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老年晚期非小细胞肺癌免疫治疗策略

医药导报 2024年第3期43卷 352-359页

作者：尹佳鑫宋羽霄章必成武汉大学人民医院肿瘤中心武汉430060

以免疫检查点抑制剂(ICIs)为代表的免疫治疗显著改变了非小细胞肺癌(NSCLC)患者的治疗现状,并已成为所有分期NSCLC的重要治疗手段,但有关老年晚期NSCLC患者的免疫治疗策略亟待进一步明确。通过评估临床研究中老年晚期NSCLC患者的生存数... 详细信息

以免疫检查点抑制剂(ICIs)为代表的免疫治疗显著改变了非小细胞肺癌(NSCLC)患者的治疗现状,并已成为所有分期NSCLC的重要治疗手段,但有关老年晚期NSCLC患者的免疫治疗策略亟待进一步明确。通过评估临床研究中老年晚期NSCLC患者的生存数据,该文作者认为在体能状态(PS)评分<2的老年晚期NSCLC患者中使用ICIs单药、ICIs双药联合、ICIs联合化学治疗等方案,能获得与年轻患者相近的生存获益和耐受性;但随着年龄继续增长(尤其是≥80岁),疗效降低且免疫相关毒副反应发生率逐步增加,因此高龄晚期NSCLC患者应慎重选择ICIs治疗。此外,相较于年龄,PS评分才是导致患者无法接受免疫治疗以及较差生存结局的关键因素。总之,老年晚期NSCLC患者的免疫治疗极具挑战性,该领域仍有大量问题需要探索和解决。

关键词：免疫检查点抑制剂免疫治疗非小细胞肺癌/老年

A DFT study on Pt single atom loaded COF for efficient photocatalytic CO_(2)reduction

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Journal of Materials Science & Technology 2024年第3期170卷 87-94页

作者： Fei Xie Chuanbiao Bie Jian Sun Zhenyi zhang bicheng Zhu Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430078China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials and Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Minzu UniversityDalian116600China

Photocatalytic CO_(2)reduction provides a promising strategy for the alleviation of greenhouse effect and energy shortage *** single atom modification is an effective method to improve the CO_(2)reduction performance of covalent organic framework(COF)photocatalysts,while the intrinsic mechanism is not revealed in ***,a Pt-COF photocatalytic system was constructed by embedding Pt single atom in TFPT-TMT-COF(TFPT:1,3,5-tris(4-formylphenyl)-triazine,TMT:2,4,6-trimethyl-1,3,5-triazine).Based on density functional theory(DFT)calculation,the geometric structure and electronic property of Pt-COF were investigated,and the CO_(2)adsorption and reduction reaction process on Pt-COF were *** results show that the Pt atom can be steadily anchored in COF via the formation of Pt-N and Pt-C ***,there is strong electronic interaction between Pt and *** incorporation of Pt atom benefits the CO_(2)reduction activity of COF from multiple aspects:(ⅰ)reducing the band gap and improving light absorption;(ⅱ)enhancing CO_(2)adsorption and activating the CO_(2)molecule;(ⅲ)decreasing the energy barrier in the hydrogenation step of CO_(2)→COOH,thus facilitating CO_(2)conversion to CO;(ⅳ)inhibiting the hydrogenation of CO,thereby increasing the selectivity of *** work brings a novel insight into the excellent CO_(2)reduction performance of Pt modified COF,and provides useful references for the design of single atom photocatalysts.

关键词： Photocatalysis Carbon dioxide reduction Covalent organic framework Pt single atom Theoretical calculation

Yolk-shell FeSe_(2)@CoSe_(2)/FeSe_(2) heterojunction as anode materials for sodium-ion batteries with high rate capability and stability

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Journal of Materials Science & Technology 2024年第5期172卷 185-195页

作者： Liuyang zhang bicheng Zhu Difa Xu Zibao Qian Ping Xie Tao Liu Jiaguo Yu Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430078China Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha 410022China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Sodium-ion batteries are promising candidates for large-scale grid storage systems and other *** foremost advantage derives from superior environmental credentials,enhanced safety as well as lower raw material costs than lithium-ion *** is still challenging to explore desirable anode *** this study,FeSe_(2)@CoSe_(2)/FeSe_(2),with a yolk-shell structure was prepared by ion exchange and *** FeSe_(2)@CoSe_(2)/FeSe_(2)prepared as anode material for sodiumion batteries exhibits excellent rate capability due to the synergistic effect of bimetallic selenides and the interfacial effect of the ***,it delivers high performance(510 mAh g^(-1)at 0.2 A g^(-1)),superior rate capa-bility(90%retention at 5 A g^(-1)),and good long-time cycling stability(78%capacity retention after 1800 cycles at a high current density of 2 A g^(-1)).The optimized sodiumion full cell with FeSe_(2)@CoSe_(2)/FeSe_(2)as the anode and Na 3 V 2(PO 4)3 as the cathode still demonstrates excellent ***,a ca-pacity of 272 mAh g^(-1)(at 1 A g^(-1))within the operating voltage from 1 to 3.8 V can be *** work illustrates the potential of bimetallic selenides with heterostructures for performance enhancement of sodium-ion batteries.

