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Journal of Oceanology and Limnology 1985年第1期3卷 86-95页

作者： Zhao Yongping, Zhang bicheng and Jing Licai (Institute of Oceanology, Academia Sinica, Qingdao) Institute of Oceanology Academia Sinica Qingdao

In this paper, the sea-air heat exchange over the Kuroshio in the East China Sea during the winters of 1954-1972 is computed and analysed. The results indicate that the year to year anomalies of sea-air heat exchange are obvious and the values are mainly controlled by the intensity of the cold air at the same time. The authors have found a close relationship between sea-air heat exchange and precipitation in the region of the Changjiang River during the early summer. Finally, the predicting indication for forecasting this precipitation around the middle and lower reaches of Changjiang River in June is given.

关键词： heat THE INFLUENCE OF THE SEA-AIR HEAT EXCHANGE OVER THE KUROSHIO IN THE EAST CHINA SEA IN WINTER ON THE PRECIPITATION IN THE MIDDLE AND LOWER REACHES OF CHANGJIANG RIVER IN FLOOD SEASON EAST SEA

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8^(+)T cell responses in HLA-A transgenic mice

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Cellular & Molecular Immunology 2021年第12期18卷 2588-2608页

作者： Xiaoxiao Jin Yan Ding Shihui Sun Xinyi Wang Zining zhou Xiaotao Liu Miaomiao Li Xian Chen Anran Shen Yandan Wu bicheng Liu Jianqiong Zhang Jian Li Yi Yang Haibo Qiu Chuanlai Shen Yuxian He Guangyu Zhao Department of Microbiology and Immunology Medical School of Southeast UniversityNanjing210009JiangsuChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing100071China Blood Component Preparation Section Jiangsu Province Blood CenterNanjing210042JiangsuChina Institute of Nephrology Zhongda HospitalMedical School of Southeast UniversityNanjing210009JiangsuChina Life Science&Technology School of Southeast University Nanjing210096JiangsuChina Jiangsu Province Key Laboratory of Critical Care Medicine Department of Critical Care MedicineZhongda HospitalMedical School of Southeast UniversityNanjing210009JiangsuChina Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and pathology in patients with coronavirus disease 2019(COVID-19),this study focused on the functional validation of T cell epitopes and the development of vaccines that induce specific T cell responses.A total of 120 CD8^(+)T cell epitopes from the E,M,N,S,and RdRp proteins were functionally *** these,110,15,6,14,and 12 epitopes were highly homologous with SARS-CoV,OC43,NL63,HKU1,and 229E,respectively;in addition,four epitopes from the S protein displayed one amino acid that was distinct from the current SARS-CoV-2 ***,31 epitopes restricted by the HLA-A2 molecule were used to generate peptide cocktail vaccines in combination with Poly(I:C),R848 or poly(lactic-co-glycolic acid)nanoparticles,and these vaccines elicited robust and specific CD8^(+)T cell responses in HLA-A2/DR1 transgenic mice as well as wild-type *** contrast to previous research,this study established a modified DC-peptide-PBL cell coculture system using healthy donor PBMCs to validate the in silico predicted epitopes,provided an epitope library restricted by nine of the most prevalent HLA-A allotypes covering broad Asian populations,and identified the HLA-A restrictions of these validated epitopes using competitive peptide binding experiments with *** cell lines expressing the indicated HLA-A allotype,which initially confirmed the in vivo feasibility of 9-or 10-mer peptide cocktail vaccines against *** data will facilitate the design and development of vaccines that induce antiviral CD8^(+)T cell responses in COVID-19 patients.

关键词： SARS-CoV-2 T cell epitope HLA-A Vaccination

Multi-time scale analysis of precipitation variation in Guyuan, China:1957-2005

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Ecological Economy 2008年第4期4卷 512-518页

作者： Liu Delin Li bicheng Research Center of Soil and Water Conservation and Ecological Environment Chinese Academy of Sciences and Ministry of Education Yangling 712100 P R. China Graduate School Chinese Academy of Sciences Beoing 100039 P.R. China

Morlet wavelet transformation is used in this paper to analyze the multi time scale characteristics of pre cipitation data series from 1957 to 2005 in Guyuan *** results showed that(1) the annual precipitation evo lution process had obvious multi time scale variation characteristics of 15 25 years,7 12 years and 3 6 years,and different time scales had different oscillation energy densities;(2) the periods at smaller time scales changed more frequently,which often nested in a biggish quasi periodic oscillations,so the concrete time domain should be ana lyzed if necessary;(3) the precipitation had three main periods(22 year,9 year and 4 year) and the 22 year period was especially outstanding,and the analysis of this main period reveals that the precipitation would be in a relative high water period until about 2012.

