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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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The intrinsic nature of materials failure and the global non-equilibrium energy criterion

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Science China(Physics,Mechanics & Astronomy) 2020年第12期63卷 80-91页

作者： biao Wang School of Physics and Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityGuangzhou 510275China

Materials failure under some sort of loading is a well-known natural phenomenon,and the reliable prediction of materials failure is the most important key issue for many different kinds of engineering structures based on their safety *** this research,instead of establishing empirical models,the material failure process was modeled as a nonequilibrium process based on the microstructural ***,the evolution equations were established and the stability analysis was carried out to obtain the critical conditions for the materials *** was found that the material strength was a global property in nature,and the commonly used local criteria based on the most dangerous point failure were not the rational *** on the idea,some examples were considered,such as the size effect of the material strength,the strength of the polycrystalline metals,the stress-strain relationship of the ultrafine crystalline metal with nanoscale growth twins,the strength of lithium niobite crystal specimens with *** of the theoretical predictions gave reasonable results compared with the experimental data.

关键词： strength theory nonequilibrium thermodynamics stability analysis size effect nanomaterials

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富血小板血浆促进创面愈合的细胞和分子机制

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中国组织工程研究 2025年第13期29卷 2793-2801页

作者：龙晨艳程飚田举广东医科大学第一临床医学院广东省湛江市524000 广东医科大学中山市人民医院烧伤整形美容科广东省中山市528400 南部战区总医院烧伤整形科广东省广州市510030

背景:尽管富血小板血浆在促进创面愈合方面显示出治疗潜力,但其临床应用仍需要进一步的研究和验证。此外,对于富血小板血浆作用的机制仍存在一些争议和不确定性。目的:通过对富血小板血浆促进创面愈合的机制进行概述和分析,以增进对该... 详细信息

背景:尽管富血小板血浆在促进创面愈合方面显示出治疗潜力,但其临床应用仍需要进一步的研究和验证。此外,对于富血小板血浆作用的机制仍存在一些争议和不确定性。目的:通过对富血小板血浆促进创面愈合的机制进行概述和分析,以增进对该治疗方法的理解,为未来的基础研究和临床应用提供有益的指导。方法:在中国知网、PubMed数据库检索2000年1月至2023年12月发表的相关文献。英文检索词为“platelet rich plasma,PRP,wound,wound healing,refractory wounds,chronic wounds,cellular and molecular mechanisms,signaling pathways,regenerative medicine”,中文检索词为“富血小板血浆,PRP,创面,伤口,创面愈合,难愈性创面,慢性创面,细胞和分子机制,信号通路,再生医学”。根据纳入和排除标准,最终对80篇文献进行综述。结果与结论:①富血小板血浆在创面愈合中具有许多潜在的优势,它能够提供丰富的生长因子和细胞因子等生物活性物质;②富血小板血浆可以调节参与创面愈合的各种细胞类型的功能,包括表皮细胞、血管内皮细胞、成纤维细胞、干细胞和炎症细胞等;③在富血小板血浆疗法中,细胞外囊泡、线粒体对于创面愈合可能扮演着重要角色;④负载富血小板血浆水凝胶可广泛用于增强组织再生和作为药物传递的功能性载体;⑤富血小板血浆对创面细胞外基质合成和降解起调节作用,从而影响伤口愈合过程中基质重建;⑥富血小板血浆可能通过动态调节多种信号通路和上皮间质转化来影响组织修复与再生,从而为创面愈合的研究提供了全新的视角。

关键词：富血小板血浆生长因子创面愈合细胞和分子机制信号通路再生医学

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Effect of interface debonding on matrix multicracking evolution of fiber-reinfroced ceramic-matrix composites

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航空动力学报 2016年第3期31卷 527-538页

作者： LI Long-biao College of Civil Aviation Nanjing University of Aeronautics and Astronautics

An analytical methodology was developed to investigate the effect of fiber/matrix interface debonding on matrix multicracking evolution of fiber-reinforced CMCs(ceramic-matrix composites).The Budiansky-Hutchinson-Evans shear-lag model was adopted to analyse the micro-stress field of the damaged *** critical matrix strain energy criterion,which presupposes the existence of an ultimate or critical matrix strain energy with matrix,was obtained to simulate the matrix multicracking evolution of *** the increase of the applied stress,the matrix multicracking and fiber/matrix interface debonding occurred to dissipate the additional energy entered into the *** fiber/matrix interface debonded length under matrix multicracking evolution was obtained by treating the interface debonding as a particular crack propagation *** conditions for no-debonding and debonding during the evolution of matrix multicracking were discussed in terms of two interfacial properties,i.e.,the interface shear stress and interface debonded *** the fiber/matrix interface was bonded,the matrix multicracking evolution was much more intense compared with the interface debonding;when the fiber/matrix interface was debonded,the matrix crack density increased with the increasing of interface shear stress and interface debonded *** theoretical results were compared with experimental data of unidirectional SiC/CAS(calcium alumina silicate),SiC/CAS-Ⅱand SiC/borosilicate composites.