关键词： Cobalt-iron selenide Heterojunctions Sodium storage Anode material Full battery

Assistive robots for Beijing Winter Paralympic torch relay: Accessible technologies to restore human functionality

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The Innovation 2024年第1期5卷 19-20页

作者： Bi zhang Mei Shuai bicheng Han Shuo Li Lianqing Liu Xingang Zhao State Key Laboratory of Robotics Shenyang Institute of AutomationCASShenyang 110016China Institutes for Robotics and Intelligent Manufacturing CASShenyang 110169China Department of Biomedical Engineering Beihang UniversityBeijing 100191China Beijing AI-Robotics Technology Co. Ltd.Beijing 100176China Zhejiang BrainCo Technology Co. Ltd.Hangzhou 311121China

The success of the Beijing Winter Olympics and Paralympics epitomized the vision of a community with a shared future for *** robots and artificial intelligence technologies were used in various games and events,such as assisting in parades,logistics,and security *** integration of unmanned robotic systems into torch relays was one of the highlights of the Winter Olympics.

关键词： Winter Access artificial

THE INFLUENCE OF THE SEA-AIR HEAT EXCHANGE OVER THE KUROSHIO IN THE EAST CHINA SEA IN WINTER ON THE PRECIPITATION IN THE MIDDLE AND LOWER REACHES OF CHANGJIANG RIVER IN FLOOD SEASON

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Journal of Oceanology and Limnology 1985年第1期3卷 86-95页

作者： Zhao Yongping, zhang bicheng and Jing Licai (Institute of Oceanology, Academia Sinica, Qingdao) Institute of Oceanology Academia Sinica Qingdao

In this paper, the sea-air heat exchange over the Kuroshio in the East China Sea during the winters of 1954-1972 is computed and analysed. The results indicate that the year to year anomalies of sea-air heat exchange are obvious and the values are mainly controlled by the intensity of the cold air at the same time. The authors have found a close relationship between sea-air heat exchange and precipitation in the region of the Changjiang River during the early summer. Finally, the predicting indication for forecasting this precipitation around the middle and lower reaches of Changjiang River in June is given.

关键词： heat THE INFLUENCE OF THE SEA-AIR HEAT EXCHANGE OVER THE KUROSHIO IN THE EAST CHINA SEA IN WINTER ON THE PRECIPITATION IN THE MIDDLE AND LOWER REACHES OF CHANGJIANG RIVER IN FLOOD SEASON EAST SEA

A novel nonviral nanoparticle gene vector: Poly-L-lysine- silica nanoparticles

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Chinese Science Bulletin 2002年第8期47卷 654-658页

作者： Shiguo Zhu Hongbin Lu Juanjuan Xiang Ke Tang bicheng zhang Ming Zhou Chen Tan Guiyuan Li Cent S Univ Xiangya Sch Med Inst Canc Res Changsha 410078 Peoples R China

DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomate-rial-poly-L-lysine-silica nanoparticles (PLL-SiNP) wasprepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that

关键词： nanoparticle gene vector silica nanoparticles poly-L-lysine-silica nanoparticles synthesis DNA delivery cell transfection.

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晚期非小细胞肺癌免疫治疗进展

科技导报 2023年第18期41卷 36-42页

作者：张志敏章必成许斌宋启斌武汉大学人民医院肿瘤中心武汉430060

免疫治疗作为目前最具影响力的肿瘤治疗手段,已全面改变晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗格局。综述了晚期NSCLC免疫治疗存在的诸多尚待解决的问题,如免疫联合治疗模式的组合和优化、免疫治疗耐药的机制和应... 详细信息

免疫治疗作为目前最具影响力的肿瘤治疗手段,已全面改变晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗格局。综述了晚期NSCLC免疫治疗存在的诸多尚待解决的问题,如免疫联合治疗模式的组合和优化、免疫治疗耐药的机制和应对策略、寻找合适的免疫治疗相关生物标志物、特殊人群特征的免疫治疗以及免疫治疗相关毒性管理等。探讨了晚期NSCLC免疫治疗的现状和未来之路。

关键词：非小细胞肺癌免疫治疗免疫检查点抑制剂

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肿瘤免疫治疗的反应模式

医药导报 2022年第3期41卷 297-302页

作者：唐家琢宋羽霄章必成武汉大学人民医院肿瘤中心武汉430060

肿瘤的免疫治疗已经取得长足进步,其中免疫检查点抑制剂最常用且最受关注。随着临床的广泛应用,研究者们逐步发现肿瘤免疫治疗存在不同的反应模式,包括持久反应、假性进展、超进展、分离反应和耐药等。不同的反应模式预后相差大,相应的... 详细信息

肿瘤的免疫治疗已经取得长足进步,其中免疫检查点抑制剂最常用且最受关注。随着临床的广泛应用,研究者们逐步发现肿瘤免疫治疗存在不同的反应模式,包括持久反应、假性进展、超进展、分离反应和耐药等。不同的反应模式预后相差大,相应的治疗策略也随之改变,临床使用中应仔细鉴别并及时调整治疗方案。该文主要介绍肿瘤免疫治疗各种反应模式的特点及临床应对策略。

关键词：免疫治疗免疫检查点抑制剂反应模式

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T-k-挠自由模的扩张闭

数学杂志 2008年第4期28卷 404-410页

作者：张必成湘潭大学数学系湖南湘潭411105 苏州大学数学科学学院

本文研究了由T-k-挠自由模所构成的mod-R的完全子模范畴IkT(R)的扩张闭.利用模的级条件和强级条件,获得了ITk(R)扩张闭的一个充分条件和一个等价刻画.

关键词： Wakamatsu倾斜模扩张闭 T-k-挠自由模