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Depositional and Bio-Sequence Stratigraphic Framework of Late Cretaceous Kawagarh Formation,Kala-Chitta Range,Pakistan:Equivalent of Gurpi Formation(Iran)

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Journal of Earth Science 2024年第2期35卷 332-348页

作者： Muhammad Awais bilal Wadood Muhammad Ishaq Muhammad bilal Zeeshan Zafar Nasar Khan Aminullah Khan Department of Geology University of SwabiAnbar-SwabiKhyber PakhtunkhwaSwabi23561Pakistan Department of Earth Environmental and Resources SciencesUniversity of Naples FedericoⅡNaples80126Italy State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an710069China National Centre of Excellence in Geology University of PeshawarPeshawarKhyber Pakhtunkhwa25130Pakistan Department of Geological Engineering School of Earth Sciences and EngineeringXi’an Shiyou UniversityXi’an610500China Department of Petroleum Geology and Engineering School of Earth ResourcesChina University of GeosciencesWuhan430074China Department of Geology University of MalakandDir Lower18800ChakdaraPakistan Department of Earth and Environmental Sciences KU LeuvenLeuven3001Belgium

The present study is focused on evaluation of deep marine pelagic sediments of Late Cretaceous Kawagarh Formation of Kala-Chitta Range in the context of microfacies analysis,paleoenvironmental interpretation,planktonic foraminiferal biostratigraphy,sequence stratigraphy and diversification of species.A total of thirty three rock samples were collected from the measured *** microfacies are interpreted,namely planktonic foraminifera wackestone,planktonic foraminifera mudstone and sandy mudstone indicating low energy depositional environment i.e.,outer *** biostratigraphic studies show plentiful planktonic foraminifera species of Globotruncana,Heterohelix and ***,no association of benthic or siliceous organisms was *** the basis of available species assemblage,a single local planktonic foraminifera biozone i.e.,Globotruncana-Heterohelix-Globotruncanita Assemblage Biozone is *** biozone information is combined with published literature and Lower Santonian to Middle Maastrichtian age has been assigned to the Kawagarh *** trend of species occurrences evinces that species number decreases over time with pulsated rise in the Kawagarh *** Kawagarh Formation carbonates show an overall Transgressive Systems Tract(TST).The Kawagarh Formation of Pakistan evinces analogous characteristics to that of the Late Cretaceous Gurpi Formation of Iran based on the geologic age,outcrop lithology,microfacies,planktonic foraminiferal assemblages,depositional setting and sequence stratigraphy.

关键词： depositional fabric biostratigraphy sequence stratigraphy Late Cretaceous Kawagarh Formation Pakistan Gurpi Formation Iran

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High glucose microenvironment and human mesenchymal stem cell behavior

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World Journal of Stem Cells 2024年第3期16卷 237-244页

作者： Muhammad Abdul mateen Nouralsalhin Alaagib Khawaja Husnain Haider Basic Sciences Sulaiman AlRajhi UniversityAlQaseem 52736Saudi Arabia Cellular and Molecular Pharmacology Sulaiman AlRajhi Medical SchoolAl Bukairiyah 51941Saudi Arabia

High glucose(HG)culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells,analogous to any other cell type in our *** interferes with diverse signaling pathways,*** target of rapamycin(mTOR)-phosphoinositide 3-kinase(PI3K)-Akt signaling,to impact physiological cellular functions,leading to low cell survival and higher cell apoptosis *** elucidating the underlying mechanism responsible for the apoptosis of adipose tissue-derived mesenchymal stem cells(MSCs),a recent study has shown that HG culture conditions dysregulate mTORPI3K-Akt signaling in addition to mitochondrial malfunctioning due to defective mitochondrial membrane potential(MtMP)that lowers ATP *** organelle-level dysfunction energy-starves the cells and increases oxidative stress and ultrastructural *** of the mitochondrial electron transport chain produces an altered mitochondrial NAD+/NADH redox state as evidenced by a low NAD+/NADH ratio that primarily contributes to the reduced cell survival in *** previous studies have also reported altered mitochondrial membrane polarity(causing hyperpolarization)and reduced mitochondrial cell mass,leading to perturbed mitochondrial *** hostile microenvironment created by HG exposure creates structural and functional changes in the mitochondria,altering their bioenergetics and reducing their capacity to produce *** are significant data,as MSCs are extensively studied for tissue regeneration and restoring their normal functioning in cell-based ***,MSCs from hyperglycemic donors should be cautiously used in clinical settings for cell-based therapy due to concerns of their poor sur-vival rates and increased rates of post engraftment *** hypergly-cemia alters the bioenergetics of donor MSCs,rectifying the loss of MtMP may be an excellent target for future research to restore the normal functioning of MSCs i