关键词： ceramic-matrix composites(CMCs) matrix cracking interface debonding micromechanics critical matrix strain energy

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Topological invariants for anomalous Floquet higher-order topological insulators

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Frontiers of physics 2023年第1期18卷 47-62页

作者： biao Huang Kavli Institute for Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China

We review the recent development in constructing higher-order topological band insulators under strong periodic *** particular,we focus on various approaches in formulating the anomalous Floquet topological invariants... 详细信息

关键词： topological Floquet higher-order

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A review of numerical analyses and experimental characterization methods for forming of textile reinforcements

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Chinese Journal of Aeronautics 2021年第8期34卷 143-163页

作者： biao LIANG Philippe BOISSE School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Universitede Lyon CNRSINSA-LyonLaMCoSF69621France

The forming of textile reinforcements is an important stage in the manufacturing of textile composite parts with Liquid Composite Molding *** orientations and part geometry obtained from this stage have significant impact on the subsequent resin injection and final mechanical properties of composite *** simulation of textile reinforcement forming is in strong demand as it can greatly reduce the time and cost in the determination of the optimized processing parameters,which is the foundation of the low-cost application of composite *** review presents the state of the art of forming modeling methods for textile reinforcement and the corresponding experimental characterization methods developed in this *** microscopic,mesoscopic and macroscopic models are *** concerning the simulation of wrinkling are also presented since it is the most common defect occurred in the textile reinforcement ***,challenges and recommendations on the future research directions for textile reinforcement modeling and experimental characterization are provided.

关键词： Experimental characterization Forming Liquid Composite Molding Numerical analysis Textile reinforcements

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A Generalized Method and Exact Solutions in Bose-Einstein Condensates in an Expulsive Parabolic Potential

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Communications in Theoretical Physics 2007年第3X期48卷 391-398页

作者： LI biao Nonlinear Science Center and Department of Mathematics Ningbo University Ningbo 315211 China Institute of Theoretical Computing East China Normal University Shanghai 200062 China MM Key Lab the Chinese Academy of Sciences Beijing 100080 China

In the paper, a generalized sub-equation method is presented to construct some exact analytical solutions of nonlinear partial differential equations. Making use of the method, we present rich exact analytical solutions of the onedimensional nonlinear Schrfdinger equation which describes the dynamics of solitons in Bose-Einstein condensates with time-dependent atomic scattering length in an expulsive parabolic potential. The solutions obtained include not only non-traveling wave and coefficient function＇s soliton solutions, but also Jacobi elliptic function solutions and *** elliptic function solutions. Some plots are given to demonstrate the properties of some exact solutions under the Feshbachmanaged nonlinear coefficient and the hyperbolic secant function coefficient.

关键词： nonlinear Schrodinger equation symbolic computation soliton

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Influence of nonlinear spatial distribution of stress and strain on solving problems of solid mechanics

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Applied Mathematics and Mechanics(English Edition) 2022年第9期43卷 1355-1366页

作者： Chunyu ZHANG biao WANG Sino-French institute of nuclear engineering and technology Sun Yat-Sen University ZhuhaiGuangzhou 519082China

The stress and the strain should be defined as statistical variables averaged over the representative volume elements for any real continuum *** is shown that their nonlinear spatial distributions undermine the classical framework of solid mechanics and may cause non-ignorable errors to the *** considering the high-order gradients of the stress and the strain,a two-step solution scheme is proposed to compensate for the *** a revisit to three simple but typical problems,i.e.,the hole size-dependence of the fracture strength of perforated plates,the indentation depth-dependence of the measured elastic modulus by micro-indentation tests,and the tensile necking of metallic materials as well as hyperelastic materials,the effect of the nonlinear spatial distribution of stress and strain on solving these problems is *** observed size effect and the instability of deformation can be quantitatively explained if the effect is properly considered by the proposed method.

关键词： nonlinear spatial distribution homogenization error high-order gradient size effect

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Tribology behavior on scratch tests: Effects of yield strength

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Friction 2017年第1期5卷 108-114页

作者： biao FENG Theoretical Division Los Alamos National Laboratory Los Alamos New Mexico 87544 USA

A three-dimensional (3D) scratch model is proposed to investigate the effects of yield strength of both coatings and *** the help of combined Coulomb and plastic friction,the obtained results comprehensively interpret the experimental phenomena in most metals that with the growth of hardness after heat treatment the scratch friction coefficient (SFC) *** interpretation could not be done *** tests on the surface with or without the coating are *** the coating the SFC increases due to the decrease of the area with plastic slippage and/or the increase of friction stress during the increase of the yield strength in the *** a softer substrate the friction stress decreases but the SFC increases,which is caused by the growth of the entire contact area and surface ***,with a stronger substrate the SFC decreases due to an intensified plastic *** obtained results pave a new way to understanding the effects of yield strength on scratch tests,interpret experimental phenomena,and should be helpful for an optimum design in experiments.

关键词： tribology behavior yield strength coating scratch finite element method

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同辈心理健康病耻感量表中文版测评中学生的效度与信度

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中国心理卫生杂志 2025年第1期39卷 63-67页

作者：彭彪韩雪王慧杨棋凯罗杰长沙民政职业技术学院马克思主义学院长沙410004 贵州医科大学马克思主义学院贵阳550025 贵州师范大学附属中学贵阳550001 清镇市广大实验学校贵阳551499 岳阳市康复医院精神科湖南岳阳414022 贵州师范大学心理学院贵阳550025

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其... 详细信息

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其中87名中学生进行重测;另外选取259名中学生(样本3),采用抑郁症病耻感量表(DSS)、专业心理支持求助态度量表简版(ATSPPHSF)进行效标效度检验。结果:探索性因子分析共提取出2个公因子,命名为病耻感意识、病耻感认同,累计方差贡献率为66.86%;验证性因子分析表明2因子模型拟合指数较好(χ~2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07);PMHSS-R中文版得分与DSS得分正相关(ICC=0.58,P<0.01),与ATSPPH-SF得分负相关(ICC=-0.40,P<0.01);总量表及2个因子的Cronbachα系数分别为0.90、0.92和0.85,重测信度(ICC)分别为0.84、0.76和0.78。结论:同辈心理健康病耻感量表(PMHSS-R)中文版评估中学生的心理健康病耻感具有良好效度与信度。

关键词：心理健康病耻感效度信度中学生

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