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DNA fragmentation in two cytometric sperm populations： relationship with clinical and ultrasound characteristics of the male genital tract

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Asian Journal of Andrology 2017年第3期19卷 272-279页

作者： Francesco Lotti Lara Tamburrino Sara Marchiani Elisa Maseroli Pasquale Vitale Gianni Forti Monica Muratori Mario Maggi elisabetta Baldi Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical Sciences Center of Excellence DeNothe University of FlorenceViale Pieraccini 6 1-50036 Florence Italy.

We investigated whether DNA fragmentation in two cytometric sperm populations （PIddimmer and PIbriehter） with different biological characteristics and clinical relevance is related to clinical and color-Doppler ultrasound （CDUS） parameters of the male genital tract. One hundred and sixty males of infertile couples without genetic abnormalities were evaluated for clinical, scrotal, and transrectal CDUS characteristics, presence of prostatitis-like symptoms （with the National Institutes of Health-Chronic Prostatitis Symptom Index） and sperm DNA fragmentation （sDF） in PIdimmer and PIbrighter populations （using TUNEIJPI method coupled with flow cytometry）. Data were adjusted for age （Model 1） along with waistline, testosterone levels, smoking habit, and sexual abstinence （Model 2）. According to the statistical Model 2, PIdi sDF was associated with testicular abnormalities, including lower clinical and ultrasound volume （r = -0.21 and r = -0.20, respectively; P 〈 0.05）, higher FSH levels （r = 0.34, P 〈 0.0001） and occurrence of testicular inhomogeneity （P 〈 0.05） and hypoechogenicity （P 〈 0.05）. PIbrighter sDF was associated with prostate-related symptoms and abnormal signs, including higher NIH-CPSI total and subdomain scores, a higher prevalence of prostatitis-like symptoms and of CDUS alterations such as macro-calcifications, severe echo-texture inhomogeneity, hyperemia （all P 〈 0.05）, and higher arterial peak systolic velocity （r = 0.25, P 〈 0.05）. Our results suggest that DNA fragmentation in PIdimmer sperm, which is related to poor semen quality, mainly originates in the testicles, likely due to apoptosis. Conversely, DNA fragmentation in PIbrighter sperm appears to mainly originate during or after transit through the prostate, increasing with the presence of an inflammatory status of the organ. These results could lead to new perspectives for the identification of therapeutic targets to reduce sDF.

关键词： color-Doppler ultrasonography DNA fragmentation male infertility male sex organs spermatozoa

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A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2

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Cancer Communications 2022年第9期42卷 892-896页

作者： Emanuele Vitale elisabetta Sauta Mila Gugnoni Federica Torricelli Veronica Manicardi Alessia Ciarrocchi Laboratory of Translational Research Azienda Unità Sanitaria Locale-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModena 41121Italy Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPavia 27100Italy

Dear Editor Aberrant gene expression sustains massive proliferation and stress adaptation under the regulation of oncogenic transcription factors(TFs)whose binding across the genome orchestrates in space and time *** dependency defines the addiction of cancer cells to TFs on top of the regulatory hierarchy governing cancer dysregulated programs[1].These factors and their dependent mechanisms are an attractive and unexplored reservoir of potential targets for new anticancer ***,while the transcriptional landscape of many cancer-supportive TFs has been revealed,this information remains purely descriptive and confined to in vitro *** foster transferability,new approaches that integrate clinical data into the transcriptional networks are needed.

关键词： addiction modal reservoir

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Commentary on “Will male semen quality improve with environmental quality?”

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Asian Journal of Andrology 2023年第2期25卷 286-286页

作者： elisabetta Tosti Department of Biology and Evolution of Marine Organisms Stazione Zoologica Anton DohrnNaples 80121Italy

The adverse effect of environmental pollution,climate change,and bad lifestyles on human reproductive fitness and health is reported in a large body of literature and is a matter of attention from the scientific community and governments all over the *** several reproductive processes from gametogenesis up to embryo and fetal development are affected by a variety of environmental stressors,most of the data available in the literature are related to sperm physiology and quality.1 I read with interests the article by Dai et al.2 that reports an improvement of sperm quality along with environmental quality in Wenzhou,a highly populated area in the south of Zhejiang province,coastal eastern China.

