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Heterosis in age-specific selected populations of a seed beetle： Sex differences in longevity and reproductive behavior

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Insect Science 2015年第2期22卷 295-309页

作者： biljana stojkovic Mirko Dordevia Jelena Jankovic Uros Savkovic Nikola Tucic Department of Evolutionary Biology Institute for Biological Research 'Sinisa Stankovie' University of Belgrade Institute of Zoology Faculty of Biology University of Belgrade Belgrade Serbia

We tested mutation accumulation hypothesis for the evolution of senescence using short-lived and long-lived populations of the seed-feeding beetle, Acanthoscelides obtectus （Say）, obtained by selection on early- and late-life for many generations. The expected consequence of the mutation accumulation hypothesis is that in short-lived pop- ulations, where the force of natural selection is the strongest early in life, the late-life fitness traits should decline due to genetic drift which increases the frequency of mutations with deleterious effects in later adult stages. Since it is unlikely that identical deleterious mutations will increase in several independent populations, hybrid vigor for late-life fit- ness is expected in offspring obtained in crosses among populations selected for early-life fitness traits. We tested longevity of both sexes, female fecundity and male reproductive behavior for hybrid vigor by comparing hybrid and nonhybrid short-lived populations. Hybrid vigor was confirmed for male virility, mating speed and copulation duration, and longevity of both sexes at late ages. In contrast to males, the results on female fecundity in short-lived populations did not support mutation accumulation as a genetic mechanism for the evolution of this trait. Contrary to the prediction of this hypothesis, male mating ability indices and female fecundity in long-lived populations exhibited hybrid vigor at all assayed age classes. We demonstrate that nonhybrid long-lived populations diverged randomly regarding female and male reproductive fitness, indicating that sexually antag- onistic selection, when accompanied with genetic drift for female fecundity and male virility, might be responsible for overriding natural selection in the independently evolving long-lived populations.

关键词： ageing antagonistic selection drift experimental evolution inbreeding depression mutation accumulation

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Perineural invasion as a prognostic factor in patients with stage Ⅰ-Ⅲ rectal cancer –5-year follow up

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 592-600页

作者： Milica stojkovic Lalosevic Tamara Milovanovic Marjan Micev Mirjana stojkovic Sanja Dragasevic Milos Stulic Ivan Rankovic Vladimir Dugalic Zoran Krivokapic Aleksandra Pavlovic Markovic Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia Clinic for Digestive Surgery-First Surgical Clinic Clinical Center of SerbiaBelgrade 11000Serbia

BACKGROUND Rectal cancer(RC)is one of the most common diagnosed cancers,and one of the major causes of cancer-related death *** of the current guidelines rely on TNM classification regarding therapy regiments,however recent studies suggest that additional histopathological findings could affect the disease *** To determine whether perineural invasion alone or in combination with lymphovascular invasion have an effect on 5-years overall survival(OS)of RC *** A prospective study included newly diagnosed stage I-III RC patients treated and followed at the Digestive Surgery Clinic,Clinical Center of Serbia,between the years of 2014–*** patients had their diagnosis histologically confirmed in accordance with both TMN and Dukes *** addition,the patient’s demographics,surgical details,postoperative pathological details,differentiation degree and their correlation with OS was *** Of 245 included patients with stage Ⅰ-Ⅲ RC,lymphovascular invasion(LVI)was identified in 92 patients(38%),whereas perineural invasion(PNI)was present in 46 patients(19%).Using Kaplan-Meier analysis for overall survival rate,we have found that both LVI and PNI were associated with lower survival rates(P<0.01).Moreover when Cox multiple regression model was used,LVI,PNI,older age,male gender were predictors of poor prognosis(HR=5.49;95%CI:2.889-10.429;P<0.05).CONCLUSION LVI and PNI were significant factors predicting worse prognosis in early and intermediate RC patients,hence more aggressive therapy should be reserved for these patients after curative resection.

关键词： Lymphovascular invasion Perineural invasion Rectal cancer

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Network science approach for identifying disruptive elements of an airline

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Data Science and Management 2023年第2期6卷 110-121页

作者： Vinod Kumar Chauhan Anna Ledwoch Alexandra Brintrup Manuel Herrera Vaggelis Giannikas Goran stojkovic Duncan Mcfarlane Institute for Manufacturing University of CambridgeCambridgeCB30FSUK Department of Engineering Science University of OxfordOxfordOX13PJUK School of Management University of BathBathBA27AZUK The Boeing Company Arlington22202US