关键词： Precipitation variation Multi-time scale Wavelet analysis Guyuan region Loess Plateau

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Temperature acclimation in hot-spring snakes and the convergence of cold response

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The Innovation 2022年第5期3卷 97-106页

作者： Chaochao Yan Wei Wu Wenqi Dong bicheng Zhu Jiang Chang Yunyun Lv Shilong Yang Jia-Tang Li CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 660223China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100085China College of Life Science Neijiang Normal UniversityNeijiangSichuan 641100China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Animals have evolved sophisticated temperature-sensing systems and mechanisms to detect and respond to ambient temperature *** a relict species endemic to the Qinghai-Tibet Plateau,hot-spring snake(Thermophis baileyi)survived the dramatic changes in climate that occurred during plateau uplift and ice ages,providing an excellent opportunity to explore the evolution of temperature sensation in *** on distributional information and behavioral experiments,we found that *** prefer hotspring habitats and respond more quickly to warmth than other two snakes,suggesting that *** may evolve an efficient thermal-sensing *** high-quality chromosome-level assembly and comparative genomic analysis,we identified cold acclimation genes experiencing convergent acceleration in high-altitude *** also discovered significant evolutionary changes in thermosensation-and thermoregulation-related genes,including the transient receptor potential(TRP)*** these genes,TRPA1 exhibited three species-specific amino acid replacements,which differed from those found in infrared imaging snakes,implying different temperature-sensing molecular strategies.

关键词： habitat spring snake

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网络新闻口语评论文本中人物对象识别方法

中文信息学报 2010年第4期24卷 25-31页

作者：林琛李弼程周杰解放军信息工程大学信息工程学院河南郑州450002

网络新闻口语评论文本中的人物对象是网络舆情的重要内容,是口语评论情感倾向性分析的基础。该文结合新闻口语评论中人物对象特点,提出了一种有效的人物对象自动识别方法。该方法首先在分词基础上,采用多频率综合判别对单字作为人物对... 详细信息

网络新闻口语评论文本中的人物对象是网络舆情的重要内容,是口语评论情感倾向性分析的基础。该文结合新闻口语评论中人物对象特点,提出了一种有效的人物对象自动识别方法。该方法首先在分词基础上,采用多频率综合判别对单字作为人物对象的可靠度进行评估,以获得稳定的识别线索;其次,根据线索划定处理窗口,利用改进频繁项挖掘算法,从窗口中提取候选人物对象;最后,对结果中存在的冗余进行优化处理。实验结果表明,新方法能够完整、有效地识别网络新闻口语评论文本中的人物对象。

关键词：计算机应用中文信息处理网络舆情口语评论人物对象频繁项挖掘

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面向网络评论的观点主题识别研究

情报学报 2010年第5期29卷 858-863页

作者：周杰林琛李弼程信息工程大学信息工程学院郑州450002

网络评论的观点分析为及时掌握广大民众的真实观点提供了渠道。观点主题识别作为观点分析的重要组成部分,用以确定观点所指的对象。本文设计了一种领域无关的观点主题识别算法,该算法以网络评论中观点主题产生的方式为依据,采用由内到... 详细信息

网络评论的观点分析为及时掌握广大民众的真实观点提供了渠道。观点主题识别作为观点分析的重要组成部分,用以确定观点所指的对象。本文设计了一种领域无关的观点主题识别算法,该算法以网络评论中观点主题产生的方式为依据,采用由内到外的识别过程,分四个部分完成观点主题识别：内部主题词识别、内部主题构建、外部主题识别和主题的组织。算法能够克服分词和短语类主题带来的影响,识别出语义完整的观点主题。对实际网络评论语料进行测试的结果表明,本文的算法能够有效地识别网络评论中的观点主题。

关键词：中文信息处理观点分析网络评论观点主题识别

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基于信息粒度的交叠类文本分类方法

情报学报 2011年第4期30卷 339-346页

作者：林琛李弼程周杰信息工程大学信息工程学院郑州450002

从信息粒度的角度分析了文本分类中出现样本错分的原因,同时结合人类认知方式,提出一种基于信息粒度的交叠类文本分类方法。新方法通过转换描述训练样本集合的粒度空间,对训练样本进行重新划分,加大训练样本之间的差异性,以此增加分类... 详细信息

