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Asian Journal of Andrology 2019年第2期21卷 201-207页

作者： Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio bianca M Gregorio Urogenital Research Unit Biomedical CenterState University of Rio de JaneiroRio de Janeiro 20551-030Brazil

High-fat diets affect male reproduction and sexual ***,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria *** Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)*** 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 *** were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further *** were analyzed by one-way ANOVA,and P<0.05 was considered statistically *** CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C ***,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis.

关键词： cafeteria diet morphology resveratrol spermatozoa testicle

Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases

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World Journal of Gastroenterology 2006年第41期12卷 6627-6633页

作者： Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina weber bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling Department of General- Visceral-Vascular-and Paediatric SurgeryUniversity of the SaarlandHomburg/Saar 66421Germany Institute of Pathology University of the SaarlandHomburg/Saar 66421Germany Institute of Medical Biometrics Epidemiologyand Medical InformaticsUniversity of the SaarlandHomburg/ Saar 66421Germany

AIM： To evaluate and compare the expression profiles of CXCL12 （SDF-1）, CCL19 （MIP-3β）, CCL20 （MIP-3a） and CCL21 （6Ckine, Exodus2） and their receptors on RNA and protein levels in hepatocellular carcinoma （HCC） versus colorectal liver metastases （CRLM） and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS： Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent nontumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS： Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up-regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION： Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up-regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies.

关键词： Chemokines Chemokine receptors Gene expression Hepatocellular carcinoma Colorectal liver metastases

Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis

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World Journal of Stem Cells 2021年第1期13卷 30-48页

作者： Irene Rosa Eloisa Romano bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti Department of Experimental and Clinical Medicine Section of Anatomy and HistologyUniversity of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine Division of RheumatologyUniversity of FlorenceFlorence 50134Italy

Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular *** preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc ***,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition ***,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy *** light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis.

关键词： Systemic sclerosis Adipose-derived stromal vascular fraction Adiposederived stem cells Therapeutic approaches Pathogenesis Adipocyte-to-myofibroblast transition

Antibiotic resistance assessment in bacteria isolated in migratory Passeriformes transiting through the Metaponto territory(Basilicata,Italy)

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Avian Research 2017年第4期8卷 255-265页

作者： Maria Foti Antonietta Mascetti Vittorio Fisichella Egidio Fulco bianca Maria Orlandella Francesco Lo Piccolo Department of Veterinary Sciences University of MessinaPolo Universitario dell’Annunziata98168 MessinaItaly Naturalistic Study Milvus Pantano Street 13485010 PignolaPZItaly

Background: Wild birds are considered to be reservoirs of human enteric pathogens and vectors of antimicrobial resistance dissemination in the *** their annual migration,they play a potential role in the epidemiology of human associated *** aim of this study was to investigate the frequency of isolation and antimicrobial susceptibility profiles of microorganisms found in the cloaca of common European ***: One hundred and twenty-one cloacal swabs were collected during a monitoring program of migratory birds in the Forest Reserve for Protection "Metaponto"(Basilicata,Italy).All samples were cultured using standard bacteriological methods and antibiotic susceptibility testing(agar disk diffusion test) of isolated strains was ***: The bacteriological analysis produced 122 strains belonging to 18 different *** most commonly isolated species were Enterobacter cloacae and Providencia rettgeri(21 strains,17.2%).Potentially pathogenic species including Klebsiella pneumoniae,Serratia marcescens and Pseudomonas *** also been *** showed significant frequencies of antimicrobial *** highest frequency of resistance was observed against amoxicillin(n = 79,64.8%);ampicillin(n = 77,63.1%);rifampicin(n Thirty-one strains(25.4%) showed resistance to imipenem a= 75,61.5%);amoxicillin–clavulanic acid(n nd 8(6.6%) to meropenem.= 66,54.1%).Conclusions: Migratory birds play an important role in the ecology,circulation and dissemination of potentially pathogenic antimicrobial resistant *** can therefore be considered sentinel species and environmental health *** results suggest that the integration of epidemiological surveillance networks during ringing campaigns of wild species can be an effective tool to study this phenomenon.

