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Degradation Rate Assessment of Biodegradable Magnesium Alloys

Materials Sciences and Applications 2024年第8期15卷 245-252页

作者： bianmei cao Limei cao David F. Kallmes Department of Radiology Mayo Clinic Rochester MN USA National Institutes for Food and Drug Control Beijing China

Biodegradable magnesium alloys have been widely used in medical implants. But safety concerns were put forward for the high degradation rate of biodegradable magnesium alloy. The optimal biodegradable magnesium alloys that give rise to the desired degradation rate hasn’t yet to be defined. Assessing the degradation rate of biodegradable magnesium alloys involves in vitro testing, in vivo testing, numerical modeling, understanding the factors influencing their degradation in physiological environments, biocompatibility testing, and clinical studies. It is important to standardize analytical tools aimed at assessing the degradation rate of biodegradable magnesium alloys. It is advisable to identify the threshold for safe degradation rate of biodegradable magnesium alloys in biomedical applications.

关键词： Magnesium Alloys Biomedical Application Biodegradation Degradation Rate Biocompatibility

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Cupric ion release and cytotoxicity for Yuangong Cu-IUDs and the release behavior of indomethacin for medicated 220 Cu-IUD

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Chinese Science Bulletin 2009年第18期54卷 3160-3166页

作者： cao bianmei XI TingFei ZHENG YuDong YANG LiFeng ZHENG Qi School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China National Institute for the Control of Pharmaceutical & Biological Products Beijing 100050 China Shenzhen Institute of Peking University Shenzhen 518057 China Wenzhou Medical College Wenzhou 325035 China

These years Yuangong copper-bearing intrauterine devices (Cu-IUDs) have been used because of less side effects in use. The corrosion of copper is essential to the success of contraception, and the release behavior of indomethacin from medicated Cu-IUD is related to its therapeutic effect. In this study, analytical methods were established to investigate the release behavior of cupric ion of three kinds of Yuangong Cu-IUDs and indomethacin of medicated Yuangong 220 Cu-IUD. Cu-IUDs were incubated in simulated uterine solution (SUS). The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption spectrometer (FAAS) for 60 days and UV/vis ?3310 spectrophotometer for 60 days, respectively. The morphology of copper after corrosion was characterized by SEM. In addition, we detected cytotoxicity by MTT of L929 mouse fibroblasts cells caused by extracts of the three Yuangong Cu-IUDs. The release behavior of cupric ion for three kinds of Yuangong Cu-IUDs was biphasic, which consisted of the initial burst release and then slow and constant release. In vitro release experiment confirmed a biphasic release of indomethacin from Yuangong 220. The copper wire of Yuangong Cu-IUDs showed uneven corrosion. The RGR value of Yuangong 365 Cu-IUD was smaller than that of medicated Yuangong 220 Cu-IUD and RGR value of medicated Yuangong 220 Cu-IUD was smaller than that of Yuangong 300 Cu-IUD. The cupric ion release and indomethacin release showed biphasic. Indomethacin increased the cupric ion release rate and might diminish the adverse effects caused by burst release of cupric ion. The toxicity grade of these three Yuangong Cu-IUDs was 4. We should canvass the adverse events of Cu-IUDs based on practical experiments, and try our best to reduce the toxicity of Cu-IUDs.

关键词：宫内节育器铜离子释放行为吲哚美辛细胞毒性避孕

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不同含铜宫内节育器在模拟宫腔液中的铜离子释放研究

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中国药事 2012年第1期26卷 22-24,34页

作者：曹变梅奚廷斐北京市医疗器械检验所北京100120 北京科技大学材料科学与工程学院中国食品药品检定研究院北京大学深圳研究生院

目的测定不同含铜宫内节育器在模拟宫腔液中的铜离子释放,进而拟合出铜离子的释放方程。方法采用火焰原子吸收法测定铜,并对测定方法进行了方法学考察。利用Excel趋势回归分析预测铜离子的释放。结果 TCu220C-IUD的时间与铜离子释放呈... 详细信息

目的测定不同含铜宫内节育器在模拟宫腔液中的铜离子释放,进而拟合出铜离子的释放方程。方法采用火焰原子吸收法测定铜,并对测定方法进行了方法学考察。利用Excel趋势回归分析预测铜离子的释放。结果 TCu220C-IUD的时间与铜离子释放呈指数函数回归关系,其他宫内节育器的时间与铜离子释放呈幂函数回归关系。铜离子释放量的变化受观测值的变化影响所占比例为94.21%～98.07%。结论运用火焰原子吸收法及Excel回归分析可得出各种含铜宫内节育器的铜离子的释放。TCu380A-IUD的铜离子的暴释现象最严重。

关键词：含铜宫内节育器模拟宫腔液铜离子释放

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