Currently,flight delays are common and they propagate from an originating flight to connecting flights,leading to large disruptions in the overall *** disruptions cause massive economic losses,affect airlines’reputations,waste passengers’time and money,and directly impact the *** study adopts a network science approach for solving the delay propagation problem by modeling and analyzing the flight schedules and historical operational data of an *** aim to determine the most disruptive airports,flights,flightconnections,and connection types in an airline *** elements are influential or critical entities in an airline *** are the elements that can either cause(airline schedules)or have caused(historical data)the largest disturbances in the *** airline can improve its operations by avoiding delays caused by the most disruptive *** proposed network science approach for disruptive element analysis was validated using a case study of an operating *** analysis indicates that potential disruptive elements in a schedule of an airline are also actual disruptive elements in the historical data and they should be considered to improve *** airline network exhibits small-world effects and delays can propagate to any part of the network with a minimum of four delayed ***,we observed that passenger connections between flights are the most disruptive connection ***,the proposed methodology provides a tool for airlines to build robust flight schedules that reduce delays and propagation.

关键词： Air transport Flight delays Airline disruptions Delay propagation Network science

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Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

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World Journal of Gastroenterology 2012年第4期18卷 331-339页

作者： Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric Department of Physiology Faculty of MedicineUniversity of Kragujevac Department of Gastroenterology and Echosonography Unit Clinical Centre of Belgrade Internal Clinic Clinical Centre "Kragujevac"Faculty of MedicineUniversity of Kragujevac Department of Physical Medicine and Rehabilitation Faculty of MedicineUniversity of Kragujevac Institute of Medical Physiology Belgrade University School of Medicine

AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal ***:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the *** di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler ***-section area,portal flow and index of vascular resistance were *** collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were ***-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) ***:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate *** O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid *** blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood ***:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension.

关键词： Portal hypertension Endothelium Nitroglycerine Oxidative stress Portal vein haemodynamics

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Combining Genetic Algorithm and Random Projection Strategy for （l,d）-Motif Discovery

Combining Genetic Algorithm and Random Projection Strategy f...

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2009 Fourth International Conference on Bio-Inspired Computing:Theories and Applications(BIC-TA2009)

作者： Vojislav stojkovic Computer Science Department Morgan State University

Identification of planted（l,d）-motifs is an important and hard challenging problem in computational *** this paper,we present an original algorithm that combines Genetic Algorithm（GA）and Random Projection Strategy（RPS）?GARPS to identify（l,d）-*** start with RPS to find good starting positions by introducing position-weight function and constructing a new hash function based on the function and return a set of candidate ***,we use the results（good candidate motifs）from RPS as the initial population of genetic algorithm to make series of iterations to refine motif *** use the global search capability of GA and RPS are explored in *** results on simulated data show that GARPS performs better than the Projection algorithm and solves the most of challenging planted motif finding problems and improves finding faint motifs.

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Software Tool for the Implementation of the Methodology for Revitalization of High-Voltage Overhead Power Lines

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Journal of Energy and Power Engineering 2014年第10期8卷 1791-1801页

作者： Aleksandar Simovic Zlatan stojkovic Miomir Dutina Faculty of Electrical Engineering University of East Sarajevo East Sarajevo 71123 Bosnia and Herzegovina Faculty of Electrical Engineering University of Belgrade Belgrade 11120 Serbia Public Enterprise "Elektromre2a Srbijie " Bulevar Kralja Petra 149 Novi Sad 21000 Serbia

In power systems, a large number of OPLs （overhead power lines） are more than 40 years old and some even exceed 50 years old. The key issue for power systems managers, public utilities companies and electrical engineers today concerns the manner in which available financial resources should be invested in these OPLs to provide the greatest impact on the power system as a whole and to address the OPLs that require urgent revitalization. This paper presents the application of the software tool RevOPL, developed using Microsoft Access utilizing the ＂methodology for revitalization of high-voltage OPLs＂. The aim is to present both the methodology and software to objectively evaluate the condition of an OPL and determine its remaining service life. The application of this software tool provides a proposal for the scheduling and scope of planned revitalization activities, which are obtained through the optimization of the technical characteristics while remaining within the available budget.

关键词： Overhead power line revitalization methodology RevOPL software tool.

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Optimization and kinetic modeling of waste lard methanolysis in a continuous reciprocating plate reactor

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2481-2490页

作者： Marija R.Miladinovic Ivan J.stojkovic Ana V.Velickovic Olivera S.Stamenkovic Ivana B.Bankovic-Ilic Vlada B.Veljkovic University of Nis Faculty of TechnologyBulevar osloboaenja 124Leskovac 16000Serbia University of Belgrade Faculty of Technology and MetallurgyKarnegijeva 4Belgrade 11000Serbia Serbian Academy of Sciences and Arts(SASA) Knez Mihailova 35Belgrade 11000Serbia

Continuous biodiesel production from a waste pig-roasting lard,methanol and KOH was carried out in a reciprocating plate reactor(RPR)using a factorial design containing three process factors,namely methanol/lard molar ratio,catalyst loading,and normalized height of the *** main goals were to optimize the influential process factors with respect to biodiesel purity using the response surface methodology and to model the kinetics of the transesterification reaction in order to describe the change of triacylglycerols(TAG)and fatty acid methyl esters(FAME)concentrations along the RPR *** first-order rate law was proved for both the reaction and the mass *** model of the changing reaction mechanism and mass transfer of TAG was also *** kinetic models agreed with the experimental concentrations of TAG and FAME determined along the RPR height.

