检索结果-南通市图书馆

Russell & Rubinstein's Pathology of Tumors of the Nervous System 7th

丛书名： Contemporary Neurology

2006年

作者： McLendon, Roger E. Rosenblum, Marc bigner, darell

ISBN: (纸本)9780340810071

Beautifully illustrated in color throughout and comprehensively referenced, this seventh edition is a clearly organized volume, integrating basic sciences within sections devoted to individual tumor entities. Entirely revised and updated throughout by a wide range of internationally revered authorities, the content reflects the latest tumour classification and grading while neuroradiologic correlation via state of the art neuroimaging techniques continues to be emphasised in all diagnostic entities.

关键词： Nervous systemTumors.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Immunotoxin Therapy for Lung Cancer

引用

Chinese Medical Journal 2017年第5期130卷 607-612页

作者： Li-Yi Xie Hai-Lan Piao Min Fan Zhen Zhang Chen Wang darell D bigner Xu-Hui Bao Department of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Pathology Duke University Medical Center Durham North Carolina USA Department of Medicine China-Japan Friendship Hospital Beijing 100029 China

INTRODUCTIONLung cancer is the leading cause for cancer-related deaths in both genders throughout the world. In the United States alone, there were 224,390 estimated new lung cancer cases and 158,080 estimated deaths ... 详细信息

关键词： Immunotherapy Immunotoxins Lung Neoplasms Molecular Targeted Therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells

引用

The Journal of Biomedical Research 2010年第6期24卷 424-435页

作者： Stewart P.Johnson Nancy Bullock Francis Ali Osman darell D.bigner Henry S.Friedman Departments of Surgery Duke University Medical Center Departments of Pathology Duke University Medical Center

Glioblastoma multiforme （GBM） is the most aggressive primary brain tumor in *** therapy includes surgery,radiation and chemotherapy with temozolomide （TMZ）.Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase （MGMT） promoter and mismatch repair （MMR） *** the MGMT promoter is methylated in 45% of cases,for the first nine months of follow-up,TMZ does not change survival ***,MMR deficiency makes little contribution to clinical resistance,suggesting that there exist unrecognized mechanisms of *** generated paired GBM cell lines whose resistance was attributed to neither MGMT nor *** show that,responding to TMZ,these cells exhibit a decoupling of DNA damage response （DDR） from ongoing DNA *** display methylation-resistant synthesis in which ongoing DNA synthesis is not *** are also defective in the activation of the S and G2 phase *** proteins ATM,Chk2,MDC1,NBS1 and gammaH2AX also fail to form discrete *** results demonstrate that failure of DDR may play an active role in chemoresistance to *** damages by TMZ are repaired by MMR proteins in a futile,reiterative process,which activates DDR signaling network that ultimately leads to the onset of cell *** cells may survive genetic insults in the absence of *** anticipate that our findings will lead to more studies that seek to further define the role of DDR in ultimately determining the fate of a tumor cell in response to TMZ and other DNA methylators.

关键词： glioblastomas multiforme temozolomide DNA damage response resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：