关键词： China. coastal pollution

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Management Accounting as a Science： From Costs and Benefits Analysis of Productions to Strategic Planning of Uncertainty

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Journal of Modern Accounting and Auditing 2016年第12期12卷 577-581页

作者： elisabetta Mafrolla University of Foggia Foggia Italy

This article discusses the role assumed by management accounting as a discipline over years. Management accounting has long lived in the shadow of financial accounting, and has been often accused of fostering productivity rather than creativity. The revolution involving the business environment in the last decades has much improved the role of creativity and innovation and the adaptability of the fn-m to the context often was a key to success. This article supports the innovative role of management accounting in the post-modem era, aimed at reducing the strategic dominance of the increasing uncertainty.

关键词： management accounting strategic planning history of accounting innovation uncertainty

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“The City Is the Best Teacher”: A Review of the Educating City in Europe and China

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China City Planning Review 2019年第2期28卷 35-43页

作者： elisabetta Patrizi Xu Zhuqing Fabrizio d’Aniello Stefano Polenta Department of Science Education Cultural Heritage and Tourism Macerata UniversityMacerata Italy Chinese Academy of Science and Technology for Development (CASTED) Beijing P. R.

The Athenians thought that a city, understood as a community made up of people with different needs and potential, had the primary task of educating its citizens, in order to favour their harmonious integration in the polis and their active participation in the polis’ *** this cultural perspective, admirably synthesized by Plutarch through the expression 'the city is the best teacher,' we can trace the roots of the current concept of the educating *** article aims to explore the various dimensions of the educating city concept, by demonstrating, how only cities that are able to activate different educational processes(formal and informal) can be authentic vehicles of social *** this direction, the city, on the one hand, can realize every person’s potential, abilities, and rights to the lifelong education;on the other hand, the city can promote the community identity itself, as well as the self-construction of the sense of ***, also through innovative conceptual proposals for overcoming the relational and aesthetic poverty of the metropolis form of the contemporary city, fosters the perception of the city as a highly complex living organism.

关键词： educating city lifelong education extra-scholastic spaces social integration metropolis form

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Complete pathological response in locally advanced non-small-cell lung cancer patient: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5540-5546页

作者： elisabetta Parisi Donatella Arpa Giuglia Ghigi Simona Micheletti Elisa Neri Luca Tontini Martina Pieri Antonino Romeo Radiotherapy Unit IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori(IRST)"Dino Amadori"Meldola 47014Italy

BACKGROUND Chemotherapy and radiotherapy followed by durvalumab is currently the standard treatment for locally advanced node-positive non-small-cell lung cancer(NSCLC).We describe the case of a patient with locally advanced node-positive NSCLC(LA-NSCLC)treated in a phase II prospective protocol with chemotherapy,accelerated hypofractionated radiotherapy(AHRT)and surgery in the preimmunotherapy *** SUMMARY A 69-year-old male,ex-smoker(20 PY),with a Karnofsky performance status of 90,was diagnosed with locally advanced squamous cell lung *** was staged by total body computed tomography(CT)scanning,and integrated 18Ffluorodeoxyglucose positron emission tomography/CT scan[cT4 cN3 cM0,stage IIIC according to TNM(tumor-node-metastasis)8th edition]and received AHRT between chemotherapy cycles,in accordance with the study protocol(EudractCT registration 2008-006525-14).At the end of the study the patient underwent surgery,which was not part of the protocol,and showed a complete pathological *** This case report confirms that AHRT can be used successfully to treat primary LA-NSCLC with bilateral mediastinal lymph node *** case is of particular interest because of the pathological response after AHRT and the lack of surgical *** hypothesize that this radiotherapeutic approach,with its proven efficacy,could be delivered as a short course reducing treatment costs,increasing patient compliance and reducing *** are currently investigating the possibility of combining hypofractionation,chemotherapy and immunotherapy for patients with LA-NSCLC.

