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Unique Clinical Features of Curaderm when Treating Skin Cancers

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Journal of Cancer Therapy 2024年第1期15卷 13-27页

作者： Tania Robyn Chase Kai elliot cham bill elliot cham Australasian Medical Research Port Vila Republic of Vanuatu

Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Consequences of these treatments include body-image issues, anxiety, post-traumatic stress disorder, depression, and poorer quality of social and family life. A progressive topical cream formulation, Curaderm, containing the natural BEC glycoalkaloids, have shown to have advantages over conventional treatments. However, comprehensive clinical features of the skin cancer lesions during treatment with Curaderm have to date not been reported. This report shows that using unpublished data from a large number of patients with varying sizes, types and locations of basal cell carcinomas when treated with Curaderm in a phase 3 trial, an initial increase in size of the lesions occur, followed by a reverse course, leading to complete removal of the skin cancer. The specificity and mode of action of Curaderm explains the superior cosmetic outcomes when compared with conventional therapies.

关键词： Curaderm Skin Cancer Basal Cell Carcinoma BEC Glycoalkaloids Conventional Treatments

The Value of Excipients and the Required Understanding of the Biological System in Product Development: An Impactful Example of Curaderm, a Topical Skin Cancer Treatment

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International Journal of Clinical Medicine 2024年第2期15卷 68-87页

作者： Tania Robyn Chase Kai elliot cham bill elliot cham Australasian Medical Research Port Vila Republic of Vanuatu

The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.

关键词： Curaderm BEC Solasodine Glycosides Solamargine Apoptosis Skin Cancer Actinic Keratosis Keratoacanthoma Basal Cell Carcinoma Squamous Cell Carcinoma

Holistic Approach in the Treatment of Actinic Keratosis: Benefits and Disadvantages of 5-Fluorouracil, Imiquimod, Diclofenac and Curaderm

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International Journal of Clinical Medicine 2023年第7期14卷 319-331页

作者： bill elliot cham Australasian Medical Research Port Vila Republic of Vanuatu

Background Actinic keratosis is the most prevalent premalignant skin disorder in the white population. Current guidelines provide no clear recommendations about preferred treatments. Methods The parameters;effectiveness, treatment duration, recurrence, side effects and cost of treatment were investigated for three frequently used topical therapies which were then compared with a most recent developed topical therapy. Published clinical data obtained from the literature was used to compare these parameters for 5-fluorouracil, imiquimod and diclofenac and relate them with the newly developed Curaderm. Results A wide variation in the concentrations of the active anti-keratotic ingredients, application frequency, duration of treatment, recurrence rates and cost of treatment exist between the different topical therapies. The efficacy rates and side effects were less variable. Overall, Curaderm is the most suitable treatment for actinic keratosis. Clinical evidence is presented illustrating the effects of Curaderm on field-directed treatments and solitary treatments of actinic keratoses. Conclusions Current medical guidelines do not provide clear recommendations on which treatment approach for actinic keratosis is preferred. Direct head-to-head comparison between treatments with emphasis on efficacy, safety, treatment duration, compliance, convenience, cosmetic outcome, patient acceptance and cost should be available to the patient, the practising physician, healthcare system and should assist in therapeutic treatment guidelines and policymaking. Given the very favourable profiles of these parameters with Curaderm when compared with other home-based treatments, it should be considered that Curaderm is first-in-line.

关键词： Actinic Keratosis Skin Cancer 5-Fluorouracil Imiquimod Diclofenac Curaderm Efficacy Recurrence Cost

Outcomes of pregnancy in patients with known Budd-Chiari syndrome

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World Journal of Hepatology 2017年第21期9卷 945-952页

作者： Faisal Khan Ian Rowe bill Martin Ellen Knox Tracey Johnston Charlie elliot Will Lester Frederick Chen Simon Olliff Homoyon Mehrzad Zergham Zia Dhiraj Tripathi Liver Unit Queen Elizabeth Hospital Birmingham Women’s Hospital Pulmonary Vascular Disease Unit Royal Hallamshire Hospital Haematology and Thrombophilia Centre Queen Elizabeth Hospital Interventional Radiology Queen Elizabeth Hospital

AIM To analyse the risk of pregnancy(a prothrombotic state) in patients with Budd-Chiari Syndrome(BCS). METHODS Retrospective study of pregnancy in women with known BCS at single center from January 2001 to December 2015. RESULTS Out of 53 females with BCS, 7 women had 16 pregnancies. Median age at diagnosis of BCS in these women was 25 years(range 21-34 years). At least one causal factor for BCS was identified in 6 women(86%). Six women had undergone radiological decompressive treatment. All patients had anticoagulation. Six fetuses were lost before 20 wk gestation in 2 women. There were 9 deliveries over 32 wk gestation and one delivery at 27 wk. All infants did well. Seven babies were born by emergency caesarean section. There were no cases of thrombosis. Two patients had notable vaginal(PV) bleeding in 3 pregnancies. None of the patients had variceal haemorrhage. Two patients were diagnosed with pulmonary hypertension, one during pregnancyand the other in the post-partum period. There was no maternal *** Maternal outcomes in patients with treated BCS are favourable and fetal outcomes beyond 20 wk gestation are good. There has been increased rate of caesarean section. Pulmonary hypertension is an important finding that needs further validation. These patients should be managed in centers experienced in treating high-risk pregnancies.

关键词： Budd-Chiari syndrome Pregnancy Portal hypertension Pulmonary hypertension Thrombophilia

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软件心理学的现状与问题

计算机科学 1988年第3期 73-81页

作者： bill Curtis elliot M.Soloway Ruven E.Brooks' John B.Black Kate Ehrlich H.Rudy Ramsey 仲源

没有经过正式的数学、工程或计算机科学训练的计算机用户与日俱增,所以人机交互问题的研究已成为关键.本文主要综述软件心理学(即研究计算机系统中人的因素)的现状.打算选择软件心理学的一个领域,即程序设计心理学来深入讨论一些研究成... 详细信息

没有经过正式的数学、工程或计算机科学训练的计算机用户与日俱增,所以人机交互问题的研究已成为关键.本文主要综述软件心理学(即研究计算机系统中人的因素)的现状.打算选择软件心理学的一个领域,即程序设计心理学来深入讨论一些研究成果.之所以选中这一领域,是因为约稿刊物的读者感兴趣.接着讨论在进行软件心理学实验研究时所涉及的一些方法论问题.还讨论了本文综述的程序设计研究与整个软件心理学领域的未来动向.结论指出,多学科训练与研究是该领域进一步发展的关键.

关键词：软件领域计算机程序员程序设计语言心理学

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软件心理学的现状与问题(续)

计算机科学 1988年第4期 76-82+29页

作者： bill Curtis elliot M. Soloway Ruven E. Brooks John B. Black Kate Ehrlich H. Rudy Ramsey 仲源

Ⅲ.软件心理学的方法论在前一节,我们讨论了在软件心理学的一个领域中已获得的某些结果。在这一节,我们将讨论用于从事这一研究的方法论。最近,出现了一些对这一领域的批评性评论论主要集中在实验研究方法论的一些缺点上。之所以出现这... 详细信息

Ⅲ.软件心理学的方法论在前一节,我们讨论了在软件心理学的一个领域中已获得的某些结果。在这一节,我们将讨论用于从事这一研究的方法论。最近,出现了一些对这一领域的批评性评论论主要集中在实验研究方法论的一些缺点上。之所以出现这些评论,在于现有的结果许多都是不可再现的,不能很好地

关键词：软件心理学研究计算机程序员文本编辑器文本编辑程序心理学