关键词： Adipose tissue Apoptosis Bioenergetics Cell survival Cell therapy Hyperglycemia Mitochondria Mesenchymal stem cells Stem cells

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Mesenchymal stem cells’“garbage bags”at work:Treating radial nerve injury with mesenchymal stem cell-derived exosomes

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World Journal of Stem Cells 2024年第5期16卷 467-478页

作者： Mazhar Mushtaq Doaa Hussein Zineldeen Muhammad Abdul mateen Khawaja Husnain Haider Department of Basic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Medical Biochemistry and Molecular Biology Department Faculty of MedicineTanta UniversityTanta 6632110Egypt

Unlike central nervous system injuries,peripheral nerve injuries(PNIs)are often characterized by more or less successful axonal ***,structural and functional recovery is a senile process involving multifaceted cellular and molecular *** contemporary treatment options are limited,with surgical intervention as the gold-standard method;however,each treatment option has its associated limitations,especially when the injury is severe with a large *** advancements in cell-based therapy and cell-free therapy approaches using stem cell-derived soluble and insoluble components of the cell secretome are fast-emerging therapeutic approaches to treating acute and chronic *** recent pilot study is a leap forward in the field,which is expected to pave the way for more enormous,systematic,and well-designed clinical trials to assess the therapeutic efficacy of mesenchymal stem cell-derived exosomes as a bio-drug either alone or as part of a combinatorial approach,in an attempt synergize the best of novel treatment approaches to address the complexity of the neural repair and regeneration.

关键词： Exosome Mesenchymal stem cells Nerve injury Stem cells Secretome Regeneration

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Photochemical reactions as synthetic tool for pharmaceutical industries

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Chinese Chemical Letters 2024年第9期35卷 9-31页

作者： Shehla Khalid Muhammad bilal Nasir Rasool Muhammad Imran Department of Chemistry Government College UniversityFaisalabad 38000Pakistan School of Chemistry and Chemical Engineering Shandong UniversityJi’nan 250100China Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

In the quest for new agrochemicals and pharmaceuticals,chemists seek access to reliable and mild synthetic techniques to allow for the systematic modification of chemical structures,exploration of unexplored chemical space,and facilitation of practical synthesis in their search for novel agrochemicals and *** this regard,photocatalytic reactions enabled the synthesis of intricate and more functionalized *** review overviews the developed synthetic methodologies and their utility in the chemical synthesis of *** review also offers in-depth insights into contemporary photoredox reactions such as allylic additions,cyclization,reductive cross-coupling,C–H activation,ring opening,oxidative cross-coupling,dehydrogenation,desulphonation,and *** provides a positive outlook for the promising future of this field.

关键词： Photocatalyst Photochemical reactions Drugs Natural products Late-stage functionalization

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A Survey of Edge Caching:Key Issues and Challenges

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Tsinghua Science and Technology 2024年第3期29卷 818-842页

作者： Hanwen Li Mingtao Sun Fan Xia Xiaolong Xu Muhammad bilal School of Computer Science Nanjing University of Information Science and TechnologyNanjing 210044China Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262700China Reading Academy Nanjing University of Information Science and TechnologyNanjing 210044China School of Software Nanjing University of Information Science and TechnologyNanjing 210044China Department of Computer Engineering Hankuk University of Foreign StudiesYongin-si 17035Republic of Korea

With the rapid development of mobile communication technology and intelligent applications,the quantity of mobile devices and data traffic in networks have been growing exponentially,which poses a great burden to networks and brings huge challenge to servicing user *** caching,which utilizes the storage and computation resources of the edge to bring resources closer to end users,is a promising way to relieve network burden and enhance user *** this paper,we aim to survey the edge caching techniques from a comprehensive and systematic *** first present an overview of edge caching,summarizing the three key issues regarding edge caching,i.e.,where,what,and how to cache,and then introducing several significant caching *** then carry out a detailed and in-depth elaboration on these three issues,which correspond to caching locations,caching objects,and caching strategies,*** particular,we innovate on the issue“what to cache”,interpreting it as the classification of the“caching objects”,which can be further classified into content cache,data cache,and service ***,we discuss several open issues and challenges of edge caching to inspire future investigations in this research area.

