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Predicting survival and prognosis of postoperative breast cancer brain metastasis:a population-based retrospective analysis

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Chinese Medical Journal 2023年第14期136卷 1699-1707页

作者： Yan Nie bicheng ying Zinan Lu Tonghui Sun Gang Sun Department of Breast and Thyroid Surgery The Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Xinjiang Cancer Center/Key Laboratory of Oncology of Xinjiang Uyghur Autonomous Region UrumqiXinjiang 830011China

Background:Breast cancer is one of the most common cancer in women and a proportion of patients experiences brain metastases with poor *** study aimed to construct a novel predictive clinical model to evaluate the overall survival(OS)of patients with postoperative brain metastasis of breast cancer(BCBM)and validate its ***:From 2010 to 2020,a total of 310 female patients with BCBM were diagnosed in The Affiliated Cancer Hospital of Xinjiang Medical University,and they were randomly assigned to the training cohort and the validation *** of another 173 BCBM patients were collected from the Surveillance,Epidemiology,and End Results Program(SEER)database as an external validation *** the training cohort,the least absolute shrinkage and selection operator(LASSO)Cox regression model was used to determine the fundamental clinical predictive indicators and the nomogram was constructed to predict *** model capability was assessed using receiver operating characteristic,C-index,and calibration ***-Meier survival analysis was performed to evaluate clinical effectiveness of the risk stratification system in the *** accuracy and prediction capability of the model were verified using the validation and SEER ***:LASSO Cox regression analysis revealed that lymph node metastasis,molecular subtype,tumor size,chemotherapy,radiotherapy,and lung metastasis were statistically significantly correlated with *** C-indexes of the survival nomogram in the training,validation,and SEER cohorts were 0.714,0.710,and 0.670,respectively,which showed good prediction *** calibration curves demonstrated that the nomogram had great forecast precision,and a dynamic diagram was drawn to increase the maneuverability of the *** Risk Stratification System showed that the OS of lowrisk patients was considerably better than that of high-risk patients(P<0.001).Conclusion:The nomogram prediction model constructed in

关键词： Breast cancer brain metastasis Nomograms Overall survival Surveillance Survival prediction model

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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou ying Hu Hua Li Qiongqiong Yang Qijun Wan bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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TDERS,an exosome RNA-derived signature predicts prognosis and immunotherapeutic response in clear cell renal cell cancer:a multicohort study

Journal of the National Cancer Center

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Journal of the National Cancer Center 2024年第4期4卷 382-394页

作者： Aimin Jiang ying Liu Ziwei He Wenqiang Liu Qiwei Yang Yu Fang Baohua Zhu Xiaofeng Wu Huamao Ye bicheng Ye Shunxiang Gao Le Qu Wenhao Xu Peng Luo Linhui Wang Department of Urology Changhai HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Urology Shanghai East HospitalTongji University School of MedicineShanghaiChina Department of Urology the Third Affiliated Hospital of Naval Military Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina School of Clinical Medicine Medical College of Yangzhou Polytechnic CollegeYangzhouChina Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghaiChina Department of Urology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Urology Fudan University Shanghai Cancer CenterState Key Laboratory of Genetic EngineeringCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesInstitute of Biomedical Sciencesand Human Phenome InstituteFudan UniversityShanghaiChina Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhouChina

Background:Tumor-derived exosomes are involved in tumor progression and immune invasion and might func-tion as promising noninvasive approaches for clinical ***,there are few reports on exosom-based markers for predicting the progression and adjuvant therapy response rate among patients with clear cell renal cell carcinoma(ccRCC).Methods:The signatures differentially expressed in exosomes from tumor and normal tissues from ccRCC pa-tients were correspondingly deregulated in ccRCC *** adopted a two-step strategy,including Lasso and bootstrapping,to construct a novel risk stratification system termed the TDERS(Tumor-Derived Exosome-Related Risk Score).During the testing and validation phases,we leveraged multiple external datasets containing over 2000 RCC cases from eight cohorts and one inhouse cohort to evaluate the accuracy of the *** addition,enrichment analysis,immune infiltration signatures,mutation landscape and therapy sensitivity between the high and low TDERS groups were ***,the impact of TDERS on the tumor microenvironment(TME)was also analysed in our single-cell ***:TDERS consisted of 12 mRNAs deregulated in both exosomes and tissues from patients with *** achieved satisfactory performance in both prognosis and immune checkpoint inhibitor(ICI)response across all ccRCC cohorts and other pathological types,since the average area under the curve(AUC)to predict 5-year overall survival(OS)was larger than 0.8 across the four *** in the TDERS high group were resistant to ICIs,while mercaptopurine might function as a promising agent for those *** with a high TDERS were characterized by coagulation and hypoxia,which induced hampered tumor antigen presentation and relative resistance to *** addition,single cells from 12 advanced samples validated this phenomenon since the interaction between dendritic cells and macrophages was ***,PLOD2,which is highly expressed i