关键词： Locally advanced non-small-cell lung cancer Hypofractionated radiotherapy Chemoradiotherapy Complete pathological response Immunotherapy Case report

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Axon degeneration： make the Schwann cell great again

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Neural Regeneration Research 2017年第4期12卷 518-524页

作者： Keit Men Wong elisabetta Babetto Bogdan Beirowski Hunter James Kelly Research Institute Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Department of Biochemistry Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA

Axonal degeneration is a pivotal feature of many neurodegenerative conditions and substantially accounts for neurological morbidity. A widely used experimental model to study the mechanisms of axonal degeneration is Wallerian degeneration （WD）, which occurs after acute axonal injury. In the peripheral nervous system （PNS）, WD is characterized by swift dismantling and clearance of injured axons with their myelin sheaths. This is a prerequisite for successful axonal regeneration. In the central nervous system （CNS）, WD is much slower, which significantly contributes to failed axonal regeneration. Although it is well documented that Schwann cells （SCs） have a critical role in the regenerative potential of the PNS, to date we have only scarce knowledge as to how SCs ＇sense＇ axonal injury and immediately respond to it. In this regard, it remains unknown as to whether SCs play the role of a passive bystander or an active director during the execution of the highly orchestrated disintegration program of axons. Older reports, together with more recent studies, suggest that SCs mount dynamic injury responses minutes after axonal injury, long before axonal breakdown occurs. The swift SC response to axonal injury could play either a pro degenerative role, or alternatively a supportive role, to the integrity of distressed axons that have not yet committed to degenerate. Indeed, supporting the latter concept, recent 昀ndings in a chronic PNS neurodegeneration model indicate that deactivation of a key molecule promoting SC injury responses exacerbates axonal loss. If this holds true in a broader spectrum of conditions, it may provide the grounds for the development of new glia-centric therapeutic approaches to counteract axonal loss.

关键词： Wallerian degeneration neurodegeneration glia oligodendrocytes myelin dedifferentiation

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Cognitive correlates of neuroimaging abnormalities in the onset of schizophrenia: A case report

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World Journal of Psychiatry 2017年第2期7卷 128-132页

作者： Silvia Grassi Giulia Orsenigo Marta Serati elisabetta Caletti Alfredo Carlo Altamura Massimiliano Buoli Department of Psychiatry University of Milan Fondazione IRCCS Ospedale Maggiore Policlinico

Increasing evidence shows that cognitive impairment and brain abnormalities can appear early in the first episodes of schizophrenia, but it is currently debated how brain changes can correlate with clinical presentation of schizophrenic patients. Of note, this report describes the case of a young schizophrenic male presenting parietal magnetic resonance/positron emission tomography abnormalities and cognitive impairment, documented by specific neuropsychological tests. In our knowledge only few studies have investigated if neuropsychological abnormalities could be concomitant with both structural and functional neuroimaging. This case shows that impairment in specific cognitive domains is associated with structural/functional brain abnormalities in the corresponding brain areas(frontal and parietal lobes), supporting the hypothesis of disconnectivity, involving a failure to integrate anatomical and functional pathways. Future research would define the role of cognitive impairment and neurodegeneration in psychiatric nosography and, in particular, their role in the early phases of illness and long-term outcome of schizophrenic patients.