关键词： edge caching edge computing caching location caching object caching strategy 5G networkarchitecture Internet of Things(IoT)

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AI-Driven Learning Management Systems:Modern Developments, Challenges and Future Trends during theAge of ChatGPT

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Computers, Materials & Continua 2024年第8期80卷 3289-3314页

作者： Sameer Qazi Muhammad bilal Kadri Muhammad Naveed bilal AKhawaja Sohaib Zia Khan Muhammad Mansoor Alam Mazliham Mohd Su’ud Department of Computer Science Faculty of EngineeringScience and TechnologyIQRA UniversityKarachi75500Pakistan College of Computer and Information Sciences Prince Sultan UniversityRiyadh11586Saudi Arabia Faculty of Engineering Department of Electrical EngineeringIslamic University of MadinahP.O.BOX 170Madinah41411Saudi Arabia Faculty of Engineering Department of Mechanical EngineeringIslamic University of MadinahP.O.BOX 170Madinah41411Saudi Arabia Faculty of Computing Riphah International UniversityIslamabad46000Pakistan Faculty of Computing and Informatics(FCI)Multimedia University Cyberjaya63100Malaysia Faculty of Engineering and Information Technology School of Computer ScienceUniversity of Technology SydneySydneyNSW 2007Australia

COVID-19 pandemic restrictions limited all social activities to curtail the spread of the *** foremost and most prime sector among those affected were schools,colleges,and *** education system of entire nations had shifted to online education during this *** shortcomings of Learning Management Systems(LMSs)were detected to support education in an online mode that spawned the research in Artificial Intelligence(AI)based tools that are being developed by the research community to improve the effectiveness of *** paper presents a detailed survey of the different enhancements to LMSs,which are led by key advances in the area of AI to enhance the real-time and non-real-time user *** AI-based enhancements proposed to the LMSs start from the Application layer and Presentation layer in the form of flipped classroom models for the efficient learning environment and appropriately designed UI/UX for efficient utilization of LMS utilities and resources,including AI-based *** layer enhancements are also required,such as AI-based online proctoring and user authentication using *** extend to the Transport layer to support real-time and rate adaptive encrypted video transmission for user security/privacy and satisfactory working of *** also needs the support of the Networking layer for IP-based geolocation features,the Virtual Private Network(VPN)feature,and the support of Software-Defined Networks(SDN)for optimum Quality of Service(QoS).Finally,in addition to these,non-real-time user experience is enhanced by other AI-based enhancements such as Plagiarism detection algorithms and Data Analytics.

关键词： Learning management systems chatbots ChatGPT online education Internet of Things(IoT) artificial intelligence(AI) convolutional neural networks natural language processing

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An Intelligent Privacy Protection Scheme for Efficient Edge Computation Offloading in IoV

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Chinese Journal of Electronics 2024年第4期33卷 910-919页

作者： Liang YAO Xiaolong XU Wanchun DOU Muhammad bilal School of Software Nanjing University of Information Science and Technology State Key Laboratory for Novel Software Technology Nanjing University Department of Computer and Electronics Systems Engineering Hankuk University of Foreign Studies

As a pivotal enabler of intelligent transportation system(ITS), Internet of vehicles(Io V) has aroused extensive attention from academia and industry. The exponential growth of computation-intensive, latency-sensitive,and privacy-aware vehicular applications in Io V result in the transformation from cloud computing to edge computing,which enables tasks to be offloaded to edge nodes(ENs) closer to vehicles for efficient execution. In ITS environment,however, due to dynamic and stochastic computation offloading requests, it is challenging to efficiently orchestrate offloading decisions for application requirements. How to accomplish complex computation offloading of vehicles while ensuring data privacy remains challenging. In this paper, we propose an intelligent computation offloading with privacy protection scheme, named COPP. In particular, an Advanced Encryption Standard-based encryption method is utilized to implement privacy protection. Furthermore, an online offloading scheme is proposed to find optimal offloading policies. Finally, experimental results demonstrate that COPP significantly outperforms benchmark schemes in the performance of both delay and energy consumption.

