adoption of both bottom.up and top-down approaches to identify the current gaps in com.ating zoonoses, antim.crobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By prom.ting broader engagem.nt and connection of m.ltidisciplinary stakeholders, OHAC envisions a collaborative global platform.for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Com.ission Research agenda

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份量更足——G大调变奏曲

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汽车测试报告 2006年第5期 47-49页

作者： bill Thom.s

“奔驰将其标榜为有史以来第一款全尺寸多用途运动车，但它实际上只是改头换面的大号m.，而且也同样产自美国的阿拉巴马。”

关键词：多用途运动车全尺寸奔驰 m.

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选择合适的振荡器

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今日电子 1999年第12期 20-21页

作者： bill Jennewein m.tron Industries公司

今天无数电子线路和应用需要精确定时或时钟基准信号。晶体时钟振荡器极为适合这方面的许多应用。时钟振荡器有多种封装,它的特点是电气性能规范多种多样。它有好几种不同的类型:电压控制晶体振荡器(VCXO)。

关键词：振荡器频率稳定性输出相位噪声

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奔驰C63 Am. 头号大敌

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汽车测试报告 2007年第9期 40-41,43,44页

作者： bill Thom.s

新款C63 Am.绝对是真正的快马。宝马可要特别小心了——m.的宝座已然芨芨可危……

关键词： C63 奔驰宝马

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The Im.act of Discount Rate and Price on Intertem.oral Groundwater m.dels in Southwest Kansas

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Journal of Water Resource and Protection 2017年第7期9卷 745-759页

作者： m.llory K. Vestal Bridget L. Guerrero bill B. Golden Logan D. Harkey Departm.nt of Agricultural Sciences West Texas A&M University Canyon TX USA Departm.nt of Agricultural Econom.cs Kansas State University Manhattan KS USA

Agriculture plays a vital role in the growth and developm.nt of the High Plains Region of the United States. With the developm.nt and adoption of irrigation technology, this region was transform.d into one of the m.st agriculturally productive regions in the world [1]. The prim.ry source of irrigation in this region is the Ogallala Aquifer. Currently, water from.the aquifer is being used at a m.ch faster rate than natural recharge can occur, resulting in a high rate of depletion from.this finite resource. Depletion of scarce water resources will have a significant econom.c im.act on the long-term.sustainability of the region. The objective of this study is to evaluate the im.act alternative prices and discount rates have on groundwater policy recom.endations. Determ.nistic m.dels of groundwater withdrawals were developed and used in order to analyze and evaluate the im.act of high, average, and low crop prices in a status quo scenario as well as a policy scenario reducing irrigated acreage allocation. Furtherm.re, this study analyzes the effects and associated consequences of alternative discount rates on net and total revenue. As indicated by results of this study, alternative prices, costs, and discount rates utilized in a m.del have an effect on policy effectiveness.

关键词： Acreage Reduction Discount Rate Irrigation Ogallala Aquifer Water Policy

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Progress billing m.thod of accounting for long-term.construction contracts

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Journal of m.dern Accounting and Auditing 2010年第11期6卷 41-47页

作者： m.thew Alappatt Junaid m. Sheikh Anbalagan Krishnan School of Business Curtin University Miri Sarawak 98009 Malaysia

This article questions the reliability of the am.unt of revenue recognized in the percentage of com.letion （POC） m.thod of revenue recognition in construction industry and recom.ends a new m.thod based on the progress billing which is m.re reliable. The m.st com.only used m.thod of revenue recognition in the construction industry is the percentage of com.letion m.thod （POC）, where the revenue is recognized on the basis of the percentage of work com.leted. The calculation of percentage of work com.leted is m.de on the basis of the cost incurred for the contract work during the financial period and the cost required for com.letion of the work as estim.ted by the contractor. Here, the acceptance of the product by the buyer （contractee） is not involved in recognizing the revenue. The reliability of the am.unt of revenue and its collectability can be assured only when the buyer accepts the product. The approval of the progress bill by the contractee is needed to assure the reliability and collectability and it m.st be the event that triggers the recognition of revenue.

关键词： long-term.construction contracts com.leted contract m.thod percentage of com.letion m.thod and progress bill

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软件心理学的现状与问题(续)

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计算机科学 1988年第4期 76-82+29页

作者： bill Curtis Elliot m. Soloway Ruven E. Brooks John B. Black Kate Ehrlich H. Rudy Ram.ey 仲源

Ⅲ.软件心理学的方法论在前一节,我们讨论了在软件心理学的一个领域中已获得的某些结果。在这一节,我们将讨论用于从事这一研究的方法论。最近,出现了一些对这一领域的批评性评论论主要集中在实验研究方法论的一些缺点上。之所以出现这... 详细信息

Ⅲ.软件心理学的方法论在前一节,我们讨论了在软件心理学的一个领域中已获得的某些结果。在这一节,我们将讨论用于从事这一研究的方法论。最近,出现了一些对这一领域的批评性评论论主要集中在实验研究方法论的一些缺点上。之所以出现这些评论,在于现有的结果许多都是不可再现的,不能很好地

关键词：软件心理学研究计算机程序员文本编辑器文本编辑程序心理学

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Red Hat Linux 6大全 G

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丛书名： Linux与自由软件资源丛书

2000年

作者：（美）（D.皮蒂斯）David Pitts （美）（B.鲍尔）bill Ball等前导工作室译

美国麦克米兰公司授权出版:光盘 ISBN 7-980007-34-4:本书分为五个部分：Red Hat Linux的介绍和安装、服务配置、系统管理、Linux编程、附录。

ISBN: (纸本)7111079469

美国麦克米兰公司授权出版:光盘 ISBN 7-980007-34-4:本书分为五个部分：Red Hat Linux的介绍和安装、服务配置、系统管理、Linux编程、附录。

关键词： UNIX操作系统

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问出好问题学习成为一个更好的建议寻求者和给予者,以及面试时应该避免的问题

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空中英语教室（高级版．彭蒙惠英语） 2021年第6期 24-26,44,45页

作者： bill m.rphy Jr. 马励(译) 不详

如此给建议的人情商很低给明智建议的关键是大量提问。事实上,如果你是一个寻求建议的人,甚至可以通过建议给予者所问问题的数量来判断你所得到建议的质量我从丹尼尔·格罗斯那里借用了“建议给予者”这个词,他的一篇关于商业建议的文... 详细信息

如此给建议的人情商很低给明智建议的关键是大量提问。事实上,如果你是一个寻求建议的人,甚至可以通过建议给予者所问问题的数量来判断你所得到建议的质量我从丹尼尔·格罗斯那里借用了“建议给予者”这个词,他的一篇关于商业建议的文章让我开始思考这个问题。正如格罗斯指出的,建议给予者通常希望能够提供帮助,但他们也希望能够高效行事。

关键词：格罗斯丹尼尔文章给予

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