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Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

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Signal Transduction and Targeted Therapy 2020年第1期5卷 663-666页

作者： biao di Hongling Jia Oscar Junhong Luo Fangqin Lin Kuibiao Li Yuanliang Zhang Huadong Wang Huiying Liang Jun Fan Zhicong Yang Guangzhou Center for disease Control and Prevention 510440 GuangzhouGuangdongChina Department of Medical Biochemistry and Molecular Biology School of MedicineJinan University510632 GuangzhouGuangdongChina Department of Systems Biomedical Sciences School of MedicineJinan University510632 GuangzhouGuangdongChina GMU-GIBH Joint School of Life Sciences Guangzhou Medical University511436 GuangzhouGuangdongChina BGI-Shenzhen.Beishan Industrial Zone 11th buildingYantian District518055 ShenzhenGuangdongChina Department of Pathophysiology Key Laboratory of National Administration of Traditional Chinese Medicine of the People’s Republic of ChinaSchool of MedicineJinan University510632 GuangzhouGuangdongChina Clinical Data Center Guangdong General Hospital/Guangdong Academy of Medical Sciences510080 GuangzhouGuangdongChina

Dear Editor,Recent study showed that around 80%of coronavirus disease-19(COVID-19)patients are moderate cases who will recover with or without conventional treatment,while the remaining 20%developed severe disease requiring intensive care.1 Early and accurate screening of new COVID-19 patients to identify those who will develop severe disease will facilitate decision-making on appropriate treatment regimens and reasonable allocation of limited healthcare ***,novel predictive factors for disease progress from moderate to severe are urgently needed.

关键词： treatment COV severe

The dengue preface to endemic in China's Mainland:the historical largest outbreak by Aedes albopictus in Guangzhou,2014

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Infectious diseases of Poverty 2017年第1期6卷 1313-1323页

作者： Lei Luo Li-Yun Jiang Xin-Cai Xiao biao di Qin-Long Jing Sheng-Yong Wang Jin-Ling Tang Ming Wang Xiao-Ping Tang Zhi-Cong Yang Guangzhou Center for disease Control and Prevention Guangzhou 510440People’s Republic of China Department of Epidemiology Medical CollegeJinan UniversityGuangzhou 510632People’s Republic of China division of Epidemiology The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong Kong 999077People’s Republic of China Department of Infectious diseases Guangzhou No.8 People’s HospitalGuangzhou 510060People’s Republic of China

Background:Dengue was regarded as a mild epidemic in China's Mainland transmitted by Aedes ***,the 2014 record-breaking outbreak in Guangzhou could change the *** order to provide an early warning of epidemic trends and provide evidence for prevention and control strategies,we seek to characterize the 2014 outbreak through application of detailed cases and entomological data,as well as phylogenetic analysis of viral envelope(E)***:We used case survey data identified through the Notifiable Infectious disease Report System,entomological surveillance and population serosurvey,along with laboratory testing for IgM/IgG,NS1,and isolation of viral samples followed by E gene sequencing and phylogenetic analysis to examine the epidemiological and molecular characteristics of the ***:The 2014 dengue outbreak in Guangzhou accounted for nearly 80%of total reported cases that year in China's Mainland;a total of 37,376 cases including 37,340 indigenous cases with incidence rate 2908.3 per million and 36 imported cases were reported in Guangzhou,with 14,055 hospitalized and 5 *** epidemic lasted for 193 days from June 11 to December 21,with the highest incidence observed in domestic workers,the unemployed and *** inapparent infection rate was 18.00%(135/750).In total,96 dengue virus 1(DENV-1)and 11 dengue virus 2(DENV-2)strains were *** analysis indicated that the DENV-1 strains were divided into genotype I and V,similar to the strains isolated in Guangzhou and Dongguan in *** DENV-2 strains isolated were similar to those imported from Thailand on May 11 in 2014 and that imported from Indonesia in ***:The 2014 dengue epidemic was confirmed to be the first co-circulation of DENV-1 and DENV-2 in *** DENV-1 strain was endemic,while the DENV-2 strain was imported,being efficiently transmitted by the Aedes albopictus vector species at levels as high as Aedes aegypti.

关键词： Dengue Co-circulation Dengue virus-1 Dengue virus-2 Endemic disease

Dengue Fever Epidemiological Status and Relationship with Meteorological Variables in Guangzhou, Southern China, 2007-2012

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Biomedical and Environmental Sciences 2013年第12期26卷 994-997页

作者： LI Tie Gang YANG Zhi Cong LUO Lei di biao WANG Ming Guangzhou Center for disease Control and Prevention

Ecological methodology plus negative binomial regression were used to identify dengue fever （DF） epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of DF in Guangzhou was 0.33, 0.11, 0.15, 0.64, 0.45, and 1.34 （per 100 000） respectively, showing an increasing trend. Each 1℃ rise of temperature corresponded to an increase of 10.23% （95% CI 7.68% to 12.83%） in the monthly number of DF cases, whereas l hPa rise of atmospheric pressure corresponded to a decrease in the number of cases by 5.14% （95% CI： 7.10%-3.14%）. Likewise, each one meter per second rise in wind velocity led to an increase by 43.80% or 107.53%, and one percent rise of relative humidity led to an increase by 2.04% or 2.19%.