关键词： Industries Privacy Energy consumption Transportation Computational efficiency Encryption Protection

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Predicting Age and Gender in Author Profiling: A Multi-Feature Exploration

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Computers, Materials & Continua 2024年第5期79卷 3333-3353页

作者： Aiman Muhammad Arshad bilal Khan Sadique Ahmad Muhammad Asim Department of Computer Science City University of Science and Information TechnologyPeshawar25000Pakistan EIAS:Data Science and Blockchain Laboratory College of Computer and Information SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia School of Computer Science and Technology Guangdong University of TechnologyGuangzhou510006China

Author Profiling (AP) is a subsection of digital forensics that focuses on the detection of the author’s personalinformation, such as age, gender, occupation, and education, based on various linguistic features, e.g., stylistic,semantic, and syntactic. The importance of AP lies in various fields, including forensics, security, medicine, andmarketing. In previous studies, many works have been done using different languages, e.g., English, Arabic, French,***, the research on RomanUrdu is not up to the ***, this study focuses on detecting the author’sage and gender based on Roman Urdu text messages. The dataset used in this study is Fire’18-MaponSMS. Thisstudy proposed an ensemble model based on AdaBoostM1 and Random Forest (AMBRF) for AP using multiplelinguistic features that are stylistic, character-based, word-based, and sentence-based. The proposed model iscontrasted with several of the well-known models fromthe literature, including J48-Decision Tree (J48),Na飗e Bays(NB), K Nearest Neighbor (KNN), and Composite Hypercube on Random Projection (CHIRP), NB-Updatable,RF, and AdaboostM1. The overall outcome shows the better performance of the proposed AdaboostM1 withRandom Forest (ABMRF) with an accuracy of 54.2857% for age prediction and 71.1429% for gender predictioncalculated on stylistic features. Regarding word-based features, age and gender were considered in 50.5714% and60%, respectively. On the other hand, KNN and CHIRP show the weakest performance using all the linguisticfeatures for age and gender prediction.

关键词： Digital forensics author profiling for security AdaBoostM1 random forest ensemble learning

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Influence of Various Earth-Retaining Walls on the Dynamic Response Comparison Based on 3D Modeling

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2835-2863页

作者： Muhammad Akbar Huali Pan Jiangcheng Huang bilal Ahmed Guoqiang Ou Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610000China Institute of International Rivers and Eco-Security Yunnan UniversityKunming650500China Department of Structural Engineering Faculty of Civil EngineeringDoctoral SchoolAkademicka 2Silesian University of TechnologyGliwice44-100Poland

The present work aims to assess earthquake-induced earth-retaining(ER)wall *** study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining *** finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics *** seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE *** also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic *** components of the created ER walls were found throughout this research *** is a granular reinforcement backfill,while the other is a wall-facing panel and base *** dynamic response effects of varied earth-retaining walls have also been *** was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER *** proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE *** results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two *** methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.

关键词： Seismic analysis finite element modeling earth-retaining ER walls dynamic response structural resilience

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Screening of glucosinolates degrading lactic acid bacteria and their utilization in rapeseed meal fermentation

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Grain & Oil Science and Technology 2024年第3期7卷 168-176页

作者： Yifang Chen Chong Xie Muhammad bilal Pei Wang Runqiang Yang College of Food Science and Technology Whole Grain Food Engineering Research CenterNanjing Agricultural UniversityNanjing 210095JiangsuChina The Sanya Institute of Nanjing Agricultural University Sanya 572024HainanChina National Technique Innovation Center for Regional Wheat Production/Key Laboratory of Crop Physiology Ecologyand ManagementMinistry of Agriculture/National Engineering and Technology Center for Information AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

Rapeseed meal is a promising food ingredient, but its utilization is limited by the presence of some potentially harmful ingredients, such as glucosinolates. Fermentation is a cost-effective method of detoxication but a food-grade starter culture with glucosinolates degradation capacity is required. In this study, 46 strains of lactic acid bacteria from traditional paocai brines were screened for their ability to glucosinolate degradation. The results showed that more than 50% of the strains significantly degraded glucosinolates. Two strains of Lactiplantibacillus(p7 and s7) with high capacity of glucosinolates degradation through producing enzymes were identified. Then,an optimized condition for rapeseed meal fermentation by p7 was established to degrade glucosinolates, which can achieve about 80% degradation. UPLC/Q-TOF-MS analysis showed that the degradation rate of individual glucosinolates was different and the degradation rate of gluconapin and progoitrin in rapeseed meal can reach more than 90%. Meanwhile, fermentation with p7 can improve safety of rapeseed meal by inhibiting the growth of Enterobacteriaceae and improve its nutritional properties by degrading phytic acid. The in vitro digestion experiments showed that the content of glucosinolates in rapeseed meal decreased significantly during gastric digestion. Meanwhile, fermentation with p7 can greatly improve the release of soluble protein and increase the contents of free essential amino acids, such as lysine(increased by 12 folds) and methionine(increased by 10 folds).

关键词： Rapeseed meal Glucosinolates Fermentation Lactic acid bacteria In vitro digestion

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