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Macrocyclic supramolecular biomaterials in anti-cancer therapeutics

Chinese Chemical Letters 2023年第11期34卷 98-115页

作者： biki hazarika Ved Prakash Singh Department of Chemistry School of Physical SciencesMizoram UniversityAizawlMizoram 796004India Department of Industrial Chemistry School of Physical SciencesMizoram UniversityAizawlMizoram 796004India

Macrocyclic supramolecular complexes demonstrate the dynamic potential to solve global biomedical challenges,a promising cancer treatment *** macrocyclic system is an important heterocyclic system widely present in natural products and synthetic *** unique structural feature of macrocyclic supramolecular complexes with desirable donor&acceptor characteristics is beneficial for readily binding with various enzymes and receptors in biological systems through diverse weak interactions,thereby exhibiting broad ***-related research and macrocyclic moleculesbased medicinal chemistry developments have become rapidly developing areas of *** macrocyclic-based molecules as clinical drugs have been extensively used in the clinic to treat various diseases with high therapeutic *** critically analyzed work systematically reviews current developments of macrocyclic supramolecular complexes-based compounds in the range of medicinal chemistry as anticancer,anti-inflammatory,and other therapeutic agents,together with their potential applications in diagnostics and *** review will be helpful for medicinal chemistry researchers to develop new thoughts in the quest for rational designs of more active and less toxic macrocyclic supramolecular complexes-based medicinal drugs,as well as more effective diagnostic agents and pathologic probes.

关键词： Supramolecular Weak interactions Self-assembly Drug-delivery Cancer Nano Tumor targeted Calixarene Cucurbituril In vivo bioimaging

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