关键词： Passeriformes Cloacal swabs Bacteriological test Antimicrobial resistance

A review of enhanced oil recovery(EOR)methods applied in Kazakhstan

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Petroleum 2021年第1期7卷 1-9页

作者： bianca Anne Bealessio Natalia ABlanquez Alonso Nicholas John Mendes Anna Vladimirovna Sande Berna Hascakir Petroleum Engineering Department Texas A&M UniversityUnited States

Application of enhanced oil recovery methods in Kazakhstan has been ongoing for decades alongside the continued discovery of new oil and gas fields in the Pre-Caspian *** objective of this review is to provide an overview of the hydrocarbon reserves and production,and the status of the petroleum industry in Kazakhstan,with a focus on the EOR methods and projects being applied to recover those reserves.A summary of the specific EOR methods in use was prepared,and existing enhanced recovery projects in Kazakhstan were reviewed and their successes and challenges were *** performance of these projects in the context of EOR performance indicators such as capillary number and mobility ratio,as well as operational and environmental issues,were *** for current and potential applications of EOR in Kazakhstan were also *** widespread application of thermal EOR methods,in use for decades in Kazakhstan’s older fields,was found to be successful,with very favorable impacts on mobility ratio from the addition of thermal energy to the *** EOR methods in Kazakhstan have had more limited success,with some significant challenges due to high concentration of hydrogen sulfide in the injected *** injection started in the late 1960s,achieving good results.A recent polymer injection pilot project has shown some promise,with a favorable impact on mobility ratio and oil production,although the project has not yet been expanded beyond two polymer *** results indicate the huge potential of existing and future EOR *** review is the first compilation of Kazakhstan’s existing oil and gas reserves,production,and EOR project performance,and should be seen as a guide to the existing applications of EOR methods in Kazakhstan.

关键词： Kazakhstan Thermal EOR Sour gas injection Polymer flooding

Biliary complications after liver transplantation:current perspectives and future strategies

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 76-92页

作者： bianca Magro Matteo Tacelli Alessandra Mazzola Filomena Conti Ciro Celsa Section of Gastroenterology and Hepatology Dipartimento di Promozione della SaluteMaterno-InfantileMedicina Interna e Specialistica di Eccellenza(PROMISE)University of PalermoPalermoItaly Service d'Hépatologie et Transplantation Hépatique Hôpital de la PitiéSalpétrièreAP-HPParisFrance

Importance:Liver transplantation(LT)is a life-saving therapy for patients with end-stage liver disease and with acute liver failure,and it is associated with excellent outcomes and survival rates at 1 and 5 *** incidence of biliary complications(BCs)after LT is reported to range from 5%to 20%,most of them occurring in the first three months,although they can occur also several years after ***:The aim of this review is to summarize the available evidences on pathophysiology,risk factors,diagnosis and therapeutic management of BCs after *** Review:a literature review was performed of papers on this topic focusing on risk factors,classifications,diagnosis and treatment Findings:Principal risk factors include surgical techniques and donor’s characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non-anastomotic biliary *** is the gold standard both for intra-and extrahepatic BCs,while invasive cholangiography should be restricted for therapeutic uses or when MRCP is *** treatment,endoscopic techniques are the first line of treatment with success rates of 70-100%.The combined success rate of ERCP and PTBD overcome 90%of *** leaks often resolve spontaneously,or with the positioning of a stent in ERCP for major bile leaks Conclusions and Relevance:BCs influence morbidity and mortality after LT,therefore further evidences are needed to identify novel possible risk factors,to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques.

关键词： Liver transplantation(LT) biliary tract diseases cholangiography cholangiopancreatography endoscopic retrograde review

The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti bianca P.Sousa Simone A.J.Rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein,Induce Apoptosis in HEp-2 and Vero Cells

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Virologica Sinica 2019年第3期34卷 262-269页

作者： Yishi Xu Carla bianca Luena Victorio Tao Meng Qiang Jia Yee-Joo Tan Kaw Bing Chua Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University Health SystemNational University of SingaporeSingapore 117545Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Institute of Molecular and Cell Biology A*STAR (Agency for ScienceTechnology and Research)Singapore 138673Singapore

Our previous work has shown that Saffold virus(SAFV)induced several rodent and primate cell lines to undergo apoptosis(Xu et *** Emerg Microb Infect 3:1-8,2014),but the essential viral proteins of SAFV involved in apoptotic activity lack *** this study,we individually transfected the viral proteins of SAFV into HEp-2 and Vero cells to assess their ability to induce apoptosis,and found that the 2B and 3C proteins are *** investigation indicated the trans-membrane domain of the 2B protein is essential for the apoptotic activity and tetramer formation of the 2B *** research provides clues for the possible mechanisms of apoptosis induced by SAFV in different cell *** also opens up new directions to study viral proteins(the 2B,3C protein),and sets the stage for future exploration of any possible link between SAFV,inclusive of its related uncultivable genotypes,and multiple sclerosis.