关键词： Dengue Fever Epidemiological Status and Relationship with Meteorological Variables in Guangzhou Southern China Wind

Epidemiological Survey and Analysis on an Outbreak of Gastroenteritis due to Water Contamination

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Biomedical and Environmental Sciences 2011年第3期24卷 275-283页

作者： YANG ZhlCong WU XinWei LI TieGang LI MeiXia ZHONG Yi LIU YuFei DENG ZhiAi di biao HUANG Cong LIANG HuiYing WANG Ming Guangzhou Center for disease Control and Prevention Guangzhou 510080 Guangdong China

Objective To document the investigation and control of an outbreak of gastroenteritis in City G, South China, and provide a reference for preventing future outbreaks. Methods An ambispective cohort study was designed. Attack rate （AR） and relative risks （RR） were calculated to identify the causes of gastroenteritis. Investigations using questionnaires included personal interviews with patients and doctors, reviews of medical records, laboratory examinations of fecal specimens and continuous hygiene monitoring of water samples from the waterworks. Results Overall, 427/71534 （AR=5.97%o） cases were identified between October 31 and November 12 2010. Geographic distribution was highly localized, with 80% of cases occurring in the areas supplied by waterworks-A. Consumption of water provided solely by waterworks-A was found to be associated with illness （RR=8.20, 95 C1%：6.12-10.99） compared with that from waterworks-B. Microbiological analyses confirmed the presence of Norovirus in six of eight fecal samples from symptomatic patients, two water samples from waterworks-A and two sewage samples. After taking effective measures, the hygienic indices of waterworks-A met health criteria again on November 9 and no cases were reported 3 days *** The outbreak reported here was caused by drinking tap water contaminated with sewage at the source. Early identification of possible contamination sources and awareness of changes that might negatively impact water quality are important preventive measures to protect public health.

关键词： Water contamination Norovirus Outbreak Survey and analysis

Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease:A case report

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Biosafety and Health 2023年第4期5卷 250-253页

作者： Wenzhe Su Qing Zeng Jinmei Geng Jingwen Liu Huaping Xie Kuibiao Li Pengzhe Qin Chaojun Xie biao di Guangzhou Center for disease Control and Prevention Guangzhou 510000China Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou 510000China Huadu Center for disease Control and Prevention Guangzhou 510803China

Human enterovirus(EV)infections can lead to various manifestations,with variable correlations between genotypes and *** enterovirus D68(EV-D68)was considered to be associated with acute respiratory disease and acute flaccid *** this short report,both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine(OPV),using a metatranscriptomic high-throughput sequencing *** nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were *** previously-reported neurovirulence-related amino acid substitution(T860N)in the EV-D68 VP1 region was observed,but the patient showed no neurological *** attention should be paid to EV-D68,and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for.

关键词： Enterovirus EV-D68 Poliovirus 3 Acute respiratory disease Whole genome sequencing Co-infection

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平台秤发展新动向

衡器 2009年第4期38卷 44-45页

作者：唐荻表上海秋豪衡器有限公司

传统模拟传感器的平台秤由于受技术的限制，采用模拟传感器和模拟接线盒，存在以下缺点：1、角差调整精度不高，调整费时。在产量较大的厂家，调整角差成了生产的瓶颈。

关键词：台秤模拟传感器调整精度接线盒角差

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上坝大桥主墩液压爬模施工技术

企业技术开发 2017年第5期36卷 18-21页

作者：王狄彪中国中铁五局集团贵州工程有限公司贵州贵阳550003

文章结合上坝大桥主墩的施工,介绍了液压爬模体系及施工工艺流程。

关键词：液压爬模施工技术

广州市2010年新发现一株基孔肯雅病毒基因特征研究

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中华流行病学杂志 2014年第6期35卷 756-758页

作者：白志军罗雷杨智聪狄飚王鸣广州市疾病预防控制中心 510440

基孔肯雅热（CHIK）是由CHIK病毒（CHIKV）经伊蚊传播的一种急性传染病。2010年广州市疾病预防控制中心监测到1名疑似登革热发热症状的患者，血样经实验室检测显示登革病毒核酸为阴性，CHIKV核酸为阳性，继而分离获得1株CHIKV。采用RT-P... 详细信息

基孔肯雅热（CHIK）是由CHIK病毒（CHIKV）经伊蚊传播的一种急性传染病。2010年广州市疾病预防控制中心监测到1名疑似登革热发热症状的患者，血样经实验室检测显示登革病毒核酸为阴性，CHIKV核酸为阳性，继而分离获得1株CHIKV。采用RT-PCR 扩增此毒株的全基因并测序，与 GenBank 中的中国地区和全球代表株进行全基因进化分析，以了解其序列特征和可能的传播来源。

关键词：基孔肯雅病毒序列

广州市2010年登革4型病毒的分离及其E基因进化分析

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中华流行病学杂志 2011年第10期32卷 1051-1053页

作者：和鹏白志军狄飚罗雷李魁彪吴忠道王鸣中山大学中山医学院广州510080 市疾病预防控制中心

登革病毒（DEN）E蛋白在病毒与宿主细胞融合和诱导机体产生抗体等过程中发挥重要作用[1]。本研究通过对分离株E基因全序列测定，从分子水平确定其型别，并与广州市历年同型DEN流行株及相关国际流行株进行同源性比较，构建系统进化树，... 详细信息

登革病毒（DEN）E蛋白在病毒与宿主细胞融合和诱导机体产生抗体等过程中发挥重要作用[1]。本研究通过对分离株E基因全序列测定，从分子水平确定其型别，并与广州市历年同型DEN流行株及相关国际流行株进行同源性比较，构建系统进化树，追踪其可能输入来源。

关键词： 4型登革病毒 E基因