关键词： Positron emission tomography Magnetic resonance Schizophrenia Neuropsychology

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Role of nutritional ketosis in the improvement of metabolic parameters following bariatric surgery

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World Journal of Diabetes 2022年第1期13卷 54-64页

作者： Fioralba Pindozzi Carlo Socci Massimiliano Bissolati Monica Marchi elisabetta Devecchi Alessandro Saibene Caterina Conte Unitàdi Chirurgia Generale Provinciale Ospedale del DeltaLagosanto(FE)44023Italy Transplant and Metabolic/Bariatric Surgery Unit IRCCS Ospedale San RaffaeleMilan 20132Italy Department of General Medicine Diabetes and EndocrinologyIRCCS Ospedale San RaffaeleMilan 20132Italy Department of Human Sciences and Promotion of the Quality of Life San Raffaele Open UniversityRome 00166Italy Department of Endocrinology Nutrition and Metabolic DiseasesIRCCS MultiMedicaMilan 20099Italy

BACKGROUND Ketone bodies(KB)might act as potential metabolic modulators besides serving as energy *** metabolic surgery(BMS)offers a unique opportunity to study nutritional ketosis,as acute postoperative caloric restriction leads to increased lipolysis and circulating free fatty *** To characterize the relationship between KB production,weight loss(WL)and metabolic changes following *** For this retrospective study we enrolled male and female subjects aged 18-65 years who underwent BMS at a single *** on demographics,anthropometrics,body composition,laboratory values and urinary KB were *** Thirty-nine patients had data available for analyses[74.4%women,mean age 46.5±9.0 years,median body mass index 41.0(38.5;45.4)kg/m^(2),fat mass 45.2%±6.2%,23.1%had diabetes,43.6%arterial hypertension and 74.4%liver steatosis].At 46.0±13.6 d post-surgery,subjects had lost 12.0%±3.6%of pre-operative ***-nine percent developed *** with nutritional ketosis were significantly younger[42.9(37.6;50.7)years vs 51.9(48.3;59.9)years,P=0.018],and had significantly lower fasting glucose[89.5(82.5;96.3)mg/dL vs 96.0(91.0;105.3)mg/dL,P=0.025]and triglyceride levels[108.0(84.5;152.5)mg/dL vs 152.0(124.0;186.0)mg/dL,P=0.045]vs those with *** 6 mo,percent WL was greater in those with postoperative ketosis(-27.5%±5.1%vs 23.8%±4.3%,P=0.035).Urinary KBs correlated with percent WL at 6 and 12 *** metabolic changes were *** Our data support the hypothesis that subjects with worse metabolic status have reduced ketogenic capacity and,thereby,exhibit a lower WL following BMS.

关键词： Obesity Ketone bodies Bariatric surgery Weight loss Glucose metabolism Lipid metabolism

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Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis:a systematic review and meta-analysis

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World Journal of Hepatology 2017年第6期9卷 333-342页

作者： Sirio Fiorino Maria Letizia Bacchi-Reggiani Paolo Leandri elisabetta Loggi Pietro Andreone Unità Operativa di Medicina Interna C Ospedale Maggiore Unità Operativa Malattie Cardiovascolari Azienda Ospedaliero Universitaria di BolognaPoliclinico Sant’Orsola-Malpighi Dipartimento di Scienze Mediche e Chirurgiche Azienda Ospedaliero Universitaria di BolognaPoliclinico Sant’Orsola-Malpighi

AIM To assess vitamin E efficacy,defined as its ability to induce hepatitis B e antigen(HBeAg) seroconversion,in children with HBeAg-positive persistent *** In July 2016,we extracted articles published in MEDLINE and the Cochrane Library using the following search terms:"chronic hepatitis B","children","childhood","therapy","treatment","vitamin E","tocopherols","tocotrienols".Only randomized controlled trials(RCTs) published in English language were *** Three RCTs met inclusion criteria and were considered in the present ***,23/122 children in the treatment group underwent HBeAg seroconversion vs 3/74 in the control group(OR=3.96,95%CI:1.18-13.25,P=0.025).CONCLUSION Although our meta-analysis has several limits,including the very small number of available studies and enrolled children with HBeAg positivity-related hepatitis,it suggests that vitamin E use may enhance the probability to induce HBeAg seroconversion in these *** well designed and adequately sized trials are required to confirm or deny these very preliminary results.

关键词： Hepatitis B Pediatric hepatology Viral hepatitis Immunology

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