关键词： Saffold virus(SAFV)Apoptosis Viral proteins

消费者参与区块链技术赋能:食品安全性与消费者信任提升的新兴潘多拉效应?

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粮油食品科技 2024年第4期32卷 24-32页

作者： bianca ROTH 蔡娣(译) 斯图加特大学社会科学系德国斯图加特德国联邦风险评估研究所风险沟通部德国柏林国家粮食和物资储备局科学研究院粮食质量安全研究所

目前,食品安全治理亟需采纳涵盖消费者参与的共治模式,以应对日益复杂的食品安全挑战。企业已经部署了基于区块链技术的去中心化食品追踪系统,这一创新举措旨在通过激发消费者主动参与,显著增强他们对食品安全治理体系的信任度。本文综... 详细信息

目前,食品安全治理亟需采纳涵盖消费者参与的共治模式,以应对日益复杂的食品安全挑战。企业已经部署了基于区块链技术的去中心化食品追踪系统,这一创新举措旨在通过激发消费者主动参与,显著增强他们对食品安全治理体系的信任度。本文综合社会科学、经济学以及食品安全治理领域的跨学科理论,深入探讨了影响消费者参与度和信任度的因素。为此,着重分析了区块链技术实施在加深消费者信任方面的潜力和影响。还提出一个包含理论分析与实证研究的综合研究议程,以期为全球食品供应链中区块链技术的应用及其对消费者信任的影响提供更深理解。

关键词：食品安全消费者参与度区块链食品可追溯性信任

Effects of triggers of senescence and senolysis in murine pancreatic cancer cells

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 628-637页

作者： Denis Revskij Aline Woitas bianca Kölle Camilla Umstätter Dietmar Zechner Faiz M Khan Georg Fuellen Robert Jaster Department of MedicineⅡ Division of GastroenterologyRostock University Medical CenterRostockGermany Rudolf-Zenker-Institute of Experimental Surgery Rostock University Medical CenterRostockGermany Department of Systems Biology and Bioinformatics Institute of Computer ScienceUniversity of RostockRostockGermany Institute for Biostatistics and Informatics in Medicine and Ageing Research Rostock University Medical CenterRostockGermany

Background:The combination of senescence triggers with senolytic drugs is considered a promising new approach to cancer ***,we studied the efficacy of the genotoxic agent etoposide(Eto)and irradiation in inducing senescence of Panc02 pancreatic cancer cells,and the capability of the Bcl-2 inhibitor navitoclax(ABT-263;Nav)to trigger ***:Panc02 cells were treated with Eto or irradiated with 5–20 Gy before exposure to *** survival,proliferation,and senescence were assessed by trypan blue staining,quantification of DNA synthesis,and staining of senescence-associatedβ-galactosidase(SA-β-Gal)-positive cells,*** of mRNA were determined by real-time polymerase chain reaction,and protein expression was analyzed by ***02 cells were also grown as pancreatic tumors in mice,which were subsequently treated with Eto and ***:Eto and irradiation had an antiproliferative effect on Panc02 cells that was significantly or tendentially enhanced by *** vivo,Eto and Nav together,but not Eto alone,significantly reduced the proportion of proliferating *** expression of the senescence markerγH2AX and tumor infiltration with T-cells were not affected by the *** vitro,almost all Eto-exposed cells and a significant proportion of cells irradiated with 20 Gy were SA-β-*** of Nav reduced the percentage of SA-β-Gal-positive cells after irradiation but not after pretreatment with *** response to triggers of senescence,cultured Panc02 cells showed increased protein levels ofγH2AX and the autophagy marker LC3B-II,and higher mRNA levels of Cdkn1a,Mdm2,and PAI-1,while the effects of Nav were ***:In vitro and in vivo,the combination of senescence triggers with Nav inhibited tumor cell growth more effectively than the triggers *** data also provide some evidence for senolytic effects of Nav in vitro.

关键词： Pancreatic cancer Panc02 cells Etoposide Irradiation Navitoclax