从信息粒度的角度分析了文本分类中出现样本错分的原因,同时结合人类认知方式,提出一种基于信息粒度的交叠类文本分类方法。新方法通过转换描述训练样本集合的粒度空间,对训练样本进行重新划分,加大训练样本之间的差异性,以此增加分类的先验知识;根据人类认知方式的特点,在划分后的训练样本集合上构建层次分类器进行分类。实验中采用了不同领域、不同类型的语料库,定量分析了类交叠程度对分类性能的影响并对新方法进行了测试。实验结果表明,新方法能够有效地提高分类性能,尤其适合于类交叠程度较高的情况。

关键词：信息粒度文本分类认知方式

The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine

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The inhibition of cytochrome P450 2A13-catalyzed NNK metabol...

H2O molecule adsorption on s-triazine-based g-C3N4

作者： Xingyu Liu Jie Zhang Chen Zhang bicheng Yang Limeng Wang Jun zhou Shanghai Tobacco Group Corporation Jiangxi Provincial Maternal And Child Health Hospital Dalian Institute of Chemical Physics University of Chinese Academy of Sciences Zhengzhou Tobacco Research Institute

NNK is considered to be the most carcinogenic compound of the four TSNAs and necessary to be metabolically activated to exert its carcinogenic effect to human. For the simultaneous intake of NNK and other compounds with similar molecular structure in the context of tobacco smoke, whether NAT, NAB and nicotine contribute to the inhibitory potency of CYP P450 enzyme-catalyzed NNK metabolism or not needs to be investigated. In the in vitro study, OPB, HPB and OPBA were established as the products of CYP2A13-catalyzed NNK metabolism and kinetic parameters were calculated from Michaelis-Menten equation. Addition of NAT, NAB or nicotine resulted in a competitive inhibition for NNK metabolism catalyzed by CYP2A13. The inhibition constant Ki value was calculated as 0.21 μM(NAT), 0.23 μM(NAB) and 8.51 μM(nicotine) for OPB formation, 0.71 μM(NAT), 0.87 μM(NAB) and 25.01 μM(nicotine) for HPB formation, 0.36 μM(NAT), 0.50 μM(NAB) and 6.57 μM(nicotine) for OPBA formation, respectively. In addition, the study of transformation of three metabolites firstly revealed OPB was not only an end product but also an intermediate product of CYP2A13-catalyzed NNK metabolism. These results suggest that structurally similar tobacco constitutes with weak or no carcinogenicity influence the metabolic activation of NNK, which interfere in its carcinogenicity to some extent.

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来源： cnki会议评论

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Chinese Journal of Catalysis 2021年第1期42卷 115-122页

作者： bicheng Zhu Liuyang Zhang Bei Cheng Yan Yu Jiaguo Yu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Key Laboratory of Eco-materials Advanced Technology College of Materials Science and EngineeringFuzhou UniversityFuzhou 350116FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina

The interaction between a gas molecule and photocatalyst is vital to trigger photocatalytic *** surface state of photocatalyst affects much in this ***,adsorption of H2O molecules on s-triazine-based g-C3N4 was thoroughly studied by first-principle *** various initial adsorption models with multifarious locations of H2O molecules were built,the optimized models with strong adsorption energy pointed to the same adsorption configuration,in which the H2O molecule hold an upright orientation above the corrugated g-C3N4 *** intermolecular O-H…N hydrogen bond formed via the binding of a polar O-H bond in H2O molecule and a two-coordinated electron-rich nitrogen atom in *** the bridging effect of this intermolecular hydrogen bond,electrons would transfer from g-C3N4 to the H2O molecule,thereby lowering the Fermi level and enlarging work function of ***,regardless of the substitute,i.e.g-C3N4 multilayer,large supercell and nanotube,this adsorption system was highly reproducible,as its geometry structure and electronic property remained *** addition,the effect of nonmetal element doping on adsorption energy was *** work not only disclosed a highly preferential H2O adsorbed g-C3N4 architecture established by intermolecular hydrogen bond,but also contributed to the deep understanding and optimized design in water-splitting process on g-C3N4-based photocatalysts.

关键词： g-C3N4 H2O Density functional theory Hydrogen bond Adsorption energy

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In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine

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In vitro metabolism of N'-Nitrosonornicotine catalyzed by cy...