关键词： Renal cell carcinoma Exosome Non-invasive biopsy Immunotherapy response Multiomics PLOD2

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混凝土结构超声阵列探头成像算法研究

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压电与声光 2012年第6期34卷 932-935,939页

作者：廖寅熊必成李秋锋孙颖马辉聪南昌航空大学无损检测技术教育部重点实验室江西南昌330063 江西旅游商贸职业学院江西南昌330100

目前对混凝土结构进行超声检测常采用双探头方式,检测效率很低。提出了一种超声阵列探头成像方法来提高检测效率,这种方法充分利用阵列中相隔探头间形成的扫描信号,最大限度增加阵列数据融合处理的有效数组维数,根据线型阵列的结构特点... 详细信息

目前对混凝土结构进行超声检测常采用双探头方式,检测效率很低。提出了一种超声阵列探头成像方法来提高检测效率,这种方法充分利用阵列中相隔探头间形成的扫描信号,最大限度增加阵列数据融合处理的有效数组维数,根据线型阵列的结构特点,结合合成孔径聚焦算法,配合有效的信号处理方法滤除结构噪声,能对混凝土结构实现有效探测。数值仿真结果表明,此方法不仅能提高检测效率,且能对检测目标实现有效聚焦和准确定位。

关键词：超声检测混凝土结构阵列探头合成孔径聚焦技术数值模拟信号处理

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黄土高原六盘山生态经济圈功能区规划研究

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生态经济 2009年第12期25卷 46-49页

作者：李壁成刘德林张膺方炫中国科学院教育部水土保持与生态环境研究中心西北农林科技大学陕西杨凌712100

六盘山区位于黄河中上游,是黄土高原西部天然生态屏障和水源涵养区,在中国生态环境建设中具有重要战略地位。本区土地资源丰富,生态环境洁净,旱作农业潜力大,草畜业兴旺。六盘山生态经济圈规划了4个功能区和7大特色农业基地产业,以六盘... 详细信息

六盘山区位于黄河中上游,是黄土高原西部天然生态屏障和水源涵养区,在中国生态环境建设中具有重要战略地位。本区土地资源丰富,生态环境洁净,旱作农业潜力大,草畜业兴旺。六盘山生态经济圈规划了4个功能区和7大特色农业基地产业,以六盘山国家自然保护区为中心,加大退耕造林种草与管护力度,到2015年基本修复六盘山区受损的森林生态系统和灌丛草原植被;以旱作农业技术体系为支撑,建立高效可持续发展的生态农业系统和绿色农牧产品基地,为经济社会发展和新农村建设提供良好的生态环境和农业基础。

关键词：黄土高原六盘山生态经济圈功能区规划

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复杂裂缝网络页岩气藏自适应网格剖分方法

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石油学报 2019年第2期40卷 197-206页

作者：糜利栋姜汉桥胡向阳李俊键胡小虎周元龙贾英严必成中国石油化工股份有限公司石油勘探开发研究院北京100083 中国石油大学(北京)石油工程学院北京102249 Texas A&M University texas77840

网格是油气藏数值模拟的基础,传统网格剖分方法制约着复杂裂缝网络页岩气藏数值模拟技术的发展,研究裂缝性介质高效网格剖分方法具有重要意义。笔者以裂缝节点为基础,基于图像像素点原理、距离最近原则和对数加密方法,提出了一种网格数... 详细信息

网格是油气藏数值模拟的基础,传统网格剖分方法制约着复杂裂缝网络页岩气藏数值模拟技术的发展,研究裂缝性介质高效网格剖分方法具有重要意义。笔者以裂缝节点为基础,基于图像像素点原理、距离最近原则和对数加密方法,提出了一种网格数量少、计算精度高、可以处理任意复杂裂缝网络分布的自适应网格剖分方法(AMM)。研究结果表明,AMM中裂缝网格控制面积比NFFLOW中的控制面积更接近实际情况;AMM可以处理任意复杂裂缝网络和复杂边界条件模型;相比已有网格剖分方法,AMM可大幅度降低计算网格数量。在用于页岩气藏数值模拟时,AMM可以同时解决由复杂裂缝引起计算网格多、精度低等问题,为实现矿场尺度页岩气藏数值模拟奠定基础。

关键词：网格剖分裂缝网络自适应页岩气藏图像处理

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应县日用陶瓷产业创新发展研究

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现代工业经济和信息化 2023年第3期13卷 23-24,30页

