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多发性硬化症患者单核细胞激肽B_1受体的表达:T2加权MRI所示病灶体积和临床残疾相关性的研究

世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 22-23页

作者： Prat A. biernacki k. Saroli T. 江山 Neuroimmunology Laboratory and Multiple Sclerosis Clinic Centre Hospitalier de l'Universitéde Montréal-Hpital No-tre-Dame 1560 Sherbrooke E Montréal Que. H2L 4M1 CanadaDr.

Back.round: We have previously shown that the inducible k.nin B1 receptor is expressed on T lymphocytes during relapses and progression in multiple sclerosis. Objective: To evaluate the correlation between the expression of B1 receptor on peripheral blood mononuclear cells derived from patients who have multiple scle rosis with serial, clinical magnetic resonance imaging and immunological study- derived measures. Design: Using frozen samples obtained from a high-frequency m agnetic resonance imaging-immunological study, we analyzed B1 receptor messenge r RNA (mRNA) expression in peripheral blood-deriv- ed mononuclear cells serially collected from 6 patients with multiple sclerosi s and 8 healthy control subjects by semiquantitative radioactive duplex reverse transcriptasepolymerase chain reaction amplification. Timecourse k.nin B1-actin mRNA ratios were subsequently compared with corresponding clinical magnetic res onance imaging and immune parameters. Results: The time-course k.nin B1-actin mRNA ratio correlated positively with the Expanded Disability Status Scale index (P k.n 2 receptor and major histocompatibility complex class II expression on CD4+lymphocytes, but not with gadoliniumenhancin g lesions. The time-course k.nin B1-actin mRNA ratios were 5 to 25 times lower in samples derived from healthy controls. Conclusion: The correlation of k.nin B1 receptor mRNA levels with dynamic clinical and magnetic resonance imaging mea sures suggests that expression of this receptor can serve as an index of disease activity in multiple sclerosis.

关键词：多发性硬化症 B1 T2加权MRI 病灶体积激肽免疫研究免疫学检查复发率 RNA 肌动蛋白

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