关键词： Biodiesel Kinetics Optimization Reciprocating plate reactor Waste lard

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Role of clinical pathway in improving the quality of care for patients with faecal incontinence:A randomised trial

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 81-89页

作者： Zeiad I Hussain Michael Lim Stevan stojkovic Interventional Radiology Guys and St Thomas Hospital Department of Colorectal Surgery Raigmore Hospital Stevan stojkovic Department of Colorectal SurgeryYork Hospital

AIMTo assess the development and implementation of the Integrated Rapid Assessment and Treatment (IRAT) pathway for the management of patients with fecal incontinence and measure its impact on patients’ care. METHODSPatients referred to the colorectal unit in our hospital for the management of faecal incontinence were randomised to either the Standard Care pathway or the newly developed IRAT pathway in this feasibility study. The IRAT pathway is designed to provide a seamless multidisciplinary care to patients with faecal incontinence in a timely fashion. On the other hand, patients in the Standard Pathway were managed in the general colorectal clinic. Percentage improvements in St. Marks Incontinence Score, Cleveland Clinic Incontinence Score and Rockwood Faecal Incontinence Quality of Life Scale after completion of treatment in both groups were the primary outcome measures. Secondary endpoints were the time required to complete the management and patients’ satisfaction score. χ2, Mann-Whitney-U and Kendall tau-c correlation coefficient tests were used for comparison of outcomes of the two study groups. A P value of 0.05 or less was considered significant. RESULTSThirty-nine patients, 34 females, consented to participate. Thirty-one (79.5%) patients completed the final assessment and were included in the outcome analysis. There was no significant difference in the quality of life scales and incontinence scores. Patients in the IRAT pathway were more satisfied with the time required to complete management (P = 0.033) and had stronger agreement that all aspects of their problem were covered (P = 0.006). CONCLUSIONDespite of the lack of significant difference in outcome measures, the new pathway has positively influenced patient’s mindset, which was reflected in a higher satisfaction score.

关键词： Pathway Fecal incontinence Quality improvement

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The cell phone in the twenty-first century: Risk for addiction or ingestion? Case report and review of the literature

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World Journal of Emergency Medicine 2021年第4期12卷 335-336页

作者： Sanja Dragasevic Milica stojkovic Lalosevic Ljubisa Toncev Tamara Milovanovic Aleksandra Pavlovic Markovic Srdjan Djuranovic Dragan Popovic Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia

Dear editor,Foreign body ingestion and food bolus impaction are frequent emergency cases in clinical practice.[1] The majority of foreign body ingestion cases occur in the pediatric population, while individuals with mental illness,neurodevelopmental disorders, alcohol intoxication, and prisoners are recognized as a high-risk adult population for foreign body ingestion.

关键词： cases clinical editor

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静脉注射多价免疫球蛋白治疗亚急性全植物神经失调综合征(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 49-50页

作者： Ramirez C. De Sè ze J. stojkovic T. 王晓琳 Servicede Neurologie D Hpital R. Salengro CHRU 59037 LilleCedex France

Introduction. Acute or sub- acute pure dysautonomia is *** report a case of sub- acute pure pandysautonomia with favorable outcome after intravenous immunoglobulin *** report. A 29- year- old right- handed student, with an uneventful medical history presented, for one month, bilateral loss of visual acuity and digestive disorders, associating diarrhea,vomiting and anorexia. Physical examination revealed bilateral intrinsec oculomotor nerve palsy, a dryness syndrome and severe orthostatic hypotension. Ophthalmologic examination showed bilateral diffuse parasympathic impairment associating an Argyll Robertson pupil and full pupil light reflex abolition. Elevated protein level (0.93g/l)was the only cerebrospinal fluid anomaly. Serum tests were negative for anti- gangliosides antibodies. The patient improved slowly after two series of intravenous immunoglobulin infusions. Conclusion. Clinical course and laboratory findings suggest that acute or sub- acute pure pandysautonomia events are likely to be related to acute polyradiculoneuritis. Therefore intravenous polyvalent immunoglobulin infusions should be attempted, even if their efficacy needs to be confirmed.

关键词：失调综合征植物神经免疫球蛋白瞳孔对光反射交感神经损伤眼科检查动眼神经麻痹消化功能紊乱体位性低血压干燥综合征

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