作者：宋必成应县经济技术开发区管委会山西应县037600

介绍了应县日用陶瓷产业发展背景,从集聚发展、政策体系、产品特点和市场动态等方面剖析了应县日用陶瓷发展现状,针对日用陶瓷发展过程中生产存在的问题,提出了相应的对策和建议,以着力推进日用陶瓷创新发展,为推动应县日用陶瓷产业高... 详细信息

介绍了应县日用陶瓷产业发展背景,从集聚发展、政策体系、产品特点和市场动态等方面剖析了应县日用陶瓷发展现状,针对日用陶瓷发展过程中生产存在的问题,提出了相应的对策和建议,以着力推进日用陶瓷创新发展,为推动应县日用陶瓷产业高质量发展提供参考。

关键词：日用陶瓷产业创新发展研究

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《钙性尿毒症性小动脉病》后续报道

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肾脏病与透析肾移植杂志 2019年第3期28卷 291-292页

作者：刘玉秋杨璨粼汤日宁仰欣钟英刘必成张晓良东南大学医学院东南大学附属中大医院肾内科

我们2018年6月报道了1例钙性尿毒症性小动脉病患者,主要表现为双侧足趾严重缺血坏死,全身多发性溃疡灶,疼痛剧烈。予硫代硫酸钠为主的综合治疗一月(中大方案),患者疼痛明显减轻,小溃疡灶好转,但是其左足深达骨面的坏死灶仍恶性进展并伴... 详细信息

我们2018年6月报道了1例钙性尿毒症性小动脉病患者,主要表现为双侧足趾严重缺血坏死,全身多发性溃疡灶,疼痛剧烈。予硫代硫酸钠为主的综合治疗一月(中大方案),患者疼痛明显减轻,小溃疡灶好转,但是其左足深达骨面的坏死灶仍恶性进展并伴反复感染,多学科会诊建议截肢。因家庭及社会原因,患者未行截肢,继续在我们随访下接受标准治疗。一年后,患者足部坏死灶完全愈合,全身病变得到控制。严格规范化使用硫代硫酸钠对钙化防御患者的治疗具有重要意义。

关键词：钙性尿毒症性小动脉病钙化防御硫代硫酸钠截肢

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基于物联网的禽畜智能养殖监控系统的设计

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电子测量技术 2014年第11期37卷 86-89页

作者：应胜斌雷必成周坤王江伟台州学院物理与电子工程学院台州318000

设计了一套基于物联网的养殖场自动监控系统。系统运用各种传感器组成无线传感网络,实现养殖棚环境中的温度、湿度、光照强度、CO2浓度、NH3浓度等物理量参数的检测。依靠2.4G无线技术、ZigBee技术和GPRS网络将采集的数据传输至远程服... 详细信息

设计了一套基于物联网的养殖场自动监控系统。系统运用各种传感器组成无线传感网络,实现养殖棚环境中的温度、湿度、光照强度、CO2浓度、NH3浓度等物理量参数的检测。依靠2.4G无线技术、ZigBee技术和GPRS网络将采集的数据传输至远程服务器。由控制器根据设定的参数控制供热、供湿、排风等设备的运作。同时将采集到的数据传送到企业的Web服务器,实现用户对养殖现场的监测与控制,达到养殖环境的全自动智能化监控功能。该套系统经过合作企业的实地测试,系统正确、实时地采集到了各节点的环境状态,充分证明了系统的可行性和稳定性,说明了系统具有准确,方便,快捷的特点。

关键词：物联网(IOT) 无线传感网络(WSN) 远程监控 ZigBee STM32

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“世界动物节”在近代中国的宣传与纪念

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社会科学战线 2023年第3期333卷 105-121,282页

作者：朱英华中师范大学中国近代史研究所湖北武汉430079

近代中国保护动物运动的兴起,始于1934年世界动物节的宣传与纪念。但在此之前,被称为“现代女界中的奇杰”的吕碧城就在报刊上对包括世界动物节在内的欧美保护动物运动,进行过介绍与宣传。中国保护动物会成立之后,积极动员,精心筹备,连... 详细信息

近代中国保护动物运动的兴起,始于1934年世界动物节的宣传与纪念。但在此之前,被称为“现代女界中的奇杰”的吕碧城就在报刊上对包括世界动物节在内的欧美保护动物运动,进行过介绍与宣传。中国保护动物会成立之后,积极动员,精心筹备,连年举办了纪念世界动物节等一系列丰富多彩的活动,与吕碧城的介绍与宣传交相辉映,使国人受到了动物保护的近代思想启蒙,保护动物运动由此在中国发端。这从一个侧面体现了近代中国从传统走向现代,以及部分国人逐步走向世界的新趋向。

关键词：保护动物运动世界动物节中国保护动物会吕碧城

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